BacMap

Definition	Azoarcus sp. BH72 chromosome, complete genome.
Accession	NC_008702
Length	4,376,040

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The map label for this gene is fabG [C]

Identifier: 119898228

GI number: 119898228

Start: 2126825

End: 2127613

Strand: Direct

Name: fabG [C]

Synonym: azo1937

Alternate gene names: 119898228

Gene position: 2126825-2127613 (Clockwise)

Preceding gene: 119898227

Following gene: 119898229

Centisome position: 48.6

GC content: 70.98

Gene sequence:

>789_bases
ATGAAGGGCCTGGACAACAAAGTCGCCATCGTCACCGGTGGCGCAACCATGATCGGCGAGGCGGTCGCGCGTGACCTGAT
CGCCCACGGCGGCCGCGTGGTGCTGGCGGACATCGACGCCGACAAGGGCGCCGCCGCGGCGGACAGGCTGGGCGCCGCCG
CCCGCTTCATCCGCACCGACGTCACCGACGATGCCGCGATCGCCGCCTGCGTGGCCGGCACCGTGGCGGCCTTCGGCGGC
GTCGACTTCCTCGTCAATTGCGCCTGCACCTACGTCGATAACGGCGCCGCCTCCACGCGCGCCGAATGGCTGCAGGCCTT
CAACGTGAATGTGGCCGGCGCGGCGATGACGCTGCAGACCTGCCGGCCGGAGATGGTCAAGCGCGGCGGCGGCGCGGTGG
TGAACTTCGCCTCCATCTCTGCCACCTCCGCCCAGGCCGGCCGCTGGCTCTACCCGATGAGCAAGGCCGCGATCCAGCAA
TTCACCCGCAGCGCCGCGCTCGACCTCGCCGCCGACCACATCCGTGTCAACTCGGTGTCGCCCGGCTGGACGTGGTCGTC
GATCATCGAAACGCTCTCCGGCGGCGACAAGGCCAAGGCCGACGAGGTCGCGGCCGACTACCACATCCTCGGTCGCCTCG
GCCTGCCCGAGGAAGTCGCCCAGGTCGTCTCCTTCCTGCTGTCCGACCACGCCAGCTTCGTCAGCGGCGCCGACTACGCC
TGCGACGGCGGCTACACCGCGCTCGGGCCGGAAGGCAGCGCCGCCGCGATCACCCGGCTGATGGCCTGA

Upstream 100 bases:

>100_bases
GGATAGGTCCAGAACGGATTCCGGATAGCCCGTCACCGGGCTGAAATGAAAACTGTGCTCCATCGACGCCGCTGCGCGTC
ACCTCAACGGAGCACAGCAG

Downstream 100 bases:

>100_bases
GACCTCCCCTTCCCTCCCCCTTCAGCAAGCATCCGCACCCATCAGGAGACTTCCATGCACCTCGCCAGCAATGCGTCCGA
AAACAAGATCACCCCGCGCA

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MKGLDNKVAIVTGGATMIGEAVARDLIAHGGRVVLADIDADKGAAAADRLGAAARFIRTDVTDDAAIAACVAGTVAAFGG
VDFLVNCACTYVDNGAASTRAEWLQAFNVNVAGAAMTLQTCRPEMVKRGGGAVVNFASISATSAQAGRWLYPMSKAAIQQ
FTRSAALDLAADHIRVNSVSPGWTWSSIIETLSGGDKAKADEVAADYHILGRLGLPEEVAQVVSFLLSDHASFVSGADYA
CDGGYTALGPEGSAAAITRLMA

Sequences:

>Translated_262_residues
MKGLDNKVAIVTGGATMIGEAVARDLIAHGGRVVLADIDADKGAAAADRLGAAARFIRTDVTDDAAIAACVAGTVAAFGG
VDFLVNCACTYVDNGAASTRAEWLQAFNVNVAGAAMTLQTCRPEMVKRGGGAVVNFASISATSAQAGRWLYPMSKAAIQQ
FTRSAALDLAADHIRVNSVSPGWTWSSIIETLSGGDKAKADEVAADYHILGRLGLPEEVAQVVSFLLSDHASFVSGADYA
CDGGYTALGPEGSAAAITRLMA
>Mature_262_residues
MKGLDNKVAIVTGGATMIGEAVARDLIAHGGRVVLADIDADKGAAAADRLGAAARFIRTDVTDDAAIAACVAGTVAAFGG
VDFLVNCACTYVDNGAASTRAEWLQAFNVNVAGAAMTLQTCRPEMVKRGGGAVVNFASISATSAQAGRWLYPMSKAAIQQ
FTRSAALDLAADHIRVNSVSPGWTWSSIIETLSGGDKAKADEVAADYHILGRLGLPEEVAQVVSFLLSDHASFVSGADYA
CDGGYTALGPEGSAAAITRLMA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=246, Percent_Identity=34.9593495934959, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=30.859375, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=33.6, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=31.25, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=29.5833333333333, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=29.8039215686275, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI126723750, Length=250, Percent_Identity=30.8, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI59889578, Length=225, Percent_Identity=30.2222222222222, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=29.6875, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI31542939, Length=200, Percent_Identity=30, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=28.90625, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI33667109, Length=184, Percent_Identity=34.7826086956522, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=27.734375, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI126723191, Length=179, Percent_Identity=33.5195530726257, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=28.0487804878049, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=31.2757201646091, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=30.3501945525292, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=31.1475409836066, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1786812, Length=195, Percent_Identity=33.8461538461538, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI2367175, Length=259, Percent_Identity=30.5019305019305, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=27.5303643724696, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=28.9156626506024, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=27.8225806451613, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787820, Length=219, Percent_Identity=25.5707762557078, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=32.1969696969697, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17555706, Length=244, Percent_Identity=31.5573770491803, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=32.9317269076305, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=30.2325581395349, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=31.6602316602317, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=29.3233082706767, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193204405, Length=273, Percent_Identity=30.03663003663, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17538480, Length=259, Percent_Identity=28.957528957529, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17565030, Length=260, Percent_Identity=30.3846153846154, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=31.0077519379845, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=29.8507462686567, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17551412, Length=273, Percent_Identity=28.9377289377289, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=28.5171102661597, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=269, Percent_Identity=28.2527881040892, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=28.0898876404494, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=272, Percent_Identity=27.9411764705882, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=258, Percent_Identity=29.8449612403101, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=27.3076923076923, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=28.6852589641434, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=258, Percent_Identity=30.2325581395349, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=268, Percent_Identity=27.6119402985075, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=29.5019157088123, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=27.8625954198473, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=144, Percent_Identity=34.0277777777778, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=28.1746031746032, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=258, Percent_Identity=26.3565891472868, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=36.71875, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=35.2713178294574, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=33.7209302325581, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=30.952380952381, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=30.0395256916996, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644337, Length=122, Percent_Identity=40.1639344262295, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24643142, Length=255, Percent_Identity=28.6274509803922, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21358495, Length=221, Percent_Identity=28.9592760180996, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26813; Mature: 26813

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLDNKVAIVTGGATMIGEAVARDLIAHGGRVVLADIDADKGAAAADRLGAAARFIRTD
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHC
VTDDAAIAACVAGTVAAFGGVDFLVNCACTYVDNGAASTRAEWLQAFNVNVAGAAMTLQT
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCHHHHHHHH
CRPEMVKRGGGAVVNFASISATSAQAGRWLYPMSKAAIQQFTRSAALDLAADHIRVNSVS
CCHHHHHCCCCCEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHEEEECCC
PGWTWSSIIETLSGGDKAKADEVAADYHILGRLGLPEEVAQVVSFLLSDHASFVSGADYA
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
CDGGYTALGPEGSAAAITRLMA
CCCCEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MKGLDNKVAIVTGGATMIGEAVARDLIAHGGRVVLADIDADKGAAAADRLGAAARFIRTD
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHC
VTDDAAIAACVAGTVAAFGGVDFLVNCACTYVDNGAASTRAEWLQAFNVNVAGAAMTLQT
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCHHHHHHHH
CRPEMVKRGGGAVVNFASISATSAQAGRWLYPMSKAAIQQFTRSAALDLAADHIRVNSVS
CCHHHHHCCCCCEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHEEEECCC
PGWTWSSIIETLSGGDKAKADEVAADYHILGRLGLPEEVAQVVSFLLSDHASFVSGADYA
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
CDGGYTALGPEGSAAAITRLMA
CCCCEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550425; 10360571 [H]