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The map label for this gene is dctB2 [H]

Identifier: 119898206

GI number: 119898206

Start: 2100821

End: 2102704

Strand: Reverse

Name: dctB2 [H]

Synonym: azo1915

Alternate gene names: 119898206

Gene position: 2102704-2100821 (Counterclockwise)

Preceding gene: 119898207

Following gene: 119898205

Centisome position: 48.05

GC content: 72.66

Gene sequence:

>1884_bases
GTGTTCAATGTCGGCCAAGGAGGAGGGCGCTTCCACCCAGTCGCCCTGACAACGATGAACATGCGGCCCCGCCTGCCGTT
TCCGACCCTGCCACGCCTCGCCCCCGCCGCGGCGCTGCCCGCGCGCTGGAAGCTGGCGCTCGCGGTACTGCTCGCGGCCC
CGCTGCTCGCCGGCATCTACCTGCACCGCTTCCAGACCGGCATCGATGAACTTGCGGCGCAGGCGCAACAGCGGCTGGCG
CTGCTGTCGGCCAGCCTCGACGCCGAGCTGCTCCGCAACGAAAGCCTGCCCACGGTGCTCGCACCGCATCCGCTGCTGAA
GGACGTGCTGCTGGGCCACGGCGGGCCGGACGCCCCGGCGCGCGCCAACGCGCTGCTGGCCGAAGTGCGCGAGCGGACCG
GCACCGGCGTCATCTACCTGATCGCGCCCTCCGGCATCACGCTGGCCGCCAGCAACTGGCGCGAGCCCGAGAGCTTCGTC
GGCGAGAACTACGGTTACCGCCCGTATTTCCGCGACGCCCTGGCCGGCCGCACCGGCATGTTCTTCGCGGTCGGCGCCAC
CACCCGCATCCCCGGCTTCTTCATTGCCCAGCCCGTGCGCGACGGTGAGCGGGTAATCGGCGTACTCGCGATCAAGGTGG
AACTGACCGGGCTGGAGAACACTTGGGCCGAGAGCGGCGAGGCGCTGCTGGTGGTCGACGGCCACGGGGTCGTCGCGCTG
TCGTCTCGCCCGCAATGGAAGTTCGCCACCCTCGGACCGCTCGGCGCTCCGTCGCGGACCACGCTCGCCGCCACCCGGCA
GTACTACACCGCCAGCCTGCAACCGCTGCCGCTGCGCTGGGACGGCGGCCAGCGCCTGACGCTGGCGGGGCGCGACTACG
CGGTCGGCGTGCGCGCGCTGCGCTGGGCAGACTGGCGCATGCTGATGCTGGTGGACACCGCGCCCGCCGCCACGGCCGCG
CGCGCGCAGGCGCTGGCGGTGGCGCTCGCGCTGTGTCTGGCCGCCATCGGCGGCCTGTTCTGGGTGCAGCGCGCACGCCG
GCTGCGCGAACGGCTGGCGGTACAGGCGATGCTGGAGGACACGGTGGCACGGCGCACCGCCGATCTCGCCGCCGCCAACG
CGCGCCTGCGCGAGGAAGTGGCGGAGCGGACTGCCGCCGAGGACAAGCTGCACAGCGCCCAGCGCGCGCTGATCGAAGCC
AACCGCCTTGCCGCGCTCGGCCAGATGGCCGCCGGCGTCGCCCACGAACTCAACCAGCCACTGCAGGCGCTGCGCGGCTT
TGCCGGCAACAGCCTGGTGTTTCTCGAACGCGGCCGGCTCGAGCCGCTGACCGACAACCTGCGCCAGATCAACGAACTGG
TGGAACGCATGGCGCGCCTCACCGCGCAGCTGAAGGTGTTCGCATCGCGCCAGCAGTCGGCCGCCGGCTCCGCCCCGGCC
GCCGCCACGCTGGCGCGCGTCGCCGGCTGGTTTGCCCCCCGCCTCGAAGCCGCCGCGATCCGCCTGGTGCAGGAGGTGAA
TGTGGAACGCCTGCCGCTCGATCCGCAGGCCCTGGAGCAGGTGGCGTCCAACCTGCTGGGCAATGCGATCGACGCACTGG
CGGGCCGCGACGGCGGCGGCCAGATCGACGTACGCGCCGGCGAGGACGAACAGGGCTGCTGGCTGGAGGTGGCCGACAAC
GGAGCGGGCATCGCCCCGGCGCTGCGCGAGAAGGTGGCGCAGCCGTTTTTCTCGACCAAGCCGCTGGGGCACGGGTTGGG
GCTCGGGCTGGCGATTGTCGGCGATTTGATCGAAGCTTCGGGCGGTAGCCTCGACATCGGCGCATCCGACGCCGGCGGGG
CGCGAATCCGCGCGTACTGGGCCCGGCCCGCCACGCGCGCCTAG

Upstream 100 bases:

>100_bases
CCGGCTTTACCGCCGACTACAGTTGGTGCCCCGACCGCGGGCACTGCGTTCCGCTGGGGGACATTCTGCCCGGCGATGGT
GGCGTGACCGAGGTCCGCGC

Downstream 100 bases:

>100_bases
GAGGAGACGAATGACTGCAATCCCGCTCCGCGTGCTCTACGTGGAGGACGATGAGGCGGTACGCATGGCCGGCTGCCAGA
CTTTTGCGCTGGCCGATCTC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MFNVGQGGGRFHPVALTTMNMRPRLPFPTLPRLAPAAALPARWKLALAVLLAAPLLAGIYLHRFQTGIDELAAQAQQRLA
LLSASLDAELLRNESLPTVLAPHPLLKDVLLGHGGPDAPARANALLAEVRERTGTGVIYLIAPSGITLAASNWREPESFV
GENYGYRPYFRDALAGRTGMFFAVGATTRIPGFFIAQPVRDGERVIGVLAIKVELTGLENTWAESGEALLVVDGHGVVAL
SSRPQWKFATLGPLGAPSRTTLAATRQYYTASLQPLPLRWDGGQRLTLAGRDYAVGVRALRWADWRMLMLVDTAPAATAA
RAQALAVALALCLAAIGGLFWVQRARRLRERLAVQAMLEDTVARRTADLAAANARLREEVAERTAAEDKLHSAQRALIEA
NRLAALGQMAAGVAHELNQPLQALRGFAGNSLVFLERGRLEPLTDNLRQINELVERMARLTAQLKVFASRQQSAAGSAPA
AATLARVAGWFAPRLEAAAIRLVQEVNVERLPLDPQALEQVASNLLGNAIDALAGRDGGGQIDVRAGEDEQGCWLEVADN
GAGIAPALREKVAQPFFSTKPLGHGLGLGLAIVGDLIEASGGSLDIGASDAGGARIRAYWARPATRA

Sequences:

>Translated_627_residues
MFNVGQGGGRFHPVALTTMNMRPRLPFPTLPRLAPAAALPARWKLALAVLLAAPLLAGIYLHRFQTGIDELAAQAQQRLA
LLSASLDAELLRNESLPTVLAPHPLLKDVLLGHGGPDAPARANALLAEVRERTGTGVIYLIAPSGITLAASNWREPESFV
GENYGYRPYFRDALAGRTGMFFAVGATTRIPGFFIAQPVRDGERVIGVLAIKVELTGLENTWAESGEALLVVDGHGVVAL
SSRPQWKFATLGPLGAPSRTTLAATRQYYTASLQPLPLRWDGGQRLTLAGRDYAVGVRALRWADWRMLMLVDTAPAATAA
RAQALAVALALCLAAIGGLFWVQRARRLRERLAVQAMLEDTVARRTADLAAANARLREEVAERTAAEDKLHSAQRALIEA
NRLAALGQMAAGVAHELNQPLQALRGFAGNSLVFLERGRLEPLTDNLRQINELVERMARLTAQLKVFASRQQSAAGSAPA
AATLARVAGWFAPRLEAAAIRLVQEVNVERLPLDPQALEQVASNLLGNAIDALAGRDGGGQIDVRAGEDEQGCWLEVADN
GAGIAPALREKVAQPFFSTKPLGHGLGLGLAIVGDLIEASGGSLDIGASDAGGARIRAYWARPATRA
>Mature_627_residues
MFNVGQGGGRFHPVALTTMNMRPRLPFPTLPRLAPAAALPARWKLALAVLLAAPLLAGIYLHRFQTGIDELAAQAQQRLA
LLSASLDAELLRNESLPTVLAPHPLLKDVLLGHGGPDAPARANALLAEVRERTGTGVIYLIAPSGITLAASNWREPESFV
GENYGYRPYFRDALAGRTGMFFAVGATTRIPGFFIAQPVRDGERVIGVLAIKVELTGLENTWAESGEALLVVDGHGVVAL
SSRPQWKFATLGPLGAPSRTTLAATRQYYTASLQPLPLRWDGGQRLTLAGRDYAVGVRALRWADWRMLMLVDTAPAATAA
RAQALAVALALCLAAIGGLFWVQRARRLRERLAVQAMLEDTVARRTADLAAANARLREEVAERTAAEDKLHSAQRALIEA
NRLAALGQMAAGVAHELNQPLQALRGFAGNSLVFLERGRLEPLTDNLRQINELVERMARLTAQLKVFASRQQSAAGSAPA
AATLARVAGWFAPRLEAAAIRLVQEVNVERLPLDPQALEQVASNLLGNAIDALAGRDGGGQIDVRAGEDEQGCWLEVADN
GAGIAPALREKVAQPFFSTKPLGHGLGLGLAIVGDLIEASGGSLDIGASDAGGARIRAYWARPATRA

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=265, Percent_Identity=30.188679245283, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=28.4518828451883, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=29.2035398230088, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=29.2372881355932, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66810; Mature: 66810

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNVGQGGGRFHPVALTTMNMRPRLPFPTLPRLAPAAALPARWKLALAVLLAAPLLAGIY
CCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHH
LHRFQTGIDELAAQAQQRLALLSASLDAELLRNESLPTVLAPHPLLKDVLLGHGGPDAPA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHCCCCCCCCH
RANALLAEVRERTGTGVIYLIAPSGITLAASNWREPESFVGENYGYRPYFRDALAGRTGM
HHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHCCCCCE
FFAVGATTRIPGFFIAQPVRDGERVIGVLAIKVELTGLENTWAESGEALLVVDGHGVVAL
EEEECCCCCCCCCEEECCCCCCCCEEEEEEEEEEEECCCHHHHCCCCEEEEECCCCEEEE
SSRPQWKFATLGPLGAPSRTTLAATRQYYTASLQPLPLRWDGGQRLTLAGRDYAVGVRAL
CCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCHHHHHHHH
RWADWRMLMLVDTAPAATAARAQALAVALALCLAAIGGLFWVQRARRLRERLAVQAMLED
EECCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVARRTADLAAANARLREEVAERTAAEDKLHSAQRALIEANRLAALGQMAAGVAHELNQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQALRGFAGNSLVFLERGRLEPLTDNLRQINELVERMARLTAQLKVFASRQQSAAGSAPA
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AATLARVAGWFAPRLEAAAIRLVQEVNVERLPLDPQALEQVASNLLGNAIDALAGRDGGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
QIDVRAGEDEQGCWLEVADNGAGIAPALREKVAQPFFSTKPLGHGLGLGLAIVGDLIEAS
EEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
GGSLDIGASDAGGARIRAYWARPATRA
CCCEECCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MFNVGQGGGRFHPVALTTMNMRPRLPFPTLPRLAPAAALPARWKLALAVLLAAPLLAGIY
CCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHH
LHRFQTGIDELAAQAQQRLALLSASLDAELLRNESLPTVLAPHPLLKDVLLGHGGPDAPA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHCCCCCCCCH
RANALLAEVRERTGTGVIYLIAPSGITLAASNWREPESFVGENYGYRPYFRDALAGRTGM
HHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHCCCCCE
FFAVGATTRIPGFFIAQPVRDGERVIGVLAIKVELTGLENTWAESGEALLVVDGHGVVAL
EEEECCCCCCCCCEEECCCCCCCCEEEEEEEEEEEECCCHHHHCCCCEEEEECCCCEEEE
SSRPQWKFATLGPLGAPSRTTLAATRQYYTASLQPLPLRWDGGQRLTLAGRDYAVGVRAL
CCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCHHHHHHHH
RWADWRMLMLVDTAPAATAARAQALAVALALCLAAIGGLFWVQRARRLRERLAVQAMLED
EECCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVARRTADLAAANARLREEVAERTAAEDKLHSAQRALIEANRLAALGQMAAGVAHELNQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQALRGFAGNSLVFLERGRLEPLTDNLRQINELVERMARLTAQLKVFASRQQSAAGSAPA
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AATLARVAGWFAPRLEAAAIRLVQEVNVERLPLDPQALEQVASNLLGNAIDALAGRDGGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
QIDVRAGEDEQGCWLEVADNGAGIAPALREKVAQPFFSTKPLGHGLGLGLAIVGDLIEAS
EEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
GGSLDIGASDAGGARIRAYWARPATRA
CCCEECCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]