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The map label for this gene is uppS [H]

Identifier: 119898196

GI number: 119898196

Start: 2089398

End: 2090198

Strand: Reverse

Name: uppS [H]

Synonym: azo1905

Alternate gene names: 119898196

Gene position: 2090198-2089398 (Counterclockwise)

Preceding gene: 119898197

Following gene: 119898195

Centisome position: 47.76

GC content: 66.79

Gene sequence:

>801_bases
ATGGCCGATATCGGCTTTACCAGTTCGACCCGGGCGATCCCCGAGGTCAGCACCGTACCGCGCCACGTCGCCATCATCAT
GGACGGCAACGGGCGCTGGGCGCGCAAGCGTTTCATGCCGCGCATTGCCGGCCACACCCGCGGAGTGGAGTCGGTCCGCA
CCACGATCCGCGCCTGCATGGACCGCGGGGTGGAATACCTGACGCTGTTCGCCTTCAGTTCCGAGAACTGGCGGCGCCCG
GCCGACGAAGTCTCCTTCCTGATGCAACTCTTCATCAAGTCGCTCAAGAAGGAAGTCGGCCGGCTGCACCAGAACGGCAT
CCGGTTGCGCATCGTCGGCGACCTCGAACGCTTCGACGCGCCCCTGATCGCCGCCATCCGCGAGGCGGAGGCGCTCACCG
CGGCCAATGACCGTTTCACGCTGACCATCGCCGCCAACTACGGCGGGCGCTGGGACATCCTCAATGCGCTCAACCGCCTC
GTGGCGCGCCACCCGGAACGGCAGGGCGCCTTTTCCGAGGAAGAGCTTGCCAGCGAGCTGTCGATGAGCTTCGCACCGGA
GCCGGATCTCTTCATCCGCACCGGGGGCGAGCAGCGCATCAGCAACTTCCTGCTCTGGCAGCTCGCTTACGCGGAGCTGT
ACTTCACCGACACCCTGTGGCCCGACTTCGACGCCGCGGAACTCGACAAGGCCATCGCCTGGTACGGCGCCCGCGAACGT
CGCTTCGGCCGCACCAGCGAACAGGTCGCCGGGGCCAGCCCCGCCCAAGCCACCGTCGCGGGTACCGAACCTCATGCTTA
A

Upstream 100 bases:

>100_bases
CCGAAATCGACAAGCTGCTCGCCCAGAAAGAGCAGGAACTGATGCAGATCTGATCTCCGGATCGACTGTTCCCAGAGCGG
ACGAGGCGAGGAGGCGGACG

Downstream 100 bases:

>100_bases
GACGCGGGTCATCACCGCCCTGGTGCTGCTGTGCGGCCTGCTCGGTGCGCTGTTTCTGCTTCCGGCCGCGTTGTGGCTGG
GCTTTGCAGCGGTGGTATGC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MADIGFTSSTRAIPEVSTVPRHVAIIMDGNGRWARKRFMPRIAGHTRGVESVRTTIRACMDRGVEYLTLFAFSSENWRRP
ADEVSFLMQLFIKSLKKEVGRLHQNGIRLRIVGDLERFDAPLIAAIREAEALTAANDRFTLTIAANYGGRWDILNALNRL
VARHPERQGAFSEEELASELSMSFAPEPDLFIRTGGEQRISNFLLWQLAYAELYFTDTLWPDFDAAELDKAIAWYGARER
RFGRTSEQVAGASPAQATVAGTEPHA

Sequences:

>Translated_266_residues
MADIGFTSSTRAIPEVSTVPRHVAIIMDGNGRWARKRFMPRIAGHTRGVESVRTTIRACMDRGVEYLTLFAFSSENWRRP
ADEVSFLMQLFIKSLKKEVGRLHQNGIRLRIVGDLERFDAPLIAAIREAEALTAANDRFTLTIAANYGGRWDILNALNRL
VARHPERQGAFSEEELASELSMSFAPEPDLFIRTGGEQRISNFLLWQLAYAELYFTDTLWPDFDAAELDKAIAWYGARER
RFGRTSEQVAGASPAQATVAGTEPHA
>Mature_265_residues
ADIGFTSSTRAIPEVSTVPRHVAIIMDGNGRWARKRFMPRIAGHTRGVESVRTTIRACMDRGVEYLTLFAFSSENWRRPA
DEVSFLMQLFIKSLKKEVGRLHQNGIRLRIVGDLERFDAPLIAAIREAEALTAANDRFTLTIAANYGGRWDILNALNRLV
ARHPERQGAFSEEELASELSMSFAPEPDLFIRTGGEQRISNFLLWQLAYAELYFTDTLWPDFDAAELDKAIAWYGARERR
FGRTSEQVAGASPAQATVAGTEPHA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=226, Percent_Identity=34.5132743362832, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI45580738, Length=226, Percent_Identity=34.5132743362832, Blast_Score=134, Evalue=7e-32,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=54.3859649122807, Blast_Score=246, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=32.5991189427313, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=219, Percent_Identity=38.8127853881278, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=35.6481481481481, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18857969, Length=219, Percent_Identity=37.8995433789954, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29876; Mature: 29745

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIGFTSSTRAIPEVSTVPRHVAIIMDGNGRWARKRFMPRIAGHTRGVESVRTTIRACM
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DRGVEYLTLFAFSSENWRRPADEVSFLMQLFIKSLKKEVGRLHQNGIRLRIVGDLERFDA
HCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHCC
PLIAAIREAEALTAANDRFTLTIAANYGGRWDILNALNRLVARHPERQGAFSEEELASEL
HHHHHHHHHHHHEECCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
SMSFAPEPDLFIRTGGEQRISNFLLWQLAYAELYFTDTLWPDFDAAELDKAIAWYGARER
HHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCHHH
RFGRTSEQVAGASPAQATVAGTEPHA
HCCCCHHHHCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
ADIGFTSSTRAIPEVSTVPRHVAIIMDGNGRWARKRFMPRIAGHTRGVESVRTTIRACM
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DRGVEYLTLFAFSSENWRRPADEVSFLMQLFIKSLKKEVGRLHQNGIRLRIVGDLERFDA
HCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHCC
PLIAAIREAEALTAANDRFTLTIAANYGGRWDILNALNRLVARHPERQGAFSEEELASEL
HHHHHHHHHHHHEECCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
SMSFAPEPDLFIRTGGEQRISNFLLWQLAYAELYFTDTLWPDFDAAELDKAIAWYGARER
HHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCHHH
RFGRTSEQVAGASPAQATVAGTEPHA
HCCCCHHHHCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]