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The map label for this gene is dxr [H]

Identifier: 119898194

GI number: 119898194

Start: 2087365

End: 2088564

Strand: Reverse

Name: dxr [H]

Synonym: azo1903

Alternate gene names: 119898194

Gene position: 2088564-2087365 (Counterclockwise)

Preceding gene: 119898195

Following gene: 119898193

Centisome position: 47.73

GC content: 68.5

Gene sequence:

>1200_bases
ATGCCCGCATCCCCTGTCCAGCAGATCACCATCCTGGGCGCCACCGGTTCCATTGGCGCCAGCACGCTCGACGTTGTAGC
CCGCCACCCCGACCGCTTCGCCGTTTTCGCCGTCAGCGCCCACCGTCAGGTGGAGCGGATGGTGGAGATCTGCCTGCGCC
ACCGCCCGCGCTACGCGGTCATGGTCGATGCCGATGCAGCCACGCGCCTCCAGCGGCTCCTGGTCCAGCAGGGCTGCCGC
ACCGAGGTCCTTGCCGGCGCGGCAGCGCTGGAGGACGTCGCCGCACATGGCGACGTTCATGCGGTGATGGCAGCCATCGT
CGGCGCCGCCGGACTCAAGCCCACGCTCGCTGCGGCCCGCGCCGGCAAGAAGGTGCTGCTGGCGAACAAGGAAGCGCTGG
TGCTGTCGGGCCGCCTGTTCATGGACACGGTGGCGGCCAGCAACGCGGTCCTGCTTCCGATCGACAGCGAACATAACGCC
GTCTTCCAGGCGCTGCCGGTCGACTATCGCCGGATCCCCGGCGCGGCCGGCGTCCGCCGCATCCTGCTGACGGCGTCCGG
CGGTCCGTTCCGCTCGACGCCGCTCGAAGCGCTCGACGCAGTCACGCCGGACCAGGCTTGCGCTCACCCAAACTGGGTCA
TGGGCCGCAAGATCTCGGTGGATTCCGCGACGATGATGAACAAGGGGCTGGAGGTGATCGAAGCCCATTGGCTCTTCGGC
GCACCGGCTTCCATCATCGAGGTGGTGGTGCACCCGCAGAGCGTGATCCACTCGATGGTGGATTACCTCGACGGCTCGGT
TCTCGCCCAGCTCGGCAATCCCGACATGCGCACCCCGATCGCCCATGCGCTTGCGTGGCCGGAGCGGATCGACTCGGGCG
TCGCGCCGCTCGATCTTTTCGCGATCGGCCAGCTTGCCTTCGAGCGCCCCGACTTCCACCGCTTCCCCTGCCTCGCACTC
GCGTACCGCGCCCTGGAAGAGGGCGGTTCTGCGGCGGCCACGCTCAACGCCGCCAACGAAGAGGCCGTCGCCGCCTTCCT
GGAAGGACAGCTCGGCTTCCGCGGCATTCCGGCCGTCATCGAAGCAACGATGGAACGTGCGGGGCAACATGCGGTCGATT
CGGTCGAAGCCGTGCTTGACGCGGATCGCCACGCCCGCCGGATCGCGCGGGAAGAAATACAGACCCGCCGGATCCCCTGA

Upstream 100 bases:

>100_bases
CATGGCGGAGTCCTGGACCGCATCGACAGCCTCACTTCAACGCTTCCGCTCCTGGGCCTTGCCGCACTGTGGCTGGCCCG
CTGAGCCTCCGGCCCGCCCT

Downstream 100 bases:

>100_bases
TGAATCTTCTCGATTACCTGATTCCGTTTGCGTTCGCACTCGGTCTGCTGATCCTCGTTCACGAACTCGGCCACTACCTG
GTGGCGCGACGCTGCGGCGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MPASPVQQITILGATGSIGASTLDVVARHPDRFAVFAVSAHRQVERMVEICLRHRPRYAVMVDADAATRLQRLLVQQGCR
TEVLAGAAALEDVAAHGDVHAVMAAIVGAAGLKPTLAAARAGKKVLLANKEALVLSGRLFMDTVAASNAVLLPIDSEHNA
VFQALPVDYRRIPGAAGVRRILLTASGGPFRSTPLEALDAVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFG
APASIIEVVVHPQSVIHSMVDYLDGSVLAQLGNPDMRTPIAHALAWPERIDSGVAPLDLFAIGQLAFERPDFHRFPCLAL
AYRALEEGGSAAATLNAANEEAVAAFLEGQLGFRGIPAVIEATMERAGQHAVDSVEAVLDADRHARRIAREEIQTRRIP

Sequences:

>Translated_399_residues
MPASPVQQITILGATGSIGASTLDVVARHPDRFAVFAVSAHRQVERMVEICLRHRPRYAVMVDADAATRLQRLLVQQGCR
TEVLAGAAALEDVAAHGDVHAVMAAIVGAAGLKPTLAAARAGKKVLLANKEALVLSGRLFMDTVAASNAVLLPIDSEHNA
VFQALPVDYRRIPGAAGVRRILLTASGGPFRSTPLEALDAVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFG
APASIIEVVVHPQSVIHSMVDYLDGSVLAQLGNPDMRTPIAHALAWPERIDSGVAPLDLFAIGQLAFERPDFHRFPCLAL
AYRALEEGGSAAATLNAANEEAVAAFLEGQLGFRGIPAVIEATMERAGQHAVDSVEAVLDADRHARRIAREEIQTRRIP
>Mature_398_residues
PASPVQQITILGATGSIGASTLDVVARHPDRFAVFAVSAHRQVERMVEICLRHRPRYAVMVDADAATRLQRLLVQQGCRT
EVLAGAAALEDVAAHGDVHAVMAAIVGAAGLKPTLAAARAGKKVLLANKEALVLSGRLFMDTVAASNAVLLPIDSEHNAV
FQALPVDYRRIPGAAGVRRILLTASGGPFRSTPLEALDAVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFGA
PASIIEVVVHPQSVIHSMVDYLDGSVLAQLGNPDMRTPIAHALAWPERIDSGVAPLDLFAIGQLAFERPDFHRFPCLALA
YRALEEGGSAAATLNAANEEAVAAFLEGQLGFRGIPAVIEATMERAGQHAVDSVEAVLDADRHARRIAREEIQTRRIP

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=60.559796437659, Blast_Score=450, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42526; Mature: 42395

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASPVQQITILGATGSIGASTLDVVARHPDRFAVFAVSAHRQVERMVEICLRHRPRYAV
CCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEE
MVDADAATRLQRLLVQQGCRTEVLAGAAALEDVAAHGDVHAVMAAIVGAAGLKPTLAAAR
EEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHH
AGKKVLLANKEALVLSGRLFMDTVAASNAVLLPIDSEHNAVFQALPVDYRRIPGAAGVRR
CCCEEEEECCCEEEEECHHHHHHHHCCCEEEEEECCCCCCEEEECCCHHHHCCCHHHHEE
ILLTASGGPFRSTPLEALDAVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFG
EEEEECCCCCCCCCHHHHHCCCCCHHHCCCCCCCCCEECCCHHHHHHCCHHHHHHHHHCC
APASIIEVVVHPQSVIHSMVDYLDGSVLAQLGNPDMRTPIAHALAWPERIDSGVAPLDLF
CCHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHCHHHHCCCCCCHHHH
AIGQLAFERPDFHRFPCLALAYRALEEGGSAAATLNAANEEAVAAFLEGQLGFRGIPAVI
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHH
EATMERAGQHAVDSVEAVLDADRHARRIAREEIQTRRIP
HHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PASPVQQITILGATGSIGASTLDVVARHPDRFAVFAVSAHRQVERMVEICLRHRPRYAV
CCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEE
MVDADAATRLQRLLVQQGCRTEVLAGAAALEDVAAHGDVHAVMAAIVGAAGLKPTLAAAR
EEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHH
AGKKVLLANKEALVLSGRLFMDTVAASNAVLLPIDSEHNAVFQALPVDYRRIPGAAGVRR
CCCEEEEECCCEEEEECHHHHHHHHCCCEEEEEECCCCCCEEEECCCHHHHCCCHHHHEE
ILLTASGGPFRSTPLEALDAVTPDQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFG
EEEEECCCCCCCCCHHHHHCCCCCHHHCCCCCCCCCEECCCHHHHHHCCHHHHHHHHHCC
APASIIEVVVHPQSVIHSMVDYLDGSVLAQLGNPDMRTPIAHALAWPERIDSGVAPLDLF
CCHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHCHHHHCCCCCCHHHH
AIGQLAFERPDFHRFPCLALAYRALEEGGSAAATLNAANEEAVAAFLEGQLGFRGIPAVI
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHH
EATMERAGQHAVDSVEAVLDADRHARRIAREEIQTRRIP
HHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA