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The map label for this gene is uvrC [H]

Identifier: 119897939

GI number: 119897939

Start: 1807351

End: 1809171

Strand: Direct

Name: uvrC [H]

Synonym: azo1648

Alternate gene names: 119897939

Gene position: 1807351-1809171 (Clockwise)

Preceding gene: 119897938

Following gene: 119897940

Centisome position: 41.3

GC content: 68.09

Gene sequence:

>1821_bases
ATGTCCACCACCCCCGCTCCGACGCCCCCCTTCGACGCCAAGGCTTTCCTCCGTACCCTGACCGAGGAGCCCGGCGTCTA
CCGCATGATCGGCGCCGAAGACAAGGTGCTCTACGTCGGCAAGGCGAAGAACCTCAAGCGCCGCGTCTCCAGCTATTTCC
AGCGTACGCTGCTGTCGCCGCGCATCGCCATGATGGTGGCCCAGGTGCAGCGTGTGGACGTCACCGCCACCCGCTCCGAG
GCCGAGGCGCTGATCCTCGAGAACAACCTCATCAAGAGCCTGGCGCCGCGCTACAACATCCTGTTCCGCGACGACAAGTC
CTACCCCTACATCGAACTCACCGGCGACGAGTTCCCGCAGCTGGCCTACCATCGCGGCGCCTTCGCCAAGGGGGCACGCT
ACTTCGGCCCTTTCCCGAGCGCCTGGGCTGTGCGCGAGAGCATCCAGCTGCTGCAAAAAACCTTCCAGCTGCGCACCTGC
GAGAACTCCGTCTTCCAGAACCGCTCGCGCCCCTGCCTGCTGCATCAGATCAAGCGCTGCACCGGGCCCTGCGTCGGGCT
GGTGTCCGCCGAGGACTACGCGGCGGACGTGCGCCTCGCATCGCGCTTTCTCGACGGCCATGGCACCGAGGTGATCGATG
CCCTGACCGACAAGATGCAGCGCGCCGCGGCGGCGCTCGACTTCGAGGCCGCGGGCGGTTGCCGCGATCAGATCCGGGCC
CTGCAGGCAGTGCTGCACCGTCAGTTTGTCGACAGCGGCAAGGATGAGGACGTGGATATCCTCGCCGCGGTGGAGGAAGA
CGGCCTCTTGTGCGTCAACATCGCGATGGTCCGCGGCGGTCGCCACCTTGGCGACAGGCCCCAGTTTCCCAGCGGCGCCG
CGGCGTGCGGCGCGGAGGATGGCCTGCTCGCGTTTGTCGAGCAGCACTACGGCGAACACCCGATGCCCGCGCGGCTCCTC
GTCAACACCGCGGTCGAAGCCGTTCGCGAGACGCTGGCCGAGATCGCCGAAAAGCCCGCGGCGGTGGTCGCGCCGCGTTT
TGCGGTGGATCGCGGCTGGATGGAAATGGCGGAAAAGAACGCCCGACTCGCGATCCAGGCGCGCGCGCGCGATACCGGTC
GCGCGGAGCAACGCCTGGAGGCGTTGCGCGATGCGCTCGGGCTGGCGGATCCACCGTTGCGCATCGAGTGCTTCGACATC
AGCCATACGATGGGCGAGGCGACCGTGGCGTCCTGCGTGGTGTGCGAAGCCGGCCAGATGAAACGGGGCGAGTATCGTCG
CTACAACATCGCCGGAATCACGCCCGGTGACGACTTCGCCGCGATGCGCCAGGCACTGGAGCGCCGCTACGGCAAGGTGG
CGGCAGGCGAGGGGCTGCGGCCCGACCTCATCCTGATCGACGGTGGCAAGGGCCAGGTGGCGGCGGCGCTCGGCATTCTC
GCGGAACTTGGGCTGGAGGACATCGCCATGATCGGCGTGGCGAAGGGCGAGGGGCGCAAGGTTGGCCTGGAGACGCTCGT
TTTTCCGGATGAACGGGAAGGGCTCGTGCTCGGCGGGGGACACGCCGCGCTGCACCTCGTCACCGAAATCCGTGACGAAG
CCCACCGCTTTGCCATCACCGGTCACCGCGCGCGCCGCGCCAAGACCCGTGTGGGGTCAAAGCTGGAAGACATCCCGGGC
GTCGGCCCCACCCGGCGTCGCAATCTGCTGGCCACCTTCGGCGGCCTGGACGGGGTGAGGGCGGCGACCGTGGAGGATCT
GTGCCGGGTGGACGGCATCAACCGGACCCTGGCGGAGCAAATCCACCAAGCGCTGCGCTGA

Upstream 100 bases:

>100_bases
GAGCGAGCGTAGTGAGCGAGTTCCGCAGCCAGCGGAACACACGCCCCGTACCGCAACATCGTAGCCGCGCAAGCCTCCCA
ACAAGCCATCGACAACCAGC

Downstream 100 bases:

>100_bases
TCTGCTTCCGCGCGCCGGCCGGGACAACAGCCGAACCGGCACCCTTAACCGCTATACTCGCCGGTGCATTCAACGCAGGC
CGCCGGCCGCTTCGCATGTC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MSTTPAPTPPFDAKAFLRTLTEEPGVYRMIGAEDKVLYVGKAKNLKRRVSSYFQRTLLSPRIAMMVAQVQRVDVTATRSE
AEALILENNLIKSLAPRYNILFRDDKSYPYIELTGDEFPQLAYHRGAFAKGARYFGPFPSAWAVRESIQLLQKTFQLRTC
ENSVFQNRSRPCLLHQIKRCTGPCVGLVSAEDYAADVRLASRFLDGHGTEVIDALTDKMQRAAAALDFEAAGGCRDQIRA
LQAVLHRQFVDSGKDEDVDILAAVEEDGLLCVNIAMVRGGRHLGDRPQFPSGAAACGAEDGLLAFVEQHYGEHPMPARLL
VNTAVEAVRETLAEIAEKPAAVVAPRFAVDRGWMEMAEKNARLAIQARARDTGRAEQRLEALRDALGLADPPLRIECFDI
SHTMGEATVASCVVCEAGQMKRGEYRRYNIAGITPGDDFAAMRQALERRYGKVAAGEGLRPDLILIDGGKGQVAAALGIL
AELGLEDIAMIGVAKGEGRKVGLETLVFPDEREGLVLGGGHAALHLVTEIRDEAHRFAITGHRARRAKTRVGSKLEDIPG
VGPTRRRNLLATFGGLDGVRAATVEDLCRVDGINRTLAEQIHQALR

Sequences:

>Translated_606_residues
MSTTPAPTPPFDAKAFLRTLTEEPGVYRMIGAEDKVLYVGKAKNLKRRVSSYFQRTLLSPRIAMMVAQVQRVDVTATRSE
AEALILENNLIKSLAPRYNILFRDDKSYPYIELTGDEFPQLAYHRGAFAKGARYFGPFPSAWAVRESIQLLQKTFQLRTC
ENSVFQNRSRPCLLHQIKRCTGPCVGLVSAEDYAADVRLASRFLDGHGTEVIDALTDKMQRAAAALDFEAAGGCRDQIRA
LQAVLHRQFVDSGKDEDVDILAAVEEDGLLCVNIAMVRGGRHLGDRPQFPSGAAACGAEDGLLAFVEQHYGEHPMPARLL
VNTAVEAVRETLAEIAEKPAAVVAPRFAVDRGWMEMAEKNARLAIQARARDTGRAEQRLEALRDALGLADPPLRIECFDI
SHTMGEATVASCVVCEAGQMKRGEYRRYNIAGITPGDDFAAMRQALERRYGKVAAGEGLRPDLILIDGGKGQVAAALGIL
AELGLEDIAMIGVAKGEGRKVGLETLVFPDEREGLVLGGGHAALHLVTEIRDEAHRFAITGHRARRAKTRVGSKLEDIPG
VGPTRRRNLLATFGGLDGVRAATVEDLCRVDGINRTLAEQIHQALR
>Mature_605_residues
STTPAPTPPFDAKAFLRTLTEEPGVYRMIGAEDKVLYVGKAKNLKRRVSSYFQRTLLSPRIAMMVAQVQRVDVTATRSEA
EALILENNLIKSLAPRYNILFRDDKSYPYIELTGDEFPQLAYHRGAFAKGARYFGPFPSAWAVRESIQLLQKTFQLRTCE
NSVFQNRSRPCLLHQIKRCTGPCVGLVSAEDYAADVRLASRFLDGHGTEVIDALTDKMQRAAAALDFEAAGGCRDQIRAL
QAVLHRQFVDSGKDEDVDILAAVEEDGLLCVNIAMVRGGRHLGDRPQFPSGAAACGAEDGLLAFVEQHYGEHPMPARLLV
NTAVEAVRETLAEIAEKPAAVVAPRFAVDRGWMEMAEKNARLAIQARARDTGRAEQRLEALRDALGLADPPLRIECFDIS
HTMGEATVASCVVCEAGQMKRGEYRRYNIAGITPGDDFAAMRQALERRYGKVAAGEGLRPDLILIDGGKGQVAAALGILA
ELGLEDIAMIGVAKGEGRKVGLETLVFPDEREGLVLGGGHAALHLVTEIRDEAHRFAITGHRARRAKTRVGSKLEDIPGV
GPTRRRNLLATFGGLDGVRAATVEDLCRVDGINRTLAEQIHQALR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=48.6885245901639, Blast_Score=547, Evalue=1e-157,
Organism=Escherichia coli, GI1788037, Length=193, Percent_Identity=29.5336787564767, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 66213; Mature: 66081

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTPAPTPPFDAKAFLRTLTEEPGVYRMIGAEDKVLYVGKAKNLKRRVSSYFQRTLLSP
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCH
RIAMMVAQVQRVDVTATRSEAEALILENNLIKSLAPRYNILFRDDKSYPYIELTGDEFPQ
HHHHHHHHHHHHCEEEECCCCCEEEHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCHH
LAYHRGAFAKGARYFGPFPSAWAVRESIQLLQKTFQLRTCENSVFQNRSRPCLLHQIKRC
HHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
TGPCVGLVSAEDYAADVRLASRFLDGHGTEVIDALTDKMQRAAAALDFEAAGGCRDQIRA
CCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHH
LQAVLHRQFVDSGKDEDVDILAAVEEDGLLCVNIAMVRGGRHLGDRPQFPSGAAACGAED
HHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
GLLAFVEQHYGEHPMPARLLVNTAVEAVRETLAEIAEKPAAVVAPRFAVDRGWMEMAEKN
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCC
ARLAIQARARDTGRAEQRLEALRDALGLADPPLRIECFDISHTMGEATVASCVVCEAGQM
CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHCHHHHHHHHHCCCCCC
KRGEYRRYNIAGITPGDDFAAMRQALERRYGKVAAGEGLRPDLILIDGGKGQVAAALGIL
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEECCCCCCCCEEEEECCCCHHHHHHHHH
AELGLEDIAMIGVAKGEGRKVGLETLVFPDEREGLVLGGGHAALHLVTEIRDEAHRFAIT
HHHCHHHHHEEEEECCCCCEECCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHEEEE
GHRARRAKTRVGSKLEDIPGVGPTRRRNLLATFGGLDGVRAATVEDLCRVDGINRTLAEQ
CCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHH
IHQALR
HHHHCC
>Mature Secondary Structure 
STTPAPTPPFDAKAFLRTLTEEPGVYRMIGAEDKVLYVGKAKNLKRRVSSYFQRTLLSP
CCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCH
RIAMMVAQVQRVDVTATRSEAEALILENNLIKSLAPRYNILFRDDKSYPYIELTGDEFPQ
HHHHHHHHHHHHCEEEECCCCCEEEHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCHH
LAYHRGAFAKGARYFGPFPSAWAVRESIQLLQKTFQLRTCENSVFQNRSRPCLLHQIKRC
HHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
TGPCVGLVSAEDYAADVRLASRFLDGHGTEVIDALTDKMQRAAAALDFEAAGGCRDQIRA
CCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHH
LQAVLHRQFVDSGKDEDVDILAAVEEDGLLCVNIAMVRGGRHLGDRPQFPSGAAACGAED
HHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
GLLAFVEQHYGEHPMPARLLVNTAVEAVRETLAEIAEKPAAVVAPRFAVDRGWMEMAEKN
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCC
ARLAIQARARDTGRAEQRLEALRDALGLADPPLRIECFDISHTMGEATVASCVVCEAGQM
CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHCHHHHHHHHHCCCCCC
KRGEYRRYNIAGITPGDDFAAMRQALERRYGKVAAGEGLRPDLILIDGGKGQVAAALGIL
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEECCCCCCCCEEEEECCCCHHHHHHHHH
AELGLEDIAMIGVAKGEGRKVGLETLVFPDEREGLVLGGGHAALHLVTEIRDEAHRFAIT
HHHCHHHHHEEEEECCCCCEECCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHEEEE
GHRARRAKTRVGSKLEDIPGVGPTRRRNLLATFGGLDGVRAATVEDLCRVDGINRTLAEQ
CCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHH
IHQALR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA