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The map label for this gene is nhaA [H]

Identifier: 119897908

GI number: 119897908

Start: 1781715

End: 1782626

Strand: Direct

Name: nhaA [H]

Synonym: azo1617

Alternate gene names: 119897908

Gene position: 1781715-1782626 (Clockwise)

Preceding gene: 119897907

Following gene: 119897911

Centisome position: 40.72

GC content: 66.23

Gene sequence:

>912_bases
GTGCTCGAAAAGCTGGCGCTCGAAGCGCTGGTGGAGCAGCGCCGCCGCCGGCGCTGGAGCGTGTTCTTCCGGTTGCTGAC
TTTCATCTACCTCGGCGTGATCCTGTGGAAAGTTGCCGACTGGGGTGAGCCGGCGGAGGCCCTCGCGCCCGCGGGCGGCT
ATACCGCGATGGTGTCCGTCGAGGGGGTGATCGACTCCGGGTCGGAGGCCAGTGCTGAACGCGTCATCGGTGCGCTGCGT
TCAGCCTACGACGACAAGGCGGTGCGCGGCGTTGTCCTGCGGATCAACAGCCCCGGCGGCAGCCCTGTCCAGGCAGGCAT
GATCAATGACGAGATTTACCGCTTGCGTGGCGAGCGCCCCGATCTGCCGGTGGTTGCGGTGGTGGAAGACATGTGTGCGT
CCGGTGGCTATTACGTCGCTGCCGCGGCCGACAAGATCATGGTCGACAAGGCGAGCCTGGTCGGATCCATCGGCGTACTG
ATGGACGGGTTCGGCTTCGTCGGCGCGATGGAAAAGCTCGGGGTCGAGCGTCGGTTGTTGGCCGCGGGCGCGAACAAGGG
CTTTCTCGACCCGTTCTCGCCGCAGCGGGAAACGCAGACCGCGCACGCGCGCGGCTTGCTCGACGACATTCATCGTCAGT
TCATCGATGTCGTCCGCAAAGGGCGGGGTCCGCGTCTCAAGGAGGGGCCGGAGTTGTTTTCCGGCTTGGTGTGGACCGGC
GCGCGCAGCGTGGAGCTGGGGCTCGCGGATGGCTACGGAACCGTTGATTCGGTTGCGCGCGACGTATTCCAGGCCGAAGA
AGTGCGCGATTTCACCGAGACCCGTTCGTTTGCCGAGCGTTTCGCCCAGCGCTTCGGCGCCGGCGTCACCGAAAGCCTCG
CCACCGCGCTGCGAGGGGTCACGCTGCGTTAG

Upstream 100 bases:

>100_bases
GGCTCATCGCGCTCAACGTGGTTGAACGTGCCGGTCACGTCTATCTGCACGAGGACGAAGGGCTATGAGTGGGACTGAGG
GGACTGGCTGGGAGCGGGGT

Downstream 100 bases:

>100_bases
CGGCTGGCTGCGGCCAGCAGGAGAAACAGCGCGGGCCGCTTGGCGAGTTGGGGGCGAGGGGTCGTCCTCCAGGTCTCGAT
CCGGTGCGTCACCAGATACT

Product: peptidase

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MLEKLALEALVEQRRRRRWSVFFRLLTFIYLGVILWKVADWGEPAEALAPAGGYTAMVSVEGVIDSGSEASAERVIGALR
SAYDDKAVRGVVLRINSPGGSPVQAGMINDEIYRLRGERPDLPVVAVVEDMCASGGYYVAAAADKIMVDKASLVGSIGVL
MDGFGFVGAMEKLGVERRLLAAGANKGFLDPFSPQRETQTAHARGLLDDIHRQFIDVVRKGRGPRLKEGPELFSGLVWTG
ARSVELGLADGYGTVDSVARDVFQAEEVRDFTETRSFAERFAQRFGAGVTESLATALRGVTLR

Sequences:

>Translated_303_residues
MLEKLALEALVEQRRRRRWSVFFRLLTFIYLGVILWKVADWGEPAEALAPAGGYTAMVSVEGVIDSGSEASAERVIGALR
SAYDDKAVRGVVLRINSPGGSPVQAGMINDEIYRLRGERPDLPVVAVVEDMCASGGYYVAAAADKIMVDKASLVGSIGVL
MDGFGFVGAMEKLGVERRLLAAGANKGFLDPFSPQRETQTAHARGLLDDIHRQFIDVVRKGRGPRLKEGPELFSGLVWTG
ARSVELGLADGYGTVDSVARDVFQAEEVRDFTETRSFAERFAQRFGAGVTESLATALRGVTLR
>Mature_303_residues
MLEKLALEALVEQRRRRRWSVFFRLLTFIYLGVILWKVADWGEPAEALAPAGGYTAMVSVEGVIDSGSEASAERVIGALR
SAYDDKAVRGVVLRINSPGGSPVQAGMINDEIYRLRGERPDLPVVAVVEDMCASGGYYVAAAADKIMVDKASLVGSIGVL
MDGFGFVGAMEKLGVERRLLAAGANKGFLDPFSPQRETQTAHARGLLDDIHRQFIDVVRKGRGPRLKEGPELFSGLVWTG
ARSVELGLADGYGTVDSVARDVFQAEEVRDFTETRSFAERFAQRFGAGVTESLATALRGVTLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=228, Percent_Identity=29.8245614035088, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788064, Length=233, Percent_Identity=25.7510729613734, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 32857; Mature: 32857

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKLALEALVEQRRRRRWSVFFRLLTFIYLGVILWKVADWGEPAEALAPAGGYTAMVSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEEEE
EGVIDSGSEASAERVIGALRSAYDDKAVRGVVLRINSPGGSPVQAGMINDEIYRLRGERP
ECHHCCCCCHHHHHHHHHHHHHHCCHHHCEEEEEEECCCCCCCCCCCCHHHHHHHCCCCC
DLPVVAVVEDMCASGGYYVAAAADKIMVDKASLVGSIGVLMDGFGFVGAMEKLGVERRLL
CCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
AAGANKGFLDPFSPQRETQTAHARGLLDDIHRQFIDVVRKGRGPRLKEGPELFSGLVWTG
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
ARSVELGLADGYGTVDSVARDVFQAEEVRDFTETRSFAERFAQRFGAGVTESLATALRGV
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
TLR
CCC
>Mature Secondary Structure
MLEKLALEALVEQRRRRRWSVFFRLLTFIYLGVILWKVADWGEPAEALAPAGGYTAMVSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEEEE
EGVIDSGSEASAERVIGALRSAYDDKAVRGVVLRINSPGGSPVQAGMINDEIYRLRGERP
ECHHCCCCCHHHHHHHHHHHHHHCCHHHCEEEEEEECCCCCCCCCCCCHHHHHHHCCCCC
DLPVVAVVEDMCASGGYYVAAAADKIMVDKASLVGSIGVLMDGFGFVGAMEKLGVERRLL
CCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
AAGANKGFLDPFSPQRETQTAHARGLLDDIHRQFIDVVRKGRGPRLKEGPELFSGLVWTG
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
ARSVELGLADGYGTVDSVARDVFQAEEVRDFTETRSFAERFAQRFGAGVTESLATALRGV
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
TLR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA