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The map label for this gene is uvrB [H]

Identifier: 119897902

GI number: 119897902

Start: 1773639

End: 1775714

Strand: Direct

Name: uvrB [H]

Synonym: azo1611

Alternate gene names: 119897902

Gene position: 1773639-1775714 (Clockwise)

Preceding gene: 119897900

Following gene: 119897903

Centisome position: 40.53

GC content: 65.32

Gene sequence:

>2076_bases
ATGCAGAGTCCGGCCGACAGCGGCTCCGACAGCACCGCCAAGGTGCTGACGTTCGAGGGCAGTCCCTTCCGCCTGCACCA
ACCCTTTCCTCCGGCGGGCGACCAGCCGGAGGCGATCCGGCTGTTGTGCGAGGGTGTCGAGGACGGCCTGATGTACCAGA
CCCTGCTGGGCGTGACCGGCTCGGGCAAGACCTACACCATGGCCAACGTCATCGCCCGCATGGGGCGGCCGGCGCTGGTG
CTGGCGCCCAACAAGACGCTGGCGGCGCAGCTCTATGCCGAGTTCCGCGAGTTCCTGCCGGAGAACGCGGTCGAGTACTT
CGTCAGCTACTACGACTACTACCAGCCCGAGGCCTACGTGCCGCAGCGCGACCTCTTCATCGAGAAGGATTCGTCGGTGA
ACGAGCACATCGAGCAGATGCGGCTGTCGGCCACCAAGAGCCTGATGGAACGCCGTGACGTGGTGATCGTGGCGACGGTG
TCGTGCATCTACGGTATCGGCGACCCGGTGGACTACCACGCGATGATCCTGCACCTGCGCGAGGGCGAGCGCGTCTCCCA
CCGCGATCTGATCGCCCGTCTGGTTGCGATGCAATACACCCGCGCCGACCTCGACTTCCGTCGTGGCACCTTCCGCGTGC
GCGGCGACGTGATCGACGTGTTCCCGTCGGAGAACGCGGAACTCGCAGTGCGCATCGAGATGTTCGACGACGAGATCGAG
CACCTGACGCTGTTCGATCCGCTCACGGGGCACCTCAAGCAGAAGCTGGTGCGCTTCACCGTCTATCCGTCCAGCCACTA
CGTCACGCCGCGCGCGACCGTGCTGAAGGCGATCGAGGCGATCAAGGAAGAGCTGAAAGACCGCATCGCCTTCTTCCAGC
GCGAGGGCAAGCTGGTGGAGGCGCAGCGGCTCGAGCAGCGCACCCGCTTCGATCTCGAGATGCTCAACGAGATGGGCTTC
TGCAAGGGCATCGAGAACTACTCCCGCCACCTGTCGGGGCGCGGCCCGGGCGAGCCGCCGCCCACGCTGATCGACTACCT
CCCGGCCGACGCGCTGATGTTCATCGACGAGTCGCACGTCGCCATCGGGCAGGTGGGCGGCATGTACAAGGGCGACCGCT
CGCGCAAGGAAAACCTCGTGGGCTACGGCTTCCGGCTGCCATCCGCGCTGGACAACCGGCCGCTGAAGTTCGAGGAGTTC
GAGCGCCTGATGCCGCAGACCGTATTCGTCTCGGCGACTCCGGCGGCCTACGAGGCGCAGCATCAGGGCCAGGTGGTGGA
GCAGGTGGTCCGCCCGACCGGGCTGATCGACCCTGTCGTCGAGATCCGTCCGGCGACGACGCAGGTGGATGACCTGCTTG
CGCAGATCAAGACCCGCATCGCGGTTCAGGAACGCGTGCTGGTGACGGTGCTGACCAAGCGGATGGCGGAGGATCTGACC
GACTACCTGGCCGACAACGGCATCAAGGTGCGCTATCTGCATTCGGACATCGACACCGTCGAGCGGGTGGAGATCATCCG
CGACCTGCGCCTGGGTCAGTTCGATGTGCTGGTCGGCATCAACCTGCTGCGCGAGGGGCTGGATATTCCCGAGGTGTCGC
TGGTGGCCATCCTCGATGCGGACAAGGAGGGTTTCCTGCGCTCGGAGCGTTCGCTGATCCAGACGATCGGCCGCGCCGCG
CGCCACATCCACGGCACCGCGATCCTGTATGCCGACCAGATCACCGATTCGATGCGCGCCGCGATCGGCGAGACCGAGCG
CCGACGTACCAAGCAGATCGCCTTCAACGAGGCGAACGGCATCGTGCCCAGGACAGTGAGCAAGCGCATCAAGGACATCA
TCGACGGCGTCTACAATGCCGATGGCGCTAGTCGCGACAGCGCCCGGGTGGGCGAAGCACGCGCCGACTATGCCGCGATG
GACGAAAAGCAACTCGCACGGGCCATCAAGAAGCTCGAGAAAGAGATGCAGGAGCACGCGCGCAACCTGGAGTTCGAAAA
GGCCGCGGCCGCGCGCGACGAACTGTTCAAGCTGCGAGAACGCGCTTTTGGCGCGGACCAGCACGGCAATACCTAG

Upstream 100 bases:

>100_bases
GACCGGGCCGTGCCTTGAGACGCGATTTGGGAAATAATCGGTGTTTCCGCCTGCTTGCCCGGATGGGCGCAGGCGCTTGA
AACAAGACGGGAATTCTAGC

Downstream 100 bases:

>100_bases
GGAGGAGTGGTGAAGCGCGTTCTATTCGTTTGCACCGGCAACATCTGCAGGTCGCCCACGGCCGAAGGGGTTGCGCTGCA
CATGATCCACAGTGGCGGCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MQSPADSGSDSTAKVLTFEGSPFRLHQPFPPAGDQPEAIRLLCEGVEDGLMYQTLLGVTGSGKTYTMANVIARMGRPALV
LAPNKTLAAQLYAEFREFLPENAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSVNEHIEQMRLSATKSLMERRDVVIVATV
SCIYGIGDPVDYHAMILHLREGERVSHRDLIARLVAMQYTRADLDFRRGTFRVRGDVIDVFPSENAELAVRIEMFDDEIE
HLTLFDPLTGHLKQKLVRFTVYPSSHYVTPRATVLKAIEAIKEELKDRIAFFQREGKLVEAQRLEQRTRFDLEMLNEMGF
CKGIENYSRHLSGRGPGEPPPTLIDYLPADALMFIDESHVAIGQVGGMYKGDRSRKENLVGYGFRLPSALDNRPLKFEEF
ERLMPQTVFVSATPAAYEAQHQGQVVEQVVRPTGLIDPVVEIRPATTQVDDLLAQIKTRIAVQERVLVTVLTKRMAEDLT
DYLADNGIKVRYLHSDIDTVERVEIIRDLRLGQFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAA
RHIHGTAILYADQITDSMRAAIGETERRRTKQIAFNEANGIVPRTVSKRIKDIIDGVYNADGASRDSARVGEARADYAAM
DEKQLARAIKKLEKEMQEHARNLEFEKAAAARDELFKLRERAFGADQHGNT

Sequences:

>Translated_691_residues
MQSPADSGSDSTAKVLTFEGSPFRLHQPFPPAGDQPEAIRLLCEGVEDGLMYQTLLGVTGSGKTYTMANVIARMGRPALV
LAPNKTLAAQLYAEFREFLPENAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSVNEHIEQMRLSATKSLMERRDVVIVATV
SCIYGIGDPVDYHAMILHLREGERVSHRDLIARLVAMQYTRADLDFRRGTFRVRGDVIDVFPSENAELAVRIEMFDDEIE
HLTLFDPLTGHLKQKLVRFTVYPSSHYVTPRATVLKAIEAIKEELKDRIAFFQREGKLVEAQRLEQRTRFDLEMLNEMGF
CKGIENYSRHLSGRGPGEPPPTLIDYLPADALMFIDESHVAIGQVGGMYKGDRSRKENLVGYGFRLPSALDNRPLKFEEF
ERLMPQTVFVSATPAAYEAQHQGQVVEQVVRPTGLIDPVVEIRPATTQVDDLLAQIKTRIAVQERVLVTVLTKRMAEDLT
DYLADNGIKVRYLHSDIDTVERVEIIRDLRLGQFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAA
RHIHGTAILYADQITDSMRAAIGETERRRTKQIAFNEANGIVPRTVSKRIKDIIDGVYNADGASRDSARVGEARADYAAM
DEKQLARAIKKLEKEMQEHARNLEFEKAAAARDELFKLRERAFGADQHGNT
>Mature_691_residues
MQSPADSGSDSTAKVLTFEGSPFRLHQPFPPAGDQPEAIRLLCEGVEDGLMYQTLLGVTGSGKTYTMANVIARMGRPALV
LAPNKTLAAQLYAEFREFLPENAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSVNEHIEQMRLSATKSLMERRDVVIVATV
SCIYGIGDPVDYHAMILHLREGERVSHRDLIARLVAMQYTRADLDFRRGTFRVRGDVIDVFPSENAELAVRIEMFDDEIE
HLTLFDPLTGHLKQKLVRFTVYPSSHYVTPRATVLKAIEAIKEELKDRIAFFQREGKLVEAQRLEQRTRFDLEMLNEMGF
CKGIENYSRHLSGRGPGEPPPTLIDYLPADALMFIDESHVAIGQVGGMYKGDRSRKENLVGYGFRLPSALDNRPLKFEEF
ERLMPQTVFVSATPAAYEAQHQGQVVEQVVRPTGLIDPVVEIRPATTQVDDLLAQIKTRIAVQERVLVTVLTKRMAEDLT
DYLADNGIKVRYLHSDIDTVERVEIIRDLRLGQFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAA
RHIHGTAILYADQITDSMRAAIGETERRRTKQIAFNEANGIVPRTVSKRIKDIIDGVYNADGASRDSARVGEARADYAAM
DEKQLARAIKKLEKEMQEHARNLEFEKAAAARDELFKLRERAFGADQHGNT

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=66.2650602409639, Blast_Score=889, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=306, Percent_Identity=24.1830065359477, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77993; Mature: 77993

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSPADSGSDSTAKVLTFEGSPFRLHQPFPPAGDQPEAIRLLCEGVEDGLMYQTLLGVTG
CCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCC
SGKTYTMANVIARMGRPALVLAPNKTLAAQLYAEFREFLPENAVEYFVSYYDYYQPEAYV
CCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
PQRDLFIEKDSSVNEHIEQMRLSATKSLMERRDVVIVATVSCIYGIGDPVDYHAMILHLR
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCCHHHEEEEEC
EGERVSHRDLIARLVAMQYTRADLDFRRGTFRVRGDVIDVFPSENAELAVRIEMFDDEIE
CCCCCHHHHHHHHHHHHHHHHCCCHHCCCEEEEECCEEEECCCCCCCEEEEEEECCCCCC
HLTLFDPLTGHLKQKLVRFTVYPSSHYVTPRATVLKAIEAIKEELKDRIAFFQREGKLVE
EEEEECHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AQRLEQRTRFDLEMLNEMGFCKGIENYSRHLSGRGPGEPPPTLIDYLPADALMFIDESHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCE
AIGQVGGMYKGDRSRKENLVGYGFRLPSALDNRPLKFEEFERLMPQTVFVSATPAAYEAQ
EHHHCCCCCCCCCHHHCCCEEECEECCHHHCCCCCCHHHHHHHCCCEEEEECCCHHHHHH
HQGQVVEQVVRPTGLIDPVVEIRPATTQVDDLLAQIKTRIAVQERVLVTVLTKRMAEDLT
HHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYLADNGIKVRYLHSDIDTVERVEIIRDLRLGQFDVLVGINLLREGLDIPEVSLVAILDA
HHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEC
DKEGFLRSERSLIQTIGRAARHIHGTAILYADQITDSMRAAIGETERRRTKQIAFNEANG
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCHHHHHHHHHHHECCCCC
IVPRTVSKRIKDIIDGVYNADGASRDSARVGEARADYAAMDEKQLARAIKKLEKEMQEHA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RNLEFEKAAAARDELFKLRERAFGADQHGNT
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQSPADSGSDSTAKVLTFEGSPFRLHQPFPPAGDQPEAIRLLCEGVEDGLMYQTLLGVTG
CCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCC
SGKTYTMANVIARMGRPALVLAPNKTLAAQLYAEFREFLPENAVEYFVSYYDYYQPEAYV
CCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
PQRDLFIEKDSSVNEHIEQMRLSATKSLMERRDVVIVATVSCIYGIGDPVDYHAMILHLR
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCCHHHEEEEEC
EGERVSHRDLIARLVAMQYTRADLDFRRGTFRVRGDVIDVFPSENAELAVRIEMFDDEIE
CCCCCHHHHHHHHHHHHHHHHCCCHHCCCEEEEECCEEEECCCCCCCEEEEEEECCCCCC
HLTLFDPLTGHLKQKLVRFTVYPSSHYVTPRATVLKAIEAIKEELKDRIAFFQREGKLVE
EEEEECHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AQRLEQRTRFDLEMLNEMGFCKGIENYSRHLSGRGPGEPPPTLIDYLPADALMFIDESHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCE
AIGQVGGMYKGDRSRKENLVGYGFRLPSALDNRPLKFEEFERLMPQTVFVSATPAAYEAQ
EHHHCCCCCCCCCHHHCCCEEECEECCHHHCCCCCCHHHHHHHCCCEEEEECCCHHHHHH
HQGQVVEQVVRPTGLIDPVVEIRPATTQVDDLLAQIKTRIAVQERVLVTVLTKRMAEDLT
HHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYLADNGIKVRYLHSDIDTVERVEIIRDLRLGQFDVLVGINLLREGLDIPEVSLVAILDA
HHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEC
DKEGFLRSERSLIQTIGRAARHIHGTAILYADQITDSMRAAIGETERRRTKQIAFNEANG
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCHHHHHHHHHHHECCCCC
IVPRTVSKRIKDIIDGVYNADGASRDSARVGEARADYAAMDEKQLARAIKKLEKEMQEHA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RNLEFEKAAAARDELFKLRERAFGADQHGNT
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA