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The map label for this gene is tyrB [H]

Identifier: 119897901

GI number: 119897901

Start: 1772287

End: 1773495

Strand: Reverse

Name: tyrB [H]

Synonym: azo1610

Alternate gene names: 119897901

Gene position: 1773495-1772287 (Counterclockwise)

Preceding gene: 119897904

Following gene: 119897898

Centisome position: 40.53

GC content: 68.07

Gene sequence:

>1209_bases
ATGTCCGCATCGATCTTCGCCGCCGTCGAGTTGGCGCCCCGTGACCCGATCCTCGGCCTCAACGAGGCCTTCGCCGCCGA
CACCCGCGCCCAGAAGGTGAACCTCGGCGTCGGCGTCTACTACGACGACAACGGCAAGATTCCGCTGCTGGCCGCCGTCC
GCGCCGCCGAAAAGGCCCGCCTCGAAGCCATGCCGCCGCGCGGCTACCAGCCGATCGAAGGCCCCGCCGCCTACAACAAC
GCGGTGCAGAACCTGCTGCTCGGCAAGGATTCCGCGCTGATCGCCAACGGCCAGGTCGTCACCGTCGAAGCACTCGGCGG
CACCGGCGCGCTGAAGGTCGGCGCCGACTACCTCAAGCGCCTGCTGCCGGGCGCCACGGTCTACATCTCCGACCCGAGCT
GGGAAAACCACCGCGCGCTGTTCGAATCGGCCGGCTTCCCGGTCGACACCTACCCTTACTACGACGCCGCCACCCGCGGC
GTGAACTTCGCCGGCATGAAGGCCAAGCTGGAAAGCCTGCCGGCCGGCTCGATCATCGTGCTGCACGCCTGCTGCCACAA
CCCGACCGGCGCGGATCTTTCCGACGCCCAGTGGGATGAGGTCGTCGCCGCCTGCCGCGCCCGCGGCCTGGTGCCCTTCC
TCGACATGGCCTACCAGGGCTTCGCCGACGGCATCGACGCCGACGCCGTCGCGGTGCGCGCCTTCTCGGCCAGCGGCCTG
CAGTTCTTCGTTTCCAGCTCGTTCTCCAAGAGCTTCTCGCTGTACGGCGAGCGCGTCGGCGCGCTGTCCATCATCACCGC
CAGCAAGGAAGAGTCCGGCCGCGTGCTGTCGCAAGTCAAGCGCGTGATCCGTACCAACTATTCCAACCCGCCGATCCACG
GCGGCGCCATCGTCGCCGCGGTGCTCAACTCCGCCGAACTGCGCCAGCAGTGGGAAGACGAACTCGCCGGCATGCGCGAC
CGCATCCGCGCGATGCGGACGGGGCTGGTCGAGCAGCTGAAGGCCGAAGGCGTGGCGCAGGACTTCTCCTTCGTGATCAA
GCAGCGCGGCATGTTCTCCTACACCGGCCTCACCGCCGCCCAGGTCGAGAAGCTGAAGACCGACTTCGGCATCTACGCGG
TGTCGACGGGCCGTATCTGCCTGGCGGCGCTGAACTCCAAGAACATCGGCTACGTCGCCAAGGCGATCGCGGCGGTGGTC
AAGGGCTGA

Upstream 100 bases:

>100_bases
CAAGCAGGCGGAAACACCGATTATTTCCCAAATCGCGTCTCAAGGCACGGCCCGGTCCGCGCCGCGGCGCGACCGAACCG
CTAGCGCAACTGGAGTCCAA

Downstream 100 bases:

>100_bases
TCATCGAGTCGGGGCGGCCGATTGCCGTGCGAACGAATAATCCGCGGCCCCGTTCTTGACGAAGCGCACATTCATGCCTA
GAATGCGCGGCTCTGTTCCT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MSASIFAAVELAPRDPILGLNEAFAADTRAQKVNLGVGVYYDDNGKIPLLAAVRAAEKARLEAMPPRGYQPIEGPAAYNN
AVQNLLLGKDSALIANGQVVTVEALGGTGALKVGADYLKRLLPGATVYISDPSWENHRALFESAGFPVDTYPYYDAATRG
VNFAGMKAKLESLPAGSIIVLHACCHNPTGADLSDAQWDEVVAACRARGLVPFLDMAYQGFADGIDADAVAVRAFSASGL
QFFVSSSFSKSFSLYGERVGALSIITASKEESGRVLSQVKRVIRTNYSNPPIHGGAIVAAVLNSAELRQQWEDELAGMRD
RIRAMRTGLVEQLKAEGVAQDFSFVIKQRGMFSYTGLTAAQVEKLKTDFGIYAVSTGRICLAALNSKNIGYVAKAIAAVV
KG

Sequences:

>Translated_402_residues
MSASIFAAVELAPRDPILGLNEAFAADTRAQKVNLGVGVYYDDNGKIPLLAAVRAAEKARLEAMPPRGYQPIEGPAAYNN
AVQNLLLGKDSALIANGQVVTVEALGGTGALKVGADYLKRLLPGATVYISDPSWENHRALFESAGFPVDTYPYYDAATRG
VNFAGMKAKLESLPAGSIIVLHACCHNPTGADLSDAQWDEVVAACRARGLVPFLDMAYQGFADGIDADAVAVRAFSASGL
QFFVSSSFSKSFSLYGERVGALSIITASKEESGRVLSQVKRVIRTNYSNPPIHGGAIVAAVLNSAELRQQWEDELAGMRD
RIRAMRTGLVEQLKAEGVAQDFSFVIKQRGMFSYTGLTAAQVEKLKTDFGIYAVSTGRICLAALNSKNIGYVAKAIAAVV
KG
>Mature_401_residues
SASIFAAVELAPRDPILGLNEAFAADTRAQKVNLGVGVYYDDNGKIPLLAAVRAAEKARLEAMPPRGYQPIEGPAAYNNA
VQNLLLGKDSALIANGQVVTVEALGGTGALKVGADYLKRLLPGATVYISDPSWENHRALFESAGFPVDTYPYYDAATRGV
NFAGMKAKLESLPAGSIIVLHACCHNPTGADLSDAQWDEVVAACRARGLVPFLDMAYQGFADGIDADAVAVRAFSASGLQ
FFVSSSFSKSFSLYGERVGALSIITASKEESGRVLSQVKRVIRTNYSNPPIHGGAIVAAVLNSAELRQQWEDELAGMRDR
IRAMRTGLVEQLKAEGVAQDFSFVIKQRGMFSYTGLTAAQVEKLKTDFGIYAVSTGRICLAALNSKNIGYVAKAIAAVVK
G

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=398, Percent_Identity=44.7236180904523, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI4504067, Length=405, Percent_Identity=41.4814814814815, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI117414139, Length=404, Percent_Identity=26.2376237623762, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1790488, Length=398, Percent_Identity=52.5125628140703, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=44.9494949494949, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=41.8136020151133, Blast_Score=348, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI25147133, Length=399, Percent_Identity=42.3558897243108, Blast_Score=337, Evalue=9e-93,
Organism=Caenorhabditis elegans, GI17569539, Length=401, Percent_Identity=38.6533665835411, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17569537, Length=403, Percent_Identity=32.7543424317618, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17550384, Length=270, Percent_Identity=36.6666666666667, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI25147136, Length=213, Percent_Identity=39.906103286385, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6323055, Length=412, Percent_Identity=39.8058252427184, Blast_Score=306, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6322743, Length=435, Percent_Identity=31.9540229885057, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24580970, Length=402, Percent_Identity=45.5223880597015, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24580972, Length=402, Percent_Identity=45.5223880597015, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19920542, Length=394, Percent_Identity=45.9390862944162, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24654046, Length=404, Percent_Identity=41.8316831683168, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI19922362, Length=402, Percent_Identity=42.0398009950249, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 42751; Mature: 42620

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASIFAAVELAPRDPILGLNEAFAADTRAQKVNLGVGVYYDDNGKIPLLAAVRAAEKAR
CCCCEEEEEEECCCCCCCCCCHHHHCCCCCEEEEEEEEEEECCCCCEEHHHHHHHHHHHH
LEAMPPRGYQPIEGPAAYNNAVQNLLLGKDSALIANGQVVTVEALGGTGALKVGADYLKR
HCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCCHHHHHHHHHH
LLPGATVYISDPSWENHRALFESAGFPVDTYPYYDAATRGVNFAGMKAKLESLPAGSIIV
HCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCEEE
LHACCHNPTGADLSDAQWDEVVAACRARGLVPFLDMAYQGFADGIDADAVAVRAFSASGL
EEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHEEEEECCCCH
QFFVSSSFSKSFSLYGERVGALSIITASKEESGRVLSQVKRVIRTNYSNPPIHGGAIVAA
HEEHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
VLNSAELRQQWEDELAGMRDRIRAMRTGLVEQLKAEGVAQDFSFVIKQRGMFSYTGLTAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCHHH
QVEKLKTDFGIYAVSTGRICLAALNSKNIGYVAKAIAAVVKG
HHHHHHHCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SASIFAAVELAPRDPILGLNEAFAADTRAQKVNLGVGVYYDDNGKIPLLAAVRAAEKAR
CCCEEEEEEECCCCCCCCCCHHHHCCCCCEEEEEEEEEEECCCCCEEHHHHHHHHHHHH
LEAMPPRGYQPIEGPAAYNNAVQNLLLGKDSALIANGQVVTVEALGGTGALKVGADYLKR
HCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCCHHHHHHHHHH
LLPGATVYISDPSWENHRALFESAGFPVDTYPYYDAATRGVNFAGMKAKLESLPAGSIIV
HCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCEEE
LHACCHNPTGADLSDAQWDEVVAACRARGLVPFLDMAYQGFADGIDADAVAVRAFSASGL
EEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHEEEEECCCCH
QFFVSSSFSKSFSLYGERVGALSIITASKEESGRVLSQVKRVIRTNYSNPPIHGGAIVAA
HEEHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
VLNSAELRQQWEDELAGMRDRIRAMRTGLVEQLKAEGVAQDFSFVIKQRGMFSYTGLTAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCHHH
QVEKLKTDFGIYAVSTGRICLAALNSKNIGYVAKAIAAVVKG
HHHHHHHCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043; 8808952 [H]