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The map label for this gene is moaA [H]

Identifier: 119897898

GI number: 119897898

Start: 1767782

End: 1768855

Strand: Reverse

Name: moaA [H]

Synonym: azo1607

Alternate gene names: 119897898

Gene position: 1768855-1767782 (Counterclockwise)

Preceding gene: 119897901

Following gene: 119897895

Centisome position: 40.42

GC content: 66.57

Gene sequence:

>1074_bases
ATGAAGGTCATCCCGATCCGCACCGCCTCCTCCGCCCGCATCGACCTGCCGCCCCCTCCGGCCGCCGGCTTGCCCTTGCT
CGACACCCGCGGCCGCAGCGTGCGCGACCTGCGCATCTCGGTAACCGACCGCTGCAACTTCCGCTGCGTCTATTGCATGC
CGCGCGAGGTGTTCGACAAGGACTATCCCTTCCTCCCGCGCGGCCAGTTGCTCAGCTTCGAGGAAATCCTGCGCGTCGCC
CGCCTGTTCGTGGCGCGCGGAGTCCGCAAGATCCGCATCACCGGCGGCGAGCCGCTGCTGCGCAAGGACATCGAGCGGCT
GGTGGAAATGCTGGCGGCGCTGGATGGCGTCGAGCTGACGCTGACCACCAACGGCGTGCTGCTGCCGCGGCTGGCCAAGA
AACTGCGCGACGCCGGCCTGCATCGCGTCACCGTCAGCCTCGACGCGCTGGACGACGCGACCTTCCGCCGCATGAACGAT
GCCGACTACCCGGTCGAACGCGTACTCGAAGGCATCGCCGCGGCGCGGGACGCCGGCTTCGAGGGCATCAAGGTGAACAT
GGTGGTCAAGCGCGGTACCAACGACCAGGACATCGAGGCGATGGCGCAGCATTTCCGCGGCAGCGGCAACATCCTGCGCT
TCATCGAATTCATGGACGTCGGCTCCAGCAACGGCTGGAAGATGGACGAAGTGCTGCCCTCGCGCGAGGTGATCGCGCGC
ATCGACCGCCTGTTTCCGCTCGAACCCATCGACCCCAACTATGAGGGCGAGGTGGCCGAACGTTGGCGCTACAAGGACGG
AAGCGGCGAGGTCGGGGTGATTTCCTCGGTGACGCAGGCGTTCTGCGGCACCTGCACCCGCATCCGCCTATCCACCGAAG
GCAAGCTCTACACCTGTCTGTTCGCCCAGCAGGGGCACGACCTGCGCCAGCTGCTGCGCGAAGGGGCCGATGATGGCCAG
CTCGATGCCGCCATCGCCCATGTGTGGCAGCAACGCGACGACCACTATTCCGAAATCCGCACTGCCGCCACGGCCAAGGC
GCACAAGATCGAGATGTCCTACATCGGCGGCTGA

Upstream 100 bases:

>100_bases
GAACACAGGCGATCGCGCTCCGCTACTTGATCGCCGACAAGGCGCAGCCGGTAAAGCGGTGCCGACAATGCAACACCGAA
CGACGGCAAGCTCGCATCCC

Downstream 100 bases:

>100_bases
GGGCTCAGCTGACGCTCAGGCCAACGCCCGCAAACTGGCAAGCGGCGGCCGCCGCAGCAGGCCGCGCGTGCCCAGCCAGC
CACCGGCCACCACCCCGGCC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKVIPIRTASSARIDLPPPPAAGLPLLDTRGRSVRDLRISVTDRCNFRCVYCMPREVFDKDYPFLPRGQLLSFEEILRVA
RLFVARGVRKIRITGGEPLLRKDIERLVEMLAALDGVELTLTTNGVLLPRLAKKLRDAGLHRVTVSLDALDDATFRRMND
ADYPVERVLEGIAAARDAGFEGIKVNMVVKRGTNDQDIEAMAQHFRGSGNILRFIEFMDVGSSNGWKMDEVLPSREVIAR
IDRLFPLEPIDPNYEGEVAERWRYKDGSGEVGVISSVTQAFCGTCTRIRLSTEGKLYTCLFAQQGHDLRQLLREGADDGQ
LDAAIAHVWQQRDDHYSEIRTAATAKAHKIEMSYIGG

Sequences:

>Translated_357_residues
MKVIPIRTASSARIDLPPPPAAGLPLLDTRGRSVRDLRISVTDRCNFRCVYCMPREVFDKDYPFLPRGQLLSFEEILRVA
RLFVARGVRKIRITGGEPLLRKDIERLVEMLAALDGVELTLTTNGVLLPRLAKKLRDAGLHRVTVSLDALDDATFRRMND
ADYPVERVLEGIAAARDAGFEGIKVNMVVKRGTNDQDIEAMAQHFRGSGNILRFIEFMDVGSSNGWKMDEVLPSREVIAR
IDRLFPLEPIDPNYEGEVAERWRYKDGSGEVGVISSVTQAFCGTCTRIRLSTEGKLYTCLFAQQGHDLRQLLREGADDGQ
LDAAIAHVWQQRDDHYSEIRTAATAKAHKIEMSYIGG
>Mature_357_residues
MKVIPIRTASSARIDLPPPPAAGLPLLDTRGRSVRDLRISVTDRCNFRCVYCMPREVFDKDYPFLPRGQLLSFEEILRVA
RLFVARGVRKIRITGGEPLLRKDIERLVEMLAALDGVELTLTTNGVLLPRLAKKLRDAGLHRVTVSLDALDDATFRRMND
ADYPVERVLEGIAAARDAGFEGIKVNMVVKRGTNDQDIEAMAQHFRGSGNILRFIEFMDVGSSNGWKMDEVLPSREVIAR
IDRLFPLEPIDPNYEGEVAERWRYKDGSGEVGVISSVTQAFCGTCTRIRLSTEGKLYTCLFAQQGHDLRQLLREGADDGQ
LDAAIAHVWQQRDDHYSEIRTAATAKAHKIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=316, Percent_Identity=37.9746835443038, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI22027536, Length=316, Percent_Identity=37.9746835443038, Blast_Score=203, Evalue=2e-52,
Organism=Escherichia coli, GI1786999, Length=338, Percent_Identity=33.4319526627219, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17561210, Length=325, Percent_Identity=36, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI32566331, Length=324, Percent_Identity=34.8765432098765, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI32566329, Length=307, Percent_Identity=36.4820846905537, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28574490, Length=316, Percent_Identity=37.9746835443038, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI28574488, Length=315, Percent_Identity=38.0952380952381, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 40014; Mature: 40014

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS01305 MOAA_NIFB_PQQE ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIPIRTASSARIDLPPPPAAGLPLLDTRGRSVRDLRISVTDRCNFRCVYCMPREVFDK
CEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHHCC
DYPFLPRGQLLSFEEILRVARLFVARGVRKIRITGGEPLLRKDIERLVEMLAALDGVELT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEE
LTTNGVLLPRLAKKLRDAGLHRVTVSLDALDDATFRRMNDADYPVERVLEGIAAARDAGF
EECCCEEHHHHHHHHHHCCCEEEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCC
EGIKVNMVVKRGTNDQDIEAMAQHFRGSGNILRFIEFMDVGSSNGWKMDEVLPSREVIAR
CCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCCCHHHHCCHHHHHHH
IDRLFPLEPIDPNYEGEVAERWRYKDGSGEVGVISSVTQAFCGTCTRIRLSTEGKLYTCL
HHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEE
FAQQGHDLRQLLREGADDGQLDAAIAHVWQQRDDHYSEIRTAATAKAHKIEMSYIGG
EECCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCC
>Mature Secondary Structure
MKVIPIRTASSARIDLPPPPAAGLPLLDTRGRSVRDLRISVTDRCNFRCVYCMPREVFDK
CEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHHCC
DYPFLPRGQLLSFEEILRVARLFVARGVRKIRITGGEPLLRKDIERLVEMLAALDGVELT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEE
LTTNGVLLPRLAKKLRDAGLHRVTVSLDALDDATFRRMNDADYPVERVLEGIAAARDAGF
EECCCEEHHHHHHHHHHCCCEEEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCC
EGIKVNMVVKRGTNDQDIEAMAQHFRGSGNILRFIEFMDVGSSNGWKMDEVLPSREVIAR
CCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCCCHHHHCCHHHHHHH
IDRLFPLEPIDPNYEGEVAERWRYKDGSGEVGVISSVTQAFCGTCTRIRLSTEGKLYTCL
HHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEE
FAQQGHDLRQLLREGADDGQLDAAIAHVWQQRDDHYSEIRTAATAKAHKIEMSYIGG
EECCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]