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The map label for this gene is sdhB [H]

Identifier: 119897843

GI number: 119897843

Start: 1700826

End: 1701536

Strand: Direct

Name: sdhB [H]

Synonym: azo1552

Alternate gene names: 119897843

Gene position: 1700826-1701536 (Clockwise)

Preceding gene: 119897842

Following gene: 119897844

Centisome position: 38.87

GC content: 62.87

Gene sequence:

>711_bases
ATGACCAAGCGTACCGTTCAATTCAAGATCTACCGCTACGATCCGGACAAGGACGAGAAGCCCTACATGCAGGACATCTC
GGTCGAACTGGAAGCCTCCGACAAGAAGCTGCTCGACGCCATCGTCCGCCTCAAGACCAAGGACGACACGCTGTCCTTCC
GCCGCTCCTGCCGCGAAGGCGTGTGCGGTTCGGACGCGATGAACATCAACGGCAAGAACGGCCTGGCCTGCCTGACCGAC
GTCGATAGCCTGGAGCAGCCGATCACGCTGCGTCCGCTGCCGGGGCTGCCGGTCATCCGCGACCTGATCGTGGACATGAC
CCAGTTCTTCAAGCAGTACCACTCGATCAAGCCCTACCTGGTCAACAACGAGCCGGTGCCGGAACGCGAGCGCCTGCAGA
CGCCGGAAGACCGTGAGGAACTCAACGGGCTCTACGAGTGCATCCTGTGCGCCTGCTGCTCGACCTCCTGCCCGTCGTTC
TGGTGGAACCCGGACAAGTTCGTCGGGCCGGCCGGTCTGCTGGCCGCTTACCGCTTCCTCGCCGACACGCGCGATCAGGC
GACCAACGAGCGTCTCGACAACCTCGAAGACCCGTACCGCCTGTTCCGCTGCCACACCATCATGAACTGCGTCGACGTGT
GTCCGAAGGGTCTCAACCCGACGCGCGCGATCGGCAAGATCAAGGACATGATGGTCCGCCGGGCGGTTTGA

Upstream 100 bases:

>100_bases
CGCCTCGACTACAAGCCGGTGAACCTGAAGCCGATGTCCGACGATGTCGAACCCATCGCGCTCGCCAAGCGTACCTACTG
AGCGCGGGAGAACAGATCAA

Downstream 100 bases:

>100_bases
GGATGAGCATCAACCGGGGGCGCGTGCGCTGGCAATGCCGTCGGGCTCTGCTCGAGCTCGATCTTGTCTTCGCACGCTTT
CTCGAGCGCGATTTCGATCG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTKRTVQFKIYRYDPDKDEKPYMQDISVELEASDKKLLDAIVRLKTKDDTLSFRRSCREGVCGSDAMNINGKNGLACLTD
VDSLEQPITLRPLPGLPVIRDLIVDMTQFFKQYHSIKPYLVNNEPVPERERLQTPEDREELNGLYECILCACCSTSCPSF
WWNPDKFVGPAGLLAAYRFLADTRDQATNERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTRAIGKIKDMMVRRAV

Sequences:

>Translated_236_residues
MTKRTVQFKIYRYDPDKDEKPYMQDISVELEASDKKLLDAIVRLKTKDDTLSFRRSCREGVCGSDAMNINGKNGLACLTD
VDSLEQPITLRPLPGLPVIRDLIVDMTQFFKQYHSIKPYLVNNEPVPERERLQTPEDREELNGLYECILCACCSTSCPSF
WWNPDKFVGPAGLLAAYRFLADTRDQATNERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTRAIGKIKDMMVRRAV
>Mature_235_residues
TKRTVQFKIYRYDPDKDEKPYMQDISVELEASDKKLLDAIVRLKTKDDTLSFRRSCREGVCGSDAMNINGKNGLACLTDV
DSLEQPITLRPLPGLPVIRDLIVDMTQFFKQYHSIKPYLVNNEPVPERERLQTPEDREELNGLYECILCACCSTSCPSFW
WNPDKFVGPAGLLAAYRFLADTRDQATNERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTRAIGKIKDMMVRRAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=234, Percent_Identity=55.1282051282051, Blast_Score=271, Evalue=4e-73,
Organism=Escherichia coli, GI1786943, Length=234, Percent_Identity=68.3760683760684, Blast_Score=342, Evalue=1e-95,
Organism=Escherichia coli, GI1790596, Length=236, Percent_Identity=33.4745762711864, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=48.7179487179487, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6322987, Length=233, Percent_Identity=51.5021459227468, Blast_Score=251, Evalue=6e-68,
Organism=Drosophila melanogaster, GI17137106, Length=232, Percent_Identity=52.1551724137931, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=52.1367521367521, Blast_Score=254, Evalue=3e-68,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27091; Mature: 26960

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRTVQFKIYRYDPDKDEKPYMQDISVELEASDKKLLDAIVRLKTKDDTLSFRRSCREG
CCCCEEEEEEEEECCCCCCCCHHHHCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCC
VCGSDAMNINGKNGLACLTDVDSLEQPITLRPLPGLPVIRDLIVDMTQFFKQYHSIKPYL
CCCCCCCEECCCCCEEEEECHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
VNNEPVPERERLQTPEDREELNGLYECILCACCSTSCPSFWWNPDKFVGPAGLLAAYRFL
ECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHH
ADTRDQATNERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTRAIGKIKDMMVRRAV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKRTVQFKIYRYDPDKDEKPYMQDISVELEASDKKLLDAIVRLKTKDDTLSFRRSCREG
CCCEEEEEEEEECCCCCCCCHHHHCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCC
VCGSDAMNINGKNGLACLTDVDSLEQPITLRPLPGLPVIRDLIVDMTQFFKQYHSIKPYL
CCCCCCCEECCCCCEEEEECHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
VNNEPVPERERLQTPEDREELNGLYECILCACCSTSCPSFWWNPDKFVGPAGLLAAYRFL
ECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHH
ADTRDQATNERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTRAIGKIKDMMVRRAV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]