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The map label for this gene is sdhA [H]

Identifier: 119897842

GI number: 119897842

Start: 1699013

End: 1700806

Strand: Direct

Name: sdhA [H]

Synonym: azo1551

Alternate gene names: 119897842

Gene position: 1699013-1700806 (Clockwise)

Preceding gene: 119897841

Following gene: 119897843

Centisome position: 38.83

GC content: 65.5

Gene sequence:

>1794_bases
GTGAACGTCGCAAAGCGTACCTTTGATGCGGTCATCGTCGGCGCCGGTGGTGCCGGCCTGCGTGCGGCCCTGCAACTCTC
CGAAGCCGGCCTCAAGACCGCCGTGCTGACCAAGGTCTTCCCCACCCGCTCCCACACCGTGGCGGCGCAGGGCGGTGTGG
CCGCTTCGCTGGGCAACTCCACCGAGGACAACTGGCACTGGCACATGTACGACACCGTCAAGGGGTCGGACTGGCTGGGC
GACCAGGATGCCATCGAGTTCATGGTCCGCAAGGCCAACGAAGTCGTGGTCGAACTCGAACACTACGGCATGCCGTTCGA
CCGTACCGACAACGGCAAGATCTACCAGCGTCCGTTCGGCGGCCATTCGATGAACTACGGCCAGGCGCCGGTGATGCGCT
CGTGCGCGGCGGCCGACCGTACCGGCCACGCCATGCTGCACGCGCTCTACCAGCGCAACGTGCGCGCGAACACCCAGTTC
TTCGTCGAGTGGATGGCGCTCGACCTGATCCGCAACAGCGAAGGCGATGTCCTCGGCGTTACCGCGCTGGAAATGGAAAC
CGGCGAAGTCTCGATCTTCCACGCCAAGGCGACCATCTTCGCCACCGGCGGTGCCGGCCGTATCTACTACAGCTCGACCA
ACGCCTTCATCAACACCGGTGACGGCGTGGGCATGGCGGCGCGCGCCGGCATCCCGCTGGAAGACATGGAGTTCTGGCAG
TTCCACCCCACCGGCGTGGCCGGCGCGGGCGTGCTGATCACCGAAGGTGTGCGCGGCGAAGGCGGCATCCTGCGCAACGC
CTCCGGCGAGCGCTTCATGGAACGCTACGCCCCGAACCTGAAGGATCTGGCCTCGCGCGACGTCGTGTCGCGTTCGATGG
TGACCGAAATCAACGAAGGTCGCGGTTGCGGTCCCGACAAGGACCACGTGTTGCTCGACATCACCCACCTGTCGCCCGAG
ACCATCATGAAGCGCCTGCCCGGCATTCGTGAAATCTCGATCCAGTTCGCCGGTGTGGACCCGATCAAGGCCCCGATCCC
GGTCGTGCCGACCTGCCACTATCAGATGGGCGGCATTCCGACCAACTACAAGGGTCAGGTCGTGGTGCCGAAGGACGGCA
ACCCGAACACCCCGGTCTCCGGCTTCTACGCCGCCGGCGAATGTGCCTGTGCTTCGGTGCACGGTGCCAACCGCCTCGGC
ACCAACTCGCTGCTCGACCTGCTGGTGTTCGGCAAGTCGGCGGGCGAAACCGTGGTTGCCGACTTCCAGGCCGGCAACCT
GGCGCTCAAGCCGCTGCCGGCCGATGCCGCCGATGCCTCGCTGGCGCGCATCAACCGCCTCGAAACGCAGAAGAACGGCA
CCAACGTGCATGAGGTCCGCCTCGCGATGCAGCGCACCATGCAGAAGCACGCCGGTGTGTTCCGCTTCAACGACCTGCTG
CAGGAAGGCGTCACCCGCATCCTCGAAGTGGCCGAACAGGCGAAGAGCACCGAGATCGGCGACAAGTCCAAGGTCTGGAA
CACCGCCCGCACCGAAGCGCTGGAACTCGACAACCTGATCGAAGTGGCCAAGGCCACCATGATCTCGGCCGAGGCCCGCA
AGGAGTCGCGCGGCGCCCACGTGCGCGATGACGCCATCGACAGCCCGGAGCGTCCGAACGGCCGCGACGACGCCAACTGG
CTCAAGCACACGCTGTGGTTCAGCGAAGGCAACCGCCTCGACTACAAGCCGGTGAACCTGAAGCCGATGTCCGACGATGT
CGAACCCATCGCGCTCGCCAAGCGTACCTACTGA

Upstream 100 bases:

>100_bases
TCAAGCCGGACGGCCTGCGCCTGTCCCTGCACCTGATTACCCTCTTTCTGCTCGTCGGCTACGCCGGCTGGGCTGCCCAG
ATCCTGTGGAGGCTGTAAGC

Downstream 100 bases:

>100_bases
GCGCGGGAGAACAGATCAAATGACCAAGCGTACCGTTCAATTCAAGATCTACCGCTACGATCCGGACAAGGACGAGAAGC
CCTACATGCAGGACATCTCG

Product: succinate dehydrogenase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MNVAKRTFDAVIVGAGGAGLRAALQLSEAGLKTAVLTKVFPTRSHTVAAQGGVAASLGNSTEDNWHWHMYDTVKGSDWLG
DQDAIEFMVRKANEVVVELEHYGMPFDRTDNGKIYQRPFGGHSMNYGQAPVMRSCAAADRTGHAMLHALYQRNVRANTQF
FVEWMALDLIRNSEGDVLGVTALEMETGEVSIFHAKATIFATGGAGRIYYSSTNAFINTGDGVGMAARAGIPLEDMEFWQ
FHPTGVAGAGVLITEGVRGEGGILRNASGERFMERYAPNLKDLASRDVVSRSMVTEINEGRGCGPDKDHVLLDITHLSPE
TIMKRLPGIREISIQFAGVDPIKAPIPVVPTCHYQMGGIPTNYKGQVVVPKDGNPNTPVSGFYAAGECACASVHGANRLG
TNSLLDLLVFGKSAGETVVADFQAGNLALKPLPADAADASLARINRLETQKNGTNVHEVRLAMQRTMQKHAGVFRFNDLL
QEGVTRILEVAEQAKSTEIGDKSKVWNTARTEALELDNLIEVAKATMISAEARKESRGAHVRDDAIDSPERPNGRDDANW
LKHTLWFSEGNRLDYKPVNLKPMSDDVEPIALAKRTY

Sequences:

>Translated_597_residues
MNVAKRTFDAVIVGAGGAGLRAALQLSEAGLKTAVLTKVFPTRSHTVAAQGGVAASLGNSTEDNWHWHMYDTVKGSDWLG
DQDAIEFMVRKANEVVVELEHYGMPFDRTDNGKIYQRPFGGHSMNYGQAPVMRSCAAADRTGHAMLHALYQRNVRANTQF
FVEWMALDLIRNSEGDVLGVTALEMETGEVSIFHAKATIFATGGAGRIYYSSTNAFINTGDGVGMAARAGIPLEDMEFWQ
FHPTGVAGAGVLITEGVRGEGGILRNASGERFMERYAPNLKDLASRDVVSRSMVTEINEGRGCGPDKDHVLLDITHLSPE
TIMKRLPGIREISIQFAGVDPIKAPIPVVPTCHYQMGGIPTNYKGQVVVPKDGNPNTPVSGFYAAGECACASVHGANRLG
TNSLLDLLVFGKSAGETVVADFQAGNLALKPLPADAADASLARINRLETQKNGTNVHEVRLAMQRTMQKHAGVFRFNDLL
QEGVTRILEVAEQAKSTEIGDKSKVWNTARTEALELDNLIEVAKATMISAEARKESRGAHVRDDAIDSPERPNGRDDANW
LKHTLWFSEGNRLDYKPVNLKPMSDDVEPIALAKRTY
>Mature_597_residues
MNVAKRTFDAVIVGAGGAGLRAALQLSEAGLKTAVLTKVFPTRSHTVAAQGGVAASLGNSTEDNWHWHMYDTVKGSDWLG
DQDAIEFMVRKANEVVVELEHYGMPFDRTDNGKIYQRPFGGHSMNYGQAPVMRSCAAADRTGHAMLHALYQRNVRANTQF
FVEWMALDLIRNSEGDVLGVTALEMETGEVSIFHAKATIFATGGAGRIYYSSTNAFINTGDGVGMAARAGIPLEDMEFWQ
FHPTGVAGAGVLITEGVRGEGGILRNASGERFMERYAPNLKDLASRDVVSRSMVTEINEGRGCGPDKDHVLLDITHLSPE
TIMKRLPGIREISIQFAGVDPIKAPIPVVPTCHYQMGGIPTNYKGQVVVPKDGNPNTPVSGFYAAGECACASVHGANRLG
TNSLLDLLVFGKSAGETVVADFQAGNLALKPLPADAADASLARINRLETQKNGTNVHEVRLAMQRTMQKHAGVFRFNDLL
QEGVTRILEVAEQAKSTEIGDKSKVWNTARTEALELDNLIEVAKATMISAEARKESRGAHVRDDAIDSPERPNGRDDANW
LKHTLWFSEGNRLDYKPVNLKPMSDDVEPIALAKRTY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=588, Percent_Identity=53.5714285714286, Blast_Score=620, Evalue=1e-178,
Organism=Escherichia coli, GI1786942, Length=598, Percent_Identity=56.0200668896321, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=40.4802744425386, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI1788928, Length=564, Percent_Identity=32.8014184397163, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=573, Percent_Identity=54.1012216404887, Blast_Score=614, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17505833, Length=579, Percent_Identity=56.1312607944732, Blast_Score=613, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6322416, Length=603, Percent_Identity=52.4046434494196, Blast_Score=618, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6322701, Length=566, Percent_Identity=54.416961130742, Blast_Score=612, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=26.5848670756646, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17137288, Length=611, Percent_Identity=53.518821603928, Blast_Score=623, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24655642, Length=611, Percent_Identity=53.518821603928, Blast_Score=623, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24655647, Length=611, Percent_Identity=53.518821603928, Blast_Score=623, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24663005, Length=609, Percent_Identity=48.9326765188834, Blast_Score=568, Evalue=1e-162,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64845; Mature: 64845

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVAKRTFDAVIVGAGGAGLRAALQLSEAGLKTAVLTKVFPTRSHTVAAQGGVAASLGNS
CCCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCEEEECCCC
TEDNWHWHMYDTVKGSDWLGDQDAIEFMVRKANEVVVELEHYGMPFDRTDNGKIYQRPFG
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEECCCC
GHSMNYGQAPVMRSCAAADRTGHAMLHALYQRNVRANTQFFVEWMALDLIRNSEGDVLGV
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
TALEMETGEVSIFHAKATIFATGGAGRIYYSSTNAFINTGDGVGMAARAGIPLEDMEFWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCCCEECCCCCCCCHHEE
FHPTGVAGAGVLITEGVRGEGGILRNASGERFMERYAPNLKDLASRDVVSRSMVTEINEG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
RGCGPDKDHVLLDITHLSPETIMKRLPGIREISIQFAGVDPIKAPIPVVPTCHYQMGGIP
CCCCCCCCCEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEECCCCC
TNYKGQVVVPKDGNPNTPVSGFYAAGECACASVHGANRLGTNSLLDLLVFGKSAGETVVA
CCCCCEEEEECCCCCCCCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEE
DFQAGNLALKPLPADAADASLARINRLETQKNGTNVHEVRLAMQRTMQKHAGVFRFNDLL
EECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
QEGVTRILEVAEQAKSTEIGDKSKVWNTARTEALELDNLIEVAKATMISAEARKESRGAH
HHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VRDDAIDSPERPNGRDDANWLKHTLWFSEGNRLDYKPVNLKPMSDDVEPIALAKRTY
CCCCCCCCCCCCCCCCHHHHHHHHEEECCCCEECCCCCCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MNVAKRTFDAVIVGAGGAGLRAALQLSEAGLKTAVLTKVFPTRSHTVAAQGGVAASLGNS
CCCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCEEEECCCC
TEDNWHWHMYDTVKGSDWLGDQDAIEFMVRKANEVVVELEHYGMPFDRTDNGKIYQRPFG
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEECCCC
GHSMNYGQAPVMRSCAAADRTGHAMLHALYQRNVRANTQFFVEWMALDLIRNSEGDVLGV
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
TALEMETGEVSIFHAKATIFATGGAGRIYYSSTNAFINTGDGVGMAARAGIPLEDMEFWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCCCEECCCCCCCCHHEE
FHPTGVAGAGVLITEGVRGEGGILRNASGERFMERYAPNLKDLASRDVVSRSMVTEINEG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
RGCGPDKDHVLLDITHLSPETIMKRLPGIREISIQFAGVDPIKAPIPVVPTCHYQMGGIP
CCCCCCCCCEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEECCCCC
TNYKGQVVVPKDGNPNTPVSGFYAAGECACASVHGANRLGTNSLLDLLVFGKSAGETVVA
CCCCCEEEEECCCCCCCCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEE
DFQAGNLALKPLPADAADASLARINRLETQKNGTNVHEVRLAMQRTMQKHAGVFRFNDLL
EECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
QEGVTRILEVAEQAKSTEIGDKSKVWNTARTEALELDNLIEVAKATMISAEARKESRGAH
HHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VRDDAIDSPERPNGRDDANWLKHTLWFSEGNRLDYKPVNLKPMSDDVEPIALAKRTY
CCCCCCCCCCCCCCCCHHHHHHHHEEECCCCEECCCCCCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA