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The map label for this gene is comA [H]

Identifier: 119897803

GI number: 119897803

Start: 1654821

End: 1657130

Strand: Direct

Name: comA [H]

Synonym: azo1512

Alternate gene names: 119897803

Gene position: 1654821-1657130 (Clockwise)

Preceding gene: 119897801

Following gene: 119897804

Centisome position: 37.82

GC content: 72.47

Gene sequence:

>2310_bases
ATGTTTGCGCTCGGAACCGCGGCGCTGCAGCTTCAACCCGAACTGCCGACGGCCGTCACAGTGGTTTGGGTGGCCGTGGC
GCTTGCCGCCGCGGTGGGCCTGGCGGCAGTGCTGCGCGGCAGAGGGCGCGCCGCCCGCCTGAGCCTGATGGCGGCCGCCG
CACTCGCCGGCTTCATCGGCGCCGCGCTGCGCGCCGACGACCGCCTGGCGGACGCCTTGCCGATGGCGTGGGAAGGGCGG
GACGTGCCGGTGGTGGGGGTGATCGACGACCTGCCACAGGCCTTTGGCGAAGGGGTACGTTTCACGCTCGCGGTCGAGTC
CGCCGAGGGGCCGGTGCCGTCGCGGGTGCAGGTGTCGTGGTATCGCGGGCGCGACGACGACAGCCCGCTGCCGCGGCTTC
TCCCGGGCGAACGCTGGGCATTCGCACTGCGGCTGAAGCGGCCGCACGGATTCGTGAATCCGGCGGGATTCGATTACGAA
GCCTGGCTGCTGGAGCGCGGCGTGCGCGCGACCGGCTACGTGCGGGCGCAGCCCGCGCCACGCCGCCTGCACGAAGACGC
CGGCGGGTGGATGACCAGGGTGCATCGCGTGCGTGCCGCGGTTCGCGACCGCTTTCTCGCGGCGCTGGGAGAGGCGCCCT
ACGCCGGCATCCTGGTTGCGCTTGCGGTGGGCGACCAGCGCGCAATTCCGGCCGAGCAGTGGGAGGTCTTCCGGCGCACC
GGTATCGCCCACCTGGTGTCGATTTCCGGCATGCACATCTCCTTGATCGCGCTGCTCGCCGGCGGCCTCGTCAATCTGTT
GTGGCGCCGTGTGCCGACGCTGGTGCTGCGCTTGCCGGCACGCAAGGCGGGCGTGCTCGCCGGCCTTGCGGCGGCCCTGG
GCTATGGTCTGCTTGCGGGCATGGGCATCCCTGTGCAGCGCGCGGCGATCATGCTCAGCATGGCCGCCATCGCGCTGATG
CTCGGGCGCGAGGTGGCGCCCAGCCGGGTACTTGCGCTCGCGGTGCTGGGCGTGCTGCTGGTCGACCCGTGGGCGGTGCT
GGCTGCCGGGTTCTGGCTATCGTTCGGGGCGGTCGGGGCGATCCTCGTGCTTGCCGGCGGGCGGATCGGTCCGGCGGCGC
GCTGGAGCGCGGCGGTGCGCCTCCAGCTTGGCATCACGCTGGCCACCGTACCGCTGCTGGTGGCACTGTTCCATTCGTTT
CCGCTGGTTTCCCCGCTGGCCAATGCGGTGGCGATTCCGCTCGTCAGTTTCGTCGTCACGCCCCTGGCCCTGCTGGCGAT
GGTCCTGCCGTGGGACCTGCTGCTGGAGGCCGCGCATTGGGTGACGGCCCGCGTGATGGACTGGTCGGTGCTGCTCGCCG
ATCTTCCCTTCGCGCTGTGGCGTCAGGCGGCCGCGCCGGGCTGGGCGCTCGCGGCGGGCGCGGTGGGCGCCTGGATGTGG
CTGTTGCCGCGCCCGCTGCCGGGGCGTGCCGGCGCGCTGCTGATGGTGGGGCTGCTGCTCGGATGGCAGCCGCCGCGCCC
CGCGCCCGGCAGCTTTCGCGCGACGGTGCTCGACGTCGGCAACGGTCTGGCAGTGCATGTGCAGACGGCTACCCACGATC
TGCTTTACGACGCCGGGCCGCCCTATGGTCCCTTGTCGGACGCCGGCGAGCGCGTCGTGCTGCCGTATCTGGCAGCGAAT
GGCGTGGCGCGGCTCGATGTGCTGGTGCTGTCGCACGACGACGCGGATCATTCCGGTGGCGCCGGCAGCGTGCTGGAGTC
GATCGCGGTGGACGAGGTCCTGGCGGGCGAGGGCGCCGGTTTTGTGCCGGCCGCCGGGGTGCCGGCGCGGGCCTGCGCTG
CCGGCGAACAGTGGGCCTGGGACGACGTGGGTTTCCAGGTTCTCCATCCCGTCGCGGGGCGCGGACCGGCGCGGCGCAAC
AACGACGACTCCTGCGTGCTGCGGATCGCCGCCGGAGGCGGCTCGCTGCTGTTGGTGGGTGACATCGAGCAGCGCGCCGA
GGCGGGGCTGGTCAGGGGTGATGCCGCCGTGCTTGCCAGCTCGGTCATCGTCGTCGCCCACCACGGCAGCCGCAGTTCGT
CGTCTCCCGCCTTCGTCGACGCCGTGCTGCCGGAGGCCGCGGTGTTCTCGGTCGGCTACCGCAACATGTTCGGCCACCCC
CACCCGATGGTGTGGGCACGCTGGGCCGAGGCGGGCGCCCGCAACTGGCGCACCGACAGCCAGGGTGCCATCGCCATCGA
GGTCGACGGATCGGGCGTCACCGTGAACGCCGCGCGCGAATCCGCCCCGCGCTACTGGCATGGACGCTAG

Upstream 100 bases:

>100_bases
ATGGATTTGCCCCGATTCTAGCCCAGCGCGGGCGCCGCCCACGCTTGCCTCGTTGTTCATTCCGTTGGCATGATCGCGGA
TTATGCGAATGTCAATTTTC

Downstream 100 bases:

>100_bases
CCGAAGGTCATGCCGCGAACGCGGTGCTAGACTCGCAACCGTCATCGACCCGTCCGCCGCGAGCCGCCATGAGCCTGCTG
TCCGCACTGCGCCGCCTGTT

Product: putative DNA uptake/competence protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MFALGTAALQLQPELPTAVTVVWVAVALAAAVGLAAVLRGRGRAARLSLMAAAALAGFIGAALRADDRLADALPMAWEGR
DVPVVGVIDDLPQAFGEGVRFTLAVESAEGPVPSRVQVSWYRGRDDDSPLPRLLPGERWAFALRLKRPHGFVNPAGFDYE
AWLLERGVRATGYVRAQPAPRRLHEDAGGWMTRVHRVRAAVRDRFLAALGEAPYAGILVALAVGDQRAIPAEQWEVFRRT
GIAHLVSISGMHISLIALLAGGLVNLLWRRVPTLVLRLPARKAGVLAGLAAALGYGLLAGMGIPVQRAAIMLSMAAIALM
LGREVAPSRVLALAVLGVLLVDPWAVLAAGFWLSFGAVGAILVLAGGRIGPAARWSAAVRLQLGITLATVPLLVALFHSF
PLVSPLANAVAIPLVSFVVTPLALLAMVLPWDLLLEAAHWVTARVMDWSVLLADLPFALWRQAAAPGWALAAGAVGAWMW
LLPRPLPGRAGALLMVGLLLGWQPPRPAPGSFRATVLDVGNGLAVHVQTATHDLLYDAGPPYGPLSDAGERVVLPYLAAN
GVARLDVLVLSHDDADHSGGAGSVLESIAVDEVLAGEGAGFVPAAGVPARACAAGEQWAWDDVGFQVLHPVAGRGPARRN
NDDSCVLRIAAGGGSLLLVGDIEQRAEAGLVRGDAAVLASSVIVVAHHGSRSSSSPAFVDAVLPEAAVFSVGYRNMFGHP
HPMVWARWAEAGARNWRTDSQGAIAIEVDGSGVTVNAARESAPRYWHGR

Sequences:

>Translated_769_residues
MFALGTAALQLQPELPTAVTVVWVAVALAAAVGLAAVLRGRGRAARLSLMAAAALAGFIGAALRADDRLADALPMAWEGR
DVPVVGVIDDLPQAFGEGVRFTLAVESAEGPVPSRVQVSWYRGRDDDSPLPRLLPGERWAFALRLKRPHGFVNPAGFDYE
AWLLERGVRATGYVRAQPAPRRLHEDAGGWMTRVHRVRAAVRDRFLAALGEAPYAGILVALAVGDQRAIPAEQWEVFRRT
GIAHLVSISGMHISLIALLAGGLVNLLWRRVPTLVLRLPARKAGVLAGLAAALGYGLLAGMGIPVQRAAIMLSMAAIALM
LGREVAPSRVLALAVLGVLLVDPWAVLAAGFWLSFGAVGAILVLAGGRIGPAARWSAAVRLQLGITLATVPLLVALFHSF
PLVSPLANAVAIPLVSFVVTPLALLAMVLPWDLLLEAAHWVTARVMDWSVLLADLPFALWRQAAAPGWALAAGAVGAWMW
LLPRPLPGRAGALLMVGLLLGWQPPRPAPGSFRATVLDVGNGLAVHVQTATHDLLYDAGPPYGPLSDAGERVVLPYLAAN
GVARLDVLVLSHDDADHSGGAGSVLESIAVDEVLAGEGAGFVPAAGVPARACAAGEQWAWDDVGFQVLHPVAGRGPARRN
NDDSCVLRIAAGGGSLLLVGDIEQRAEAGLVRGDAAVLASSVIVVAHHGSRSSSSPAFVDAVLPEAAVFSVGYRNMFGHP
HPMVWARWAEAGARNWRTDSQGAIAIEVDGSGVTVNAARESAPRYWHGR
>Mature_769_residues
MFALGTAALQLQPELPTAVTVVWVAVALAAAVGLAAVLRGRGRAARLSLMAAAALAGFIGAALRADDRLADALPMAWEGR
DVPVVGVIDDLPQAFGEGVRFTLAVESAEGPVPSRVQVSWYRGRDDDSPLPRLLPGERWAFALRLKRPHGFVNPAGFDYE
AWLLERGVRATGYVRAQPAPRRLHEDAGGWMTRVHRVRAAVRDRFLAALGEAPYAGILVALAVGDQRAIPAEQWEVFRRT
GIAHLVSISGMHISLIALLAGGLVNLLWRRVPTLVLRLPARKAGVLAGLAAALGYGLLAGMGIPVQRAAIMLSMAAIALM
LGREVAPSRVLALAVLGVLLVDPWAVLAAGFWLSFGAVGAILVLAGGRIGPAARWSAAVRLQLGITLATVPLLVALFHSF
PLVSPLANAVAIPLVSFVVTPLALLAMVLPWDLLLEAAHWVTARVMDWSVLLADLPFALWRQAAAPGWALAAGAVGAWMW
LLPRPLPGRAGALLMVGLLLGWQPPRPAPGSFRATVLDVGNGLAVHVQTATHDLLYDAGPPYGPLSDAGERVVLPYLAAN
GVARLDVLVLSHDDADHSGGAGSVLESIAVDEVLAGEGAGFVPAAGVPARACAAGEQWAWDDVGFQVLHPVAGRGPARRN
NDDSCVLRIAAGGGSLLLVGDIEQRAEAGLVRGDAAVLASSVIVVAHHGSRSSSSPAFVDAVLPEAAVFSVGYRNMFGHP
HPMVWARWAEAGARNWRTDSQGAIAIEVDGSGVTVNAARESAPRYWHGR

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=665, Percent_Identity=29.6240601503759, Blast_Score=228, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 80658; Mature: 80658

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALGTAALQLQPELPTAVTVVWVAVALAAAVGLAAVLRGRGRAARLSLMAAAALAGFIG
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AALRADDRLADALPMAWEGRDVPVVGVIDDLPQAFGEGVRFTLAVESAEGPVPSRVQVSW
HHHHCCHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEE
YRGRDDDSPLPRLLPGERWAFALRLKRPHGFVNPAGFDYEAWLLERGVRATGYVRAQPAP
ECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCH
RRLHEDAGGWMTRVHRVRAAVRDRFLAALGEAPYAGILVALAVGDQRAIPAEQWEVFRRT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCHHHHHHHHHH
GIAHLVSISGMHISLIALLAGGLVNLLWRRVPTLVLRLPARKAGVLAGLAAALGYGLLAG
CHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
MGIPVQRAAIMLSMAAIALMLGREVAPSRVLALAVLGVLLVDPWAVLAAGFWLSFGAVGA
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ILVLAGGRIGPAARWSAAVRLQLGITLATVPLLVALFHSFPLVSPLANAVAIPLVSFVVT
HHHHCCCCCCCCHHHCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
PLALLAMVLPWDLLLEAAHWVTARVMDWSVLLADLPFALWRQAAAPGWALAAGAVGAWMW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHH
LLPRPLPGRAGALLMVGLLLGWQPPRPAPGSFRATVLDVGNGLAVHVQTATHDLLYDAGP
HCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCHHHHCCCCC
PYGPLSDAGERVVLPYLAANGVARLDVLVLSHDDADHSGGAGSVLESIAVDEVLAGEGAG
CCCCCCCCCCEEEEEEHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
FVPAAGVPARACAAGEQWAWDDVGFQVLHPVAGRGPARRNNDDSCVLRIAAGGGSLLLVG
CCCCCCCCHHHHCCCCCCCCHHCCHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEE
DIEQRAEAGLVRGDAAVLASSVIVVAHHGSRSSSSPAFVDAVLPEAAVFSVGYRNMFGHP
CHHHHHHCCCCCCCHHHHHCCEEEEEECCCCCCCCCCHHHHHCCHHHHHHCCHHHHCCCC
HPMVWARWAEAGARNWRTDSQGAIAIEVDGSGVTVNAARESAPRYWHGR
CCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEECHHCCCCCCCCCC
>Mature Secondary Structure
MFALGTAALQLQPELPTAVTVVWVAVALAAAVGLAAVLRGRGRAARLSLMAAAALAGFIG
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AALRADDRLADALPMAWEGRDVPVVGVIDDLPQAFGEGVRFTLAVESAEGPVPSRVQVSW
HHHHCCHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEE
YRGRDDDSPLPRLLPGERWAFALRLKRPHGFVNPAGFDYEAWLLERGVRATGYVRAQPAP
ECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCH
RRLHEDAGGWMTRVHRVRAAVRDRFLAALGEAPYAGILVALAVGDQRAIPAEQWEVFRRT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCHHHHHHHHHH
GIAHLVSISGMHISLIALLAGGLVNLLWRRVPTLVLRLPARKAGVLAGLAAALGYGLLAG
CHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
MGIPVQRAAIMLSMAAIALMLGREVAPSRVLALAVLGVLLVDPWAVLAAGFWLSFGAVGA
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ILVLAGGRIGPAARWSAAVRLQLGITLATVPLLVALFHSFPLVSPLANAVAIPLVSFVVT
HHHHCCCCCCCCHHHCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
PLALLAMVLPWDLLLEAAHWVTARVMDWSVLLADLPFALWRQAAAPGWALAAGAVGAWMW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHH
LLPRPLPGRAGALLMVGLLLGWQPPRPAPGSFRATVLDVGNGLAVHVQTATHDLLYDAGP
HCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCHHHHCCCCC
PYGPLSDAGERVVLPYLAANGVARLDVLVLSHDDADHSGGAGSVLESIAVDEVLAGEGAG
CCCCCCCCCCEEEEEEHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
FVPAAGVPARACAAGEQWAWDDVGFQVLHPVAGRGPARRNNDDSCVLRIAAGGGSLLLVG
CCCCCCCCHHHHCCCCCCCCHHCCHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEE
DIEQRAEAGLVRGDAAVLASSVIVVAHHGSRSSSSPAFVDAVLPEAAVFSVGYRNMFGHP
CHHHHHHCCCCCCCHHHHHCCEEEEEECCCCCCCCCCHHHHHCCHHHHHHCCHHHHCCCC
HPMVWARWAEAGARNWRTDSQGAIAIEVDGSGVTVNAARESAPRYWHGR
CCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEECHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]