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The map label for this gene is ggt [H]

Identifier: 119897766

GI number: 119897766

Start: 1606678

End: 1608399

Strand: Direct

Name: ggt [H]

Synonym: azo1475

Alternate gene names: 119897766

Gene position: 1606678-1608399 (Clockwise)

Preceding gene: 119897765

Following gene: 119897770

Centisome position: 36.72

GC content: 74.62

Gene sequence:

>1722_bases
ATGCGCGCGGCGATCCTGTTCGCGGTCTGGCTGTGGCTTGCGGCCACGGCGGCCGCGCAGCCGCCCGCGCCCGAGGCCGC
GACCGGCTTCTCACCGCGACCGGCGGTATGCGCTTCCAACGCAATGGTGGTGACCGCCCACCCGCTTGCCACCGACGCCG
CGCTTGCCGTGTTGGGCGAGGGTGGTTCGGCCGCGGATGCCGCGATTGCCGCGGCGCTGGTGCTCAATGTGGTCGAACCG
CAATCGTCCGGCATCGGCGGCGGCGGTTTCCTGCTCCACTACGACGCTGCCGCGCAGCGTCTTGCCGCCTGGGACGGCCG
CGAAAGCGCGCCTGCGGCGGTGGAGGCGGACTGGTTCCTGGACGAGGCCGGGCGCCCGCTGCACTTCTTCGACGCGGTGG
TGGGCGGCCGCGCGGTGGGTGTGCCGGGTTTGCCGCGCCTGCTCGAAGCCGCCCATCGGCGCCACGGCGTGCTGCCCTTG
GCGCGCCTGTTCGCGCCCGCGATTGCACTGGCGCGGGAGGGCTTCGCGGTGTCGCCGCGCCTGCACGCGCACATCGCGCG
CGACCGCTTCCTGCGCGCCGACCCCGCCGCGCGCCTGCTGTTCTTCGATGGGGGCGGTGCGCCGCTGGCGGTGGGTGCGA
CGCTGCGCAATCCGGCGCTCGCCGCGACGCTGGAGCTGCTCGCGCGCGACGGCGCCGAGGTCTTCTACCGCGGCGAGGTG
GCGCGCGATCTCGTCGCCGCGGTGGCGCGTGCCCCGGCGCCGGGCGCGCTCACGCTGGACGACCTTCGCACCTACGAGGT
GGTCGAGCGCCCGGCGCTGTGCGGCCCGTACCGCGCCTGGCGGGTGTGCGGCATGCCGCCCCCCAGCGCCGGCGGTGCGA
GCGTGCTGGCCCTGCTCGGCGTGTTGCAACGCTTCGACCTGCCTGCGATCGCGCCGGATTCGGCTTTTGCCGCGCACCTC
TTCGCCGAGGCGGGCCGGCTTGCCTATGCGGACCGCGAAGCCTGGTATGGCGACCCCGCGGAGATGACGCTAGCGCCCGC
GCAGTTGCTGGCGCCGCGCTACCTCGCCCACCGCGCCGCGCTGATCGCGCTCGACGGCAGCATGGGGACCGCGCCGGCGG
GCGTGCCGGACCCCGCTGTGGCAGCGGTGGCGGCGAGCAGCCCGGAGTTGCCCGCCACCACGCACATATCGGTGGTGGAT
GCAGGCGGCAACGCGGTGTCGCTGACCGCCTCGATCGAGAACGCCTTCGGCAGCCGGCGCATGGTGCGCGGCTTCCTGCT
CAACAACCAGCTCACCGATTTTTCGTTTGTCCCGGGCGGTGAGCACGGGGCACATCCCAACCGCGCCGGGCCGCGCAAGC
GCCCGCTCAGCTCGATGGCGCCGACGCTGGTGTTTGCGCCGGATGGACGGCTGCACGCGGTACTCGGCTCGCCCGGCGGC
AGCGCCATCATCAACTACGTGGCGGCCGCGCTGGTGGGCGTGCTCGACTGGGGCCTAGCGCCCGACGCGGCGCTGGCGCG
GCCGCACGCGGGCAGCCGCAATGGCCCGACCGAAGTGGAGGACAACGCCGCCGGCCGCGCGCTGGCGGGCCGACTCGCGC
TGTTCGGGCACCGCCCGCAACTGCGTGACCTCACCAGCGGCACCAGCCTGATCGTGCGTGAAGCTGGAGGCTGGGCGGGC
GCGGCCGATCCGCGCCGCGAGGGCAGCGCGGCGGGTTACTGA

Upstream 100 bases:

>100_bases
TGCCGACCCACGCCGGTCTGCCCGACTACTTCCAACTGCAACTCGCACCCCAACCGCGCCGGCTGCCTGCCTGGACGCGC
TGAGCGCGGGCGGCAGGCCG

Downstream 100 bases:

>100_bases
GCGGTCAGCGCCGGCCGCGCAGCACGCGCGCGGGCGGGCAGCACCTCGCGTTCGGGCCGGCCGACGTGGTAGCCCTGCGC
ATAGTCGATGCCGAACTCGC

Product: Ggt protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MRAAILFAVWLWLAATAAAQPPAPEAATGFSPRPAVCASNAMVVTAHPLATDAALAVLGEGGSAADAAIAAALVLNVVEP
QSSGIGGGGFLLHYDAAAQRLAAWDGRESAPAAVEADWFLDEAGRPLHFFDAVVGGRAVGVPGLPRLLEAAHRRHGVLPL
ARLFAPAIALAREGFAVSPRLHAHIARDRFLRADPAARLLFFDGGGAPLAVGATLRNPALAATLELLARDGAEVFYRGEV
ARDLVAAVARAPAPGALTLDDLRTYEVVERPALCGPYRAWRVCGMPPPSAGGASVLALLGVLQRFDLPAIAPDSAFAAHL
FAEAGRLAYADREAWYGDPAEMTLAPAQLLAPRYLAHRAALIALDGSMGTAPAGVPDPAVAAVAASSPELPATTHISVVD
AGGNAVSLTASIENAFGSRRMVRGFLLNNQLTDFSFVPGGEHGAHPNRAGPRKRPLSSMAPTLVFAPDGRLHAVLGSPGG
SAIINYVAAALVGVLDWGLAPDAALARPHAGSRNGPTEVEDNAAGRALAGRLALFGHRPQLRDLTSGTSLIVREAGGWAG
AADPRREGSAAGY

Sequences:

>Translated_573_residues
MRAAILFAVWLWLAATAAAQPPAPEAATGFSPRPAVCASNAMVVTAHPLATDAALAVLGEGGSAADAAIAAALVLNVVEP
QSSGIGGGGFLLHYDAAAQRLAAWDGRESAPAAVEADWFLDEAGRPLHFFDAVVGGRAVGVPGLPRLLEAAHRRHGVLPL
ARLFAPAIALAREGFAVSPRLHAHIARDRFLRADPAARLLFFDGGGAPLAVGATLRNPALAATLELLARDGAEVFYRGEV
ARDLVAAVARAPAPGALTLDDLRTYEVVERPALCGPYRAWRVCGMPPPSAGGASVLALLGVLQRFDLPAIAPDSAFAAHL
FAEAGRLAYADREAWYGDPAEMTLAPAQLLAPRYLAHRAALIALDGSMGTAPAGVPDPAVAAVAASSPELPATTHISVVD
AGGNAVSLTASIENAFGSRRMVRGFLLNNQLTDFSFVPGGEHGAHPNRAGPRKRPLSSMAPTLVFAPDGRLHAVLGSPGG
SAIINYVAAALVGVLDWGLAPDAALARPHAGSRNGPTEVEDNAAGRALAGRLALFGHRPQLRDLTSGTSLIVREAGGWAG
AADPRREGSAAGY
>Mature_573_residues
MRAAILFAVWLWLAATAAAQPPAPEAATGFSPRPAVCASNAMVVTAHPLATDAALAVLGEGGSAADAAIAAALVLNVVEP
QSSGIGGGGFLLHYDAAAQRLAAWDGRESAPAAVEADWFLDEAGRPLHFFDAVVGGRAVGVPGLPRLLEAAHRRHGVLPL
ARLFAPAIALAREGFAVSPRLHAHIARDRFLRADPAARLLFFDGGGAPLAVGATLRNPALAATLELLARDGAEVFYRGEV
ARDLVAAVARAPAPGALTLDDLRTYEVVERPALCGPYRAWRVCGMPPPSAGGASVLALLGVLQRFDLPAIAPDSAFAAHL
FAEAGRLAYADREAWYGDPAEMTLAPAQLLAPRYLAHRAALIALDGSMGTAPAGVPDPAVAAVAASSPELPATTHISVVD
AGGNAVSLTASIENAFGSRRMVRGFLLNNQLTDFSFVPGGEHGAHPNRAGPRKRPLSSMAPTLVFAPDGRLHAVLGSPGG
SAIINYVAAALVGVLDWGLAPDAALARPHAGSRNGPTEVEDNAAGRALAGRLALFGHRPQLRDLTSGTSLIVREAGGWAG
AADPRREGSAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=533, Percent_Identity=34.3339587242026, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI73915090, Length=533, Percent_Identity=34.3339587242026, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI73915096, Length=533, Percent_Identity=34.3339587242026, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI73915094, Length=533, Percent_Identity=34.3339587242026, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI113429324, Length=535, Percent_Identity=33.2710280373832, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI113429326, Length=540, Percent_Identity=33.3333333333333, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI153266885, Length=562, Percent_Identity=33.0960854092527, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI153266901, Length=563, Percent_Identity=32.8596802841918, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI153266907, Length=562, Percent_Identity=31.6725978647687, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI109148539, Length=477, Percent_Identity=31.0272536687631, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI30581157, Length=214, Percent_Identity=35.5140186915888, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI30581155, Length=214, Percent_Identity=35.5140186915888, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI218505805, Length=216, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI310124095, Length=197, Percent_Identity=34.010152284264, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789856, Length=552, Percent_Identity=35.8695652173913, Blast_Score=272, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17542894, Length=597, Percent_Identity=29.9832495812395, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI193208247, Length=569, Percent_Identity=29.8769771528998, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI193208245, Length=569, Percent_Identity=29.8769771528998, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI212646519, Length=495, Percent_Identity=30.5050505050505, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI72000294, Length=495, Percent_Identity=30.5050505050505, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17506189, Length=473, Percent_Identity=29.8097251585624, Blast_Score=159, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6323330, Length=191, Percent_Identity=31.413612565445, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859893, Length=462, Percent_Identity=33.5497835497836, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24642670, Length=546, Percent_Identity=29.4871794871795, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24642666, Length=546, Percent_Identity=29.4871794871795, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI161077880, Length=546, Percent_Identity=29.3040293040293, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45551474, Length=546, Percent_Identity=29.4871794871795, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI161077878, Length=546, Percent_Identity=29.3040293040293, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161077496, Length=453, Percent_Identity=29.3598233995585, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI18859741, Length=484, Percent_Identity=30.7851239669421, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58787; Mature: 58787

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAILFAVWLWLAATAAAQPPAPEAATGFSPRPAVCASNAMVVTAHPLATDAALAVLGE
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEC
GGSAADAAIAAALVLNVVEPQSSGIGGGGFLLHYDAAAQRLAAWDGRESAPAAVEADWFL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCEEECHHHH
DEAGRPLHFFDAVVGGRAVGVPGLPRLLEAAHRRHGVLPLARLFAPAIALAREGFAVSPR
HCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEECCH
LHAHIARDRFLRADPAARLLFFDGGGAPLAVGATLRNPALAATLELLARDGAEVFYRGEV
HHHHHHHHHHCCCCCCEEEEEEECCCCCEEECCHHCCCHHHHHHHHHHCCCCCEEECHHH
ARDLVAAVARAPAPGALTLDDLRTYEVVERPALCGPYRAWRVCGMPPPSAGGASVLALLG
HHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHEECCCCCCCCCHHHHHHHHH
VLQRFDLPAIAPDSAFAAHLFAEAGRLAYADREAWYGDPAEMTLAPAQLLAPRYLAHRAA
HHHHCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECHHHHHHHHHHHHCEE
LIALDGSMGTAPAGVPDPAVAAVAASSPELPATTHISVVDAGGNAVSLTASIENAFGSRR
EEEECCCCCCCCCCCCCHHHHEEECCCCCCCCEEEEEEEECCCCEEEEEEEHHHHHCCHH
MVRGFLLNNQLTDFSFVPGGEHGAHPNRAGPRKRPLSSMAPTLVFAPDGRLHAVLGSPGG
HHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHCCEEEECCCCCEEEEEECCCH
SAIINYVAAALVGVLDWGLAPDAALARPHAGSRNGPTEVEDNAAGRALAGRLALFGHRPQ
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
LRDLTSGTSLIVREAGGWAGAADPRREGSAAGY
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRAAILFAVWLWLAATAAAQPPAPEAATGFSPRPAVCASNAMVVTAHPLATDAALAVLGE
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEC
GGSAADAAIAAALVLNVVEPQSSGIGGGGFLLHYDAAAQRLAAWDGRESAPAAVEADWFL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCEEECHHHH
DEAGRPLHFFDAVVGGRAVGVPGLPRLLEAAHRRHGVLPLARLFAPAIALAREGFAVSPR
HCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEECCH
LHAHIARDRFLRADPAARLLFFDGGGAPLAVGATLRNPALAATLELLARDGAEVFYRGEV
HHHHHHHHHHCCCCCCEEEEEEECCCCCEEECCHHCCCHHHHHHHHHHCCCCCEEECHHH
ARDLVAAVARAPAPGALTLDDLRTYEVVERPALCGPYRAWRVCGMPPPSAGGASVLALLG
HHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHEECCCCCCCCCHHHHHHHHH
VLQRFDLPAIAPDSAFAAHLFAEAGRLAYADREAWYGDPAEMTLAPAQLLAPRYLAHRAA
HHHHCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECHHHHHHHHHHHHCEE
LIALDGSMGTAPAGVPDPAVAAVAASSPELPATTHISVVDAGGNAVSLTASIENAFGSRR
EEEECCCCCCCCCCCCCHHHHEEECCCCCCCCEEEEEEEECCCCEEEEEEEHHHHHCCHH
MVRGFLLNNQLTDFSFVPGGEHGAHPNRAGPRKRPLSSMAPTLVFAPDGRLHAVLGSPGG
HHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHCCEEEECCCCCEEEEEECCCH
SAIINYVAAALVGVLDWGLAPDAALARPHAGSRNGPTEVEDNAAGRALAGRLALFGHRPQ
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
LRDLTSGTSLIVREAGGWAGAADPRREGSAAGY
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA