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The map label for this gene is purE [H]

Identifier: 119897669

GI number: 119897669

Start: 1505580

End: 1506092

Strand: Direct

Name: purE [H]

Synonym: azo1378

Alternate gene names: 119897669

Gene position: 1505580-1506092 (Clockwise)

Preceding gene: 119897668

Following gene: 119897670

Centisome position: 34.41

GC content: 69.59

Gene sequence:

>513_bases
ATGAGCGAACAGCAGACGTCCGCCGCGCCCGTCGTCGGAATCATCATGGGCTCGAACTCCGACTGGCCCACCATGCAGGC
AGCCGCCAAGATCCTCGCCGACTTCGGCGTGCCTTACGAGGCGCGGGTCGTGTCGGCGCACCGCACCCCGGACCTGATGT
TCGAGTACGCAGCCGGCGCGCGTGGCCGCGGCCTCAAGGCCATCATCGCGGGCGCTGGCGGCGCGGCACATCTGCCGGGC
ATGGTGGCGGCCAAGACCACGCTGCCGGTGCTGGGCGTTCCGGTCCAGTCGCGCGCGCTGTCCGGGCAGGATTCGCTGCT
CTCCATCGTGCAGATGCCGAAGGGCGTGCCGGTTGCCACCTTTGCCATCGGTGAAGCGGGGGCGGCAAACGCCGGCCTCT
TCGCGGTGGCACTGCTCGCAACCGGAAATCCCGAACTGGCAGAGCGGCTTGACCGCTTCCGCCAGGTGCAGACCGACACC
GTGCTGGCGATGGAGTTGCCGCCGCCCGTCTGA

Upstream 100 bases:

>100_bases
GTGCCGGGCGGGGTGGGGCCGATGACCATCACCATGCTGCTCGAAAACACCGTGATTTCGGCCGAGCGCAGCGCCCGCGC
TGCGGGCAAGTGAGGCGGGC

Downstream 100 bases:

>100_bases
GGGCCGCGTAGTTGCTCCTCGCCGCAGCCGGGGAAGGGCACGCCGGATGTCATCGCCCCGACGTGCTTCCGGCGCCGTCC
CTCTTCCGTCCATCTCCCTT

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MSEQQTSAAPVVGIIMGSNSDWPTMQAAAKILADFGVPYEARVVSAHRTPDLMFEYAAGARGRGLKAIIAGAGGAAHLPG
MVAAKTTLPVLGVPVQSRALSGQDSLLSIVQMPKGVPVATFAIGEAGAANAGLFAVALLATGNPELAERLDRFRQVQTDT
VLAMELPPPV

Sequences:

>Translated_170_residues
MSEQQTSAAPVVGIIMGSNSDWPTMQAAAKILADFGVPYEARVVSAHRTPDLMFEYAAGARGRGLKAIIAGAGGAAHLPG
MVAAKTTLPVLGVPVQSRALSGQDSLLSIVQMPKGVPVATFAIGEAGAANAGLFAVALLATGNPELAERLDRFRQVQTDT
VLAMELPPPV
>Mature_169_residues
SEQQTSAAPVVGIIMGSNSDWPTMQAAAKILADFGVPYEARVVSAHRTPDLMFEYAAGARGRGLKAIIAGAGGAAHLPGM
VAAKTTLPVLGVPVQSRALSGQDSLLSIVQMPKGVPVATFAIGEAGAANAGLFAVALLATGNPELAERLDRFRQVQTDTV
LAMELPPPV

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=63.2911392405063, Blast_Score=166, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6324702, Length=153, Percent_Identity=58.8235294117647, Blast_Score=172, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17430; Mature: 17299

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQQTSAAPVVGIIMGSNSDWPTMQAAAKILADFGVPYEARVVSAHRTPDLMFEYAAGA
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCC
RGRGLKAIIAGAGGAAHLPGMVAAKTTLPVLGVPVQSRALSGQDSLLSIVQMPKGVPVAT
CCCCEEEEEECCCCCHHCCCCEEHHCCCCEECCCCHHHCCCCHHHHHHHHHCCCCCCEEE
FAIGEAGAANAGLFAVALLATGNPELAERLDRFRQVQTDTVLAMELPPPV
EEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCC
>Mature Secondary Structure 
SEQQTSAAPVVGIIMGSNSDWPTMQAAAKILADFGVPYEARVVSAHRTPDLMFEYAAGA
CCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCC
RGRGLKAIIAGAGGAAHLPGMVAAKTTLPVLGVPVQSRALSGQDSLLSIVQMPKGVPVAT
CCCCEEEEEECCCCCHHCCCCEEHHCCCCEECCCCHHHCCCCHHHHHHHHHCCCCCCEEE
FAIGEAGAANAGLFAVALLATGNPELAERLDRFRQVQTDTVLAMELPPPV
EEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]