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The map label for this gene is icd1 [H]

Identifier: 119897438

GI number: 119897438

Start: 1234547

End: 1235824

Strand: Direct

Name: icd1 [H]

Synonym: azo1147

Alternate gene names: 119897438

Gene position: 1234547-1235824 (Clockwise)

Preceding gene: 119897437

Following gene: 119897439

Centisome position: 28.21

GC content: 63.77

Gene sequence:

>1278_bases
TTGGTCGAATCGAACAACCAGGAGGGGGTAGACATGAGCACGTCCCACATCAAGGTTCCGGCAGGTGGCCAGAAGATCGT
CCCGGGCCAGCCGATTCCCGACAATCCGATCATTCCGTACATCGAAGGCGACGGCATCGGCATCGATATCACGCCGGTGA
TGATCAAGGTCATCGACGCCGCGGTGGACAAGGCCTACGGCGGCGGCAGGAAGATCCACTGGATGGAGGTCTTCGCCGGC
GAGAAATCGACCCGGCTGTACGGCCCGGATGAATGGCTGCCGAAGGAAACCTTCGACGCGCTGAAGGAATACTCGGTATC
GATCAAGGGGCCGATGACCACGCCGGTGGGCGGCGGCATCCGCTCGCTCAACGTCGCGCTGCGCCAGGAACTGGACCTGT
ACCAGTGCGTGCGCCCGGTGCGCTATTTCAATGGCGTGCCCTCGCCGTTGAAGGACCCGAGCAAGGTGGACATGGTGATC
TTCCGCGAGAACACCGAAGACATCTACGCCGGCATCGAATGGGCTGCGGAATCCGACAGTGCGAAGAAGGTGATCCGCTT
CCTGCAGGAGGAAATGGGCGTCAAGAAGATCCGTTTCCCCGCCACCTCGGGCATCGGCATCAAGCCCATCTCGCGCGAAG
GCACCACCCGCCTGGTGCGCGCGGCGCTGCGCTACGCGATCGACAACGACCGCCGCAATCTCACGATCGTGCACAAGGGC
AACATCATGAAGTTCACCGAGGGTGCCTTCCGCGACTGGGCCTACGAGGTGGCGCAGAAGGAGTTCGGCGCCGAGCCGAT
CGACGGCGGGCCTTGGTGCCGCTTCAAGAACCCGAAAACGGGGCGCGAGATCGTGGTCAAGGATGCGATCGCCGATGCCT
TCCTGCAGCAGATCCTGCTGCGTCCGGCCGAGTACGACGTGATCGCCTGCTGCAATCTCAACGGCGACTACATCTCCGAC
GCGCTGGCCGCGCAGGTGGGCGGCATCGGCATCGCGCCGGGCGCCAACATCTCCGACCAGTACGCCTGCTTCGAGGCCAC
CCACGGCACCGCGCCCAAGTACGCCGGGCTGGACAAGGTGAATCCCGGCTCGATCATCCTGTCGGCGGAGATGATGTTGC
GCCACCTCGGCTGGACCGAGGCGGCCGACCTCGTGATCCGCTCGATGGAGGCGGCGATTGGCGACAAGGTCGTCACCTAC
GATTTCGCCCGCCTGATGGAGGGCGCGCAGGAGGTGAGCTGCTCTGCTTTTGGCGATGCGATGATCGCCCGCATGTAA

Upstream 100 bases:

>100_bases
CCGCCAGCGGCGGCGCGACGGGCCGCCGCGGGAATCCTCCCCTGTCGTTTTCGCCCATAATCCAGCCAGCGGCCCCGTAC
GCTGCGTTCGGGGAAGCCCG

Downstream 100 bases:

>100_bases
GTCGGGCCTGGCGGAGCACGCCGCACGCGACCGGAACCGTTGCTGACTCGCTGAGTGGGCAACGGTTTTCTTTGCGCTCA
GCGCCGTGCGCCATTCCGCA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MVESNNQEGVDMSTSHIKVPAGGQKIVPGQPIPDNPIIPYIEGDGIGIDITPVMIKVIDAAVDKAYGGGRKIHWMEVFAG
EKSTRLYGPDEWLPKETFDALKEYSVSIKGPMTTPVGGGIRSLNVALRQELDLYQCVRPVRYFNGVPSPLKDPSKVDMVI
FRENTEDIYAGIEWAAESDSAKKVIRFLQEEMGVKKIRFPATSGIGIKPISREGTTRLVRAALRYAIDNDRRNLTIVHKG
NIMKFTEGAFRDWAYEVAQKEFGAEPIDGGPWCRFKNPKTGREIVVKDAIADAFLQQILLRPAEYDVIACCNLNGDYISD
ALAAQVGGIGIAPGANISDQYACFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHLGWTEAADLVIRSMEAAIGDKVVTY
DFARLMEGAQEVSCSAFGDAMIARM

Sequences:

>Translated_425_residues
MVESNNQEGVDMSTSHIKVPAGGQKIVPGQPIPDNPIIPYIEGDGIGIDITPVMIKVIDAAVDKAYGGGRKIHWMEVFAG
EKSTRLYGPDEWLPKETFDALKEYSVSIKGPMTTPVGGGIRSLNVALRQELDLYQCVRPVRYFNGVPSPLKDPSKVDMVI
FRENTEDIYAGIEWAAESDSAKKVIRFLQEEMGVKKIRFPATSGIGIKPISREGTTRLVRAALRYAIDNDRRNLTIVHKG
NIMKFTEGAFRDWAYEVAQKEFGAEPIDGGPWCRFKNPKTGREIVVKDAIADAFLQQILLRPAEYDVIACCNLNGDYISD
ALAAQVGGIGIAPGANISDQYACFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHLGWTEAADLVIRSMEAAIGDKVVTY
DFARLMEGAQEVSCSAFGDAMIARM
>Mature_425_residues
MVESNNQEGVDMSTSHIKVPAGGQKIVPGQPIPDNPIIPYIEGDGIGIDITPVMIKVIDAAVDKAYGGGRKIHWMEVFAG
EKSTRLYGPDEWLPKETFDALKEYSVSIKGPMTTPVGGGIRSLNVALRQELDLYQCVRPVRYFNGVPSPLKDPSKVDMVI
FRENTEDIYAGIEWAAESDSAKKVIRFLQEEMGVKKIRFPATSGIGIKPISREGTTRLVRAALRYAIDNDRRNLTIVHKG
NIMKFTEGAFRDWAYEVAQKEFGAEPIDGGPWCRFKNPKTGREIVVKDAIADAFLQQILLRPAEYDVIACCNLNGDYISD
ALAAQVGGIGIAPGANISDQYACFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHLGWTEAADLVIRSMEAAIGDKVVTY
DFARLMEGAQEVSCSAFGDAMIARM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=392, Percent_Identity=31.8877551020408, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=27.8409090909091, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=27.8409090909091, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI28178838, Length=380, Percent_Identity=27.3684210526316, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4758582, Length=310, Percent_Identity=29.0322580645161, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=32.5966850828729, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787381, Length=414, Percent_Identity=73.4299516908213, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=378, Percent_Identity=28.3068783068783, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87081683, Length=404, Percent_Identity=24.009900990099, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=32.0512820512821, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI25144293, Length=303, Percent_Identity=31.6831683168317, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=312, Percent_Identity=29.4871794871795, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550882, Length=383, Percent_Identity=26.3707571801567, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324709, Length=417, Percent_Identity=28.7769784172662, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322097, Length=363, Percent_Identity=30.0275482093664, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324291, Length=306, Percent_Identity=30.3921568627451, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24643268, Length=411, Percent_Identity=33.0900243309002, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24643270, Length=391, Percent_Identity=33.5038363171356, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=30.8483290488432, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI161078637, Length=306, Percent_Identity=28.7581699346405, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078633, Length=306, Percent_Identity=28.7581699346405, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24650122, Length=306, Percent_Identity=28.7581699346405, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078635, Length=306, Percent_Identity=28.7581699346405, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078639, Length=306, Percent_Identity=28.7581699346405, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI20130355, Length=350, Percent_Identity=25.7142857142857, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281362242, Length=391, Percent_Identity=26.5984654731458, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24648872, Length=391, Percent_Identity=26.5984654731458, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46511; Mature: 46511

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVESNNQEGVDMSTSHIKVPAGGQKIVPGQPIPDNPIIPYIEGDGIGIDITPVMIKVIDA
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHH
AVDKAYGGGRKIHWMEVFAGEKSTRLYGPDEWLPKETFDALKEYSVSIKGPMTTPVGGGI
HHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCH
RSLNVALRQELDLYQCVRPVRYFNGVPSPLKDPSKVDMVIFRENTEDIYAGIEWAAESDS
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHCEEECCCCCH
AKKVIRFLQEEMGVKKIRFPATSGIGIKPISREGTTRLVRAALRYAIDNDRRNLTIVHKG
HHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
NIMKFTEGAFRDWAYEVAQKEFGAEPIDGGPWCRFKNPKTGREIVVKDAIADAFLQQILL
CEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEHHHHHHHHHHHHHHC
RPAEYDVIACCNLNGDYISDALAAQVGGIGIAPGANISDQYACFEATHGTAPKYAGLDKV
CCCCCCEEEEECCCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEECCCCCCCCCCCCCCC
NPGSIILSAEMMLRHLGWTEAADLVIRSMEAAIGDKVVTYDFARLMEGAQEVSCSAFGDA
CCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
MIARM
HHHCC
>Mature Secondary Structure
MVESNNQEGVDMSTSHIKVPAGGQKIVPGQPIPDNPIIPYIEGDGIGIDITPVMIKVIDA
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHH
AVDKAYGGGRKIHWMEVFAGEKSTRLYGPDEWLPKETFDALKEYSVSIKGPMTTPVGGGI
HHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCH
RSLNVALRQELDLYQCVRPVRYFNGVPSPLKDPSKVDMVIFRENTEDIYAGIEWAAESDS
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHCEEECCCCCH
AKKVIRFLQEEMGVKKIRFPATSGIGIKPISREGTTRLVRAALRYAIDNDRRNLTIVHKG
HHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
NIMKFTEGAFRDWAYEVAQKEFGAEPIDGGPWCRFKNPKTGREIVVKDAIADAFLQQILL
CEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEHHHHHHHHHHHHHHC
RPAEYDVIACCNLNGDYISDALAAQVGGIGIAPGANISDQYACFEATHGTAPKYAGLDKV
CCCCCCEEEEECCCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEECCCCCCCCCCCCCCC
NPGSIILSAEMMLRHLGWTEAADLVIRSMEAAIGDKVVTYDFARLMEGAQEVSCSAFGDA
CCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
MIARM
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]