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The map label for this gene is icd2 [H]

Identifier: 119897437

GI number: 119897437

Start: 1232133

End: 1234370

Strand: Direct

Name: icd2 [H]

Synonym: azo1146

Alternate gene names: 119897437

Gene position: 1232133-1234370 (Clockwise)

Preceding gene: 119897435

Following gene: 119897438

Centisome position: 28.16

GC content: 63.58

Gene sequence:

>2238_bases
ATGCCTTCGCAGCAGCCGACCATCATCTACACCATCACCGACGAAGCGCCGATGCTGGCGACCGCCGCCTTCCTGCCGGT
CATCCGCAGCTTCACCAAGCCGGCGGGCATCCAGATCGAAGAGGCGGATATCTCGCTCGCTGGCCGCATCCTGGCCGAAT
TTCCCGATTTCCTGAGCGATGCGCAGAAGGTGCCGAACACCCTGGCCGAACTCGGCGCGCTGACCCTGAAGCCCGAAGCC
AACATCATCAAGCTGCCCAACATCAGCGCCTCGGTGGCGCAGCTGAAGGCCGCGATCAAGGAGCTGCAGGGCAAGGGCTA
CAAGATTCCCGACTTCCCGGAAGACCCGAAGAACGACGAAGAGAAGGCGATCAAGACGCGCTACTCCAAGTGTCTGGGCT
CGTCGGTGAACCCGGTGCTGCGCGAAGGCAACTCCGACCGCCGCGCGCCCGCCGCGGTCAAGAACTACGCCAAGAAGCAC
CCGCACTCGATGGGCGACTGGAAGCAGTGGTCGCGCACGCACGTGTCGCACATGGAGCATGGCGACTTCTACCACGGCGA
AAAGTCGATGACGCTGGACAAGGCGCGCGACGTGAAGATGGAGTTGCTGACCAAGAGCGGCAAGGCCATCGTGCTCAAGC
CCAAGGTCGCGCTGCTGGACGGCGAAGTCATCGATTCGATGTTCATGAGCAAGAAGGCGCTGCTCGAGTTCTACGAGCAG
CAGCTCGAAGACTGCCGCGAAGCGGGCATCCTGTTCTCGCTGCACGTGAAGGCGACGATGATGAAGGTGTCGCACCCCAT
CGTCTTCGGCCACTGCGTCAAGATCTACTACAAGGAAGCCTTCGAGAAGCACGGCAAGCTGTTCGACGAGCTGGGCATCA
ACGTCAACAACGGCATGGTCGACCTGTTCGACAAGATCAAGACCCTGCCGGAGTCCAAGCGCGACGAGATCATCCGTGAC
CTGCACGCCTGCCACGAGCATCGCCCCGAACTGGCGATGGTGGATTCGGCCAAGGGCATCACCAACTTCCACTCGCCCAA
CGACGTCATCGTCGACGCCTCGATGCCGGCGATGATCCGCGCGGGCGGCAAGATGTACGGCGCCGACGGCAAGCCCTACG
ACTGCAAGGCGGTGATGCCGGAGTCGACCTTCGCCCGCATCTACCAGGAGATGATCAACTTCTGCAAATGGCACGGCAAC
TTCGACCCGCGCACGATGGGCACGGTGCCGAACGTCGGCCTGATGGCGCAGAAGGCCGAAGAGTACGGCTCGCACGACAA
GACCTTCGAGATTCCGGAAGACGGCGTCGCCAACATCACCGACCTGGCTACCGGCGAAGTGCTGCTGTCGCAGAATGTGG
AAGCGGGCGACATCTGGCGCATGTGCCAGGTCAAGGACGCGCCGATCCGCGACTGGGTGAAGCTCGCCGTCACCCGCGCG
CGCAACTCCGGCATGCCGGCGGTCTTCTGGCTCGACCCCTATCGTCCGCACGAAAACGAGCTGATCAAGAAGGTCGAGAA
GTATCTGAAGGATCACGACACCAGCGGCCTCGAGATCCGGATCATGAGCCAGGTCCGCGCCATGCGTTTCACGCTGGAGC
GCGTCGTCCGCGGCCTCGACACCATCTCGGTCACCGGCAACATCCTGCGCGACTACCTCACCGACCTGTTCCCGATCATG
GAGCTGGGCACCTCGGCCAAGATGCTGTCCATCGTTCCGCTGATGAACGGCGGCGGCATGTACGAAACCGGCGCCGGCGG
TTCCGCGCCCAAGCACGTGCAGCAGCTGGTCGAGGAAAACCACCTGCGCTGGGATTCGCTCGGCGAATTCCTCGCGCTGG
CGGTGTCGCTGGAAGAACTCGGCATCAAGACCGGCAACGCCAAGGCCAAGGTGCTCGCCAAGACGCTGGACGAAGCCACC
GGCAAGCTGCTGGACCTGGACAAGTCGCCCTCGCGTCGCACCGGCGAACTCGACAACCGCGGCAGCCAGTTCTATCTGTC
GCTGTACTGGGCGCAGGCGCTGGCGGCGCAGACCGACGACGCCGAACTGGCCGCGCAGTTCGGCCCGCTCGCCAAGACGC
TGGCCGAGAACGAGCAGAAGATCGTCGACGAGCTGAAGGCGGTGCAGGGCAAGCCCGCTGAGATCGGCGGCTACTACCGC
GTCGACGTCGAGAAGTGCACCGCGGTGATGCGTCCGAGTGCCACCTTCAACGCCGCGATCGCCAGCATCGCCGGCTGA

Upstream 100 bases:

>100_bases
GTCGCCAAGGTCTTTCAACGCGCCCGCCGCAGCGCCCGCGCCGGGCAGCCCGTGCCGTCGTTCGACACGCTCTACCACGA
CAATGAGGGAGATACCTGTA

Downstream 100 bases:

>100_bases
TCCATCGCGGTCTGCAGTCCCGAAACGCCAGGGGTTTCCCTGGCGTTTTTTTTCGTCCGGCGGCGCAAGGACGTCGCCGC
CAGCGGCGGCGCGACGGGCC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MPSQQPTIIYTITDEAPMLATAAFLPVIRSFTKPAGIQIEEADISLAGRILAEFPDFLSDAQKVPNTLAELGALTLKPEA
NIIKLPNISASVAQLKAAIKELQGKGYKIPDFPEDPKNDEEKAIKTRYSKCLGSSVNPVLREGNSDRRAPAAVKNYAKKH
PHSMGDWKQWSRTHVSHMEHGDFYHGEKSMTLDKARDVKMELLTKSGKAIVLKPKVALLDGEVIDSMFMSKKALLEFYEQ
QLEDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMVDLFDKIKTLPESKRDEIIRD
LHACHEHRPELAMVDSAKGITNFHSPNDVIVDASMPAMIRAGGKMYGADGKPYDCKAVMPESTFARIYQEMINFCKWHGN
FDPRTMGTVPNVGLMAQKAEEYGSHDKTFEIPEDGVANITDLATGEVLLSQNVEAGDIWRMCQVKDAPIRDWVKLAVTRA
RNSGMPAVFWLDPYRPHENELIKKVEKYLKDHDTSGLEIRIMSQVRAMRFTLERVVRGLDTISVTGNILRDYLTDLFPIM
ELGTSAKMLSIVPLMNGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEELGIKTGNAKAKVLAKTLDEAT
GKLLDLDKSPSRRTGELDNRGSQFYLSLYWAQALAAQTDDAELAAQFGPLAKTLAENEQKIVDELKAVQGKPAEIGGYYR
VDVEKCTAVMRPSATFNAAIASIAG

Sequences:

>Translated_745_residues
MPSQQPTIIYTITDEAPMLATAAFLPVIRSFTKPAGIQIEEADISLAGRILAEFPDFLSDAQKVPNTLAELGALTLKPEA
NIIKLPNISASVAQLKAAIKELQGKGYKIPDFPEDPKNDEEKAIKTRYSKCLGSSVNPVLREGNSDRRAPAAVKNYAKKH
PHSMGDWKQWSRTHVSHMEHGDFYHGEKSMTLDKARDVKMELLTKSGKAIVLKPKVALLDGEVIDSMFMSKKALLEFYEQ
QLEDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMVDLFDKIKTLPESKRDEIIRD
LHACHEHRPELAMVDSAKGITNFHSPNDVIVDASMPAMIRAGGKMYGADGKPYDCKAVMPESTFARIYQEMINFCKWHGN
FDPRTMGTVPNVGLMAQKAEEYGSHDKTFEIPEDGVANITDLATGEVLLSQNVEAGDIWRMCQVKDAPIRDWVKLAVTRA
RNSGMPAVFWLDPYRPHENELIKKVEKYLKDHDTSGLEIRIMSQVRAMRFTLERVVRGLDTISVTGNILRDYLTDLFPIM
ELGTSAKMLSIVPLMNGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEELGIKTGNAKAKVLAKTLDEAT
GKLLDLDKSPSRRTGELDNRGSQFYLSLYWAQALAAQTDDAELAAQFGPLAKTLAENEQKIVDELKAVQGKPAEIGGYYR
VDVEKCTAVMRPSATFNAAIASIAG
>Mature_744_residues
PSQQPTIIYTITDEAPMLATAAFLPVIRSFTKPAGIQIEEADISLAGRILAEFPDFLSDAQKVPNTLAELGALTLKPEAN
IIKLPNISASVAQLKAAIKELQGKGYKIPDFPEDPKNDEEKAIKTRYSKCLGSSVNPVLREGNSDRRAPAAVKNYAKKHP
HSMGDWKQWSRTHVSHMEHGDFYHGEKSMTLDKARDVKMELLTKSGKAIVLKPKVALLDGEVIDSMFMSKKALLEFYEQQ
LEDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMVDLFDKIKTLPESKRDEIIRDL
HACHEHRPELAMVDSAKGITNFHSPNDVIVDASMPAMIRAGGKMYGADGKPYDCKAVMPESTFARIYQEMINFCKWHGNF
DPRTMGTVPNVGLMAQKAEEYGSHDKTFEIPEDGVANITDLATGEVLLSQNVEAGDIWRMCQVKDAPIRDWVKLAVTRAR
NSGMPAVFWLDPYRPHENELIKKVEKYLKDHDTSGLEIRIMSQVRAMRFTLERVVRGLDTISVTGNILRDYLTDLFPIME
LGTSAKMLSIVPLMNGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEELGIKTGNAKAKVLAKTLDEATG
KLLDLDKSPSRRTGELDNRGSQFYLSLYWAQALAAQTDDAELAAQFGPLAKTLAENEQKIVDELKAVQGKPAEIGGYYRV
DVEKCTAVMRPSATFNAAIASIAG

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82585; Mature: 82454

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSQQPTIIYTITDEAPMLATAAFLPVIRSFTKPAGIQIEEADISLAGRILAEFPDFLSD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHH
AQKVPNTLAELGALTLKPEANIIKLPNISASVAQLKAAIKELQGKGYKIPDFPEDPKNDE
HHHHHHHHHHHCCEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
EKAIKTRYSKCLGSSVNPVLREGNSDRRAPAAVKNYAKKHPHSMGDWKQWSRTHVSHMEH
HHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
GDFYHGEKSMTLDKARDVKMELLTKSGKAIVLKPKVALLDGEVIDSMFMSKKALLEFYEQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEECCHHHHHHHHHHHHHHHHHHHH
QLEDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMV
HHHHHHHCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLFDKIKTLPESKRDEIIRDLHACHEHRPELAMVDSAKGITNFHSPNDVIVDASMPAMIR
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCCHHHH
AGGKMYGADGKPYDCKAVMPESTFARIYQEMINFCKWHGNFDPRTMGTVPNVGLMAQKAE
CCCEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFEIPEDGVANITDLATGEVLLSQNVEAGDIWRMCQVKDAPIRDWVKLAVTRA
HHCCCCCEEECCCCCCCCHHHHCCCCHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
RNSGMPAVFWLDPYRPHENELIKKVEKYLKDHDTSGLEIRIMSQVRAMRFTLERVVRGLD
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCC
TISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMNGGGMYETGAGGSAPKHVQQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEELGIKTGNAKAKVLAKTLDEATGKLLDLDKSPSRRTGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCC
GSQFYLSLYWAQALAAQTDDAELAAQFGPLAKTLAENEQKIVDELKAVQGKPAEIGGYYR
CCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
VDVEKCTAVMRPSATFNAAIASIAG
EEHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PSQQPTIIYTITDEAPMLATAAFLPVIRSFTKPAGIQIEEADISLAGRILAEFPDFLSD
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHH
AQKVPNTLAELGALTLKPEANIIKLPNISASVAQLKAAIKELQGKGYKIPDFPEDPKNDE
HHHHHHHHHHHCCEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
EKAIKTRYSKCLGSSVNPVLREGNSDRRAPAAVKNYAKKHPHSMGDWKQWSRTHVSHMEH
HHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
GDFYHGEKSMTLDKARDVKMELLTKSGKAIVLKPKVALLDGEVIDSMFMSKKALLEFYEQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEECCHHHHHHHHHHHHHHHHHHHH
QLEDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMV
HHHHHHHCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLFDKIKTLPESKRDEIIRDLHACHEHRPELAMVDSAKGITNFHSPNDVIVDASMPAMIR
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCCHHHH
AGGKMYGADGKPYDCKAVMPESTFARIYQEMINFCKWHGNFDPRTMGTVPNVGLMAQKAE
CCCEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFEIPEDGVANITDLATGEVLLSQNVEAGDIWRMCQVKDAPIRDWVKLAVTRA
HHCCCCCEEECCCCCCCCHHHHCCCCHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
RNSGMPAVFWLDPYRPHENELIKKVEKYLKDHDTSGLEIRIMSQVRAMRFTLERVVRGLD
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCC
TISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMNGGGMYETGAGGSAPKHVQQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEELGIKTGNAKAKVLAKTLDEATGKLLDLDKSPSRRTGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCC
GSQFYLSLYWAQALAAQTDDAELAAQFGPLAKTLAENEQKIVDELKAVQGKPAEIGGYYR
CCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
VDVEKCTAVMRPSATFNAAIASIAG
EEHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]