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The map label for this gene is dapA

Identifier: 119897387

GI number: 119897387

Start: 1179632

End: 1180510

Strand: Direct

Name: dapA

Synonym: azo1096

Alternate gene names: 119897387

Gene position: 1179632-1180510 (Clockwise)

Preceding gene: 119897386

Following gene: 119897388

Centisome position: 26.96

GC content: 66.89

Gene sequence:

>879_bases
ATGATTACCGGATCGATTGTCGCCATCGTCACGCCGATGCACGAGGATGGCAGCCTTGATTTTCCCCGTCTGCGCAGCCT
GATCGACTGGCACGTCGCGGAAGGAACGGACGGCATCGTGATCGTCGGCACGACCGGCGAGTCGCCCACCGTCAGCGTCG
ATGAGCATTGCGAACTGATCCGGGTCGCGGTCGAGCATGCCGCGGGTCGCATCCCCGTCATCGCCGGTACCGGCGCCAAC
TCCACTGCCGAGGCCATCGCCCTGGCACGTTATGCCCAGCAGGCAGGGGCGGTGGCGCATCTGTCGGTCGTCCCCTACTA
CAACCGACCCTCGCAGGAGGGGCTGTACCAGCACTTCCGCTCGGTCGCCGAAGCGGTCGAACTGCCCCTGATCCTCTACA
ACGTGCCCGGACGCACCGTGGCCGACCTGTCGAACGACACCGCGCTGCGACTGGCCGAGATTCCCAACATCATCGGCCTC
AAGGACGCCACCGGCAGCATCGACCGCGCCTGCGATCTCATCGAGCGCGCGCCCGAGGGCTTTGCCCTCTATAGCGGCGA
CGACATGACCGTCGCGGCCTTCATCCTCCTCGGCGGCCACGGCACCATTTCCGTAACCGCCAACGTCGCGCCGCGCGCAA
TGCACGAGATGTGCGCGGCTGCGCTGGCAGGCGACGCGGCAAAGGCGCGGACGATCAACGCGCGACTGGTGGGCCTGCAT
CGCCACCTGTTCTGTGAGGCGAATCCGATTCCGGTGAAGTGGGCGGTGCAGCGCATGGGGCTGGTCGAAGGCGGGCTCCG
CCTGCCGCTGACGCCGCTTGCCGAATCTTTCCACGACCGCGTTCTCACGGCCATGCGCCAGGCCGGCATTCAGGCCTGA

Upstream 100 bases:

>100_bases
GACGCCCCCGCAACGGGGCGCGCCCGGGTTTGCCGATAGCGCCCATGTCCGACTTTCGGCGATCGGTTAGAATCGTCGCT
TTATCGTAACGGCCAACCCC

Downstream 100 bases:

>100_bases
ACCGTCCATCCCACGCCAGGAACCTCATGAACCGCTTTACGCGCCCGTCCCTTTCCGTCATTGCGTTGTCGCTGATGCTG
GCCGGTTGCTCGGGGTCGCT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MITGSIVAIVTPMHEDGSLDFPRLRSLIDWHVAEGTDGIVIVGTTGESPTVSVDEHCELIRVAVEHAAGRIPVIAGTGAN
STAEAIALARYAQQAGAVAHLSVVPYYNRPSQEGLYQHFRSVAEAVELPLILYNVPGRTVADLSNDTALRLAEIPNIIGL
KDATGSIDRACDLIERAPEGFALYSGDDMTVAAFILLGGHGTISVTANVAPRAMHEMCAAALAGDAAKARTINARLVGLH
RHLFCEANPIPVKWAVQRMGLVEGGLRLPLTPLAESFHDRVLTAMRQAGIQA

Sequences:

>Translated_292_residues
MITGSIVAIVTPMHEDGSLDFPRLRSLIDWHVAEGTDGIVIVGTTGESPTVSVDEHCELIRVAVEHAAGRIPVIAGTGAN
STAEAIALARYAQQAGAVAHLSVVPYYNRPSQEGLYQHFRSVAEAVELPLILYNVPGRTVADLSNDTALRLAEIPNIIGL
KDATGSIDRACDLIERAPEGFALYSGDDMTVAAFILLGGHGTISVTANVAPRAMHEMCAAALAGDAAKARTINARLVGLH
RHLFCEANPIPVKWAVQRMGLVEGGLRLPLTPLAESFHDRVLTAMRQAGIQA
>Mature_292_residues
MITGSIVAIVTPMHEDGSLDFPRLRSLIDWHVAEGTDGIVIVGTTGESPTVSVDEHCELIRVAVEHAAGRIPVIAGTGAN
STAEAIALARYAQQAGAVAHLSVVPYYNRPSQEGLYQHFRSVAEAVELPLILYNVPGRTVADLSNDTALRLAEIPNIIGL
KDATGSIDRACDLIERAPEGFALYSGDDMTVAAFILLGGHGTISVTANVAPRAMHEMCAAALAGDAAKARTINARLVGLH
RHLFCEANPIPVKWAVQRMGLVEGGLRLPLTPLAESFHDRVLTAMRQAGIQA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=240, Percent_Identity=27.5, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI13540533, Length=235, Percent_Identity=27.6595744680851, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=55.6701030927835, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI87082415, Length=295, Percent_Identity=32.5423728813559, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786463, Length=233, Percent_Identity=36.480686695279, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789620, Length=278, Percent_Identity=28.4172661870504, Blast_Score=114, Evalue=7e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_AZOSB (A1K4F8)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932600.1
- ProteinModelPortal:   A1K4F8
- SMR:   A1K4F8
- STRING:   A1K4F8
- GeneID:   4606688
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1096
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   A1K4F8
- ProtClustDB:   PRK03170
- BioCyc:   ASP62928:AZO1096-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 30961; Mature: 30961

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGSIVAIVTPMHEDGSLDFPRLRSLIDWHVAEGTDGIVIVGTTGESPTVSVDEHCELI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEHHHHHHHH
RVAVEHAAGRIPVIAGTGANSTAEAIALARYAQQAGAVAHLSVVPYYNRPSQEGLYQHFR
HHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHH
SVAEAVELPLILYNVPGRTVADLSNDTALRLAEIPNIIGLKDATGSIDRACDLIERAPEG
HHHHHHCCCEEEEECCCCEEECCCCCCEEEHHHCCCEEECCCCCCCHHHHHHHHHHCCCC
FALYSGDDMTVAAFILLGGHGTISVTANVAPRAMHEMCAAALAGDAAKARTINARLVGLH
EEEECCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHEEEEHEEEEEE
RHLFCEANPIPVKWAVQRMGLVEGGLRLPLTPLAESFHDRVLTAMRQAGIQA
HEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITGSIVAIVTPMHEDGSLDFPRLRSLIDWHVAEGTDGIVIVGTTGESPTVSVDEHCELI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEHHHHHHHH
RVAVEHAAGRIPVIAGTGANSTAEAIALARYAQQAGAVAHLSVVPYYNRPSQEGLYQHFR
HHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHH
SVAEAVELPLILYNVPGRTVADLSNDTALRLAEIPNIIGLKDATGSIDRACDLIERAPEG
HHHHHHCCCEEEEECCCCEEECCCCCCEEEHHHCCCEEECCCCCCCHHHHHHHHHHCCCC
FALYSGDDMTVAAFILLGGHGTISVTANVAPRAMHEMCAAALAGDAAKARTINARLVGLH
EEEECCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHEEEEHEEEEEE
RHLFCEANPIPVKWAVQRMGLVEGGLRLPLTPLAESFHDRVLTAMRQAGIQA
HEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA