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The map label for this gene is glcD1 [H]

Identifier: 119897289

GI number: 119897289

Start: 1072863

End: 1074362

Strand: Direct

Name: glcD1 [H]

Synonym: azo0998

Alternate gene names: 119897289

Gene position: 1072863-1074362 (Clockwise)

Preceding gene: 119897288

Following gene: 119897290

Centisome position: 24.52

GC content: 69.67

Gene sequence:

>1500_bases
GTGGCGCCGGAGGAGGCGGGGATCGCGGAGCGCGACTTTTCCGCGCTCGACAAGGCGCGCGTGGTCGAGGCCCTGGCGCG
GGTGTTGCCGGCAGGCGCCTTGATGTTTGAAGCCGAGGATTTGCGGCCTTACGAGTGCGACGGCTTGTCGGCCTACCGCG
CGCTGCCGCTGGCGGTGGTGCTGCCGGCCACGGAGGACGAAGTGGTGGCGGTGCTGACGGTGTGCGCCGAACTCGGCGTG
CCGGTGGTCGCGCGCGGCGCCGGCACCGGCTTGTCCGGCGGCGCGCTGCCGCATCGCCACGGCGTGCTGCTGTCGCTCGC
GCGATTCACCCGCATCCTGCATCTCGATCCGCATGCCCGTACCGCGGTGGTGCAGCCGGGTGTGCGCAACCTCGCGATCT
CGGAGGCGGCGGCGCCTTACGGGCTGTACTACGCGCCCGATCCGTCGTCGCAGATCGCCTGCACCATCGGCGGCAACGTG
GCGGAAAACTCCGGCGGCGTGCATTGCCTGAAGTACGGCCTGACCGTGCATAACCTGCTGCGGGTGCGAGGGGTGACGAT
CGAGGGGGAGGTGGTGGAGTTCGGCAGCCATGCGCTCGATACGCCGGGCTACGACCTGCTGGCCCTGGTCACCGGCTCGG
AGGGCATGCTCGCGGTCGTCACCGAGGTGACGGTGCGGCTGACGCCCAAGCCGCAGCTGGCGCAGTGCGTGCTGGCGGCG
TTCGACGACGTGGTCAAGGCGGGGGAGGCGGTGGCGGCCATCATCGCTGCGGGCATTATCCCTGCCGGGCTGGAAATGAT
GGACCAGCCGGCGACCGCCGCGGTGGAGCAGTTCGTCCATGCCGGTTATCCGCTCGATGCACGCGCCATCCTGCTGTGCG
AATCCGACGGCACGCCCGAAGAGGTGGCGGAGGAAATCGTCGCCGTGCGCGCGGTGCTCGAGGCCAGCGGCGCGACGGAG
ATCCGCGTCTCGCAGGATGAGGCCGAGCGCCTGCGTTTCTGGGCCGGACGCAAGGCCGCCTTTCCTGCCGCGGGGCGGCT
CTCGCCCGACTACTACTGCATGGACGGCACCATCCCGCGCAAGCGCCTGGGCGAAATGCTGGAGGCGATCCAGGGCATGG
AGCAGAAGTACGGTCTTGCCTGCATCAACGTCTTCCACGCCGGGGACGGTAACCTGCATCCGTTGATCCTGTTCGACGCC
AACCAGCCGGGCGAACTCGAGCGCGCGGAGGCCTTCGGCACCGACATCCTCGAGTTGTCGGTGGCCCTGGGCGGCACGGT
GACCGGCGAGCACGGCGTGGGCGTCGAGAAGATCAACCAGATGTGCAGCCAGTTCGGTGAAGGCGAGCGGCTGCAGTTCT
TCCGCGTCAAGGCCGCGTTCGATCCGCTCGGCCTGCTCAACCCGGGCAAGGCGATTCCCACCCTGCACCGCTGCGCGGAA
TACGGCCGCATGCGCGTCAGCGGGGGCGCCCTGCCGCATCCCGAACTGCCGCGGTTCTGA

Upstream 100 bases:

>100_bases
TCCCTGATCCGCGGGGCGACACCGGGCCGACGGGGCGCAGACCGGCGGCTGCCATGAACGACGACGGGAGGTGGACGTGA
CAGAGAGCGGTGGAGTGGAC

Downstream 100 bases:

>100_bases
AGCCATGGGCGACAAGGCCTGGGTGCAATTCCTGTTCGTCGCAGTGCCGGTGCTGTCGCTCGTCGGGGCGTGGCTGGCGC
TGCGCGCGGTCGGTGGGCGC

Product: glycolate oxidase subunit GlcD

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MAPEEAGIAERDFSALDKARVVEALARVLPAGALMFEAEDLRPYECDGLSAYRALPLAVVLPATEDEVVAVLTVCAELGV
PVVARGAGTGLSGGALPHRHGVLLSLARFTRILHLDPHARTAVVQPGVRNLAISEAAAPYGLYYAPDPSSQIACTIGGNV
AENSGGVHCLKYGLTVHNLLRVRGVTIEGEVVEFGSHALDTPGYDLLALVTGSEGMLAVVTEVTVRLTPKPQLAQCVLAA
FDDVVKAGEAVAAIIAAGIIPAGLEMMDQPATAAVEQFVHAGYPLDARAILLCESDGTPEEVAEEIVAVRAVLEASGATE
IRVSQDEAERLRFWAGRKAAFPAAGRLSPDYYCMDGTIPRKRLGEMLEAIQGMEQKYGLACINVFHAGDGNLHPLILFDA
NQPGELERAEAFGTDILELSVALGGTVTGEHGVGVEKINQMCSQFGEGERLQFFRVKAAFDPLGLLNPGKAIPTLHRCAE
YGRMRVSGGALPHPELPRF

Sequences:

>Translated_499_residues
MAPEEAGIAERDFSALDKARVVEALARVLPAGALMFEAEDLRPYECDGLSAYRALPLAVVLPATEDEVVAVLTVCAELGV
PVVARGAGTGLSGGALPHRHGVLLSLARFTRILHLDPHARTAVVQPGVRNLAISEAAAPYGLYYAPDPSSQIACTIGGNV
AENSGGVHCLKYGLTVHNLLRVRGVTIEGEVVEFGSHALDTPGYDLLALVTGSEGMLAVVTEVTVRLTPKPQLAQCVLAA
FDDVVKAGEAVAAIIAAGIIPAGLEMMDQPATAAVEQFVHAGYPLDARAILLCESDGTPEEVAEEIVAVRAVLEASGATE
IRVSQDEAERLRFWAGRKAAFPAAGRLSPDYYCMDGTIPRKRLGEMLEAIQGMEQKYGLACINVFHAGDGNLHPLILFDA
NQPGELERAEAFGTDILELSVALGGTVTGEHGVGVEKINQMCSQFGEGERLQFFRVKAAFDPLGLLNPGKAIPTLHRCAE
YGRMRVSGGALPHPELPRF
>Mature_498_residues
APEEAGIAERDFSALDKARVVEALARVLPAGALMFEAEDLRPYECDGLSAYRALPLAVVLPATEDEVVAVLTVCAELGVP
VVARGAGTGLSGGALPHRHGVLLSLARFTRILHLDPHARTAVVQPGVRNLAISEAAAPYGLYYAPDPSSQIACTIGGNVA
ENSGGVHCLKYGLTVHNLLRVRGVTIEGEVVEFGSHALDTPGYDLLALVTGSEGMLAVVTEVTVRLTPKPQLAQCVLAAF
DDVVKAGEAVAAIIAAGIIPAGLEMMDQPATAAVEQFVHAGYPLDARAILLCESDGTPEEVAEEIVAVRAVLEASGATEI
RVSQDEAERLRFWAGRKAAFPAAGRLSPDYYCMDGTIPRKRLGEMLEAIQGMEQKYGLACINVFHAGDGNLHPLILFDAN
QPGELERAEAFGTDILELSVALGGTVTGEHGVGVEKINQMCSQFGEGERLQFFRVKAAFDPLGLLNPGKAIPTLHRCAEY
GRMRVSGGALPHPELPRF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=423, Percent_Identity=30.2600472813239, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI37595754, Length=446, Percent_Identity=29.1479820627803, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI119964728, Length=469, Percent_Identity=27.5053304904051, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4501993, Length=237, Percent_Identity=24.8945147679325, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1789351, Length=484, Percent_Identity=64.4628099173554, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1787977, Length=501, Percent_Identity=24.3512974051896, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI48994907, Length=493, Percent_Identity=21.9066937119675, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71992373, Length=434, Percent_Identity=26.7281105990783, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71992381, Length=434, Percent_Identity=25.3456221198157, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71992392, Length=359, Percent_Identity=25.6267409470752, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17534361, Length=491, Percent_Identity=26.2729124236253, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17556096, Length=229, Percent_Identity=24.0174672489083, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320023, Length=463, Percent_Identity=29.3736501079914, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320027, Length=435, Percent_Identity=26.2068965517241, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320764, Length=458, Percent_Identity=26.2008733624454, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI18921117, Length=447, Percent_Identity=29.082774049217, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24639277, Length=447, Percent_Identity=29.082774049217, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24639275, Length=447, Percent_Identity=29.082774049217, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24653753, Length=232, Percent_Identity=28.0172413793103, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 52777; Mature: 52646

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPEEAGIAERDFSALDKARVVEALARVLPAGALMFEAEDLRPYECDGLSAYRALPLAVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHCCEEEE
LPATEDEVVAVLTVCAELGVPVVARGAGTGLSGGALPHRHGVLLSLARFTRILHLDPHAR
ECCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCC
TAVVQPGVRNLAISEAAAPYGLYYAPDPSSQIACTIGGNVAENSGGVHCLKYGLTVHNLL
EEEECCCCHHEEHHHCCCCCCEEECCCCCCCEEEEECCCEECCCCCEEEEEECHHHHHHH
RVRGVTIEGEVVEFGSHALDTPGYDLLALVTGSEGMLAVVTEVTVRLTPKPQLAQCVLAA
HHHCEEEECHHEECCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEECCCHHHHHHHHHH
FDDVVKAGEAVAAIIAAGIIPAGLEMMDQPATAAVEQFVHAGYPLDARAILLCESDGTPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHH
EVAEEIVAVRAVLEASGATEIRVSQDEAERLRFWAGRKAAFPAAGRLSPDYYCMDGTIPR
HHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCH
KRLGEMLEAIQGMEQKYGLACINVFHAGDGNLHPLILFDANQPGELERAEAFGTDILELS
HHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHCCHHEEEH
VALGGTVTGEHGVGVEKINQMCSQFGEGERLQFFRVKAAFDPLGLLNPGKAIPTLHRCAE
HHHCCEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
YGRMRVSGGALPHPELPRF
HCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
APEEAGIAERDFSALDKARVVEALARVLPAGALMFEAEDLRPYECDGLSAYRALPLAVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHCCEEEE
LPATEDEVVAVLTVCAELGVPVVARGAGTGLSGGALPHRHGVLLSLARFTRILHLDPHAR
ECCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCC
TAVVQPGVRNLAISEAAAPYGLYYAPDPSSQIACTIGGNVAENSGGVHCLKYGLTVHNLL
EEEECCCCHHEEHHHCCCCCCEEECCCCCCCEEEEECCCEECCCCCEEEEEECHHHHHHH
RVRGVTIEGEVVEFGSHALDTPGYDLLALVTGSEGMLAVVTEVTVRLTPKPQLAQCVLAA
HHHCEEEECHHEECCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEECCCHHHHHHHHHH
FDDVVKAGEAVAAIIAAGIIPAGLEMMDQPATAAVEQFVHAGYPLDARAILLCESDGTPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHH
EVAEEIVAVRAVLEASGATEIRVSQDEAERLRFWAGRKAAFPAAGRLSPDYYCMDGTIPR
HHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCH
KRLGEMLEAIQGMEQKYGLACINVFHAGDGNLHPLILFDANQPGELERAEAFGTDILELS
HHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHCCHHEEEH
VALGGTVTGEHGVGVEKINQMCSQFGEGERLQFFRVKAAFDPLGLLNPGKAIPTLHRCAE
HHHCCEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
YGRMRVSGGALPHPELPRF
HCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]