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The map label for this gene is glcC [H]

Identifier: 119897288

GI number: 119897288

Start: 1072050

End: 1072769

Strand: Direct

Name: glcC [H]

Synonym: azo0997

Alternate gene names: 119897288

Gene position: 1072050-1072769 (Clockwise)

Preceding gene: 119897287

Following gene: 119897289

Centisome position: 24.5

GC content: 71.94

Gene sequence:

>720_bases
ATGTCCGCGCTTCTGCCCCGCCCACAGCGCCTCAGCGATACCGTTGCGCGCCAGCTCGAATCCTTGATCCGGGACGAGGG
CATGGCACCCGGCGCGCGACTGCCGACCGAAAAGGTCTTGTGCGAGCGCCTGGGCGTCAGCCGTGCGGTGGTGCGCGAGG
CCGTGTCCCGCCTGAAGGCGGAGGGCAGCGTGGAAACCCGGCAAGGCCTCGGCGCCTTTGTCGCTGCCAGCCCCGGCCAG
GGCAGCTTTCGCCTTGTGCGCGGCGGAAAGGCGTCGCTTGCCGAGGTGGAGGAAATCTTCGAGATACGCTGCGTGGTCGA
GGCAGGCGCGGCCGAACTCGCCGCCCGCCGCCGCAGCGCCGCGGACCTTTCGCGCCTGGCGGCGGCATTGAGCCGCATGG
ATCGCGCGCTGGACGGCGCGCCCGACGGCGCCCAGGCCGACGATGCGTTTCATGTGGCGATCGCGGCAGCCACCGGCAAC
ACCCAGCTCGAACGCTTTCTCGCCTTTGTCGGCCGCCAGTTCTCCGAAACCCGCGCACCGACCTGGGATGCCGGCGGACT
ACGATCGGGCCGCGCCGCCGAGGCGCAGGCCGAGCACCGCCGCATCTTCAGCGCAATCGAGGCGGGGGATGCCGAAGCGG
CGCGGGCCGCGGCACGCGCGCATCTGGTTGCGGCGGCGCGAAGACTGGGGCTGACCGGCCTCGCCGCGGCATTTCCCTGA

Upstream 100 bases:

>100_bases
TCCCATTTCCTGCCGGGGCCGCCCGGCCGGACGGCAAGGGGTGACAGCCCGCCGGTGAGCAGCTAGGATGCAGCTTACTT
GTCCGACAAGTAGATGACCA

Downstream 100 bases:

>100_bases
TCCGCGGGGCGACACCGGGCCGACGGGGCGCAGACCGGCGGCTGCCATGAACGACGACGGGAGGTGGACGTGACAGAGAG
CGGTGGAGTGGACGTGGCGC

Product: glc operon transcriptional activator

Products: NA

Alternate protein names: L-lactate utilization operon repressor [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSALLPRPQRLSDTVARQLESLIRDEGMAPGARLPTEKVLCERLGVSRAVVREAVSRLKAEGSVETRQGLGAFVAASPGQ
GSFRLVRGGKASLAEVEEIFEIRCVVEAGAAELAARRRSAADLSRLAAALSRMDRALDGAPDGAQADDAFHVAIAAATGN
TQLERFLAFVGRQFSETRAPTWDAGGLRSGRAAEAQAEHRRIFSAIEAGDAEAARAAARAHLVAAARRLGLTGLAAAFP

Sequences:

>Translated_239_residues
MSALLPRPQRLSDTVARQLESLIRDEGMAPGARLPTEKVLCERLGVSRAVVREAVSRLKAEGSVETRQGLGAFVAASPGQ
GSFRLVRGGKASLAEVEEIFEIRCVVEAGAAELAARRRSAADLSRLAAALSRMDRALDGAPDGAQADDAFHVAIAAATGN
TQLERFLAFVGRQFSETRAPTWDAGGLRSGRAAEAQAEHRRIFSAIEAGDAEAARAAARAHLVAAARRLGLTGLAAAFP
>Mature_238_residues
SALLPRPQRLSDTVARQLESLIRDEGMAPGARLPTEKVLCERLGVSRAVVREAVSRLKAEGSVETRQGLGAFVAASPGQG
SFRLVRGGKASLAEVEEIFEIRCVVEAGAAELAARRRSAADLSRLAAALSRMDRALDGAPDGAQADDAFHVAIAAATGNT
QLERFLAFVGRQFSETRAPTWDAGGLRSGRAAEAQAEHRRIFSAIEAGDAEAARAAARAHLVAAARRLGLTGLAAAFP

Specific function: Negatively regulates the transcription of the lutABC operon, which is required for L-lactate utilization. LutR activity is regulated by lactate, since presence of L-lactate, that probably binds to lutR, leads to derepression of the operon. Also appears to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790780, Length=232, Percent_Identity=31.8965517241379, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790032, Length=225, Percent_Identity=32.4444444444444, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786303, Length=222, Percent_Identity=31.0810810810811, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789353, Length=230, Percent_Identity=28.695652173913, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082208, Length=228, Percent_Identity=28.0701754385965, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994955, Length=233, Percent_Identity=26.6094420600858, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 25093; Mature: 24961

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALLPRPQRLSDTVARQLESLIRDEGMAPGARLPTEKVLCERLGVSRAVVREAVSRLKA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHC
EGSVETRQGLGAFVAASPGQGSFRLVRGGKASLAEVEEIFEIRCVVEAGAAELAARRRSA
CCCCHHHHCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLSRLAAALSRMDRALDGAPDGAQADDAFHVAIAAATGNTQLERFLAFVGRQFSETRAP
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
TWDAGGLRSGRAAEAQAEHRRIFSAIEAGDAEAARAAARAHLVAAARRLGLTGLAAAFP
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCC
>Mature Secondary Structure 
SALLPRPQRLSDTVARQLESLIRDEGMAPGARLPTEKVLCERLGVSRAVVREAVSRLKA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHC
EGSVETRQGLGAFVAASPGQGSFRLVRGGKASLAEVEEIFEIRCVVEAGAAELAARRRSA
CCCCHHHHCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLSRLAAALSRMDRALDGAPDGAQADDAFHVAIAAATGNTQLERFLAFVGRQFSETRAP
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
TWDAGGLRSGRAAEAQAEHRRIFSAIEAGDAEAARAAARAHLVAAARRLGLTGLAAAFP
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]