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The map label for this gene is ecaA [H]

Identifier: 119897133

GI number: 119897133

Start: 904277

End: 905893

Strand: Direct

Name: ecaA [H]

Synonym: azo0842

Alternate gene names: 119897133

Gene position: 904277-905893 (Clockwise)

Preceding gene: 119897129

Following gene: 119897135

Centisome position: 20.66

GC content: 72.97

Gene sequence:

>1617_bases
ATGAAGCTCCGTCACCTCGCCGCGCTGCTGATCTTGCCCCTGTCACCCGGGTGGGTGCCGCACGCCCATGCGGACGAGTG
GCAACTGGTGCTGAGCGACCGCGAGCGCCGGGTGGAGATCGACCGCGCCAGCATCTTCGATTCCGATCGCGGCACCAAGG
TCTCGTGGGGGCGGGTGGTGCTGGCGCCCGAGGAGGCACGCAAGGCGGGCTACGGCACCGTGCGCGCGCTCAATCGCTAC
GACTGCATGAACCGCAGCTTTTTCACCATCAAGCGGGTGTACCTCGACACCGCCGGCCGGGTCGTCCGCGAAGAGGCGGT
GACCGACACCAGCCCGGTGATGGTCACGCGCAATTCGGTGGACGAGCGGATGTGGCGTGAGGTGTGCCGCCCGCCCACCG
TCAGCGATCTGCAGAAGGTTGCCGCCGCGGCGGGCCGATCGGCGGCAGAAACCCGCCCGGCGCCGACGCCCGCCGCCAAG
CCCGCGGCTGCCGAGCTGAAGCCGGCGCCGAGCGCACGCACCGAGACCAAGGGCGCCGCGCCGACTCCGCCCGTTCCCCC
TAAAACAGAACCGGCCGCTACGCCCGCTGCCGGGCCCGCGCCTGCCGTGGTGGCCCGCGCAGGTGCCGCCGAAACCCGCG
ATCCCCCCCGCAGCGAGGGGCTGCGCCCGGCCGACTTCCAAGCGCCCCAGGCCGCGGCCGCGGCCGCTGCCCGGCCCGCG
ACTCCTGCAGCGACGCCGGTTTCCACCGCGGCCGCGGCGCCGGCCACCCCGACCACCCCGGCCACCCCGGTGTTGCCCGG
CACGCCGGGTGCTCCGCCTGTTGCTGCCGCGCCGGCGGCGCCGGCCGTCCCCACCCCGGTGCAGTCCGCCGCGCGCGTGC
CGGCCCCGCGCGTGGCGCCTGCGCCGGTAGAGGCGGCACCGCGCCCCGCCGCCGCCCTGGAGCAGAGGTGGAGCTACGAC
GGCGAGACCGGCCCCGAGCATTGGGCCCGGCTGCGGCCCGACTGGCGGGTGTGCGGCGACGGCAAACGCCAGTCGCCGAT
CGACCTGCGCGAAGGCGTGGGGGTGGACCTCGAGCCGGTCCGCTTCGACTATCGCAGCACGCGCTTCCGCATCGCCGACA
CGGGCACCACGCTGCAGGTCAACGTGGGTGAGGGCATGGGCATGGAAGTGCGCGGCCGGCGCTACGAGCTGACCCATTTC
ACGCTGCATCGTCCTTCCGAGGAGCGCGTGGGCGGGCGCGCGGCCGACATGACGGTTCACTTCCACCATCGCGATGCCGA
GGGCCGTCTGGCCATGGTGTCGGTGATGCTGGAGCGCGGCGCCGAAGCCAACCCCCTGCTGCAGGCCTTGTGGAACAACC
TGCCGCTGGAGAAGGGGACTGCCTACATGCCGGCGTCGTCGATCGACCTCGGCGCGCTGCTGCCGGCCAGTCCCGGCCAC
TTCCTCTACATGGGCTCGCTCACCACGCCGCCCTGCACCGAGGGCGTGCTGTGGGTGGTGATGAAGACGCCGGTCACGAT
CTCGGACGAACAGCTCGGCATCTTCGCCCGCCTGTATCCACGCAACGCGCGACCCATCCAGCCCGCCAACGGCCGCCTGA
TCCTTGAATCGCGCTGA

Upstream 100 bases:

>100_bases
GCCGTGACCGGGTGCGCGCGGGCGAGAAGGTCTGCCTGGTTACGCTCAAGATATTCCTGTGCTTGCCGAAACAGGAGCTG
TAAGCCTCCCGGATCGCACC

Downstream 100 bases:

>100_bases
CGCGCGCCGCGCTCACAGTGCCGCGAGCGTGTCGCCGAGAAAGCGTTCGAGCACTTTCTCCGCCGAGAACGCGACGTTGA
AGCGCAGCCACGGGCTGGCC

Product: putative carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MKLRHLAALLILPLSPGWVPHAHADEWQLVLSDRERRVEIDRASIFDSDRGTKVSWGRVVLAPEEARKAGYGTVRALNRY
DCMNRSFFTIKRVYLDTAGRVVREEAVTDTSPVMVTRNSVDERMWREVCRPPTVSDLQKVAAAAGRSAAETRPAPTPAAK
PAAAELKPAPSARTETKGAAPTPPVPPKTEPAATPAAGPAPAVVARAGAAETRDPPRSEGLRPADFQAPQAAAAAAARPA
TPAATPVSTAAAAPATPTTPATPVLPGTPGAPPVAAAPAAPAVPTPVQSAARVPAPRVAPAPVEAAPRPAAALEQRWSYD
GETGPEHWARLRPDWRVCGDGKRQSPIDLREGVGVDLEPVRFDYRSTRFRIADTGTTLQVNVGEGMGMEVRGRRYELTHF
TLHRPSEERVGGRAADMTVHFHHRDAEGRLAMVSVMLERGAEANPLLQALWNNLPLEKGTAYMPASSIDLGALLPASPGH
FLYMGSLTTPPCTEGVLWVVMKTPVTISDEQLGIFARLYPRNARPIQPANGRLILESR

Sequences:

>Translated_538_residues
MKLRHLAALLILPLSPGWVPHAHADEWQLVLSDRERRVEIDRASIFDSDRGTKVSWGRVVLAPEEARKAGYGTVRALNRY
DCMNRSFFTIKRVYLDTAGRVVREEAVTDTSPVMVTRNSVDERMWREVCRPPTVSDLQKVAAAAGRSAAETRPAPTPAAK
PAAAELKPAPSARTETKGAAPTPPVPPKTEPAATPAAGPAPAVVARAGAAETRDPPRSEGLRPADFQAPQAAAAAAARPA
TPAATPVSTAAAAPATPTTPATPVLPGTPGAPPVAAAPAAPAVPTPVQSAARVPAPRVAPAPVEAAPRPAAALEQRWSYD
GETGPEHWARLRPDWRVCGDGKRQSPIDLREGVGVDLEPVRFDYRSTRFRIADTGTTLQVNVGEGMGMEVRGRRYELTHF
TLHRPSEERVGGRAADMTVHFHHRDAEGRLAMVSVMLERGAEANPLLQALWNNLPLEKGTAYMPASSIDLGALLPASPGH
FLYMGSLTTPPCTEGVLWVVMKTPVTISDEQLGIFARLYPRNARPIQPANGRLILESR
>Mature_538_residues
MKLRHLAALLILPLSPGWVPHAHADEWQLVLSDRERRVEIDRASIFDSDRGTKVSWGRVVLAPEEARKAGYGTVRALNRY
DCMNRSFFTIKRVYLDTAGRVVREEAVTDTSPVMVTRNSVDERMWREVCRPPTVSDLQKVAAAAGRSAAETRPAPTPAAK
PAAAELKPAPSARTETKGAAPTPPVPPKTEPAATPAAGPAPAVVARAGAAETRDPPRSEGLRPADFQAPQAAAAAAARPA
TPAATPVSTAAAAPATPTTPATPVLPGTPGAPPVAAAPAAPAVPTPVQSAARVPAPRVAPAPVEAAPRPAAALEQRWSYD
GETGPEHWARLRPDWRVCGDGKRQSPIDLREGVGVDLEPVRFDYRSTRFRIADTGTTLQVNVGEGMGMEVRGRRYELTHF
TLHRPSEERVGGRAADMTVHFHHRDAEGRLAMVSVMLERGAEANPLLQALWNNLPLEKGTAYMPASSIDLGALLPASPGH
FLYMGSLTTPPCTEGVLWVVMKTPVTISDEQLGIFARLYPRNARPIQPANGRLILESR

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=258, Percent_Identity=29.4573643410853, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI192447434, Length=258, Percent_Identity=29.4573643410853, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI192447432, Length=258, Percent_Identity=29.4573643410853, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI192447430, Length=258, Percent_Identity=29.4573643410853, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4502517, Length=258, Percent_Identity=29.4573643410853, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4885101, Length=260, Percent_Identity=31.5384615384615, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI45935383, Length=283, Percent_Identity=30.0353356890459, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4502515, Length=283, Percent_Identity=30.0353356890459, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38348436, Length=258, Percent_Identity=31.0077519379845, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI6912284, Length=265, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI169636420, Length=264, Percent_Identity=31.0606060606061, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4557395, Length=260, Percent_Identity=28.4615384615385, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI194097398, Length=268, Percent_Identity=28.3582089552239, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4885099, Length=261, Percent_Identity=26.4367816091954, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4502521, Length=249, Percent_Identity=29.718875502008, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI6005723, Length=236, Percent_Identity=28.8135593220339, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4502519, Length=279, Percent_Identity=27.9569892473118, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI130979954, Length=253, Percent_Identity=25.296442687747, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI130979679, Length=253, Percent_Identity=25.296442687747, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI9910366, Length=253, Percent_Identity=25.296442687747, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI62240989, Length=202, Percent_Identity=31.6831683168317, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI91208428, Length=235, Percent_Identity=27.2340425531915, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17568715, Length=259, Percent_Identity=28.1853281853282, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995280, Length=263, Percent_Identity=26.9961977186312, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737413, Length=261, Percent_Identity=29.1187739463602, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221329761, Length=264, Percent_Identity=26.1363636363636, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18858185, Length=246, Percent_Identity=28.0487804878049, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21358169, Length=285, Percent_Identity=28.0701754385965, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 57564; Mature: 57564

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRHLAALLILPLSPGWVPHAHADEWQLVLSDRERRVEIDRASIFDSDRGTKVSWGRVV
CCHHHEEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEHHHHHCCCCCCCEEECCEEE
LAPEEARKAGYGTVRALNRYDCMNRSFFTIKRVYLDTAGRVVREEAVTDTSPVMVTRNSV
ECCHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCH
DERMWREVCRPPTVSDLQKVAAAAGRSAAETRPAPTPAAKPAAAELKPAPSARTETKGAA
HHHHHHHHHCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PTPPVPPKTEPAATPAAGPAPAVVARAGAAETRDPPRSEGLRPADFQAPQAAAAAAARPA
CCCCCCCCCCCCCCCCCCCCCHHHEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHCCCC
TPAATPVSTAAAAPATPTTPATPVLPGTPGAPPVAAAPAAPAVPTPVQSAARVPAPRVAP
CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCC
APVEAAPRPAAALEQRWSYDGETGPEHWARLRPDWRVCGDGKRQSPIDLREGVGVDLEPV
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCEECCCCCCCCCCHHHHCCCCCCCCE
RFDYRSTRFRIADTGTTLQVNVGEGMGMEVRGRRYELTHFTLHRPSEERVGGRAADMTVH
EECCCCCEEEEEECCCEEEEECCCCCCEEECCCEEEEEEEEEECCCHHHHCCEEEEEEEE
FHHRDAEGRLAMVSVMLERGAEANPLLQALWNNLPLEKGTAYMPASSIDLGALLPASPGH
EEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCCCEECCCCCCC
FLYMGSLTTPPCTEGVLWVVMKTPVTISDEQLGIFARLYPRNARPIQPANGRLILESR
EEEECCCCCCCCCCCEEEEEEECCEEECCCCCEEEEEECCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKLRHLAALLILPLSPGWVPHAHADEWQLVLSDRERRVEIDRASIFDSDRGTKVSWGRVV
CCHHHEEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEHHHHHCCCCCCCEEECCEEE
LAPEEARKAGYGTVRALNRYDCMNRSFFTIKRVYLDTAGRVVREEAVTDTSPVMVTRNSV
ECCHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCH
DERMWREVCRPPTVSDLQKVAAAAGRSAAETRPAPTPAAKPAAAELKPAPSARTETKGAA
HHHHHHHHHCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PTPPVPPKTEPAATPAAGPAPAVVARAGAAETRDPPRSEGLRPADFQAPQAAAAAAARPA
CCCCCCCCCCCCCCCCCCCCCHHHEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHCCCC
TPAATPVSTAAAAPATPTTPATPVLPGTPGAPPVAAAPAAPAVPTPVQSAARVPAPRVAP
CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCC
APVEAAPRPAAALEQRWSYDGETGPEHWARLRPDWRVCGDGKRQSPIDLREGVGVDLEPV
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCEECCCCCCCCCCHHHHCCCCCCCCE
RFDYRSTRFRIADTGTTLQVNVGEGMGMEVRGRRYELTHFTLHRPSEERVGGRAADMTVH
EECCCCCEEEEEECCCEEEEECCCCCCEEECCCEEEEEEEEEECCCHHHHCCEEEEEEEE
FHHRDAEGRLAMVSVMLERGAEANPLLQALWNNLPLEKGTAYMPASSIDLGALLPASPGH
EEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCCCEECCCCCCC
FLYMGSLTTPPCTEGVLWVVMKTPVTISDEQLGIFARLYPRNARPIQPANGRLILESR
EEEECCCCCCCCCCCEEEEEEECCEEECCCCCEEEEEECCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006032; 11759840 [H]