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The map label for this gene is thiD1 [H]

Identifier: 119897132

GI number: 119897132

Start: 903169

End: 904023

Strand: Reverse

Name: thiD1 [H]

Synonym: azo0841

Alternate gene names: 119897132

Gene position: 904023-903169 (Counterclockwise)

Preceding gene: 119897134

Following gene: 119897131

Centisome position: 20.66

GC content: 69.12

Gene sequence:

>855_bases
ATGAGTTCATCCAGCACCCATCCCAGTTCCATCCCGAATGTGCTTTCCATCGCCGGAGTCGATCCGAGCGGTGGCGCCGG
CATTTTCGCGGACATCAAGACCTTCTCCGCGCTCGGCGCCTATGGCTGCGGTGTCATTGCCGCGCTGACCGCACAGAACA
CCCAGGCGGTCACCGGCGTGCATGTGCCGCCGACCGACTTCCTGCGCCTGCAGCTCGACACCCTGTTCGCCGACGTCGCG
GTGCACGCCACCAAGATCGGCATGCTCGGCAGCGCCGAGGTCACCGCCACCGTCGCCGACCGCCTCGCCCACTGGCAGGC
CGCCAACGTGGTGCTCGATCCGGTCATGGTGGCCAAGAGCGGCGACACCCTGCTGGCGAAGAACGCGATCGCGATGATGC
GCGAGGCGCTGTTTCCGCAGTCTTTCATGATCACCCCCAACCTGCCCGAAGCCGGGGTGCTGCTGGAGCAGCGCGCACCG
GAATCGGTGAAGGAGATGTACCGCGCCGCCGAGCGCCTGCGCGAGCTGCTGCCGCTGTCGTCCGAGCGCTGGGTGATGCT
GAAGGGTGGCCACCTGCCCGGCAGCGAGGTCGTCGATCTGCTGTTCGACGGCGACCGCATGATCGAACTGCCGGCGCCGC
GCATCGACACCAGGAACACCCACGGCACCGGCTGCACGCTGTCGTCGGCGATCGCCGCACTGCTGCCGCAGACCGCCGGG
GGCTTTCGCGGCGTCGAGGCGGCGGTGCGCCAGGCACGCCAGTGGCTGCTCGGCGCCATCGCCCATAGCGGCGACCTCGG
CGTCGGCAGCGGCCACGGCCCGGTGCATCACTTCCACGCGCTGTGGCGACGCTGA

Upstream 100 bases:

>100_bases
TCGCGGGCTTGCCGTTAGGGGTGCCCGCGCAAGGTTGCGGCGGGCTGAGAGAGTCCCTCAACACCTGATCCGGATCGTGC
CGGCGTAGGGAAACGCGTTC

Downstream 100 bases:

>100_bases
GGCGGTCGCGCCGTCCGTCCACATCCGCACATTCCACAAGAAGCAGTCCTCAGCCTGCCTGCTCCATACCCGTACCCCAG
GAGACCCCCATGAACGCCAA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSSSSTHPSSIPNVLSIAGVDPSGGAGIFADIKTFSALGAYGCGVIAALTAQNTQAVTGVHVPPTDFLRLQLDTLFADVA
VHATKIGMLGSAEVTATVADRLAHWQAANVVLDPVMVAKSGDTLLAKNAIAMMREALFPQSFMITPNLPEAGVLLEQRAP
ESVKEMYRAAERLRELLPLSSERWVMLKGGHLPGSEVVDLLFDGDRMIELPAPRIDTRNTHGTGCTLSSAIAALLPQTAG
GFRGVEAAVRQARQWLLGAIAHSGDLGVGSGHGPVHHFHALWRR

Sequences:

>Translated_284_residues
MSSSSTHPSSIPNVLSIAGVDPSGGAGIFADIKTFSALGAYGCGVIAALTAQNTQAVTGVHVPPTDFLRLQLDTLFADVA
VHATKIGMLGSAEVTATVADRLAHWQAANVVLDPVMVAKSGDTLLAKNAIAMMREALFPQSFMITPNLPEAGVLLEQRAP
ESVKEMYRAAERLRELLPLSSERWVMLKGGHLPGSEVVDLLFDGDRMIELPAPRIDTRNTHGTGCTLSSAIAALLPQTAG
GFRGVEAAVRQARQWLLGAIAHSGDLGVGSGHGPVHHFHALWRR
>Mature_283_residues
SSSSTHPSSIPNVLSIAGVDPSGGAGIFADIKTFSALGAYGCGVIAALTAQNTQAVTGVHVPPTDFLRLQLDTLFADVAV
HATKIGMLGSAEVTATVADRLAHWQAANVVLDPVMVAKSGDTLLAKNAIAMMREALFPQSFMITPNLPEAGVLLEQRAPE
SVKEMYRAAERLRELLPLSSERWVMLKGGHLPGSEVVDLLFDGDRMIELPAPRIDTRNTHGTGCTLSSAIAALLPQTAGG
FRGVEAAVRQARQWLLGAIAHSGDLGVGSGHGPVHHFHALWRR

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=270, Percent_Identity=51.4814814814815, Blast_Score=254, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6325378, Length=284, Percent_Identity=30.6338028169014, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6324997, Length=290, Percent_Identity=33.7931034482759, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324517, Length=290, Percent_Identity=33.448275862069, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29976; Mature: 29845

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSSTHPSSIPNVLSIAGVDPSGGAGIFADIKTFSALGAYGCGVIAALTAQNTQAVTGV
CCCCCCCCCCCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
HVPPTDFLRLQLDTLFADVAVHATKIGMLGSAEVTATVADRLAHWQAANVVLDPVMVAKS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEECCEEEECC
GDTLLAKNAIAMMREALFPQSFMITPNLPEAGVLLEQRAPESVKEMYRAAERLRELLPLS
CCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCC
SERWVMLKGGHLPGSEVVDLLFDGDRMIELPAPRIDTRNTHGTGCTLSSAIAALLPQTAG
CCCEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
GFRGVEAAVRQARQWLLGAIAHSGDLGVGSGHGPVHHFHALWRR
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SSSSTHPSSIPNVLSIAGVDPSGGAGIFADIKTFSALGAYGCGVIAALTAQNTQAVTGV
CCCCCCCCCCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
HVPPTDFLRLQLDTLFADVAVHATKIGMLGSAEVTATVADRLAHWQAANVVLDPVMVAKS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEECCEEEECC
GDTLLAKNAIAMMREALFPQSFMITPNLPEAGVLLEQRAPESVKEMYRAAERLRELLPLS
CCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCC
SERWVMLKGGHLPGSEVVDLLFDGDRMIELPAPRIDTRNTHGTGCTLSSAIAALLPQTAG
CCCEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
GFRGVEAAVRQARQWLLGAIAHSGDLGVGSGHGPVHHFHALWRR
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]