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The map label for this gene is macA [H]

Identifier: 119897126

GI number: 119897126

Start: 893195

End: 894343

Strand: Reverse

Name: macA [H]

Synonym: azo0835

Alternate gene names: 119897126

Gene position: 894343-893195 (Counterclockwise)

Preceding gene: 119897127

Following gene: 119897125

Centisome position: 20.44

GC content: 72.15

Gene sequence:

>1149_bases
ATGGCCCTCTCCCGCCGCCTGATTCCCGTTGTCATCGTCATCGCGCTGCTCGGCGCCGCCGGCTGGTGGTTCACCCGCCC
CAAGCCGATCGTGGTCGTCGTCCATGAAGTGGCCCGCGGCCGCGTCGAGGCGAGCGTGGCCAACACCCGCGCCGGCGAGG
TCGAGGCCTGCCAGCGCACCAAGCTCGCCACCATCACCGGCGGCCGCATCGACTACCTCGGCGTCAAGGAAGGCGACCGG
GTGCAGGCCGGGCAGGTGCTGATGCGGCTGTGGCAGGGCGACCTGCGCTCGCGCGCCGCCGTGGCCGAAGCCCAGCTCGC
CACCGCCCGCCAGCGCAGCACCGAGGCCTGCACGGTGGCGGCCAACGCGCGCAGCGAGGCGGAACGCCAGGCGGCACTGG
TCAAGCGTGGCTTCGTTTCCGCCAGCGTCGAGGAAAAGGCGCGCACCGAGGCCGCCGCCCGCGCCGCCGGCTGCGCCAGC
GCGCAGGCGGACGTGAAGACCGCGGAACGCCAGCTCGAAGCCGCCGGCATCGACCTCAACCGCGTCGTCATCGTCGCGCC
CTTCGCCGGCACCGTCGCCAAGATCACCGGCGAACTCGGCGAGATCTCCACCCCCTCGCCCCCCGGCGTGCCGACACCGC
CCGCGATCGACCTGATCGACGACTCCTGCCTGTACGTGAAGGCGCCGATGGACGAGGTCGACGCCCCCAAGATCCACCCC
GGTCAACCCGCCCGCATCAGCTTCGAGGCGCTGCCGGGCAAGACCTTCGCCGGCCGCGTGAAGCGGGTGGCGCCCTACAT
CACCGCAGTGGAAAAACAGGCGCGCACGGTCGAGGTGGATATCGACTTCGCCAACCCGGAAGAAGCACGCGGCCTGCTGG
TGGGCTACAGCGTGGATGTCGAGATCGTGCTCGAGACGCGCGACGACGTGCTGCGCGTGCCGTCCGCCGCAATCCGCGAA
GGCAACCGCGTGCTGGTGCTCGGCGCGGACGGCCTGATCGCCGAGCGCAGCATCCGCCCCGGCCTCGCCAACTGGGAACA
GACCGAGGTGCTGGAGGGCCTCGCCGCGGGTGACCGCGTGGTCACCTCGCTCGAACGTGCCGGCGTCGTACCCGGCGCGC
ACGCCACCGCCGAAGCCGGCGCGAACTGA

Upstream 100 bases:

>100_bases
AGCCTCGCCGGTGCGCGGCCGCCACACCGTCCTAGCCGCAACCCCAACGCCTCCCCCTTGAATGGGAAGGCGCAACCCAC
CACCCGCCTGCCGACAGATC

Downstream 100 bases:

>100_bases
GGCGCAGCCGCCGATGGCCCAGATCGAACTGAGCGGCATCGAGCGCGTCTTCACGCTGGGTGACAGCCAGGTCCATGCGC
TGCGCGACGTCTCGCTCGAG

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MALSRRLIPVVIVIALLGAAGWWFTRPKPIVVVVHEVARGRVEASVANTRAGEVEACQRTKLATITGGRIDYLGVKEGDR
VQAGQVLMRLWQGDLRSRAAVAEAQLATARQRSTEACTVAANARSEAERQAALVKRGFVSASVEEKARTEAAARAAGCAS
AQADVKTAERQLEAAGIDLNRVVIVAPFAGTVAKITGELGEISTPSPPGVPTPPAIDLIDDSCLYVKAPMDEVDAPKIHP
GQPARISFEALPGKTFAGRVKRVAPYITAVEKQARTVEVDIDFANPEEARGLLVGYSVDVEIVLETRDDVLRVPSAAIRE
GNRVLVLGADGLIAERSIRPGLANWEQTEVLEGLAAGDRVVTSLERAGVVPGAHATAEAGAN

Sequences:

>Translated_382_residues
MALSRRLIPVVIVIALLGAAGWWFTRPKPIVVVVHEVARGRVEASVANTRAGEVEACQRTKLATITGGRIDYLGVKEGDR
VQAGQVLMRLWQGDLRSRAAVAEAQLATARQRSTEACTVAANARSEAERQAALVKRGFVSASVEEKARTEAAARAAGCAS
AQADVKTAERQLEAAGIDLNRVVIVAPFAGTVAKITGELGEISTPSPPGVPTPPAIDLIDDSCLYVKAPMDEVDAPKIHP
GQPARISFEALPGKTFAGRVKRVAPYITAVEKQARTVEVDIDFANPEEARGLLVGYSVDVEIVLETRDDVLRVPSAAIRE
GNRVLVLGADGLIAERSIRPGLANWEQTEVLEGLAAGDRVVTSLERAGVVPGAHATAEAGAN
>Mature_381_residues
ALSRRLIPVVIVIALLGAAGWWFTRPKPIVVVVHEVARGRVEASVANTRAGEVEACQRTKLATITGGRIDYLGVKEGDRV
QAGQVLMRLWQGDLRSRAAVAEAQLATARQRSTEACTVAANARSEAERQAALVKRGFVSASVEEKARTEAAARAAGCASA
QADVKTAERQLEAAGIDLNRVVIVAPFAGTVAKITGELGEISTPSPPGVPTPPAIDLIDDSCLYVKAPMDEVDAPKIHPG
QPARISFEALPGKTFAGRVKRVAPYITAVEKQARTVEVDIDFANPEEARGLLVGYSVDVEIVLETRDDVLRVPSAAIREG
NRVLVLGADGLIAERSIRPGLANWEQTEVLEGLAAGDRVVTSLERAGVVPGAHATAEAGAN

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=366, Percent_Identity=29.5081967213115, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789929, Length=326, Percent_Identity=27.9141104294479, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081951, Length=270, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082036, Length=326, Percent_Identity=25.1533742331288, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790519, Length=235, Percent_Identity=31.063829787234, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40329; Mature: 40198

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSRRLIPVVIVIALLGAAGWWFTRPKPIVVVVHEVARGRVEASVANTRAGEVEACQRT
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCEEEHHHCCCCCCHHHHHCC
KLATITGGRIDYLGVKEGDRVQAGQVLMRLWQGDLRSRAAVAEAQLATARQRSTEACTVA
EEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ANARSEAERQAALVKRGFVSASVEEKARTEAAARAAGCASAQADVKTAERQLEAAGIDLN
ECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
RVVIVAPFAGTVAKITGELGEISTPSPPGVPTPPAIDLIDDSCLYVKAPMDEVDAPKIHP
EEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCC
GQPARISFEALPGKTFAGRVKRVAPYITAVEKQARTVEVDIDFANPEEARGLLVGYSVDV
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHCEEEEEEEEEE
EIVLETRDDVLRVPSAAIREGNRVLVLGADGLIAERSIRPGLANWEQTEVLEGLAAGDRV
EEEEECCCHHHHCCCHHHHCCCEEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHCCHHH
VTSLERAGVVPGAHATAEAGAN
HHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALSRRLIPVVIVIALLGAAGWWFTRPKPIVVVVHEVARGRVEASVANTRAGEVEACQRT
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCEEEHHHCCCCCCHHHHHCC
KLATITGGRIDYLGVKEGDRVQAGQVLMRLWQGDLRSRAAVAEAQLATARQRSTEACTVA
EEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ANARSEAERQAALVKRGFVSASVEEKARTEAAARAAGCASAQADVKTAERQLEAAGIDLN
ECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
RVVIVAPFAGTVAKITGELGEISTPSPPGVPTPPAIDLIDDSCLYVKAPMDEVDAPKIHP
EEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCC
GQPARISFEALPGKTFAGRVKRVAPYITAVEKQARTVEVDIDFANPEEARGLLVGYSVDV
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHCEEEEEEEEEE
EIVLETRDDVLRVPSAAIREGNRVLVLGADGLIAERSIRPGLANWEQTEVLEGLAAGDRV
EEEEECCCHHHHCCCHHHHCCCEEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHCCHHH
VTSLERAGVVPGAHATAEAGAN
HHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]