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The map label for this gene is kefBC [H]

Identifier: 119897086

GI number: 119897086

Start: 852075

End: 854042

Strand: Direct

Name: kefBC [H]

Synonym: azo0795

Alternate gene names: 119897086

Gene position: 852075-854042 (Clockwise)

Preceding gene: 119897079

Following gene: 119897097

Centisome position: 19.47

GC content: 68.85

Gene sequence:

>1968_bases
ATGTTGAACACCCTCGATCTCGTCCTGTTGCTGCTGGCCGCGGCCGTCGTGCTGGTGGCCGTGCTGCGCAGCGTCAATCT
CCCGCCCGTGCTCGGCTACCTGCTGGTCGGCGCGATGGTGGGGCCGCACGCCTTCAACCTGGTGCCCGACTCCGCGGGCG
CCCGCCATCTCGCCGAGTTCGGCGTCGTCTTCCTGATGTTCTCGATCGGGCTCGAATTCTCGTTGCCGCGGTTGCTGGCG
ATGAAGAACATCGTCTTCGGGCTGGGCGCCGCCCAGGTAGTCGGCAGCATCGCGCTGACGCTGGTGCTTGGCAGGCTGGG
CGGACTGGGGTGGGCGGCGGCGTTCGCACTGGGCGGCACCATCGCGATGTCCTCCACCGCGATCCTGTCGAAGCTCCTGG
CCGACCGGCTCGAACTCGACAGCCGGCACGGGCGGGAGATCATCGGCGTGCTGCTGTTCCAGGATCTCGCGGTGGTGCCG
CTGCTGATCCTGCTGCCGGCCCTGTCGCGCCCTGCCGAGGAACTCGCCGTCACGCTCGGGCTGGCCGGGATCAAGGCGGT
GGTGCTGCTGGCGCTGGTGCTGGTGTTCGGCCCCCGGCTGATGCGGTGGTGGTTCACGCTGGTGGCGCGGCGCCGATCCG
GCGAGTTGTTCATGCTCAACGTGCTGTTCATTACGCTGGGCCTGGCCTGGCTGTCGGAACTGGTGGGCCTGTCGCTGGCG
CTGGGTGCCTTCCTCGCCGGCATGCTGATTTCCGAAACCGAGTATCGCTACCAGGTCGAGGAGGACATCAAACCGTTCCG
CGACGTGCTGCTCGGACTGTTCTTCGTCACCGTCGGGATGTTCCTCGACGTCGAGACGATCGTGTGGCACCTGCCGGCCG
TCATCGGCCTGGTGGTGGCCTTGCTGGCCGCCAAGTTCCTGATCGTGTTCGCCGCTTCGCGCGCGTTCCGCTCGCCACCG
GGGACCGCCATGCGCTCGGGCCTTTGGTTGTGCGCCGGCGGGGAGTTCGGCTTCGTGCTGCTGTCCGAAATCGTGGGGCT
GCGGCTGATGCCGGCGGGGCTGGTGCAGGTCACGGTGGCGGCGCTGGTGCTGTCGATGCTGGTGGCGCCGCTGATCGTGC
AGGTCAGCGACAAGCTGGTGATGCGCTTCGTCGCTTCCGAATGGCTGCTGCGGTCGATGGAGCTGACGCGGGTCGCGGCC
CAGTCGCTCAATACCGACAAGCACATCATCGTGTGCGGTTACGGCCGCAGCGGCCAGTACATGGCGCGCTTCCTCGAGCA
GGAGAACCTGAGCTACGTCGCGCTGGACCTGGACCCGGAACGGGTGCGCGAGGCCGGCGCGGCCGGCGACACCGTGGTTT
ATGGGGACGCGGCGCGGCGCGAGACGCTGATGGCGGCCGGGATCATGCGCGCCAGTGCGTTGGTGATTTCGTTTGCCGAG
GTCGAGGCTGCGCTGCGGGTGATGCACCACGCGCATGCGCTGCGCCCCGGCCTGCCCATCGTGGTGCGGGCGGTGGACGA
GGCCGACATGGAAAAGCTGTCGCTGGGCGGCGCGGCGGAAGTGGTGCCGGAGGCCTTCGAAGGCAGCATCATGCTGGCCT
CGCATGCGCTGGCGCTGATCGGCGTACCGCTCAGCCGCGTGGTCAAGCGCATCCGCGACATCCGCAACCAGCGCTACGCG
TTGATGCGCGGCTTCTTCCATGGCGCCACCGACATCGGCGAAGTGGCGGAGAACAGTCAGGCGCGCCTGCATTCGGTGAC
GGTGCCCGACGCGGCGCCTGCGGTCGGGCGGACGATAGGCGAACTCGCGCTGGAAGAGTTTGGCGTGGGGGTCTCCGCGG
TACGCCGCCGCGGCATCCGGGGCCTGTCGCCCGGCCCCGAAACCCGCATCGTCGCCGGCGACGTGCTGGTGCTGCTCGGC
CTGCCGCAGGGGCTGGAGCAGGCCGAGGAGCGCGTGCTGAAGGGTTGA

Upstream 100 bases:

>100_bases
CGGCAAAGCGTGCTGCAGTGCGGCGGCGAATGATCGGCCCGCGATTGTATAACAAATGGGCGGCCCACCCGGCACGCTCC
GGACAAGGCCCGCCCGCCCG

Downstream 100 bases:

>100_bases
TGCGCGCTCAGAATCCGAGGCAGAGCACGTAGGTCGCGGCATCGTCCACCGGCGTGTCGGCGGCCAGCGCGGTCAATCCG
CCCGCCCCCTGGGTACCGGC

Product: putative glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MLNTLDLVLLLLAAAVVLVAVLRSVNLPPVLGYLLVGAMVGPHAFNLVPDSAGARHLAEFGVVFLMFSIGLEFSLPRLLA
MKNIVFGLGAAQVVGSIALTLVLGRLGGLGWAAAFALGGTIAMSSTAILSKLLADRLELDSRHGREIIGVLLFQDLAVVP
LLILLPALSRPAEELAVTLGLAGIKAVVLLALVLVFGPRLMRWWFTLVARRRSGELFMLNVLFITLGLAWLSELVGLSLA
LGAFLAGMLISETEYRYQVEEDIKPFRDVLLGLFFVTVGMFLDVETIVWHLPAVIGLVVALLAAKFLIVFAASRAFRSPP
GTAMRSGLWLCAGGEFGFVLLSEIVGLRLMPAGLVQVTVAALVLSMLVAPLIVQVSDKLVMRFVASEWLLRSMELTRVAA
QSLNTDKHIIVCGYGRSGQYMARFLEQENLSYVALDLDPERVREAGAAGDTVVYGDAARRETLMAAGIMRASALVISFAE
VEAALRVMHHAHALRPGLPIVVRAVDEADMEKLSLGGAAEVVPEAFEGSIMLASHALALIGVPLSRVVKRIRDIRNQRYA
LMRGFFHGATDIGEVAENSQARLHSVTVPDAAPAVGRTIGELALEEFGVGVSAVRRRGIRGLSPGPETRIVAGDVLVLLG
LPQGLEQAEERVLKG

Sequences:

>Translated_655_residues
MLNTLDLVLLLLAAAVVLVAVLRSVNLPPVLGYLLVGAMVGPHAFNLVPDSAGARHLAEFGVVFLMFSIGLEFSLPRLLA
MKNIVFGLGAAQVVGSIALTLVLGRLGGLGWAAAFALGGTIAMSSTAILSKLLADRLELDSRHGREIIGVLLFQDLAVVP
LLILLPALSRPAEELAVTLGLAGIKAVVLLALVLVFGPRLMRWWFTLVARRRSGELFMLNVLFITLGLAWLSELVGLSLA
LGAFLAGMLISETEYRYQVEEDIKPFRDVLLGLFFVTVGMFLDVETIVWHLPAVIGLVVALLAAKFLIVFAASRAFRSPP
GTAMRSGLWLCAGGEFGFVLLSEIVGLRLMPAGLVQVTVAALVLSMLVAPLIVQVSDKLVMRFVASEWLLRSMELTRVAA
QSLNTDKHIIVCGYGRSGQYMARFLEQENLSYVALDLDPERVREAGAAGDTVVYGDAARRETLMAAGIMRASALVISFAE
VEAALRVMHHAHALRPGLPIVVRAVDEADMEKLSLGGAAEVVPEAFEGSIMLASHALALIGVPLSRVVKRIRDIRNQRYA
LMRGFFHGATDIGEVAENSQARLHSVTVPDAAPAVGRTIGELALEEFGVGVSAVRRRGIRGLSPGPETRIVAGDVLVLLG
LPQGLEQAEERVLKG
>Mature_655_residues
MLNTLDLVLLLLAAAVVLVAVLRSVNLPPVLGYLLVGAMVGPHAFNLVPDSAGARHLAEFGVVFLMFSIGLEFSLPRLLA
MKNIVFGLGAAQVVGSIALTLVLGRLGGLGWAAAFALGGTIAMSSTAILSKLLADRLELDSRHGREIIGVLLFQDLAVVP
LLILLPALSRPAEELAVTLGLAGIKAVVLLALVLVFGPRLMRWWFTLVARRRSGELFMLNVLFITLGLAWLSELVGLSLA
LGAFLAGMLISETEYRYQVEEDIKPFRDVLLGLFFVTVGMFLDVETIVWHLPAVIGLVVALLAAKFLIVFAASRAFRSPP
GTAMRSGLWLCAGGEFGFVLLSEIVGLRLMPAGLVQVTVAALVLSMLVAPLIVQVSDKLVMRFVASEWLLRSMELTRVAA
QSLNTDKHIIVCGYGRSGQYMARFLEQENLSYVALDLDPERVREAGAAGDTVVYGDAARRETLMAAGIMRASALVISFAE
VEAALRVMHHAHALRPGLPIVVRAVDEADMEKLSLGGAAEVVPEAFEGSIMLASHALALIGVPLSRVVKRIRDIRNQRYA
LMRGFFHGATDIGEVAENSQARLHSVTVPDAAPAVGRTIGELALEEFGVGVSAVRRRGIRGLSPGPETRIVAGDVLVLLG
LPQGLEQAEERVLKG

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=372, Percent_Identity=28.2258064516129, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1786232, Length=637, Percent_Identity=30.6122448979592, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1789749, Length=577, Percent_Identity=33.1022530329289, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI1786685, Length=518, Percent_Identity=30.8880308880309, Blast_Score=199, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 70085; Mature: 70085

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTLDLVLLLLAAAVVLVAVLRSVNLPPVLGYLLVGAMVGPHAFNLVPDSAGARHLAEF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHH
GVVFLMFSIGLEFSLPRLLAMKNIVFGLGAAQVVGSIALTLVLGRLGGLGWAAAFALGGT
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
IAMSSTAILSKLLADRLELDSRHGREIIGVLLFQDLAVVPLLILLPALSRPAEELAVTLG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LAGIKAVVLLALVLVFGPRLMRWWFTLVARRRSGELFMLNVLFITLGLAWLSELVGLSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
LGAFLAGMLISETEYRYQVEEDIKPFRDVLLGLFFVTVGMFLDVETIVWHLPAVIGLVVA
HHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAAKFLIVFAASRAFRSPPGTAMRSGLWLCAGGEFGFVLLSEIVGLRLMPAGLVQVTVA
HHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHH
ALVLSMLVAPLIVQVSDKLVMRFVASEWLLRSMELTRVAAQSLNTDKHIIVCGYGRSGQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHH
MARFLEQENLSYVALDLDPERVREAGAAGDTVVYGDAARRETLMAAGIMRASALVISFAE
HHHHHHHCCCCEEEEECCHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
VEAALRVMHHAHALRPGLPIVVRAVDEADMEKLSLGGAAEVVPEAFEGSIMLASHALALI
HHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHH
GVPLSRVVKRIRDIRNQRYALMRGFFHGATDIGEVAENSQARLHSVTVPDAAPAVGRTIG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHEEEEECCCCCHHHHHHHH
ELALEEFGVGVSAVRRRGIRGLSPGPETRIVAGDVLVLLGLPQGLEQAEERVLKG
HHHHHHHCCCHHHHHHCCCCCCCCCCCCEEECCHHHHECCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLNTLDLVLLLLAAAVVLVAVLRSVNLPPVLGYLLVGAMVGPHAFNLVPDSAGARHLAEF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHH
GVVFLMFSIGLEFSLPRLLAMKNIVFGLGAAQVVGSIALTLVLGRLGGLGWAAAFALGGT
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
IAMSSTAILSKLLADRLELDSRHGREIIGVLLFQDLAVVPLLILLPALSRPAEELAVTLG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LAGIKAVVLLALVLVFGPRLMRWWFTLVARRRSGELFMLNVLFITLGLAWLSELVGLSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
LGAFLAGMLISETEYRYQVEEDIKPFRDVLLGLFFVTVGMFLDVETIVWHLPAVIGLVVA
HHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAAKFLIVFAASRAFRSPPGTAMRSGLWLCAGGEFGFVLLSEIVGLRLMPAGLVQVTVA
HHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHH
ALVLSMLVAPLIVQVSDKLVMRFVASEWLLRSMELTRVAAQSLNTDKHIIVCGYGRSGQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHH
MARFLEQENLSYVALDLDPERVREAGAAGDTVVYGDAARRETLMAAGIMRASALVISFAE
HHHHHHHCCCCEEEEECCHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
VEAALRVMHHAHALRPGLPIVVRAVDEADMEKLSLGGAAEVVPEAFEGSIMLASHALALI
HHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHH
GVPLSRVVKRIRDIRNQRYALMRGFFHGATDIGEVAENSQARLHSVTVPDAAPAVGRTIG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHEEEEECCCCCHHHHHHHH
ELALEEFGVGVSAVRRRGIRGLSPGPETRIVAGDVLVLLGLPQGLEQAEERVLKG
HHHHHHHCCCHHHHHHCCCCCCCCCCCCEEECCHHHHECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]