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The map label for this gene is rnhA1 [H]

Identifier: 119897063

GI number: 119897063

Start: 826594

End: 827043

Strand: Reverse

Name: rnhA1 [H]

Synonym: azo0772

Alternate gene names: 119897063

Gene position: 827043-826594 (Counterclockwise)

Preceding gene: 119897064

Following gene: 119897062

Centisome position: 18.9

GC content: 59.78

Gene sequence:

>450_bases
ATGATCGAGCCACCCGTCACGATCTACACGGACGGCGCTTGTCGAGGCAATCCCGGCCCCGGAGGCTGGGGAGTCATCCT
GTCGCGTGGTCGCCAGTACAAGGAACTGTACGGTGGAGAACCTGAGACCACAAACAACCGGATGGAACTGACAGCAGCTA
TCAAGGCACTGGAAGCCCTCAAGCGCCCCCTCCCGGTCATCCTCTACACGGACTCGAAGTACCTTGTTCAGGGGATGACC
CAATGGCTCCCCAAGTGGAAAGCCAAGGGGTGGCGCAAGGCTGACGGAAAGCCGGTCGAGAACGCCGACCTGTGGAAGGT
TCTTGATGAGGCGGCATCAGTCCATGACGTTCAGTGGCATTGGGTACGAGGCCACAACGGCAACCCCGGAAATGAACGCG
CCGATACACTGGCGAATCTCGGGATAGACACGATCCACGCAGCACCCTGA

Upstream 100 bases:

>100_bases
ACATGGACAAACTCAAGGCCATCCTTCTGGAGTCGTTCGGCGGCAGGATCAACCCGGCTGACTATGGCTTCGCTGCTAAC
GACGCCATCGAGGAAGCGGC

Downstream 100 bases:

>100_bases
GTCCGTCAGGACGTACTGAAACGACGAAGCCCAAGGCTACCCATTGCGAGGTGGTCTTGGGCTTTTTTTTCGCAGATCTG
GCACGACTCTTGTCGGAACT

Product: RnhA1 protein

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MIEPPVTIYTDGACRGNPGPGGWGVILSRGRQYKELYGGEPETTNNRMELTAAIKALEALKRPLPVILYTDSKYLVQGMT
QWLPKWKAKGWRKADGKPVENADLWKVLDEAASVHDVQWHWVRGHNGNPGNERADTLANLGIDTIHAAP

Sequences:

>Translated_149_residues
MIEPPVTIYTDGACRGNPGPGGWGVILSRGRQYKELYGGEPETTNNRMELTAAIKALEALKRPLPVILYTDSKYLVQGMT
QWLPKWKAKGWRKADGKPVENADLWKVLDEAASVHDVQWHWVRGHNGNPGNERADTLANLGIDTIHAAP
>Mature_149_residues
MIEPPVTIYTDGACRGNPGPGGWGVILSRGRQYKELYGGEPETTNNRMELTAAIKALEALKRPLPVILYTDSKYLVQGMT
QWLPKWKAKGWRKADGKPVENADLWKVLDEAASVHDVQWHWVRGHNGNPGNERADTLANLGIDTIHAAP

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=141, Percent_Identity=37.5886524822695, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1786408, Length=134, Percent_Identity=59.7014925373134, Blast_Score=162, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI115532542, Length=142, Percent_Identity=42.2535211267606, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17505482, Length=134, Percent_Identity=35.0746268656716, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=36.3013698630137, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=36.3013698630137, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16525; Mature: 16525

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEPPVTIYTDGACRGNPGPGGWGVILSRGRQYKELYGGEPETTNNRMELTAAIKALEAL
CCCCCEEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KRPLPVILYTDSKYLVQGMTQWLPKWKAKGWRKADGKPVENADLWKVLDEAASVHDVQWH
HCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEE
WVRGHNGNPGNERADTLANLGIDTIHAAP
EEECCCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIEPPVTIYTDGACRGNPGPGGWGVILSRGRQYKELYGGEPETTNNRMELTAAIKALEAL
CCCCCEEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KRPLPVILYTDSKYLVQGMTQWLPKWKAKGWRKADGKPVENADLWKVLDEAASVHDVQWH
HCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEE
WVRGHNGNPGNERADTLANLGIDTIHAAP
EEECCCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA