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The map label for this gene is pth

Identifier: 119897044

GI number: 119897044

Start: 805193

End: 805849

Strand: Reverse

Name: pth

Synonym: azo0753

Alternate gene names: 119897044

Gene position: 805849-805193 (Counterclockwise)

Preceding gene: 119897045

Following gene: 119897043

Centisome position: 18.42

GC content: 69.41

Gene sequence:

>657_bases
ATGAGCGCCGCACCTCCGCGTCTCGTCGTCGGTCTCGGCAATCCGGGCGCCGAATATTCCGAAACCCGGCACAACGCCGG
GTTTTGGTTTTGTGAGCGGCTCGCCGACACGCTCGGCGTACGCTTCTCGCACGAATCCCGTTTTCACGGCCTGGTCGCCA
ACGCGCGCGAGGCCGGGGTCTGGCTGCTGATGCCGCAGACCTACATGAACCGCTCCGGCCAGGCAATCGGCGCACTGGCG
CGCTTCTACCGCATCGCACCGGCCGAAATCCTGGTGGTGCACGACGAACTCGACATCCCGCCCGGCCAGCTGCGGCTGAA
GTTCGGCGGCGGTCTCGGCGGCCACAACGGCCTCAAGGACACCTCCGCCCACCTCGGCACCAACGACTACTGGCGCCTGC
GCGTCGGCATCGGCCACCCGGGCGACCGCAACGAGGTGGTGAACTTCGTGCTCAAGCCCGCCCGCCGCGAGGAACAGACG
CTGATCGACGAAAGTCTCGATCGCGCGCTCGCCGCCTGGCCCACGCTCGCCAAGGGCGACTGGAACACCGCCACCCAGCG
GCTCAACGCCCGCCCCGCGCCCCCCAAACCGCCCAAGGCCCCGAAGGCGCCCCAGCCCGCCGCGGCCGACCAACCCAAGG
ACGAATCCCAGCCATGA

Upstream 100 bases:

>100_bases
GGCCTCGGCCCAGACCACCCGTGGCGCGGCTGCCGCCGAAGGCGAAGGCGAAGCGGCCTAAGGCCCGCTTCCCGCCCGCA
ATGCCGGAGACCGACACCTG

Downstream 100 bases:

>100_bases
GCCTGAAATGCGGAATCGTCGGCCTGCCCAACGTCGGCAAGTCGACCCTGTTCAACGCCCTCACCAAGGCCGGTATCGAA
GCGGCGAACTACCCCTTCTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSAAPPRLVVGLGNPGAEYSETRHNAGFWFCERLADTLGVRFSHESRFHGLVANAREAGVWLLMPQTYMNRSGQAIGALA
RFYRIAPAEILVVHDELDIPPGQLRLKFGGGLGGHNGLKDTSAHLGTNDYWRLRVGIGHPGDRNEVVNFVLKPARREEQT
LIDESLDRALAAWPTLAKGDWNTATQRLNARPAPPKPPKAPKAPQPAAADQPKDESQP

Sequences:

>Translated_218_residues
MSAAPPRLVVGLGNPGAEYSETRHNAGFWFCERLADTLGVRFSHESRFHGLVANAREAGVWLLMPQTYMNRSGQAIGALA
RFYRIAPAEILVVHDELDIPPGQLRLKFGGGLGGHNGLKDTSAHLGTNDYWRLRVGIGHPGDRNEVVNFVLKPARREEQT
LIDESLDRALAAWPTLAKGDWNTATQRLNARPAPPKPPKAPKAPQPAAADQPKDESQP
>Mature_217_residues
SAAPPRLVVGLGNPGAEYSETRHNAGFWFCERLADTLGVRFSHESRFHGLVANAREAGVWLLMPQTYMNRSGQAIGALAR
FYRIAPAEILVVHDELDIPPGQLRLKFGGGLGGHNGLKDTSAHLGTNDYWRLRVGIGHPGDRNEVVNFVLKPARREEQTL
IDESLDRALAAWPTLAKGDWNTATQRLNARPAPPKPPKAPKAPQPAAADQPKDESQP

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=166, Percent_Identity=39.1566265060241, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=51.5789473684211, Blast_Score=166, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321983, Length=190, Percent_Identity=31.0526315789474, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_AZOSB (A1K3G5)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932257.1
- ProteinModelPortal:   A1K3G5
- SMR:   A1K3G5
- STRING:   A1K3G5
- GeneID:   4610159
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo0753
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- PhylomeDB:   A1K3G5
- ProtClustDB:   PRK05426
- BioCyc:   ASP62928:AZO0753-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 23832; Mature: 23701

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPPRLVVGLGNPGAEYSETRHNAGFWFCERLADTLGVRFSHESRFHGLVANAREAGV
CCCCCCEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCE
WLLMPQTYMNRSGQAIGALARFYRIAPAEILVVHDELDIPPGQLRLKFGGGLGGHNGLKD
EEEECHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCC
TSAHLGTNDYWRLRVGIGHPGDRNEVVNFVLKPARREEQTLIDESLDRALAAWPTLAKGD
CHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
WNTATQRLNARPAPPKPPKAPKAPQPAAADQPKDESQP
CHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAAPPRLVVGLGNPGAEYSETRHNAGFWFCERLADTLGVRFSHESRFHGLVANAREAGV
CCCCCEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCE
WLLMPQTYMNRSGQAIGALARFYRIAPAEILVVHDELDIPPGQLRLKFGGGLGGHNGLKD
EEEECHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCC
TSAHLGTNDYWRLRVGIGHPGDRNEVVNFVLKPARREEQTLIDESLDRALAAWPTLAKGD
CHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
WNTATQRLNARPAPPKPPKAPKAPQPAAADQPKDESQP
CHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA