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The map label for this gene is ubiB [H]

Identifier: 119896668

GI number: 119896668

Start: 401938

End: 403467

Strand: Reverse

Name: ubiB [H]

Synonym: azo0377

Alternate gene names: 119896668

Gene position: 403467-401938 (Counterclockwise)

Preceding gene: 119896669

Following gene: 119896667

Centisome position: 9.22

GC content: 67.65

Gene sequence:

>1530_bases
GTGCGCCTCCTCCGCCTCGCCAAGATCATCACCGTCAGCCTGCGTTTCGGCCTCGATCGCATGATCCTCGACGCCGACGC
CAGCGGCCGCCTCGGTCGCATCTGGCACCGGGTGTTCTTCTGGCGGCGTTTCTCGGAGCCGCGCGCGGTGCGCTTGCGCA
AGGCACTCGAATCGCTCGGGCCGATCTTCGTCAAGTTCGGCCAGATGCTGTCCACCCGGCGCGACCTGCTGCCGCCCGAT
CTCGCCGACGAACTCGCGCTGCTCCAGGACCGCGTGCCGCCCTTCCCCACCGAGCAGGCGCTGGCAGTGCTGGAAGGCTT
CTACGGCCGGCCGGTGGACGCGGTGTTCCGCGACTTCGAGCGCACGCCGGTGGCCTCGGCCTCCGTCGCACAGGTGCATT
TCGCCCGCCTGCCCGACGGCACCGAGGTGGCGGTCAAGATCCTGCGGCCCGGCATCGAACGCGTGATCGCGCACGACCTC
GCGCTGATGGAAGTCGGCGCGATGCTGCTGGACAAGGCCTGGCCGGAAGGCCGGCGGCTGAAGCCGCGCGAGGTAGTCGC
CGAGTTCAGCAAATACCTGCGCGACGAACTCGACCTGATGCGCGAGGCCGCCAACTGCTCGCAGCTGCGGCGCAACTTCA
AGGATTCGCCGCTGCTGCTGGTACCCGAGGTGTATTGGGACTGGTGCGGGCGCAGCGTGATGGTGATGGAGCGCATGCAC
GGCGTGCCGATCTCGCAGACCGCCGCGGTCACCGCCCAGGGCACCGACCTCAAGGCCCTGTCGCGCGCCGGTGTCGAGAT
CTTCTTCACCCAGGTGTTCCGCGACGGCTTCTTCCACGCCGACATGCACCCGGGCAACATCTTCGTTCATGCCGACGGCC
GCTACATCGCGCTCGACTTCGGCATCATGGGCACGCTCAACGAGGTGGACAAGAACTACCTAGCGCAGAACTTCCTCGCC
TTCTTCAAGCGCGACTACAAGCGCGTGGCGATGGCCCACATCGAAGCGGGCTGGGTGCCGGCCAAGACCCGCGTCGATGA
ATTCGAGGCCGCGATCCGCACCGTGTGCGAGCCGATCTTCGACAAACCGCTGAAGGACATCTCCTTCGGCAAGACCCTGC
TGCGCCTGTTCCAGACCGCGCGCCGCTTCGAAATGGAAGTGCAGCCGCAGCTGGTGCTGCTGCAGAAGACCTTGCTCAAC
ATCGAAGGCCTCGGCCGCCAGCTCGACCCCGAGCTGGACCTGTGGAAGACCGCGAAGCCCTTCCTCGAGCGCTGGATGAA
CGAGCAGATGGGCTGGCGCGCCCTCGTGCGCGGCATCAAGGAAGAAGCGCCCGCCTGGGCCGGCACGCTGCCACAGCTGC
CGCGCCTGGTGCATCACAACCTGGTCGAATCCAGCCATCACCACGTCGTGCACCAGGCTGCACTCGCCAGCCTGGCGGTC
ACCCAGCGCCGCCAGGGCCGACTGCTCGCGCTGCTGGTGATCGCCGCCGCGGCGCTGGTCGCGCTCGAACTCCACCGCCT
GCTCGGCTGA

Upstream 100 bases:

>100_bases
GAAGGGGGAGGCGCAACCCCGCGCCCCGCCCCGCCCTTTCCCCGTCCCCCGCTTTCCGGCTAAAGTCCGCGCTTCTCCGC
CGTCCGTTCCCCGCCCTCTC

Downstream 100 bases:

>100_bases
ACGTTTCCGCCGCCCCCCGGCTCCAAGCCTTACGCTCAATGCTTATTCGCCCGCGCTAGCGCAACCCGCCGGCAAGGGCT
CGACGGGAGGCACGCCATGA

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MRLLRLAKIITVSLRFGLDRMILDADASGRLGRIWHRVFFWRRFSEPRAVRLRKALESLGPIFVKFGQMLSTRRDLLPPD
LADELALLQDRVPPFPTEQALAVLEGFYGRPVDAVFRDFERTPVASASVAQVHFARLPDGTEVAVKILRPGIERVIAHDL
ALMEVGAMLLDKAWPEGRRLKPREVVAEFSKYLRDELDLMREAANCSQLRRNFKDSPLLLVPEVYWDWCGRSVMVMERMH
GVPISQTAAVTAQGTDLKALSRAGVEIFFTQVFRDGFFHADMHPGNIFVHADGRYIALDFGIMGTLNEVDKNYLAQNFLA
FFKRDYKRVAMAHIEAGWVPAKTRVDEFEAAIRTVCEPIFDKPLKDISFGKTLLRLFQTARRFEMEVQPQLVLLQKTLLN
IEGLGRQLDPELDLWKTAKPFLERWMNEQMGWRALVRGIKEEAPAWAGTLPQLPRLVHHNLVESSHHHVVHQAALASLAV
TQRRQGRLLALLVIAAAALVALELHRLLG

Sequences:

>Translated_509_residues
MRLLRLAKIITVSLRFGLDRMILDADASGRLGRIWHRVFFWRRFSEPRAVRLRKALESLGPIFVKFGQMLSTRRDLLPPD
LADELALLQDRVPPFPTEQALAVLEGFYGRPVDAVFRDFERTPVASASVAQVHFARLPDGTEVAVKILRPGIERVIAHDL
ALMEVGAMLLDKAWPEGRRLKPREVVAEFSKYLRDELDLMREAANCSQLRRNFKDSPLLLVPEVYWDWCGRSVMVMERMH
GVPISQTAAVTAQGTDLKALSRAGVEIFFTQVFRDGFFHADMHPGNIFVHADGRYIALDFGIMGTLNEVDKNYLAQNFLA
FFKRDYKRVAMAHIEAGWVPAKTRVDEFEAAIRTVCEPIFDKPLKDISFGKTLLRLFQTARRFEMEVQPQLVLLQKTLLN
IEGLGRQLDPELDLWKTAKPFLERWMNEQMGWRALVRGIKEEAPAWAGTLPQLPRLVHHNLVESSHHHVVHQAALASLAV
TQRRQGRLLALLVIAAAALVALELHRLLG
>Mature_509_residues
MRLLRLAKIITVSLRFGLDRMILDADASGRLGRIWHRVFFWRRFSEPRAVRLRKALESLGPIFVKFGQMLSTRRDLLPPD
LADELALLQDRVPPFPTEQALAVLEGFYGRPVDAVFRDFERTPVASASVAQVHFARLPDGTEVAVKILRPGIERVIAHDL
ALMEVGAMLLDKAWPEGRRLKPREVVAEFSKYLRDELDLMREAANCSQLRRNFKDSPLLLVPEVYWDWCGRSVMVMERMH
GVPISQTAAVTAQGTDLKALSRAGVEIFFTQVFRDGFFHADMHPGNIFVHADGRYIALDFGIMGTLNEVDKNYLAQNFLA
FFKRDYKRVAMAHIEAGWVPAKTRVDEFEAAIRTVCEPIFDKPLKDISFGKTLLRLFQTARRFEMEVQPQLVLLQKTLLN
IEGLGRQLDPELDLWKTAKPFLERWMNEQMGWRALVRGIKEEAPAWAGTLPQLPRLVHHNLVESSHHHVVHQAALASLAV
TQRRQGRLLALLVIAAAALVALELHRLLG

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=31.5018315018315, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI40254938, Length=272, Percent_Identity=29.0441176470588, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI32261307, Length=335, Percent_Identity=27.4626865671642, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI217035081, Length=241, Percent_Identity=28.6307053941909, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI34147522, Length=344, Percent_Identity=27.906976744186, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI27363457, Length=261, Percent_Identity=30.6513409961686, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI217416386, Length=237, Percent_Identity=29.957805907173, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI2367309, Length=507, Percent_Identity=54.6351084812623, Blast_Score=526, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17559152, Length=275, Percent_Identity=28, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32565180, Length=264, Percent_Identity=27.6515151515151, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=438, Percent_Identity=27.8538812785388, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323282, Length=246, Percent_Identity=28.0487804878049, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=262, Percent_Identity=26.7175572519084, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22024280, Length=271, Percent_Identity=29.8892988929889, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24662575, Length=252, Percent_Identity=31.3492063492063, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI18859849, Length=274, Percent_Identity=26.6423357664234, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57948; Mature: 57948

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLRLAKIITVSLRFGLDRMILDADASGRLGRIWHRVFFWRRFSEPRAVRLRKALESLG
CHHHHHHHHHHHHHHHCCHHHEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
PIFVKFGQMLSTRRDLLPPDLADELALLQDRVPPFPTEQALAVLEGFYGRPVDAVFRDFE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RTPVASASVAQVHFARLPDGTEVAVKILRPGIERVIAHDLALMEVGAMLLDKAWPEGRRL
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KPREVVAEFSKYLRDELDLMREAANCSQLRRNFKDSPLLLVPEVYWDWCGRSVMVMERMH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCHHHHHHHHC
GVPISQTAAVTAQGTDLKALSRAGVEIFFTQVFRDGFFHADMHPGNIFVHADGRYIALDF
CCCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEC
GIMGTLNEVDKNYLAQNFLAFFKRDYKRVAMAHIEAGWVPAKTRVDEFEAAIRTVCEPIF
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
DKPLKDISFGKTLLRLFQTARRFEMEVQPQLVLLQKTLLNIEGLGRQLDPELDLWKTAKP
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FLERWMNEQMGWRALVRGIKEEAPAWAGTLPQLPRLVHHNLVESSHHHVVHQAALASLAV
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TQRRQGRLLALLVIAAAALVALELHRLLG
HHHHCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRLLRLAKIITVSLRFGLDRMILDADASGRLGRIWHRVFFWRRFSEPRAVRLRKALESLG
CHHHHHHHHHHHHHHHCCHHHEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
PIFVKFGQMLSTRRDLLPPDLADELALLQDRVPPFPTEQALAVLEGFYGRPVDAVFRDFE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RTPVASASVAQVHFARLPDGTEVAVKILRPGIERVIAHDLALMEVGAMLLDKAWPEGRRL
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KPREVVAEFSKYLRDELDLMREAANCSQLRRNFKDSPLLLVPEVYWDWCGRSVMVMERMH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCHHHHHHHHC
GVPISQTAAVTAQGTDLKALSRAGVEIFFTQVFRDGFFHADMHPGNIFVHADGRYIALDF
CCCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEC
GIMGTLNEVDKNYLAQNFLAFFKRDYKRVAMAHIEAGWVPAKTRVDEFEAAIRTVCEPIF
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
DKPLKDISFGKTLLRLFQTARRFEMEVQPQLVLLQKTLLNIEGLGRQLDPELDLWKTAKP
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FLERWMNEQMGWRALVRGIKEEAPAWAGTLPQLPRLVHHNLVESSHHHVVHQAALASLAV
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TQRRQGRLLALLVIAAAALVALELHRLLG
HHHHCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]