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The map label for this gene is nhoA [H]

Identifier: 119896633

GI number: 119896633

Start: 365077

End: 365901

Strand: Reverse

Name: nhoA [H]

Synonym: azo0342

Alternate gene names: 119896633

Gene position: 365901-365077 (Counterclockwise)

Preceding gene: 119896636

Following gene: 119896631

Centisome position: 8.36

GC content: 70.42

Gene sequence:

>825_bases
ATGACGCCGCCCCTCGACCTCGACGCCTACCTCGCCCGCATCGGCGGCCTCGCCGCAGCGCCCGACACCACGCTGACCAC
GCTCAATGCGCTGATCGCGCAGCATGTGGCAGCGATTCCCTTCGAAAACCTGTCGCCGCTGCTGGGCGAGCCGGTGGATA
TCAGCCCCGCCGCGGTGCAGGCCAAGCTGGTGGCGGGCGGGCGCGGCGGCTACTGTTACGAGCACAACCGGCTCTTCGCC
GACGTGCTGCGCCATCTCGGCTTCACCGTGCATGAACTCGGCGCGCGCGTGGTGTGGAACCAGCCGCCCGGGGCGATCAC
GCCGCGCTCGCACATGCTGCTGGAAGTGGATACCGCGGATGGCCCGCGCCTGGTCGATGTGGGCTTCGGCGGCCTGACGC
TGACCAGCGCGCTGCGCCTGCAGGCGGATATCGAGCAGATCACGCCGCACGAACCCTTCCGCCTGCTGCGCGATGGCGAC
GACTGGACGCTGCAGGCCCGTCTGGGCGAGGCCTGGAAGCCGCTCTACCGCTTCGACCGCGTGCGCCACCACGCCTGCGA
CTACATCGCGCCCAACTACTTCCTCGCCACCCACCCGGATTCGGTCTTCACCGCCAACCTGATGCTGGCCCGCGCCGGCC
GCAACCAGCGCTGGACGCTGTTCAACCGCGACTACGCCGAATACCACGGCGACGGCCGCATCGTGCGCCGCACGCTGGCC
GACATGGCGGAGCTGACGGAGGTTTTGCAGCGCGCGTTCGGCATCCCGCCTGCGCTCTGCGCCACAGCGCAGCCGCGGCT
CGCGCGCCTGTTCGACGCCGGCTGA

Upstream 100 bases:

>100_bases
GCCGCGCATGGGCGGGCAACCTGGCCCCGGTCATCCGGTGGTCATACGCGGCGGCGCCTCGATGTGCGACCATGCACGCC
CACCCCGGGAGACCCCTCCG

Downstream 100 bases:

>100_bases
GCGCCGGCGGGTCGCTTACTTTTCCTTGAAGCGGTCGTGGCAGCTCTTGCAGCTGCCGTAGACCTTCTCGTACGCCGCCT
TGGCCTGCGCCTGATCGCGG

Product: N-hydroxyarylamine O-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MTPPLDLDAYLARIGGLAAAPDTTLTTLNALIAQHVAAIPFENLSPLLGEPVDISPAAVQAKLVAGGRGGYCYEHNRLFA
DVLRHLGFTVHELGARVVWNQPPGAITPRSHMLLEVDTADGPRLVDVGFGGLTLTSALRLQADIEQITPHEPFRLLRDGD
DWTLQARLGEAWKPLYRFDRVRHHACDYIAPNYFLATHPDSVFTANLMLARAGRNQRWTLFNRDYAEYHGDGRIVRRTLA
DMAELTEVLQRAFGIPPALCATAQPRLARLFDAG

Sequences:

>Translated_274_residues
MTPPLDLDAYLARIGGLAAAPDTTLTTLNALIAQHVAAIPFENLSPLLGEPVDISPAAVQAKLVAGGRGGYCYEHNRLFA
DVLRHLGFTVHELGARVVWNQPPGAITPRSHMLLEVDTADGPRLVDVGFGGLTLTSALRLQADIEQITPHEPFRLLRDGD
DWTLQARLGEAWKPLYRFDRVRHHACDYIAPNYFLATHPDSVFTANLMLARAGRNQRWTLFNRDYAEYHGDGRIVRRTLA
DMAELTEVLQRAFGIPPALCATAQPRLARLFDAG
>Mature_273_residues
TPPLDLDAYLARIGGLAAAPDTTLTTLNALIAQHVAAIPFENLSPLLGEPVDISPAAVQAKLVAGGRGGYCYEHNRLFAD
VLRHLGFTVHELGARVVWNQPPGAITPRSHMLLEVDTADGPRLVDVGFGGLTLTSALRLQADIEQITPHEPFRLLRDGDD
WTLQARLGEAWKPLYRFDRVRHHACDYIAPNYFLATHPDSVFTANLMLARAGRNQRWTLFNRDYAEYHGDGRIVRRTLAD
MAELTEVLQRAFGIPPALCATAQPRLARLFDAG

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649132, Length=276, Percent_Identity=27.536231884058, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI237649130, Length=276, Percent_Identity=27.536231884058, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI237649128, Length=277, Percent_Identity=28.5198555956679, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI237649126, Length=277, Percent_Identity=28.5198555956679, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI237649124, Length=277, Percent_Identity=28.5198555956679, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI237649122, Length=277, Percent_Identity=28.5198555956679, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI237649119, Length=277, Percent_Identity=28.5198555956679, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI42741671, Length=277, Percent_Identity=28.5198555956679, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI237649009, Length=277, Percent_Identity=28.5198555956679, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787736, Length=256, Percent_Identity=41.40625, Blast_Score=178, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 30234; Mature: 30103

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPLDLDAYLARIGGLAAAPDTTLTTLNALIAQHVAAIPFENLSPLLGEPVDISPAAVQ
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHE
AKLVAGGRGGYCYEHNRLFADVLRHLGFTVHELGARVVWNQPPGAITPRSHMLLEVDTAD
EEEEECCCCCEEEECCCHHHHHHHHCCCCHHHCCCEEEECCCCCCCCCCCCEEEEEECCC
GPRLVDVGFGGLTLTSALRLQADIEQITPHEPFRLLRDGDDWTLQARLGEAWKPLYRFDR
CCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEHHCHHHHHHHHHHH
VRHHACDYIAPNYFLATHPDSVFTANLMLARAGRNQRWTLFNRDYAEYHGDGRIVRRTLA
HHHHHHCCCCCCCEEEECCCCHHHHHHHHEECCCCCEEEEECCHHHHHCCCCHHHHHHHH
DMAELTEVLQRAFGIPPALCATAQPRLARLFDAG
HHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
TPPLDLDAYLARIGGLAAAPDTTLTTLNALIAQHVAAIPFENLSPLLGEPVDISPAAVQ
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHE
AKLVAGGRGGYCYEHNRLFADVLRHLGFTVHELGARVVWNQPPGAITPRSHMLLEVDTAD
EEEEECCCCCEEEECCCHHHHHHHHCCCCHHHCCCEEEECCCCCCCCCCCCEEEEEECCC
GPRLVDVGFGGLTLTSALRLQADIEQITPHEPFRLLRDGDDWTLQARLGEAWKPLYRFDR
CCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEHHCHHHHHHHHHHH
VRHHACDYIAPNYFLATHPDSVFTANLMLARAGRNQRWTLFNRDYAEYHGDGRIVRRTLA
HHHHHHCCCCCCCEEEECCCCHHHHHHHHEECCCCCEEEEECCHHHHHCCCCHHHHHHHH
DMAELTEVLQRAFGIPPALCATAQPRLARLFDAG
HHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]