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The map label for this gene is trxC1 [C]

Identifier: 119896484

GI number: 119896484

Start: 213319

End: 213780

Strand: Reverse

Name: trxC1 [C]

Synonym: azo0193

Alternate gene names: 119896484

Gene position: 213780-213319 (Counterclockwise)

Preceding gene: 119896487

Following gene: 119896480

Centisome position: 4.89

GC content: 69.26

Gene sequence:

>462_bases
ATGCATGCCGAGGAGGCCCACATGAATCCATCAATCCATCTGGTTTGCCCGCACTGCGACGCCGTGAATCGGCTGCCCGC
GGAGCGCATGGCGGAGCATCCTGCCTGTGGCCAGTGCCACCGCCCGCTCTTCATCGGGGAGCCGCTGGCACTGGACGGTG
CGCGGTTCGAGCGCCATCTGACGCGCAACGACCTTCCGGTGCTGATCGATTTCTGGGCCCCGTGGTGCGGCCCGTGCCGG
ATGATGGCGCCGGCTTTCGCCGCCGCAGCGGCCCAACTCGAACCGCAACTGCGGCTCGCGAAGGTGAATACCGAGGCGGA
ACCCGCCCTCGCGCAGCGCTTCGGCATCCGCAGCGTCCCCACGATCGCGCTGTTCCAGGGCGGCCGCGAAGTGACGCGGC
AGGCGGGCGCGATGAACACCGAGCAGCTGGTGCGCTGGGTGCGCGGGCAACTCGGCAGGTGA

Upstream 100 bases:

>100_bases
GCATGCGGGGAAGTGCTTTGAAATATTACTAAAGTTGCATTGCGCGCGCCTGCCGCGGGTTGCTCCGGCGGTCGGCCGGC
AGCCGGCGGAAAATTGGCGC

Downstream 100 bases:

>100_bases
GGGATTCAGCAGCGGTCGGCGTCGATCTGCCCGAGGAGGGTGTGAAGCGCGCGGTGGGTAGGAACGGCGGCCCCATTCCC
GTCGGCAAGACGCAGGAAGG

Product: protein-disulfide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MHAEEAHMNPSIHLVCPHCDAVNRLPAERMAEHPACGQCHRPLFIGEPLALDGARFERHLTRNDLPVLIDFWAPWCGPCR
MMAPAFAAAAAQLEPQLRLAKVNTEAEPALAQRFGIRSVPTIALFQGGREVTRQAGAMNTEQLVRWVRGQLGR

Sequences:

>Translated_153_residues
MHAEEAHMNPSIHLVCPHCDAVNRLPAERMAEHPACGQCHRPLFIGEPLALDGARFERHLTRNDLPVLIDFWAPWCGPCR
MMAPAFAAAAAQLEPQLRLAKVNTEAEPALAQRFGIRSVPTIALFQGGREVTRQAGAMNTEQLVRWVRGQLGR
>Mature_153_residues
MHAEEAHMNPSIHLVCPHCDAVNRLPAERMAEHPACGQCHRPLFIGEPLALDGARFERHLTRNDLPVLIDFWAPWCGPCR
MMAPAFAAAAAQLEPQLRLAKVNTEAEPALAQRFGIRSVPTIALFQGGREVTRQAGAMNTEQLVRWVRGQLGR

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI20070125, Length=91, Percent_Identity=36.2637362637363, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4758304, Length=84, Percent_Identity=39.2857142857143, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI5031973, Length=102, Percent_Identity=31.3725490196078, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI42794771, Length=119, Percent_Identity=31.0924369747899, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21361403, Length=101, Percent_Identity=28.7128712871287, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI224493972, Length=119, Percent_Identity=31.0924369747899, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=33.7209302325581, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI94966757, Length=91, Percent_Identity=35.1648351648352, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1788936, Length=140, Percent_Identity=45, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI87082331, Length=97, Percent_Identity=36.0824742268041, Blast_Score=88, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17554386, Length=107, Percent_Identity=37.3831775700935, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=31.25, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17507915, Length=110, Percent_Identity=30.9090909090909, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=107, Percent_Identity=28.0373831775701, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=107, Percent_Identity=28.0373831775701, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=107, Percent_Identity=28.0373831775701, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=103, Percent_Identity=32.0388349514563, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=105, Percent_Identity=32.3809523809524, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=105, Percent_Identity=32.3809523809524, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=86, Percent_Identity=34.8837209302326, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=105, Percent_Identity=32.3809523809524, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=106, Percent_Identity=26.4150943396226, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647799, Length=100, Percent_Identity=36, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=33.695652173913, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=31.1688311688312, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358065, Length=118, Percent_Identity=28.8135593220339, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 16977; Mature: 16977

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAEEAHMNPSIHLVCPHCDAVNRLPAERMAEHPACGQCHRPLFIGEPLALDGARFERHL
CCCCCCCCCCCEEEEECCCCHHHCCCHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHHHH
TRNDLPVLIDFWAPWCGPCRMMAPAFAAAAAQLEPQLRLAKVNTEAEPALAQRFGIRSVP
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCCC
TIALFQGGREVTRQAGAMNTEQLVRWVRGQLGR
CCEEECCCHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MHAEEAHMNPSIHLVCPHCDAVNRLPAERMAEHPACGQCHRPLFIGEPLALDGARFERHL
CCCCCCCCCCCEEEEECCCCHHHCCCHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHHHH
TRNDLPVLIDFWAPWCGPCRMMAPAFAAAAAQLEPQLRLAKVNTEAEPALAQRFGIRSVP
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCCC
TIALFQGGREVTRQAGAMNTEQLVRWVRGQLGR
CCEEECCCHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8652661 [H]