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The map label for this gene is garR [H]

Identifier: 119871460

GI number: 119871460

Start: 5671452

End: 5672369

Strand: Direct

Name: garR [H]

Synonym: Mkms_5436

Alternate gene names: 119871460

Gene position: 5671452-5672369 (Clockwise)

Preceding gene: 119871459

Following gene: 119871461

Centisome position: 98.85

GC content: 70.48

Gene sequence:

>918_bases
ATGAACGTCGGATTCATCGGCCTCGGTGTGATGGGCAAGCCCATGGCCGGCCATCTCGTCGACGCCGGCCACCACGTCGT
GGTCTTCAACCGCTCCCGCGCCAAGGTCGACGAACTGGAGGCGCGGGGCGCCGTCGGCGCCACGAGCCCGGCGCATGCCG
GGGAGAAGGCAGATGTCGTCATCACCATGCTCCCCGACTCTCCGGAGGTCGAGGAAGTGCTGTTCGGGCCCGCCGGGGTG
ACCACCACGCTGCGGCCGGGATCGCTGGTGATCGACTGCAGCACAATCTCTCCGGACGCCGCCGTCGCGATCGGCGCACG
GTTGGCCGAGAAGGACATCGCGTTCGTGGACGCACCGGTCAGCGGCGGGGAGGCCGGGGCCATCGCCGGCGCACTCGCGG
TCATGATGGGCGGCGACGAGGACGCGGTGCGGCGGGCCGCCACGGTGCTCGACGCGGTGGCCGCGACGTCGGTCCACGTC
GGTCCCGTCGGCGCCGGGCAGCTGGTGAAGGCCGCCAACCAGATGCTCGTGGCCGGCAATATCGCCCTGGTCGGTGAGGC
GGTGACGCTGCTGCAGCGCACCGGGGTCGACGTCGATGCGGCGCTGGCAGTTCTGGGCGGCGGCCTGGCGGCCAGCAAGG
TGCTCGAGGCCAAGGCGCCGAAGATGCTGGCCCGCGATTTCGCGCCGGGCTTCCGGATCGACCTGCACTACAAGGATCTC
AAGATCGCGCTGGCCGCCGCGGAGCAGGCCCGGATCGCGGTACCGCTGACCGGCATCATCACCCAACTCGTCCAGGCGCT
GCGGTCCGCCGGGGACGGCGGGCTGGACCACAGCGCCCTCATCAAGGCGCTCGAACGACTGAGCGGGGCAGACGCCAGTG
GAAACCGGAAGGAAGTGGAGTCGTGCCAACAGCATTGA

Upstream 100 bases:

>100_bases
CCAGGTGGACGTGTTCGTCGACAACCTGCAACGGCTCGTCGCCGGGCGCGAATTCCGCAACGTCGTCGACCTGTCGCTGG
GCTACTGAGGAGGACTGCTC

Downstream 100 bases:

>100_bases
TCTGCGGCGGTGGAGTCGCGGGACTGTCGTCCGCCCTGCACCTGAAGCAGCAGGGCTGGAAGGTCCAGATCTTCGAAAGT
GATTCGGAGTTGCGGACCGC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNVGFIGLGVMGKPMAGHLVDAGHHVVVFNRSRAKVDELEARGAVGATSPAHAGEKADVVITMLPDSPEVEEVLFGPAGV
TTTLRPGSLVIDCSTISPDAAVAIGARLAEKDIAFVDAPVSGGEAGAIAGALAVMMGGDEDAVRRAATVLDAVAATSVHV
GPVGAGQLVKAANQMLVAGNIALVGEAVTLLQRTGVDVDAALAVLGGGLAASKVLEAKAPKMLARDFAPGFRIDLHYKDL
KIALAAAEQARIAVPLTGIITQLVQALRSAGDGGLDHSALIKALERLSGADASGNRKEVESCQQH

Sequences:

>Translated_305_residues
MNVGFIGLGVMGKPMAGHLVDAGHHVVVFNRSRAKVDELEARGAVGATSPAHAGEKADVVITMLPDSPEVEEVLFGPAGV
TTTLRPGSLVIDCSTISPDAAVAIGARLAEKDIAFVDAPVSGGEAGAIAGALAVMMGGDEDAVRRAATVLDAVAATSVHV
GPVGAGQLVKAANQMLVAGNIALVGEAVTLLQRTGVDVDAALAVLGGGLAASKVLEAKAPKMLARDFAPGFRIDLHYKDL
KIALAAAEQARIAVPLTGIITQLVQALRSAGDGGLDHSALIKALERLSGADASGNRKEVESCQQH
>Mature_305_residues
MNVGFIGLGVMGKPMAGHLVDAGHHVVVFNRSRAKVDELEARGAVGATSPAHAGEKADVVITMLPDSPEVEEVLFGPAGV
TTTLRPGSLVIDCSTISPDAAVAIGARLAEKDIAFVDAPVSGGEAGAIAGALAVMMGGDEDAVRRAATVLDAVAATSVHV
GPVGAGQLVKAANQMLVAGNIALVGEAVTLLQRTGVDVDAALAVLGGGLAASKVLEAKAPKMLARDFAPGFRIDLHYKDL
KIALAAAEQARIAVPLTGIITQLVQALRSAGDGGLDHSALIKALERLSGADASGNRKEVESCQQH

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=293, Percent_Identity=33.1058020477816, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=27.6595744680851, Blast_Score=131, Evalue=8e-31,
Organism=Escherichia coli, GI145693186, Length=288, Percent_Identity=46.1805555555556, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=40.2777777777778, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=36.426116838488, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789092, Length=290, Percent_Identity=32.0689655172414, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788341, Length=210, Percent_Identity=27.6190476190476, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=293, Percent_Identity=32.0819112627986, Blast_Score=124, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6321695, Length=221, Percent_Identity=28.9592760180996, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=32.6530612244898, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=32.6530612244898, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=25.7142857142857, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30814; Mature: 30814

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVGFIGLGVMGKPMAGHLVDAGHHVVVFNRSRAKVDELEARGAVGATSPAHAGEKADVV
CCCEEEEECCCCCCCCCCEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCEE
ITMLPDSPEVEEVLFGPAGVTTTLRPGSLVIDCSTISPDAAVAIGARLAEKDIAFVDAPV
EEECCCCCCHHHHHCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEECCC
SGGEAGAIAGALAVMMGGDEDAVRRAATVLDAVAATSVHVGPVGAGQLVKAANQMLVAGN
CCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHCCEEEECC
IALVGEAVTLLQRTGVDVDAALAVLGGGLAASKVLEAKAPKMLARDFAPGFRIDLHYKDL
EEHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHCCCCCEEEEEECCE
KIALAAAEQARIAVPLTGIITQLVQALRSAGDGGLDHSALIKALERLSGADASGNRKEVE
EEEEEECCCCEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
SCQQH
HHHCC
>Mature Secondary Structure
MNVGFIGLGVMGKPMAGHLVDAGHHVVVFNRSRAKVDELEARGAVGATSPAHAGEKADVV
CCCEEEEECCCCCCCCCCEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCEE
ITMLPDSPEVEEVLFGPAGVTTTLRPGSLVIDCSTISPDAAVAIGARLAEKDIAFVDAPV
EEECCCCCCHHHHHCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEECCC
SGGEAGAIAGALAVMMGGDEDAVRRAATVLDAVAATSVHVGPVGAGQLVKAANQMLVAGN
CCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHCCEEEECC
IALVGEAVTLLQRTGVDVDAALAVLGGGLAASKVLEAKAPKMLARDFAPGFRIDLHYKDL
EEHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHCCCCCEEEEEECCE
KIALAAAEQARIAVPLTGIITQLVQALRSAGDGGLDHSALIKALERLSGADASGNRKEVE
EEEEEECCCCEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
SCQQH
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]