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The map label for this gene is ycdW [C]

Identifier: 119871459

GI number: 119871459

Start: 5670405

End: 5671439

Strand: Direct

Name: ycdW [C]

Synonym: Mkms_5435

Alternate gene names: 119871459

Gene position: 5670405-5671439 (Clockwise)

Preceding gene: 119871458

Following gene: 119871460

Centisome position: 98.84

GC content: 66.76

Gene sequence:

>1035_bases
GTGTCACTCAACGTCGTAGTCGCAGGTCTACCCAAGGCAGTACAGAACGCCGAGGACCCCGACGAGGGGATCTGGCTGAC
TCCCGAGCAGAAGGACCGGATCACCGCAGTCGCCGATGACGTTTGGCTCGAACACATCCCGGTCTCGGAGCTCAACGCCG
GCAAGGCGCCACAACGGCCGCCGCACGCGATCATGGTCGAGACCAGCGGCTCCAAGAAGGAGATCGAGATCGAGCAGGGC
ATCCTGAAGATGCCCGGCCTGCAACAGCTGTTCAACCCGGATCTCAAACTGCTGCAGTCGATGAGCGCAGGGGCCGAGCA
CCTCGTCAACATCATGCCCGAGGGTGTGGTGCTGGCGAACGCATCCGGTGTGGCGGCCAACGCCATCGCCGAGACCGTGA
TCGCCGGCATCCTGGCACAGGCGAAGATGCTGCGGGAACGCTGGAGCAACCAGGCCGCGCGGGAGTGGAAGGAACTTCCC
GCGCGTGAACTGGCGGACACCACCATGACCGTGCTCGGAACCGGCAACATCGGGGCCAGGACGGCGACGATCGCCGGCGT
GCTGGGTATCCGGACGATCGGCGTCAACCGGCGCGGCAACGCAGTCGAGGGATTCGACGAGACGGTCCCCACCGCACAGC
TGCACGACGTGCTCGCCGAATCGGACTACCTGGTGATCGCGGCGCCGCTGACGCCGGCCACCCGCGGACTGATCGACGCG
AAAGCGTTGGCGGCGTTGAAGCCCGGCGGGTGGGTGGCCAACGTCGCTCGCGGTGCCATCCATGACGCCGACGCGCTCAC
CGATGCGCTCGAACGGGGGCATCTGTCCGGGGCGCTCATCGACTGCCACGTCACCGAGCCGCTGCCGGCCGACGACCCGC
TGTGGAAAGCGCCGGGAGCCATGGTCTTCCCACACGATTCGCACGCATCTCAGCTGCTCGGCGACCGCCAGGTGGACGTG
TTCGTCGACAACCTGCAACGGCTCGTCGCCGGGCGCGAATTCCGCAACGTCGTCGACCTGTCGCTGGGCTACTGA

Upstream 100 bases:

>100_bases
CGTGGTCGACGCCTGCCTGCGTGAGCTCGTGCAACCACGTGCCGCCGCAGCGCATTTGACATCAATCAAGTAGAGATCCG
AGAGCAGGAGAAATAGACGC

Downstream 100 bases:

>100_bases
GGAGGACTGCTCATGAACGTCGGATTCATCGGCCTCGGTGTGATGGGCAAGCCCATGGCCGGCCATCTCGTCGACGCCGG
CCACCACGTCGTGGTCTTCA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSLNVVVAGLPKAVQNAEDPDEGIWLTPEQKDRITAVADDVWLEHIPVSELNAGKAPQRPPHAIMVETSGSKKEIEIEQG
ILKMPGLQQLFNPDLKLLQSMSAGAEHLVNIMPEGVVLANASGVAANAIAETVIAGILAQAKMLRERWSNQAAREWKELP
ARELADTTMTVLGTGNIGARTATIAGVLGIRTIGVNRRGNAVEGFDETVPTAQLHDVLAESDYLVIAAPLTPATRGLIDA
KALAALKPGGWVANVARGAIHDADALTDALERGHLSGALIDCHVTEPLPADDPLWKAPGAMVFPHDSHASQLLGDRQVDV
FVDNLQRLVAGREFRNVVDLSLGY

Sequences:

>Translated_344_residues
MSLNVVVAGLPKAVQNAEDPDEGIWLTPEQKDRITAVADDVWLEHIPVSELNAGKAPQRPPHAIMVETSGSKKEIEIEQG
ILKMPGLQQLFNPDLKLLQSMSAGAEHLVNIMPEGVVLANASGVAANAIAETVIAGILAQAKMLRERWSNQAAREWKELP
ARELADTTMTVLGTGNIGARTATIAGVLGIRTIGVNRRGNAVEGFDETVPTAQLHDVLAESDYLVIAAPLTPATRGLIDA
KALAALKPGGWVANVARGAIHDADALTDALERGHLSGALIDCHVTEPLPADDPLWKAPGAMVFPHDSHASQLLGDRQVDV
FVDNLQRLVAGREFRNVVDLSLGY
>Mature_343_residues
SLNVVVAGLPKAVQNAEDPDEGIWLTPEQKDRITAVADDVWLEHIPVSELNAGKAPQRPPHAIMVETSGSKKEIEIEQGI
LKMPGLQQLFNPDLKLLQSMSAGAEHLVNIMPEGVVLANASGVAANAIAETVIAGILAQAKMLRERWSNQAAREWKELPA
RELADTTMTVLGTGNIGARTATIAGVLGIRTIGVNRRGNAVEGFDETVPTAQLHDVLAESDYLVIAAPLTPATRGLIDAK
ALAALKPGGWVANVARGAIHDADALTDALERGHLSGALIDCHVTEPLPADDPLWKAPGAMVFPHDSHASQLLGDRQVDVF
VDNLQRLVAGREFRNVVDLSLGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=26.5625, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI23308577, Length=232, Percent_Identity=28.0172413793103, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI145580578, Length=243, Percent_Identity=26.3374485596708, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4557499, Length=243, Percent_Identity=26.3374485596708, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI145580575, Length=243, Percent_Identity=26.3374485596708, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI61743967, Length=241, Percent_Identity=24.896265560166, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4557497, Length=241, Percent_Identity=24.896265560166, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI87081824, Length=229, Percent_Identity=25.3275109170306, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082289, Length=255, Percent_Identity=26.2745098039216, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789279, Length=214, Percent_Identity=29.4392523364486, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=192, Percent_Identity=27.0833333333333, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=175, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=182, Percent_Identity=28.021978021978, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=225, Percent_Identity=26.2222222222222, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585516, Length=233, Percent_Identity=29.1845493562232, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574286, Length=228, Percent_Identity=26.7543859649123, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921140, Length=229, Percent_Identity=31.0043668122271, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45552429, Length=251, Percent_Identity=26.6932270916335, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585514, Length=248, Percent_Identity=26.2096774193548, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574282, Length=248, Percent_Identity=26.2096774193548, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574284, Length=248, Percent_Identity=26.2096774193548, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551003, Length=248, Percent_Identity=26.2096774193548, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28571528, Length=223, Percent_Identity=27.8026905829596, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646446, Length=243, Percent_Identity=25.1028806584362, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24646448, Length=243, Percent_Identity=25.1028806584362, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24646452, Length=243, Percent_Identity=25.1028806584362, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24646450, Length=243, Percent_Identity=25.1028806584362, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI62472511, Length=243, Percent_Identity=24.2798353909465, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 36640; Mature: 36509

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNVVVAGLPKAVQNAEDPDEGIWLTPEQKDRITAVADDVWLEHIPVSELNAGKAPQRP
CCCEEEEECCCHHHCCCCCCCCCEEECCCCCCCEEHHHHHHHHHCCCHHHCCCCCCCCCC
PHAIMVETSGSKKEIEIEQGILKMPGLQQLFNPDLKLLQSMSAGAEHLVNIMPEGVVLAN
CCEEEEECCCCCCEEEHHHCHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEC
ASGVAANAIAETVIAGILAQAKMLRERWSNQAAREWKELPARELADTTMTVLGTGNIGAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCEEEEEECCCCCCH
TATIAGVLGIRTIGVNRRGNAVEGFDETVPTAQLHDVLAESDYLVIAAPLTPATRGLIDA
HHHHHHHHHHEEECCCCCCCCCCCCHHCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
KALAALKPGGWVANVARGAIHDADALTDALERGHLSGALIDCHVTEPLPADDPLWKAPGA
HHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
MVFPHDSHASQLLGDRQVDVFVDNLQRLVAGREFRNVVDLSLGY
EEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLNVVVAGLPKAVQNAEDPDEGIWLTPEQKDRITAVADDVWLEHIPVSELNAGKAPQRP
CCEEEEECCCHHHCCCCCCCCCEEECCCCCCCEEHHHHHHHHHCCCHHHCCCCCCCCCC
PHAIMVETSGSKKEIEIEQGILKMPGLQQLFNPDLKLLQSMSAGAEHLVNIMPEGVVLAN
CCEEEEECCCCCCEEEHHHCHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEC
ASGVAANAIAETVIAGILAQAKMLRERWSNQAAREWKELPARELADTTMTVLGTGNIGAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCEEEEEECCCCCCH
TATIAGVLGIRTIGVNRRGNAVEGFDETVPTAQLHDVLAESDYLVIAAPLTPATRGLIDA
HHHHHHHHHHEEECCCCCCCCCCCCHHCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
KALAALKPGGWVANVARGAIHDADALTDALERGHLSGALIDCHVTEPLPADDPLWKAPGA
HHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
MVFPHDSHASQLLGDRQVDVFVDNLQRLVAGREFRNVVDLSLGY
EEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]