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The map label for this gene is fdhA [H]

Identifier: 119871333

GI number: 119871333

Start: 5544423

End: 5544992

Strand: Direct

Name: fdhA [H]

Synonym: Mkms_5307

Alternate gene names: 119871333

Gene position: 5544423-5544992 (Clockwise)

Preceding gene: 119871332

Following gene: 119871334

Centisome position: 96.64

GC content: 66.84

Gene sequence:

>570_bases
GTGGACTTCAGGAAGCGGATCGAGTCGTGGCCGGTGTACCGGCAGCTCACCGGCGACGACGCATTGGGCCGAGGTAAGGC
CGCCCAGTCGAAGCGCTCCCTGACCCTGACGCCCCGCACCGCCGACGCCGACCACGTCGCCCACTCCGTGTGCCCGTTCT
GCGCGGTCGGCTGCGCGCAGAAGGTGTACGTCAAGGACGAGAAGGTCGTCCAGATCGAGGGCAATCCGGACAGCCCGATA
TCCCGGGGCCGCCTGTGCCCCAAGGGTTCTGCGAGCAAGCAACTGGTCACCGGTCCGCAACGGCTGACCAAGGTGCGCTA
CCGGCCGCCGTACGCCACCGAATGGCAGGACCTCGACCTCGACACGGCGATGGACATGGTCGCCGACCGCCTGCTCGACG
CGCGCGAGAAGGGCTGGCAGCAGTTCGACGCCGACCGCAACACCCTGCGCCGCACCATGGGGATCGCCAGCCTGGGCGGT
GCGACGCTCGACAACGAAGAGAACTACCTGATCAAGAAGCTCTTCACCGCCCTGGGTGCGTTACAGATCGAGAACCAGGC
GCGTATTTGA

Upstream 100 bases:

>100_bases
GCGGTGGCTCTCGTCGTGATTCCGCCGGCCTTCGACTTCGTGTAGAAGTGGTTTGATCGCAGGTGCGCCGGGTATCGCCA
GCCCACTCGAGGAGGACGGT

Downstream 100 bases:

>100_bases
CACAGCGCCACGGTTCCCGGTCTGGGGGCCTCCTTCGGTCGCGGCGGGGCGACGGACTACCAGCAGGACCTCGTCAACTC
GGACTTCATCGTCATCATGG

Product: molybdopterin oxidoreductase Fe4S4 region

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MDFRKRIESWPVYRQLTGDDALGRGKAAQSKRSLTLTPRTADADHVAHSVCPFCAVGCAQKVYVKDEKVVQIEGNPDSPI
SRGRLCPKGSASKQLVTGPQRLTKVRYRPPYATEWQDLDLDTAMDMVADRLLDAREKGWQQFDADRNTLRRTMGIASLGG
ATLDNEENYLIKKLFTALGALQIENQARI

Sequences:

>Translated_189_residues
MDFRKRIESWPVYRQLTGDDALGRGKAAQSKRSLTLTPRTADADHVAHSVCPFCAVGCAQKVYVKDEKVVQIEGNPDSPI
SRGRLCPKGSASKQLVTGPQRLTKVRYRPPYATEWQDLDLDTAMDMVADRLLDAREKGWQQFDADRNTLRRTMGIASLGG
ATLDNEENYLIKKLFTALGALQIENQARI
>Mature_189_residues
MDFRKRIESWPVYRQLTGDDALGRGKAAQSKRSLTLTPRTADADHVAHSVCPFCAVGCAQKVYVKDEKVVQIEGNPDSPI
SRGRLCPKGSASKQLVTGPQRLTKVRYRPPYATEWQDLDLDTAMDMVADRLLDAREKGWQQFDADRNTLRRTMGIASLGG
ATLDNEENYLIKKLFTALGALQIENQARI

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868720, Length=181, Percent_Identity=30.3867403314917, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI3868719, Length=148, Percent_Identity=31.0810810810811, Blast_Score=87, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 21123; Mature: 21123

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRKRIESWPVYRQLTGDDALGRGKAAQSKRSLTLTPRTADADHVAHSVCPFCAVGCAQ
CCHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KVYVKDEKVVQIEGNPDSPISRGRLCPKGSASKQLVTGPQRLTKVRYRPPYATEWQDLDL
HEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHCCHHHHHEECCCCCCCCCCCCCCH
DTAMDMVADRLLDAREKGWQQFDADRNTLRRTMGIASLGGATLDNEENYLIKKLFTALGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LQIENQARI
HHCCCCCCC
>Mature Secondary Structure
MDFRKRIESWPVYRQLTGDDALGRGKAAQSKRSLTLTPRTADADHVAHSVCPFCAVGCAQ
CCHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KVYVKDEKVVQIEGNPDSPISRGRLCPKGSASKQLVTGPQRLTKVRYRPPYATEWQDLDL
HEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHCCHHHHHEECCCCCCCCCCCCCCH
DTAMDMVADRLLDAREKGWQQFDADRNTLRRTMGIASLGGATLDNEENYLIKKLFTALGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LQIENQARI
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA