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The map label for this gene is fusA [C]

Identifier: 119871252

GI number: 119871252

Start: 5466256

End: 5468397

Strand: Direct

Name: fusA [C]

Synonym: Mkms_5225

Alternate gene names: 119871252

Gene position: 5466256-5468397 (Clockwise)

Preceding gene: 119871250

Following gene: 119871254

Centisome position: 95.28

GC content: 69.42

Gene sequence:

>2142_bases
ATGGCCGACAGGACTACGCCGCAGACGGTGCCGACCGCGGACGCACCCGACGCCATCCGCAACATCGCGCTGGTCGGACC
GTCGGGCGGCGGGAAGACCACCCTGGTCGAATCTCTGCTGGTCGCCGCGGGTGTCCTCACGCGGGCCGGCGCGGTCACGG
AGGGCACGACGGTCTGCGACAGCGACGAGGTCGAGGTGTCCCAGCAGCGTTCGGTCGGCCTGGCGCTCGCGCCGTTGCTG
CACGACGGCGTGAAGATCAACCTCATCGACACCCCGGGATATGCGGACTTCGTCGGGGAACTGCGGGCCGGCCTGCGTGC
CGCCGACTGCGCGCTGTTCGTGATCGCCGCCAACGAGGGTGTCGACGAACCGACGAAACTGCTGTGGCAGGAGTGCGATG
CGGTGTCCATGCCGCGCGCGGTCGCGATCACCAAACTCGACCACGCCCGGGCCGACTACACCGGTGCGCTGGCCGCGGCG
CGGACGGCGTTCGGCGACAAGGTCGTTCCGCTGTACTTCCTGGCCGATGCCGGCGTGATCGGTCTGCTGACCGGCAGGCA
CTACGAGTACCGCGACGGCGTCCGCACCGTTCACGACCCCGGCGCGCCGCACCTCGACGAGTACACCGAACTGCGCGGCT
CCCTGATCGAGGGGATCATCGAGGAGTCCGAGGACGAATCCCTGATGGAGCGCTACCTCGGCGGCGAGGACATCGACCAG
GCCCTGTTGATCGCCGATCTGGAGAAGGCGGTGGCCCGCGGATCGTTCTTCCCGGTGATCCCGGTCTGCAGCAGCAGCGG
GGTGGGCACGATGGAACTGCTCGAGGTGGCCACCCGCGGTTTCCCCTCTCCGAAGGAACATCCGCTTCCCGAGGTGTTCA
CCCCACAGGGCGCTCCCCGGCCGAACCCCGGGTGCGATCCGGCGGGCCCACTGTTGGCCGAGGTGGTCAAGACGACATCG
GACCCCTACGTCGGCAGAGTGAGCCTCACCCGGGTGTTCTCGGGGACGATCAGGCCCGACATGACCGTGCACGTGTCGGG
CCATTTCTCGTCGTTCTTCGGTGCCGCAGCGGATTCGGCGACCGGATCCGGCCACCCCGACCATGACGAGGACGAGCGCA
TCGGCACCCTGTCCTTCCCGCTGGGCCGACAGCAGCGGCCGGCCCCGTCGGTGGTGGCCGGCGACATCTGCGCGATCGGC
AGGCTGACCCGCGCCGAGACCGGGGACACGTTGTCCGGCAAGGACGATCCGCTGGTGCTCAAACCGTGGACGATGCCCGA
ACCGCTGCTCCCGATCGCCGTGCAGCCCCGCGCGAAGACCGATGAGGACAAGCTGTCGGTCGGGTTGACACGCCTGGCCG
CCGAAGATCCGACCCTGCGCATCGAACAGAATCCGCAGACACACCAGATCGTGCTGTGGTGCATGGGTGAGGCGCACGCC
GCCGTCGTCCTCGACGCGCTGTCGCGGCGCTACGGCGTGACCGTCGACGTCATCGAACTGCGCATCCCGCTGCGTGAGAC
GTTCGGCGGCAGCGCCAAAGGCCACGGCAGGCACGTGAAACAGTCCGGCGGACACGGGCAGTACGCGGTGTGCGACATCG
AGGTCGAACCCCTGCCCGAAGGCGCCGGGTTCGAGTTCGTCGACAAGGTCGTCGGCGGGGCCGTTCCCCGGCAGTTCATC
CCGAGCGTCGAGAAGGGTGTGCGCGCGCAGATGGACAAGGGTGTCGGGCCCGGTTATCCGGTGGTCGACATCCGGGTGAC
GCTGGTCGACGGTAAGGCGCACAGCGTGGATTCGTCGGACTATGCGTTCCAGATGGCCGGTGCGCTCGCACTGCGCGAGG
CTGCCGCGGCGACCACCGTGAACCTGCTCGAACCCGTGGACGCGGTGACCATCACGGTGCCCGACGATCTGGTGGGCACG
GTGATGGGTGACCTGTCCGGCCGCCGCGGCCGGGTACTGGGCACCGAACAGGCCGGTGCGGACCGGACGGTGGTGCGCGC
CGAGGTCCCCCAGGTCGAGCTGACCCGGTACGCGGTGGATCTGCGCTCACTGGCCCACGGCGCCGGCGTGTTCCACCGGT
CCTTCGCCCGCTACGAGCCGATGCCGGAGAACGCGGCCGCCAAGGTGCGCGCGGCGAGCTGA

Upstream 100 bases:

>100_bases
GTCGGACCCGCGCCACGGTTGCTCATGTTTCACCCACCCCTTGTGTTGCAGGTCACATCGGAGCAGGGTGGAGACGCGGG
CCGGACGCAGGAGGGAAGTC

Downstream 100 bases:

>100_bases
CGGTCAGTCCGCCTCGTAGAACTCCGGCCGGCCCGCCCATGGTTCGGGCTCCACACCGAAGGTGTTGAGCGCCGTGGCCA
TCACCCCGTAGCCGCCGGCG

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 712

Protein sequence:

>713_residues
MADRTTPQTVPTADAPDAIRNIALVGPSGGGKTTLVESLLVAAGVLTRAGAVTEGTTVCDSDEVEVSQQRSVGLALAPLL
HDGVKINLIDTPGYADFVGELRAGLRAADCALFVIAANEGVDEPTKLLWQECDAVSMPRAVAITKLDHARADYTGALAAA
RTAFGDKVVPLYFLADAGVIGLLTGRHYEYRDGVRTVHDPGAPHLDEYTELRGSLIEGIIEESEDESLMERYLGGEDIDQ
ALLIADLEKAVARGSFFPVIPVCSSSGVGTMELLEVATRGFPSPKEHPLPEVFTPQGAPRPNPGCDPAGPLLAEVVKTTS
DPYVGRVSLTRVFSGTIRPDMTVHVSGHFSSFFGAAADSATGSGHPDHDEDERIGTLSFPLGRQQRPAPSVVAGDICAIG
RLTRAETGDTLSGKDDPLVLKPWTMPEPLLPIAVQPRAKTDEDKLSVGLTRLAAEDPTLRIEQNPQTHQIVLWCMGEAHA
AVVLDALSRRYGVTVDVIELRIPLRETFGGSAKGHGRHVKQSGGHGQYAVCDIEVEPLPEGAGFEFVDKVVGGAVPRQFI
PSVEKGVRAQMDKGVGPGYPVVDIRVTLVDGKAHSVDSSDYAFQMAGALALREAAAATTVNLLEPVDAVTITVPDDLVGT
VMGDLSGRRGRVLGTEQAGADRTVVRAEVPQVELTRYAVDLRSLAHGAGVFHRSFARYEPMPENAAAKVRAAS

Sequences:

>Translated_713_residues
MADRTTPQTVPTADAPDAIRNIALVGPSGGGKTTLVESLLVAAGVLTRAGAVTEGTTVCDSDEVEVSQQRSVGLALAPLL
HDGVKINLIDTPGYADFVGELRAGLRAADCALFVIAANEGVDEPTKLLWQECDAVSMPRAVAITKLDHARADYTGALAAA
RTAFGDKVVPLYFLADAGVIGLLTGRHYEYRDGVRTVHDPGAPHLDEYTELRGSLIEGIIEESEDESLMERYLGGEDIDQ
ALLIADLEKAVARGSFFPVIPVCSSSGVGTMELLEVATRGFPSPKEHPLPEVFTPQGAPRPNPGCDPAGPLLAEVVKTTS
DPYVGRVSLTRVFSGTIRPDMTVHVSGHFSSFFGAAADSATGSGHPDHDEDERIGTLSFPLGRQQRPAPSVVAGDICAIG
RLTRAETGDTLSGKDDPLVLKPWTMPEPLLPIAVQPRAKTDEDKLSVGLTRLAAEDPTLRIEQNPQTHQIVLWCMGEAHA
AVVLDALSRRYGVTVDVIELRIPLRETFGGSAKGHGRHVKQSGGHGQYAVCDIEVEPLPEGAGFEFVDKVVGGAVPRQFI
PSVEKGVRAQMDKGVGPGYPVVDIRVTLVDGKAHSVDSSDYAFQMAGALALREAAAATTVNLLEPVDAVTITVPDDLVGT
VMGDLSGRRGRVLGTEQAGADRTVVRAEVPQVELTRYAVDLRSLAHGAGVFHRSFARYEPMPENAAAKVRAAS
>Mature_712_residues
ADRTTPQTVPTADAPDAIRNIALVGPSGGGKTTLVESLLVAAGVLTRAGAVTEGTTVCDSDEVEVSQQRSVGLALAPLLH
DGVKINLIDTPGYADFVGELRAGLRAADCALFVIAANEGVDEPTKLLWQECDAVSMPRAVAITKLDHARADYTGALAAAR
TAFGDKVVPLYFLADAGVIGLLTGRHYEYRDGVRTVHDPGAPHLDEYTELRGSLIEGIIEESEDESLMERYLGGEDIDQA
LLIADLEKAVARGSFFPVIPVCSSSGVGTMELLEVATRGFPSPKEHPLPEVFTPQGAPRPNPGCDPAGPLLAEVVKTTSD
PYVGRVSLTRVFSGTIRPDMTVHVSGHFSSFFGAAADSATGSGHPDHDEDERIGTLSFPLGRQQRPAPSVVAGDICAIGR
LTRAETGDTLSGKDDPLVLKPWTMPEPLLPIAVQPRAKTDEDKLSVGLTRLAAEDPTLRIEQNPQTHQIVLWCMGEAHAA
VVLDALSRRYGVTVDVIELRIPLRETFGGSAKGHGRHVKQSGGHGQYAVCDIEVEPLPEGAGFEFVDKVVGGAVPRQFIP
SVEKGVRAQMDKGVGPGYPVVDIRVTLVDGKAHSVDSSDYAFQMAGALALREAAAATTVNLLEPVDAVTITVPDDLVGTV
MGDLSGRRGRVLGTEQAGADRTVVRAEVPQVELTRYAVDLRSLAHGAGVFHRSFARYEPMPENAAAKVRAAS

Specific function: This Protein Promotes The GTP-Dependent Translocation Of The Nascent Protein Chain From The A-Site To The P-Site Of The Ribosome. [C]

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=710, Percent_Identity=28.8732394366197, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI19923640, Length=741, Percent_Identity=25.2361673414305, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI25306287, Length=359, Percent_Identity=25.0696378830084, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI25306283, Length=422, Percent_Identity=26.7772511848341, Blast_Score=104, Evalue=3e-22,
Organism=Escherichia coli, GI1789738, Length=711, Percent_Identity=31.6455696202532, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI48994988, Length=139, Percent_Identity=30.9352517985612, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790835, Length=342, Percent_Identity=24.5614035087719, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17533571, Length=722, Percent_Identity=26.7313019390582, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17556745, Length=153, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323098, Length=706, Percent_Identity=24.5042492917847, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322359, Length=812, Percent_Identity=24.5073891625616, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24582462, Length=702, Percent_Identity=29.7720797720798, Blast_Score=260, Evalue=3e-69,
Organism=Drosophila melanogaster, GI221458488, Length=726, Percent_Identity=23.8292011019284, Blast_Score=155, Evalue=1e-37,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 75492; Mature: 75361

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRTTPQTVPTADAPDAIRNIALVGPSGGGKTTLVESLLVAAGVLTRAGAVTEGTTVCD
CCCCCCCCCCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECC
SDEVEVSQQRSVGLALAPLLHDGVKINLIDTPGYADFVGELRAGLRAADCALFVIAANEG
CCCCCHHHHHCCCEEEHHHHHCCEEEEEEECCCHHHHHHHHHHCCEECCEEEEEEECCCC
VDEPTKLLWQECDAVSMPRAVAITKLDHARADYTGALAAARTAFGDKVVPLYFLADAGVI
CCHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCEE
GLLTGRHYEYRDGVRTVHDPGAPHLDEYTELRGSLIEGIIEESEDESLMERYLGGEDIDQ
EEECCCCEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHH
ALLIADLEKAVARGSFFPVIPVCSSSGVGTMELLEVATRGFPSPKEHPLPEVFTPQGAPR
HHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PNPGCDPAGPLLAEVVKTTSDPYVGRVSLTRVFSGTIRPDMTVHVSGHFSSFFGAAADSA
CCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCEEEEEECCHHHHHCCCCCCC
TGSGHPDHDEDERIGTLSFPLGRQQRPAPSVVAGDICAIGRLTRAETGDTLSGKDDPLVL
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHCCHHHHCCHHHCCCCCCCCCCCCCEEE
KPWTMPEPLLPIAVQPRAKTDEDKLSVGLTRLAAEDPTLRIEQNPQTHQIVLWCMGEAHA
CCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCHH
AVVLDALSRRYGVTVDVIELRIPLRETFGGSAKGHGRHVKQSGGHGQYAVCDIEVEPLPE
HHHHHHHHHHHCCEEEEEEEEECHHHHCCCCCCCCCCCHHCCCCCCCEEEEEEEEECCCC
GAGFEFVDKVVGGAVPRQFIPSVEKGVRAQMDKGVGPGYPVVDIRVTLVDGKAHSVDSSD
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCC
YAFQMAGALALREAAAATTVNLLEPVDAVTITVPDDLVGTVMGDLSGRRGRVLGTEQAGA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCEEECCCCCC
DRTVVRAEVPQVELTRYAVDLRSLAHGAGVFHRSFARYEPMPENAAAKVRAAS
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECC
>Mature Secondary Structure 
ADRTTPQTVPTADAPDAIRNIALVGPSGGGKTTLVESLLVAAGVLTRAGAVTEGTTVCD
CCCCCCCCCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECC
SDEVEVSQQRSVGLALAPLLHDGVKINLIDTPGYADFVGELRAGLRAADCALFVIAANEG
CCCCCHHHHHCCCEEEHHHHHCCEEEEEEECCCHHHHHHHHHHCCEECCEEEEEEECCCC
VDEPTKLLWQECDAVSMPRAVAITKLDHARADYTGALAAARTAFGDKVVPLYFLADAGVI
CCHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCEE
GLLTGRHYEYRDGVRTVHDPGAPHLDEYTELRGSLIEGIIEESEDESLMERYLGGEDIDQ
EEECCCCEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHH
ALLIADLEKAVARGSFFPVIPVCSSSGVGTMELLEVATRGFPSPKEHPLPEVFTPQGAPR
HHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PNPGCDPAGPLLAEVVKTTSDPYVGRVSLTRVFSGTIRPDMTVHVSGHFSSFFGAAADSA
CCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCEEEEEECCHHHHHCCCCCCC
TGSGHPDHDEDERIGTLSFPLGRQQRPAPSVVAGDICAIGRLTRAETGDTLSGKDDPLVL
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHCCHHHHCCHHHCCCCCCCCCCCCCEEE
KPWTMPEPLLPIAVQPRAKTDEDKLSVGLTRLAAEDPTLRIEQNPQTHQIVLWCMGEAHA
CCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCHH
AVVLDALSRRYGVTVDVIELRIPLRETFGGSAKGHGRHVKQSGGHGQYAVCDIEVEPLPE
HHHHHHHHHHHCCEEEEEEEEECHHHHCCCCCCCCCCCHHCCCCCCCEEEEEEEEECCCC
GAGFEFVDKVVGGAVPRQFIPSVEKGVRAQMDKGVGPGYPVVDIRVTLVDGKAHSVDSSD
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCC
YAFQMAGALALREAAAATTVNLLEPVDAVTITVPDDLVGTVMGDLSGRRGRVLGTEQAGA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCEEECCCCCC
DRTVVRAEVPQVELTRYAVDLRSLAHGAGVFHRSFARYEPMPENAAAKVRAAS
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]