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The map label for this gene is msrA [H]

Identifier: 119871207

GI number: 119871207

Start: 5426338

End: 5426853

Strand: Direct

Name: msrA [H]

Synonym: Mkms_5180

Alternate gene names: 119871207

Gene position: 5426338-5426853 (Clockwise)

Preceding gene: 119871206

Following gene: 119871209

Centisome position: 94.58

GC content: 66.47

Gene sequence:

>516_bases
ATGAGTGACCACAAGAAGGCCATCCTGGCGGGCGGCTGCTTCTGGGGTATGCAGGATCTGATCCGCAAGCAACCGGGTGT
GGTGTCGACCCGCGTCGGCTACACCGGCGGGCAGAACGACCACCCCACCTACCGGAATCACCCGGGCCACGCCGAGTCGA
TCGAGATCACCTACGACCCGGCGCAGACCGACTACCGGGCCCTGCTCGAGTTCTTCTTCCAGATCCACGATCCGACGACG
AAGAACCGTCAGGGCAACGACGTCGGCACCAGCTACCGGTCGGCCATCTTCTACGTCGACGACGAGCAGAAGCGCGTCGC
GCTCGACACCATCGCCGACGTGGACGCGTCCGGGCTGTGGCCGGGCAAGGTGGTCACCGAGGTGACCCCGGCCGGTGAGT
TCTGGGAGGCCGAGCCCGAACACCAGGACTACCTGGAGCGGATGCCGTGGGGATACACCTGCCACTTCCCGCGGCCGGAC
TGGAAGCTGCCGAAGCGGGCCGACGCGAAAGCCTGA

Upstream 100 bases:

>100_bases
GCATCAACTCCGCGGCGTTGCGGTTCATCCACCTCGACGACCTCGAGGCGCAAGGATATGGCGAATACAGGACGTTGTTC
ACCAAGGAGGACGCACAGTC

Downstream 100 bases:

>100_bases
TCAGGCCAGCGGCTGGGGCCGGCGGTGCAGGGTGACCTGCCCGCCGGCCTTCGGCGTATAGGCGACCCCGCGTGAGTGCA
CCTTCTCCCCCGGCGCCGTG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MSDHKKAILAGGCFWGMQDLIRKQPGVVSTRVGYTGGQNDHPTYRNHPGHAESIEITYDPAQTDYRALLEFFFQIHDPTT
KNRQGNDVGTSYRSAIFYVDDEQKRVALDTIADVDASGLWPGKVVTEVTPAGEFWEAEPEHQDYLERMPWGYTCHFPRPD
WKLPKRADAKA

Sequences:

>Translated_171_residues
MSDHKKAILAGGCFWGMQDLIRKQPGVVSTRVGYTGGQNDHPTYRNHPGHAESIEITYDPAQTDYRALLEFFFQIHDPTT
KNRQGNDVGTSYRSAIFYVDDEQKRVALDTIADVDASGLWPGKVVTEVTPAGEFWEAEPEHQDYLERMPWGYTCHFPRPD
WKLPKRADAKA
>Mature_170_residues
SDHKKAILAGGCFWGMQDLIRKQPGVVSTRVGYTGGQNDHPTYRNHPGHAESIEITYDPAQTDYRALLEFFFQIHDPTTK
NRQGNDVGTSYRSAIFYVDDEQKRVALDTIADVDASGLWPGKVVTEVTPAGEFWEAEPEHQDYLERMPWGYTCHFPRPDW
KLPKRADAKA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=37.1794871794872, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=37.1794871794872, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=37.962962962963, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=44, Blast_Score=120, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=144, Percent_Identity=38.1944444444444, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=170, Percent_Identity=37.6470588235294, Blast_Score=104, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=37.5886524822695, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.2352941176471, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=36.1702127659575, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19443; Mature: 19312

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHKKAILAGGCFWGMQDLIRKQPGVVSTRVGYTGGQNDHPTYRNHPGHAESIEITYDP
CCCCCCEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
AQTDYRALLEFFFQIHDPTTKNRQGNDVGTSYRSAIFYVDDEQKRVALDTIADVDASGLW
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEHHHHHCCCCCCCC
PGKVVTEVTPAGEFWEAEPEHQDYLERMPWGYTCHFPRPDWKLPKRADAKA
CCCEEEEECCCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDHKKAILAGGCFWGMQDLIRKQPGVVSTRVGYTGGQNDHPTYRNHPGHAESIEITYDP
CCCCCEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
AQTDYRALLEFFFQIHDPTTKNRQGNDVGTSYRSAIFYVDDEQKRVALDTIADVDASGLW
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEHHHHHCCCCCCCC
PGKVVTEVTPAGEFWEAEPEHQDYLERMPWGYTCHFPRPDWKLPKRADAKA
CCCEEEEECCCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA