Click here to switch to the map view.

The map label for this gene is tipA [H]

Identifier: 119871170

GI number: 119871170

Start: 5389076

End: 5389831

Strand: Direct

Name: tipA [H]

Synonym: Mkms_5143

Alternate gene names: 119871170

Gene position: 5389076-5389831 (Clockwise)

Preceding gene: 119871169

Following gene: 119871171

Centisome position: 93.93

GC content: 68.78

Gene sequence:

>756_bases
ATGCAAGCCAGCACGGTCGGTACGGTCGCCGCGCTCACCGGTGTCTCGGTGCGCACGCTGCATCACTACGACCACATCGG
TCTGGTGGTGCCCAGCGTCCGCACCGCGGCCGGGTACCGCGGGTACACCGACGCCGATGTCGAACGACTGCACCTCGTGC
TGGTGTACCGGTCGGTGGGCCTGCCACTCGAGGAGATCCGCACGCTGCTCGACGATCCGCAGGCCGACATCCTCGCCCGG
CTCGAACGTCAGCTCGAGCTGTTGCACGAACGCGCCGACCGCATCCGGCACACCATCAAGTCAGTGGAGGAACTGATGAA
CGCGCACCGCGACGGAATCCAGCTGACCGCCCAGGAGCAGGTCGAGATCTTCGGCAGCGTCGTGCACACCGACGACTACG
CCGCCGAGGCGCAACAGCGCTGGGGTGACACCGAGGCCTGGCGCCAGTCCCGGCAGCGCACTGCCCGGATGAGCAAGCAG
GACTGGATCGAGGTCCGCGACGAAGGCGAGGTGCTGCTGGCCGATCTCGCGGCGGCGAAACGCGACGGGATCGCGCCGGG
CAGCCCGGAGGCCGACCGGCTCGCCGCGCGGCACCGCGCCTCGATCGAGCGGTTCTACGACTGCGACGACGCGATGCAGC
TGTGCCTGGTGGAGATGTACCTGGCCGACGAACGCTTCACCCGCCACTACGACGACCGCGAGCCGGGGCTGGCCCGGTAT
CTGCACGATGTGGTCGTCGCTAGCATCGAGCGGTGA

Upstream 100 bases:

>100_bases
GGTGGCAACCGCCGTCCTCGTCCTGCTCGCCGTCCTCGTCGCCCGCCGCCGCTGATTTTCCCTTGACCCTGACGCCACGT
CAGGGTGCAAGGTGGCGTAC

Downstream 100 bases:

>100_bases
CCATCGAACCGCGCGCCACCGCCGACCTCGTCGACGACATCGGACCCGACGTCCGCAGTTGTGATCTGCAGCTTCGCCAG
TTCGGCAGGCGACCGGAATT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MQASTVGTVAALTGVSVRTLHHYDHIGLVVPSVRTAAGYRGYTDADVERLHLVLVYRSVGLPLEEIRTLLDDPQADILAR
LERQLELLHERADRIRHTIKSVEELMNAHRDGIQLTAQEQVEIFGSVVHTDDYAAEAQQRWGDTEAWRQSRQRTARMSKQ
DWIEVRDEGEVLLADLAAAKRDGIAPGSPEADRLAARHRASIERFYDCDDAMQLCLVEMYLADERFTRHYDDREPGLARY
LHDVVVASIER

Sequences:

>Translated_251_residues
MQASTVGTVAALTGVSVRTLHHYDHIGLVVPSVRTAAGYRGYTDADVERLHLVLVYRSVGLPLEEIRTLLDDPQADILAR
LERQLELLHERADRIRHTIKSVEELMNAHRDGIQLTAQEQVEIFGSVVHTDDYAAEAQQRWGDTEAWRQSRQRTARMSKQ
DWIEVRDEGEVLLADLAAAKRDGIAPGSPEADRLAARHRASIERFYDCDDAMQLCLVEMYLADERFTRHYDDREPGLARY
LHDVVVASIER
>Mature_251_residues
MQASTVGTVAALTGVSVRTLHHYDHIGLVVPSVRTAAGYRGYTDADVERLHLVLVYRSVGLPLEEIRTLLDDPQADILAR
LERQLELLHERADRIRHTIKSVEELMNAHRDGIQLTAQEQVEIFGSVVHTDDYAAEAQQRWGDTEAWRQSRQRTARMSKQ
DWIEVRDEGEVLLADLAAAKRDGIAPGSPEADRLAARHRASIERFYDCDDAMQLCLVEMYLADERFTRHYDDREPGLARY
LHDVVVASIER

Specific function: Transcriptional activator. Is activated when bound to the antibiotic thiostrepton [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 28552; Mature: 28552

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQASTVGTVAALTGVSVRTLHHYDHIGLVVPSVRTAAGYRGYTDADVERLHLVLVYRSVG
CCCCHHHHHHHHHCCHHHHHHHHCCHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHC
LPLEEIRTLLDDPQADILARLERQLELLHERADRIRHTIKSVEELMNAHRDGIQLTAQEQ
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHH
VEIFGSVVHTDDYAAEAQQRWGDTEAWRQSRQRTARMSKQDWIEVRDEGEVLLADLAAAK
HHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHH
RDGIAPGSPEADRLAARHRASIERFYDCDDAMQLCLVEMYLADERFTRHYDDREPGLARY
HCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LHDVVVASIER
HHHHHHHHCCC
>Mature Secondary Structure
MQASTVGTVAALTGVSVRTLHHYDHIGLVVPSVRTAAGYRGYTDADVERLHLVLVYRSVG
CCCCHHHHHHHHHCCHHHHHHHHCCHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHC
LPLEEIRTLLDDPQADILARLERQLELLHERADRIRHTIKSVEELMNAHRDGIQLTAQEQ
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHH
VEIFGSVVHTDDYAAEAQQRWGDTEAWRQSRQRTARMSKQDWIEVRDEGEVLLADLAAAK
HHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHH
RDGIAPGSPEADRLAARHRASIERFYDCDDAMQLCLVEMYLADERFTRHYDDREPGLARY
HCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LHDVVVASIER
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]