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The map label for this gene is tcyB [H]

Identifier: 119871057

GI number: 119871057

Start: 5270132

End: 5271601

Strand: Direct

Name: tcyB [H]

Synonym: Mkms_5030

Alternate gene names: 119871057

Gene position: 5270132-5271601 (Clockwise)

Preceding gene: 119871056

Following gene: 119871058

Centisome position: 91.86

GC content: 67.55

Gene sequence:

>1470_bases
GTGAGGTTTCTTCGGGCGCTCCTGCTGCTGCTCGCCGTCCTGACCGTGGCGTCCTGCGCATCGGCGGATGACGGCAGCGA
CGAGCCGATCAAGTCGGCGGGCGTGCTGCGGGTCGGCACCGAGGGGGTGTACGCCCCGTTCAGCTATCACGACGCCTCCG
GTCAACTGGTCGGCTACGACGTCGACGTGGCGCGCGCGGTGGCCGACAAGATCGGAGTGCGCGCCGAGTTCGTGGAGACG
CCGTGGGACGCGATGTTCGCCGCCCTGGAGGCGGGCCGGTTCGACGTGGTCGCCAACGAGGTGACCATCAACGCCGAGCG
GCGGGCGAAATACGACCTGTCACAACCGTATTCGGTGGGCGAGGGAGTGATCGTCACCCGCGCCGACGACGATTCGATCA
CCACGCTCGACGATCTCGCGGGCAAGGTCGCCGCCGAGAACGCGACCAGCAACTGGTCGGAGGTCGCGCGTGAGGCCGGG
GCGCGGGTGGAGGCCGTGGAGGGTTTCACCCAGGCCATCACGCTGCTCAATCAGGGCCGGGTCGACGTCGTCGTCAACGA
CAGCATCGCGGTGTACGCCTACCTCGCCGAAACGGGCGACACCTCGGTGAAGATCGCGGGCACGGTCGGTGAGAAGAGCG
AACAGGGCTTCGCCGCCCGCAAGGACAGCGGCCTGCTGCCCGAACTCAACCGGGCACTCGACGAACTGCGCGCCGACGGC
ACGCTTGCCGAGATCTCCCAGCGGTACCTCAAGGCCAACGCCTCAGGTGCGCCGGAGTCCGATCAAGCGGACACCGCGGG
CGCTCCCCGTTCCACGTGGCAGCTGATCCTCGACAACCTGTGGCCGCTCGCGCGGGCGGCGCTGACGATGACGATCCCGC
TGACAGTCATCAGCTTCGCTATCGGTCTGGTGATCGCGCTCGGGGTCGCGCTGGCCCGGTTGTCGCCGAATGTGGTGCTG
ACCAACGTCGCCCGCTTCTATATCTCGATCATCCGCGGCACCCCACTGCTCGTGCAGTTGTTCATCGTGTTCTTCGCGCT
GCCGGAGTTCGGGATCCGGATCGACCCGTTCCCGGCGGCGGTGATCGCGTTCTCGCTCAACGTCGGCGGGTACGCCGCCG
AGATCATCCGCTCGGCGATCCTGTCCATCCCGAAGGGTCAGTGGGAGGCCGCCGAGACGATCGGCATGAACTACCCGACG
TCGCTGCGCCGCATCGTGCTGCCGCAGGCCGCCCGGGTGGCCGTACCGCCGCTGTCGAACACGCTGATCTCCCTGGTCAA
GGACACCTCACTGGCGTCGACCATCCTGGTGACCGAACTGCTGCGGCAGGCGCAGATCGTCGCGGCCCCGACGTTCGAGT
TCTTCGCGCTGTACGGCACCGCCGCGGTGTACTACTGGGTGATCTGCCTGGTGTTGTCGTTCGGTCAGGGCCGCATCGAG
CGCCGGCTGGAAAGGTACGTGGCGAGATGA

Upstream 100 bases:

>100_bases
CGGAGTTCGACCCGGCCCGGCTGCCGCGGCACCCGTGGATATACGTGCCGGACTGATCGGAACCCTTCTGTGGCGGCGGC
GGGCTTGTTAGCGTCCGCCG

Downstream 100 bases:

>100_bases
CCGAGGATCGGGTGGTCGCCGAGGGTTTGCACAAGGCCTTCGGCGACAACGAAGTGCTCAAAGGGGTGTCGTTCCGGGTG
CCGGCAGGGTCGGTGACCAC

Product: polar amino acid ABC transporter inner membrane subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MRFLRALLLLLAVLTVASCASADDGSDEPIKSAGVLRVGTEGVYAPFSYHDASGQLVGYDVDVARAVADKIGVRAEFVET
PWDAMFAALEAGRFDVVANEVTINAERRAKYDLSQPYSVGEGVIVTRADDDSITTLDDLAGKVAAENATSNWSEVAREAG
ARVEAVEGFTQAITLLNQGRVDVVVNDSIAVYAYLAETGDTSVKIAGTVGEKSEQGFAARKDSGLLPELNRALDELRADG
TLAEISQRYLKANASGAPESDQADTAGAPRSTWQLILDNLWPLARAALTMTIPLTVISFAIGLVIALGVALARLSPNVVL
TNVARFYISIIRGTPLLVQLFIVFFALPEFGIRIDPFPAAVIAFSLNVGGYAAEIIRSAILSIPKGQWEAAETIGMNYPT
SLRRIVLPQAARVAVPPLSNTLISLVKDTSLASTILVTELLRQAQIVAAPTFEFFALYGTAAVYYWVICLVLSFGQGRIE
RRLERYVAR

Sequences:

>Translated_489_residues
MRFLRALLLLLAVLTVASCASADDGSDEPIKSAGVLRVGTEGVYAPFSYHDASGQLVGYDVDVARAVADKIGVRAEFVET
PWDAMFAALEAGRFDVVANEVTINAERRAKYDLSQPYSVGEGVIVTRADDDSITTLDDLAGKVAAENATSNWSEVAREAG
ARVEAVEGFTQAITLLNQGRVDVVVNDSIAVYAYLAETGDTSVKIAGTVGEKSEQGFAARKDSGLLPELNRALDELRADG
TLAEISQRYLKANASGAPESDQADTAGAPRSTWQLILDNLWPLARAALTMTIPLTVISFAIGLVIALGVALARLSPNVVL
TNVARFYISIIRGTPLLVQLFIVFFALPEFGIRIDPFPAAVIAFSLNVGGYAAEIIRSAILSIPKGQWEAAETIGMNYPT
SLRRIVLPQAARVAVPPLSNTLISLVKDTSLASTILVTELLRQAQIVAAPTFEFFALYGTAAVYYWVICLVLSFGQGRIE
RRLERYVAR
>Mature_489_residues
MRFLRALLLLLAVLTVASCASADDGSDEPIKSAGVLRVGTEGVYAPFSYHDASGQLVGYDVDVARAVADKIGVRAEFVET
PWDAMFAALEAGRFDVVANEVTINAERRAKYDLSQPYSVGEGVIVTRADDDSITTLDDLAGKVAAENATSNWSEVAREAG
ARVEAVEGFTQAITLLNQGRVDVVVNDSIAVYAYLAETGDTSVKIAGTVGEKSEQGFAARKDSGLLPELNRALDELRADG
TLAEISQRYLKANASGAPESDQADTAGAPRSTWQLILDNLWPLARAALTMTIPLTVISFAIGLVIALGVALARLSPNVVL
TNVARFYISIIRGTPLLVQLFIVFFALPEFGIRIDPFPAAVIAFSLNVGGYAAEIIRSAILSIPKGQWEAAETIGMNYPT
SLRRIVLPQAARVAVPPLSNTLISLVKDTSLASTILVTELLRQAQIVAAPTFEFFALYGTAAVYYWVICLVLSFGQGRIE
RRLERYVAR

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788226, Length=212, Percent_Identity=51.8867924528302, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788228, Length=258, Percent_Identity=35.2713178294574, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1787030, Length=205, Percent_Identity=43.4146341463415, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787087, Length=237, Percent_Identity=32.0675105485232, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788645, Length=208, Percent_Identity=35.0961538461538, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1787086, Length=211, Percent_Identity=30.8056872037915, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082239, Length=276, Percent_Identity=29.3478260869565, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786874, Length=172, Percent_Identity=30.2325581395349, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788648, Length=234, Percent_Identity=27.3504273504274, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787085, Length=225, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788649, Length=235, Percent_Identity=28.0851063829787, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786873, Length=218, Percent_Identity=30.7339449541284, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788646, Length=211, Percent_Identity=29.3838862559242, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787088, Length=232, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1787031, Length=248, Percent_Identity=26.2096774193548, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI48994930, Length=77, Percent_Identity=42.8571428571429, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 52478; Mature: 52478

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50928 ABC_TM1 ; PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLRALLLLLAVLTVASCASADDGSDEPIKSAGVLRVGTEGVYAPFSYHDASGQLVGYD
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEECCCEEECCCCCEEEEC
VDVARAVADKIGVRAEFVETPWDAMFAALEAGRFDVVANEVTINAERRAKYDLSQPYSVG
HHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCEEEEEEEEEECHHHHCCCCCCCCCCCC
EGVIVTRADDDSITTLDDLAGKVAAENATSNWSEVAREAGARVEAVEGFTQAITLLNQGR
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
VDVVVNDSIAVYAYLAETGDTSVKIAGTVGEKSEQGFAARKDSGLLPELNRALDELRADG
EEEEECCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
TLAEISQRYLKANASGAPESDQADTAGAPRSTWQLILDNLWPLARAALTMTIPLTVISFA
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLVIALGVALARLSPNVVLTNVARFYISIIRGTPLLVQLFIVFFALPEFGIRIDPFPAA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCE
VIAFSLNVGGYAAEIIRSAILSIPKGQWEAAETIGMNYPTSLRRIVLPQAARVAVPPLSN
EEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHCCCHHHEECCCHHH
TLISLVKDTSLASTILVTELLRQAQIVAAPTFEFFALYGTAAVYYWVICLVLSFGQGRIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RRLERYVAR
HHHHHHHCC
>Mature Secondary Structure
MRFLRALLLLLAVLTVASCASADDGSDEPIKSAGVLRVGTEGVYAPFSYHDASGQLVGYD
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEECCCEEECCCCCEEEEC
VDVARAVADKIGVRAEFVETPWDAMFAALEAGRFDVVANEVTINAERRAKYDLSQPYSVG
HHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCEEEEEEEEEECHHHHCCCCCCCCCCCC
EGVIVTRADDDSITTLDDLAGKVAAENATSNWSEVAREAGARVEAVEGFTQAITLLNQGR
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
VDVVVNDSIAVYAYLAETGDTSVKIAGTVGEKSEQGFAARKDSGLLPELNRALDELRADG
EEEEECCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
TLAEISQRYLKANASGAPESDQADTAGAPRSTWQLILDNLWPLARAALTMTIPLTVISFA
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLVIALGVALARLSPNVVLTNVARFYISIIRGTPLLVQLFIVFFALPEFGIRIDPFPAA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCE
VIAFSLNVGGYAAEIIRSAILSIPKGQWEAAETIGMNYPTSLRRIVLPQAARVAVPPLSN
EEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHCCCHHHEECCCHHH
TLISLVKDTSLASTILVTELLRQAQIVAAPTFEFFALYGTAAVYYWVICLVLSFGQGRIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RRLERYVAR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]