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The map label for this gene is ape2 [H]

Identifier: 119870901

GI number: 119870901

Start: 5104332

End: 5105660

Strand: Direct

Name: ape2 [H]

Synonym: Mkms_4873

Alternate gene names: 119870901

Gene position: 5104332-5105660 (Clockwise)

Preceding gene: 119870900

Following gene: 119870902

Centisome position: 88.97

GC content: 66.59

Gene sequence:

>1329_bases
GTGACGCGGTCGAAGAAGGGGAAGAACACCCCGGCCGTCATCGACCCCTATCTGCCCGAGACCGGCAACTTCGGGTACCG
GGTGTCGCGGTACGAACTCGACCTGGAGTACAAGGTCGCGATCAACCGGTTGTCGGGTTCGGCGTCGATCACGGCCGTCA
CGCTGGCCGCGCTGCGCACCTTCACCCTGGATCTGGCCGACACCCTGCGGGTGACGAAGGTGGCGGTCAACGGCCGCCGA
CCCGCCCGGTTCTCCTGTGCGAACGACAAGCTGCGGGTCGAGTTGTCCTCGGCGTTGCCTGCGGGCGCGGCGCTGGTCGT
GGAGGTCCGGTACGGCGGCACCCCCGAGCCGATCGAAACCCTCTGGGGTGACGTCGGTTTCGAGGAGCTGACGAACGGGG
CGCTGGTCGCGGGGCAGCCCAACGGCGCGTCCTCGTGGTTCCCGTGCGACGACCACCCCAGCGCGAAGGCCAGCTACCGC
ATCCAGATCAGCACCGACAGCCCGTACCGCGCGATCGCCAACGGCGAGTTGGTGTCCCGCCGCGCCAGGGCGGGTCACAC
CGTGTGGACCTACGAGCAGGCCGAACCGACGTCGACGTACCTGATCACGTTGCAGATCGGCATGTACGACGTGCACAAGC
TGGCGAAGTCGCCGGTGCCCATCCAGGCCGCCCTTCCGGCCCGGCTGCGGAGCAACTTCGACCACAGCTTCGGCCGCCAA
CCACAGATGATGAAACTGTTCGAGAAGCTGTTCGGACCGTACCCGCTGGCGAGTGGCTACACCGTGGTGGTCACCGACGA
CGCCCTCGAGATACCCCTTGAGGCACAAGGTATTTCGATTTTCGGCGCCAACCATTGCGACGGCACTCGAAGGGCCGAGC
GGTTGATCGCGCACGAGTTGGCCCACCAGTGGTTCGGCAACTCGGTCACCGTGCGTCGGTGGCGCGACATCTGGCTGCAC
GAGGGTTTCGCGTGTTACGCGGAGTGGTTGTGGTCGGAGAACTCCGGCGGCCGCAGCGCCGACGAATGGGCCCACCACTA
TCACGGACGGCTGACCGATCTGCCCCAGGACCTCCTGCTCGCCGACCCCGGTCCGAAGGACATGTTTGACGACCGGGTGT
ACAAACGCGGCGCGCTGACACTGCACGTGCTGCGCACCCGCATCGGCGACGAGAAGTTCTTCGCCCTGCTGCGGGACTGG
ACGGCGCGACACCGTCACAGCACCGCGTTCACCGACGACTTCACCGGTCTGGCAGCCAATTACGCCGACGAGTCACTGCG
CCCGCTGTGGGATGCCTGGCTCTACGCCGAGGATCTGCCGAAGCTGTGA

Upstream 100 bases:

>100_bases
AGGGCAATCCGATCGCGCCGTGGAATCCGTTGCGCAAGAAGCGCGGCGAGGCGCCGGCGAAGAAGAAGAAGGCCGCCCGT
GACCCCGAGGACTCGGCCGC

Downstream 100 bases:

>100_bases
CCGACGCGGCGCCGTCGACCGGCCCGGTCACGCGGAGCAGCGTGGCGCGGGTCGGCATCGCGACGGCCGTGACCGCGCTG
TGCGGCTACGCGGTGCTCTA

Product: peptidase M1, membrane alanine aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTRSKKGKNTPAVIDPYLPETGNFGYRVSRYELDLEYKVAINRLSGSASITAVTLAALRTFTLDLADTLRVTKVAVNGRR
PARFSCANDKLRVELSSALPAGAALVVEVRYGGTPEPIETLWGDVGFEELTNGALVAGQPNGASSWFPCDDHPSAKASYR
IQISTDSPYRAIANGELVSRRARAGHTVWTYEQAEPTSTYLITLQIGMYDVHKLAKSPVPIQAALPARLRSNFDHSFGRQ
PQMMKLFEKLFGPYPLASGYTVVVTDDALEIPLEAQGISIFGANHCDGTRRAERLIAHELAHQWFGNSVTVRRWRDIWLH
EGFACYAEWLWSENSGGRSADEWAHHYHGRLTDLPQDLLLADPGPKDMFDDRVYKRGALTLHVLRTRIGDEKFFALLRDW
TARHRHSTAFTDDFTGLAANYADESLRPLWDAWLYAEDLPKL

Sequences:

>Translated_442_residues
MTRSKKGKNTPAVIDPYLPETGNFGYRVSRYELDLEYKVAINRLSGSASITAVTLAALRTFTLDLADTLRVTKVAVNGRR
PARFSCANDKLRVELSSALPAGAALVVEVRYGGTPEPIETLWGDVGFEELTNGALVAGQPNGASSWFPCDDHPSAKASYR
IQISTDSPYRAIANGELVSRRARAGHTVWTYEQAEPTSTYLITLQIGMYDVHKLAKSPVPIQAALPARLRSNFDHSFGRQ
PQMMKLFEKLFGPYPLASGYTVVVTDDALEIPLEAQGISIFGANHCDGTRRAERLIAHELAHQWFGNSVTVRRWRDIWLH
EGFACYAEWLWSENSGGRSADEWAHHYHGRLTDLPQDLLLADPGPKDMFDDRVYKRGALTLHVLRTRIGDEKFFALLRDW
TARHRHSTAFTDDFTGLAANYADESLRPLWDAWLYAEDLPKL
>Mature_441_residues
TRSKKGKNTPAVIDPYLPETGNFGYRVSRYELDLEYKVAINRLSGSASITAVTLAALRTFTLDLADTLRVTKVAVNGRRP
ARFSCANDKLRVELSSALPAGAALVVEVRYGGTPEPIETLWGDVGFEELTNGALVAGQPNGASSWFPCDDHPSAKASYRI
QISTDSPYRAIANGELVSRRARAGHTVWTYEQAEPTSTYLITLQIGMYDVHKLAKSPVPIQAALPARLRSNFDHSFGRQP
QMMKLFEKLFGPYPLASGYTVVVTDDALEIPLEAQGISIFGANHCDGTRRAERLIAHELAHQWFGNSVTVRRWRDIWLHE
GFACYAEWLWSENSGGRSADEWAHHYHGRLTDLPQDLLLADPGPKDMFDDRVYKRGALTLHVLRTRIGDEKFFALLRDWT
ARHRHSTAFTDDFTGLAANYADESLRPLWDAWLYAEDLPKL

Specific function: Preferentially acts as a leucyl-aminopeptidase, although it also has activity against other substrates [H]

COG id: COG0308

COG function: function code E; Aminopeptidase N

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M1 family [H]

Homologues:

Organism=Homo sapiens, GI94818891, Length=299, Percent_Identity=27.7591973244147, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI94818901, Length=299, Percent_Identity=27.7591973244147, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4505029, Length=437, Percent_Identity=24.4851258581236, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI61742777, Length=419, Percent_Identity=23.3890214797136, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI61742775, Length=419, Percent_Identity=23.3890214797136, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI132814467, Length=335, Percent_Identity=25.3731343283582, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI194306629, Length=315, Percent_Identity=27.3015873015873, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI11641261, Length=315, Percent_Identity=27.3015873015873, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI158937236, Length=336, Percent_Identity=24.1071428571429, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI310123622, Length=305, Percent_Identity=25.2459016393443, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310133497, Length=305, Percent_Identity=24.9180327868852, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI40316915, Length=302, Percent_Identity=24.8344370860927, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI194239713, Length=393, Percent_Identity=24.4274809160305, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI7019561, Length=310, Percent_Identity=26.4516129032258, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI157266300, Length=207, Percent_Identity=29.4685990338164, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4507347, Length=226, Percent_Identity=25.6637168141593, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1787163, Length=292, Percent_Identity=25.6849315068493, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533278, Length=459, Percent_Identity=23.9651416122004, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI115533276, Length=459, Percent_Identity=23.9651416122004, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71984339, Length=448, Percent_Identity=23.8839285714286, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71984353, Length=449, Percent_Identity=24.2761692650334, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193206928, Length=402, Percent_Identity=23.6318407960199, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193206926, Length=402, Percent_Identity=23.6318407960199, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71989071, Length=323, Percent_Identity=22.6006191950464, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71989076, Length=323, Percent_Identity=22.6006191950464, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI133903840, Length=324, Percent_Identity=25, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17544504, Length=400, Percent_Identity=23.25, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17569221, Length=205, Percent_Identity=27.8048780487805, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569225, Length=187, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI9755335, Length=329, Percent_Identity=25.8358662613982, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321837, Length=332, Percent_Identity=24.0963855421687, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322054, Length=485, Percent_Identity=23.2989690721649, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324283, Length=329, Percent_Identity=24.3161094224924, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24651025, Length=303, Percent_Identity=27.3927392739274, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24651023, Length=303, Percent_Identity=27.3927392739274, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24651021, Length=303, Percent_Identity=27.3927392739274, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24651016, Length=282, Percent_Identity=28.3687943262411, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646514, Length=303, Percent_Identity=25.0825082508251, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646518, Length=303, Percent_Identity=25.0825082508251, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646516, Length=303, Percent_Identity=25.0825082508251, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21358341, Length=301, Percent_Identity=26.578073089701, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24646512, Length=463, Percent_Identity=23.7580993520518, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646510, Length=463, Percent_Identity=23.7580993520518, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550350, Length=429, Percent_Identity=25.1748251748252, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585062, Length=429, Percent_Identity=25.1748251748252, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585064, Length=429, Percent_Identity=25.1748251748252, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585066, Length=429, Percent_Identity=25.1748251748252, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650973, Length=286, Percent_Identity=27.972027972028, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550850, Length=286, Percent_Identity=27.972027972028, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161078673, Length=491, Percent_Identity=23.0142566191446, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571901, Length=485, Percent_Identity=23.0927835051546, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24655274, Length=391, Percent_Identity=21.9948849104859, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24655260, Length=391, Percent_Identity=21.9948849104859, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24655265, Length=391, Percent_Identity=21.9948849104859, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24655268, Length=391, Percent_Identity=21.9948849104859, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24655257, Length=391, Percent_Identity=21.9948849104859, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24655252, Length=391, Percent_Identity=21.9948849104859, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI221330574, Length=321, Percent_Identity=25.2336448598131, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281362224, Length=320, Percent_Identity=26.5625, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI221458256, Length=320, Percent_Identity=26.5625, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641062, Length=318, Percent_Identity=24.2138364779874, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001930
- InterPro:   IPR014782 [H]

Pfam domain/function: PF01433 Peptidase_M1 [H]

EC number: =3.4.11.1 [H]

Molecular weight: Translated: 49481; Mature: 49350

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSKKGKNTPAVIDPYLPETGNFGYRVSRYELDLEYKVAINRLSGSASITAVTLAALRT
CCCCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHH
FTLDLADTLRVTKVAVNGRRPARFSCANDKLRVELSSALPAGAALVVEVRYGGTPEPIET
HHHHHHHHHEEEEEEECCCCCCEEECCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHH
LWGDVGFEELTNGALVAGQPNGASSWFPCDDHPSAKASYRIQISTDSPYRAIANGELVSR
HHCCCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCHHHHH
RARAGHTVWTYEQAEPTSTYLITLQIGMYDVHKLAKSPVPIQAALPARLRSNFDHSFGRQ
HHHCCCEEEEECCCCCCEEEEEEEEECHHHHHHHHCCCCCEEECCCHHHHCCCCHHCCCC
PQMMKLFEKLFGPYPLASGYTVVVTDDALEIPLEAQGISIFGANHCDGTRRAERLIAHEL
CHHHHHHHHHCCCCCCCCCCEEEEECCCEECCEEECCEEEEECCCCCHHHHHHHHHHHHH
AHQWFGNSVTVRRWRDIWLHEGFACYAEWLWSENSGGRSADEWAHHYHGRLTDLPQDLLL
HHHHCCCCEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHEE
ADPGPKDMFDDRVYKRGALTLHVLRTRIGDEKFFALLRDWTARHRHSTAFTDDFTGLAAN
CCCCCCHHHHHHHHHCCCCEEEHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
YADESLRPLWDAWLYAEDLPKL
CCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRSKKGKNTPAVIDPYLPETGNFGYRVSRYELDLEYKVAINRLSGSASITAVTLAALRT
CCCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHH
FTLDLADTLRVTKVAVNGRRPARFSCANDKLRVELSSALPAGAALVVEVRYGGTPEPIET
HHHHHHHHHEEEEEEECCCCCCEEECCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHH
LWGDVGFEELTNGALVAGQPNGASSWFPCDDHPSAKASYRIQISTDSPYRAIANGELVSR
HHCCCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCHHHHH
RARAGHTVWTYEQAEPTSTYLITLQIGMYDVHKLAKSPVPIQAALPARLRSNFDHSFGRQ
HHHCCCEEEEECCCCCCEEEEEEEEECHHHHHHHHCCCCCEEECCCHHHHCCCCHHCCCC
PQMMKLFEKLFGPYPLASGYTVVVTDDALEIPLEAQGISIFGANHCDGTRRAERLIAHEL
CHHHHHHHHHCCCCCCCCCCEEEEECCCEECCEEECCEEEEECCCCCHHHHHHHHHHHHH
AHQWFGNSVTVRRWRDIWLHEGFACYAEWLWSENSGGRSADEWAHHYHGRLTDLPQDLLL
HHHHCCCCEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHEE
ADPGPKDMFDDRVYKRGALTLHVLRTRIGDEKFFALLRDWTARHRHSTAFTDDFTGLAAN
CCCCCCHHHHHHHHHCCCCEEEHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
YADESLRPLWDAWLYAEDLPKL
CCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9723917; 8899719; 11427726 [H]