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The map label for this gene is caiC [H]

Identifier: 119870741

GI number: 119870741

Start: 4936111

End: 4937613

Strand: Direct

Name: caiC [H]

Synonym: Mkms_4712

Alternate gene names: 119870741

Gene position: 4936111-4937613 (Clockwise)

Preceding gene: 119870740

Following gene: 119870745

Centisome position: 86.04

GC content: 69.66

Gene sequence:

>1503_bases
GTGGGTGCGGATCCGACGGTCGCAAATCTGCTGCGGCCGTTGGCCGATGTCGACGACCGCGGGATCCACGCCGACGGTGA
GTTCGCCAGCTGGCGTGAGCACATCCGGTCCGCGGCCGCGGTCGGGGCGGCGCTGCGGGGGCGGCTGGATCCGGCCACGC
CGCCACATGTCGGGGTGCTGCTGGGCAACACGCCGTTCTTCTCCAGGGTGCTGGTGGCCGCCGCGCTCGCCGGCCTGGTG
CCGGTCGGGCTGAACCCGACCCGGCGCGGGGAGGCGCTGGTCCGCGACATCGAACACGCCGATTGCCAGGTGGTGCTCAC
CGACGACCCGACCGGGGTGCCCGACGGAGTGGAGTTCATCGACGTCGAATCCGCGCACTGGCGTGCGGAGTTGGCCGCGT
ACGCCGACACCCCCGTCCGTTTCGCTGATCCGGATCCCGATGACCTGTTCATGTTGATCTTCACCTCGGGCACGAGCGGC
GAACCCAAGGCGGTGCGGGTGACCCACGAGAAGGTGGCGGTGCCGGGGCGGATGCTGGCCGCCCGCTTCGGCCTCGGGCC
GTCGGACACCTGCTACCTGTCGATGCCGCTGTTCCACTCCAACGCCGTGATGGCCGGCTGGTCGGTGGGAGTGGCGGCGG
GCGCATCGCTCGCGTTGCGCCGGAAGTTCTCGGCGTCTCAGTTCATTCCCGATGTCCGTCGGTACCACGCGACGTACGCG
AACTACGTCGGCAAGCCGCTGTCGTACATCCTCGCGACACCGCCGCGCGACGACGATGCGGACAACCCCCTGAAGATCAT
GTACGGCAACGAGGGCGCACCGCGCGATCTCGACCGGTTCGCGCGGCGGTTCGGGGTGACCGTCGTCGACGGCTTCGGAT
CCACCGAGGGCGGTGTGGCGATCGCCAGGACACCCGACACCCCCGAGGGATCACTGGGGCCGCTGGGCCCCGACATCGCG
ATCGTCGATGTCGAGACCGGCGAGCGTTGTGCCCCAGGGCAGGTGGGCGAGTTGATCAACCCCAACGGGCGCGGCCAGTT
CCGCGGCTACTACAACGACACCGCGGCCGAGGCCGAGCGGATGGCCGGCGGCATGTACCACAGCGGAGACCTGGCGTACC
GCGACGAGAACGGGTTCATCTACTTCGCGGGCCGCCTCGGGGACTGGATGCGAGTCGACGGGGAGAACCTGGGAACGGCG
CCGATCGAGCGAGTCCTCCTGCGCCACAACGATGTCGTCGAGGTGGCCGTCTATCCGGTTCCGGACCCCGCGGTGGGCGA
CCGGGTGATGGCGGCCCTCGTGTTGCGGCCGGGCGCAGAGTTCGCGGTCGAGAAGTTCCAGGCCTTCCTCGCCGAACAGT
CGGACCTGGGGCCGAAACAGTGGCCGTCGTTCGTCCGGGTCAGTTCGAGCCTGCCGCGCACCGAGACGTTCAAGGTGCTC
AAGCGGCACCTGTCGGCAGAGGGCACCGACTGCGCGGATCCGGTCTACCCGATCACCCGCTGA

Upstream 100 bases:

>100_bases
GGTACTTCCTGTCTGCCAAGCAGACCGAGTTCGCGGTCGGCGGCGCGACGGGACAGTTGCTGCGCATCGGGCGCGAGCTG
GCCGACACCCCGGTGTGACC

Downstream 100 bases:

>100_bases
CCCGCGCCCTCGTGGACGAACGGTCCGCGCCACAGGTGCGGCCGGAAACGGCGCACCGCCCGTTCGACCTGCTGGGCCGC
TGCGCCGTACGGCGAGACGG

Product: acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MGADPTVANLLRPLADVDDRGIHADGEFASWREHIRSAAAVGAALRGRLDPATPPHVGVLLGNTPFFSRVLVAAALAGLV
PVGLNPTRRGEALVRDIEHADCQVVLTDDPTGVPDGVEFIDVESAHWRAELAAYADTPVRFADPDPDDLFMLIFTSGTSG
EPKAVRVTHEKVAVPGRMLAARFGLGPSDTCYLSMPLFHSNAVMAGWSVGVAAGASLALRRKFSASQFIPDVRRYHATYA
NYVGKPLSYILATPPRDDDADNPLKIMYGNEGAPRDLDRFARRFGVTVVDGFGSTEGGVAIARTPDTPEGSLGPLGPDIA
IVDVETGERCAPGQVGELINPNGRGQFRGYYNDTAAEAERMAGGMYHSGDLAYRDENGFIYFAGRLGDWMRVDGENLGTA
PIERVLLRHNDVVEVAVYPVPDPAVGDRVMAALVLRPGAEFAVEKFQAFLAEQSDLGPKQWPSFVRVSSSLPRTETFKVL
KRHLSAEGTDCADPVYPITR

Sequences:

>Translated_500_residues
MGADPTVANLLRPLADVDDRGIHADGEFASWREHIRSAAAVGAALRGRLDPATPPHVGVLLGNTPFFSRVLVAAALAGLV
PVGLNPTRRGEALVRDIEHADCQVVLTDDPTGVPDGVEFIDVESAHWRAELAAYADTPVRFADPDPDDLFMLIFTSGTSG
EPKAVRVTHEKVAVPGRMLAARFGLGPSDTCYLSMPLFHSNAVMAGWSVGVAAGASLALRRKFSASQFIPDVRRYHATYA
NYVGKPLSYILATPPRDDDADNPLKIMYGNEGAPRDLDRFARRFGVTVVDGFGSTEGGVAIARTPDTPEGSLGPLGPDIA
IVDVETGERCAPGQVGELINPNGRGQFRGYYNDTAAEAERMAGGMYHSGDLAYRDENGFIYFAGRLGDWMRVDGENLGTA
PIERVLLRHNDVVEVAVYPVPDPAVGDRVMAALVLRPGAEFAVEKFQAFLAEQSDLGPKQWPSFVRVSSSLPRTETFKVL
KRHLSAEGTDCADPVYPITR
>Mature_499_residues
GADPTVANLLRPLADVDDRGIHADGEFASWREHIRSAAAVGAALRGRLDPATPPHVGVLLGNTPFFSRVLVAAALAGLVP
VGLNPTRRGEALVRDIEHADCQVVLTDDPTGVPDGVEFIDVESAHWRAELAAYADTPVRFADPDPDDLFMLIFTSGTSGE
PKAVRVTHEKVAVPGRMLAARFGLGPSDTCYLSMPLFHSNAVMAGWSVGVAAGASLALRRKFSASQFIPDVRRYHATYAN
YVGKPLSYILATPPRDDDADNPLKIMYGNEGAPRDLDRFARRFGVTVVDGFGSTEGGVAIARTPDTPEGSLGPLGPDIAI
VDVETGERCAPGQVGELINPNGRGQFRGYYNDTAAEAERMAGGMYHSGDLAYRDENGFIYFAGRLGDWMRVDGENLGTAP
IERVLLRHNDVVEVAVYPVPDPAVGDRVMAALVLRPGAEFAVEKFQAFLAEQSDLGPKQWPSFVRVSSSLPRTETFKVLK
RHLSAEGTDCADPVYPITR

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=515, Percent_Identity=28.5436893203883, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI13236579, Length=405, Percent_Identity=32.0987654320988, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI40807357, Length=386, Percent_Identity=31.3471502590674, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI62865631, Length=495, Percent_Identity=28.0808080808081, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI13325055, Length=495, Percent_Identity=28.0808080808081, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI38524616, Length=377, Percent_Identity=30.5039787798408, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI13325057, Length=379, Percent_Identity=30.3430079155673, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI227499621, Length=306, Percent_Identity=31.6993464052288, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI42544132, Length=385, Percent_Identity=25.4545454545455, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI58082049, Length=355, Percent_Identity=26.1971830985915, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI157311624, Length=355, Percent_Identity=25.3521126760563, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI157311622, Length=355, Percent_Identity=25.3521126760563, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI156151445, Length=361, Percent_Identity=27.7008310249307, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI115511026, Length=361, Percent_Identity=26.8698060941828, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI122937307, Length=380, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38505220, Length=388, Percent_Identity=26.2886597938144, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI28416953, Length=503, Percent_Identity=24.8508946322068, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI8923896, Length=398, Percent_Identity=25.1256281407035, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI253970489, Length=398, Percent_Identity=25.1256281407035, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI221142682, Length=347, Percent_Identity=27.9538904899135, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI145693145, Length=345, Percent_Identity=27.536231884058, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788107, Length=369, Percent_Identity=26.2872628726287, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786810, Length=356, Percent_Identity=27.8089887640449, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790505, Length=428, Percent_Identity=25.9345794392523, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17551278, Length=496, Percent_Identity=27.8225806451613, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI115534440, Length=488, Percent_Identity=27.8688524590164, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531443, Length=370, Percent_Identity=25.6756756756757, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17558820, Length=343, Percent_Identity=26.2390670553936, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17559526, Length=361, Percent_Identity=27.4238227146814, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17560140, Length=374, Percent_Identity=24.331550802139, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=341, Percent_Identity=24.3401759530792, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982997, Length=470, Percent_Identity=26.3829787234043, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71985884, Length=349, Percent_Identity=26.3610315186246, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=382, Percent_Identity=24.0837696335079, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983001, Length=218, Percent_Identity=32.1100917431193, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319515, Length=414, Percent_Identity=26.3285024154589, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319699, Length=361, Percent_Identity=25.4847645429363, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319264, Length=405, Percent_Identity=24.6913580246914, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=418, Percent_Identity=23.2057416267943, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573631, Length=490, Percent_Identity=27.3469387755102, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20130353, Length=490, Percent_Identity=27.3469387755102, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24583465, Length=487, Percent_Identity=26.694045174538, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24583463, Length=487, Percent_Identity=26.694045174538, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI281364798, Length=487, Percent_Identity=26.694045174538, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI45552801, Length=492, Percent_Identity=27.4390243902439, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45550496, Length=492, Percent_Identity=27.4390243902439, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI18859661, Length=510, Percent_Identity=25.0980392156863, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24581924, Length=527, Percent_Identity=24.0986717267552, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI20130357, Length=357, Percent_Identity=25.4901960784314, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648253, Length=338, Percent_Identity=24.8520710059172, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648260, Length=345, Percent_Identity=24.9275362318841, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355181, Length=347, Percent_Identity=24.207492795389, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648255, Length=337, Percent_Identity=24.0356083086053, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356441, Length=330, Percent_Identity=25.7575757575758, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24653035, Length=343, Percent_Identity=25.6559766763848, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648257, Length=349, Percent_Identity=22.6361031518625, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356947, Length=455, Percent_Identity=25.2747252747253, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281365686, Length=338, Percent_Identity=24.2603550295858, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161076582, Length=350, Percent_Identity=25.7142857142857, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21358303, Length=328, Percent_Identity=26.5243902439024, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 53791; Mature: 53660

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGADPTVANLLRPLADVDDRGIHADGEFASWREHIRSAAAVGAALRGRLDPATPPHVGVL
CCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
LGNTPFFSRVLVAAALAGLVPVGLNPTRRGEALVRDIEHADCQVVLTDDPTGVPDGVEFI
ECCCHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCEEE
DVESAHWRAELAAYADTPVRFADPDPDDLFMLIFTSGTSGEPKAVRVTHEKVAVPGRMLA
ECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEHHHHCCCHHHHH
ARFGLGPSDTCYLSMPLFHSNAVMAGWSVGVAAGASLALRRKFSASQFIPDVRRYHATYA
HHHCCCCCCCEEEEECEEECCCEEECCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHH
NYVGKPLSYILATPPRDDDADNPLKIMYGNEGAPRDLDRFARRFGVTVVDGFGSTEGGVA
HHHCCCCEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCEE
IARTPDTPEGSLGPLGPDIAIVDVETGERCAPGQVGELINPNGRGQFRGYYNDTAAEAER
EEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEECEECCCHHHHHHH
MAGGMYHSGDLAYRDENGFIYFAGRLGDWMRVDGENLGTAPIERVLLRHNDVVEVAVYPV
HHCCCEECCCEEEECCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEC
PDPAVGDRVMAALVLRPGAEFAVEKFQAFLAEQSDLGPKQWPSFVRVSSSLPRTETFKVL
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHCCCCCHHHHHHH
KRHLSAEGTDCADPVYPITR
HHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GADPTVANLLRPLADVDDRGIHADGEFASWREHIRSAAAVGAALRGRLDPATPPHVGVL
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
LGNTPFFSRVLVAAALAGLVPVGLNPTRRGEALVRDIEHADCQVVLTDDPTGVPDGVEFI
ECCCHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCEEE
DVESAHWRAELAAYADTPVRFADPDPDDLFMLIFTSGTSGEPKAVRVTHEKVAVPGRMLA
ECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEHHHHCCCHHHHH
ARFGLGPSDTCYLSMPLFHSNAVMAGWSVGVAAGASLALRRKFSASQFIPDVRRYHATYA
HHHCCCCCCCEEEEECEEECCCEEECCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHH
NYVGKPLSYILATPPRDDDADNPLKIMYGNEGAPRDLDRFARRFGVTVVDGFGSTEGGVA
HHHCCCCEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCEE
IARTPDTPEGSLGPLGPDIAIVDVETGERCAPGQVGELINPNGRGQFRGYYNDTAAEAER
EEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEECEECCCHHHHHHH
MAGGMYHSGDLAYRDENGFIYFAGRLGDWMRVDGENLGTAPIERVLLRHNDVVEVAVYPV
HHCCCEECCCEEEECCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEC
PDPAVGDRVMAALVLRPGAEFAVEKFQAFLAEQSDLGPKQWPSFVRVSSSLPRTETFKVL
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHCCCCCHHHHHHH
KRHLSAEGTDCADPVYPITR
HHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA