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The map label for this gene is fadB [H]

Identifier: 119870424

GI number: 119870424

Start: 4617347

End: 4618114

Strand: Direct

Name: fadB [H]

Synonym: Mkms_4395

Alternate gene names: 119870424

Gene position: 4617347-4618114 (Clockwise)

Preceding gene: 119870423

Following gene: 119870425

Centisome position: 80.48

GC content: 72.79

Gene sequence:

>768_bases
ATGAGCACCCTCGTCCGCTACGCCGTCGACGGCCCCGTCGCCCGGCTGACGCTCGACTCGCCGCAGAACCGCAACGCCCT
GTCGACCGTCCTGGTCGAGCAACTGCACGACGGTCTGCGCAGGGCCGCCGCCGACGCCGGGGTGCGGACCGTCGTGCTCG
GCCACACCGGGGGCACGTTCTGTGCGGGCGCCGATCTGCGGGAGGCCGCCGGACGGGATCCGGGTGACGTCGCGGTCGAC
CGCGCGCGGGAACTCACCGGGACGCTGCGGGCGATCCTCGAGTCGCCGGTGCCGGTGATCGCCGCGATCGACGGTCATGT
GCGGGCCGGCGGACTCGGCCTCGTCGGCGCCTGCGACATCGTGGTCGCCGGGACGGGCAGCACCTTCGCGCTGACCGAGG
CGCGCATCGGCGTCGCGCCGTCGATCATCTCGCTGACGCTGCTGCCGAAGATGACGCCACGGGCGGCGGGCCGGTATTTC
GTGACCGGTGAGACGTTCGGCGCGCAGGAGGCCGAGCGGATCGGACTGGCGACTGTCGCGACCGACGACGTCGAGTCAAC
GGTCGCGGAGCTGGCCGCGCAGATCGGCCGTGGTTCACCGCAGGGGTTGGCGGCCTCGAAGGCGTTGACGACGGCCGCGC
TGTTGCAGGCGTTCGACCGCGACGCCGCCGCGCTGACCGAACAGTCCGCCGCGCTGTTCGTCTCCGAAGAGGCGCGCGAG
GGCATGCTGGCGTTCCTCGAGAAGCGCCCGCCGAGATGGATCGGCTGA

Upstream 100 bases:

>100_bases
CGGTGACCGCGTCCCGGCTCGCGCGCATCGCTCCGGTGAGCCGCGAGATGATCCTCAACTTCGTCGCGCAGACCTCGCTC
GGCCTGCCCCGCTCGTACTG

Downstream 100 bases:

>100_bases
CCGGCCACTGCGCGCGGACGGCCCGTCGCGGCGAACAATGTGGTTGAAATCGCAGCAATCCGGAACGGCCGCGGCACATT
ACACATTCGGCGTCGAATGA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSTLVRYAVDGPVARLTLDSPQNRNALSTVLVEQLHDGLRRAAADAGVRTVVLGHTGGTFCAGADLREAAGRDPGDVAVD
RARELTGTLRAILESPVPVIAAIDGHVRAGGLGLVGACDIVVAGTGSTFALTEARIGVAPSIISLTLLPKMTPRAAGRYF
VTGETFGAQEAERIGLATVATDDVESTVAELAAQIGRGSPQGLAASKALTTAALLQAFDRDAAALTEQSAALFVSEEARE
GMLAFLEKRPPRWIG

Sequences:

>Translated_255_residues
MSTLVRYAVDGPVARLTLDSPQNRNALSTVLVEQLHDGLRRAAADAGVRTVVLGHTGGTFCAGADLREAAGRDPGDVAVD
RARELTGTLRAILESPVPVIAAIDGHVRAGGLGLVGACDIVVAGTGSTFALTEARIGVAPSIISLTLLPKMTPRAAGRYF
VTGETFGAQEAERIGLATVATDDVESTVAELAAQIGRGSPQGLAASKALTTAALLQAFDRDAAALTEQSAALFVSEEARE
GMLAFLEKRPPRWIG
>Mature_254_residues
STLVRYAVDGPVARLTLDSPQNRNALSTVLVEQLHDGLRRAAADAGVRTVVLGHTGGTFCAGADLREAAGRDPGDVAVDR
ARELTGTLRAILESPVPVIAAIDGHVRAGGLGLVGACDIVVAGTGSTFALTEARIGVAPSIISLTLLPKMTPRAAGRYFV
TGETFGAQEAERIGLATVATDDVESTVAELAAQIGRGSPQGLAASKALTTAALLQAFDRDAAALTEQSAALFVSEEAREG
MLAFLEKRPPRWIG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=248, Percent_Identity=28.6290322580645, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI194097323, Length=244, Percent_Identity=28.6885245901639, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4502327, Length=256, Percent_Identity=30.859375, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI70995211, Length=152, Percent_Identity=31.5789473684211, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI260274832, Length=259, Percent_Identity=25.0965250965251, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI45643119, Length=261, Percent_Identity=25.2873563218391, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI260275230, Length=261, Percent_Identity=25.2873563218391, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=33.1983805668016, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI221142681, Length=263, Percent_Identity=30.7984790874525, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082183, Length=263, Percent_Identity=29.277566539924, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1787660, Length=270, Percent_Identity=29.2592592592593, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788597, Length=261, Percent_Identity=26.8199233716475, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=257, Percent_Identity=31.9066147859922, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=29.4354838709677, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17540306, Length=251, Percent_Identity=29.0836653386454, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=253, Percent_Identity=26.4822134387352, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=255, Percent_Identity=24.7058823529412, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=32.512315270936, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17540714, Length=201, Percent_Identity=29.3532338308458, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=201, Percent_Identity=29.3532338308458, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24653139, Length=252, Percent_Identity=32.9365079365079, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI19922422, Length=263, Percent_Identity=26.9961977186312, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129971, Length=244, Percent_Identity=28.2786885245902, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24653477, Length=244, Percent_Identity=28.2786885245902, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357171, Length=240, Percent_Identity=27.9166666666667, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583165, Length=244, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 26295; Mature: 26164

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLVRYAVDGPVARLTLDSPQNRNALSTVLVEQLHDGLRRAAADAGVRTVVLGHTGGTF
CCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCE
CAGADLREAAGRDPGDVAVDRARELTGTLRAILESPVPVIAAIDGHVRAGGLGLVGACDI
ECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCEEEEEEE
VVAGTGSTFALTEARIGVAPSIISLTLLPKMTPRAAGRYFVTGETFGAQEAERIGLATVA
EEECCCCEEEEEHHHCCCCHHHHHEECCCCCCHHHCCCEEEECCCCCCCHHHHHCEEEEE
TDDVESTVAELAAQIGRGSPQGLAASKALTTAALLQAFDRDAAALTEQSAALFVSEEARE
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEHHHHH
GMLAFLEKRPPRWIG
HHHHHHHCCCCCCCC
>Mature Secondary Structure 
STLVRYAVDGPVARLTLDSPQNRNALSTVLVEQLHDGLRRAAADAGVRTVVLGHTGGTF
CCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCE
CAGADLREAAGRDPGDVAVDRARELTGTLRAILESPVPVIAAIDGHVRAGGLGLVGACDI
ECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCEEEEEEE
VVAGTGSTFALTEARIGVAPSIISLTLLPKMTPRAAGRYFVTGETFGAQEAERIGLATVA
EEECCCCEEEEEHHHCCCCHHHHHEECCCCCCHHHCCCEEEECCCCCCCHHHHHCEEEEE
TDDVESTVAELAAQIGRGSPQGLAASKALTTAALLQAFDRDAAALTEQSAALFVSEEARE
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEHHHHH
GMLAFLEKRPPRWIG
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]