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The map label for this gene is mscL [H]

Identifier: 119870409

GI number: 119870409

Start: 4600017

End: 4600472

Strand: Direct

Name: mscL [H]

Synonym: Mkms_4380

Alternate gene names: 119870409

Gene position: 4600017-4600472 (Clockwise)

Preceding gene: 119870408

Following gene: 119870410

Centisome position: 80.18

GC content: 64.25

Gene sequence:

>456_bases
ATGTTGAAAGGGTTCAAAGAGTTCCTGGCCCGCGGCAACATCATCGACCTGGCCACCGCGGTGGTCATCGGCACCGCGTT
CACCGGGCTGGTCACGGCGTTCACCAATGCCGTCATCGAACCGCTGATCAACCGCATCGGAGCGGGTGGTGACGCGGAAT
ACGGGATCCTGCGGATCGGCATCGGCGGAGGTCAGGCCATCGATCTCAACTTGGTGTTGTCGGCCATCATCAACTTCCTG
CTGATCGCCGCCGTGGTGTACTTCGTGATCCTCATGCCGTACAAGAAGCTGCGCGAACGGGGCAAGGTGGAACAGGCCCA
GGACACGGAGCTGAGCCTGCTCACCGAGATCCGCAACATCCTGGCCGACACCAGCGGGACGCCGAGGCAGGTCACCGGCC
CGGGTACCGGCCCCAGCCCGGACACCGCGGAGACCACCAGCGCCGACAGACGCTGA

Upstream 100 bases:

>100_bases
TTGACGCAGGCAGTCACGCTGACCTTCCACTGAGGAGCCCGGGCGAGGTCTAACGTTGCCCTGGATCGGCCGTCCACTCA
ATGACTAAGGGGATTTGCGC

Downstream 100 bases:

>100_bases
ACTGCGGAAACGAGACAGCCCCCGGATTTCAGCGGGTTCACACGGTCGTCGCAACGCTCTCATTTGAGAGGTTGCGGCGA
CCGTGTCGTTTCGGAGGACT

Product: large-conductance mechanosensitive channel

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MLKGFKEFLARGNIIDLATAVVIGTAFTGLVTAFTNAVIEPLINRIGAGGDAEYGILRIGIGGGQAIDLNLVLSAIINFL
LIAAVVYFVILMPYKKLRERGKVEQAQDTELSLLTEIRNILADTSGTPRQVTGPGTGPSPDTAETTSADRR

Sequences:

>Translated_151_residues
MLKGFKEFLARGNIIDLATAVVIGTAFTGLVTAFTNAVIEPLINRIGAGGDAEYGILRIGIGGGQAIDLNLVLSAIINFL
LIAAVVYFVILMPYKKLRERGKVEQAQDTELSLLTEIRNILADTSGTPRQVTGPGTGPSPDTAETTSADRR
>Mature_151_residues
MLKGFKEFLARGNIIDLATAVVIGTAFTGLVTAFTNAVIEPLINRIGAGGDAEYGILRIGIGGGQAIDLNLVLSAIINFL
LIAAVVYFVILMPYKKLRERGKVEQAQDTELSLLTEIRNILADTSGTPRQVTGPGTGPSPDTAETTSADRR

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185
- InterPro:   IPR015089 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 16002; Mature: 16002

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGFKEFLARGNIIDLATAVVIGTAFTGLVTAFTNAVIEPLINRIGAGGDAEYGILRIG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
IGGGQAIDLNLVLSAIINFLLIAAVVYFVILMPYKKLRERGKVEQAQDTELSLLTEIRNI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
LADTSGTPRQVTGPGTGPSPDTAETTSADRR
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLKGFKEFLARGNIIDLATAVVIGTAFTGLVTAFTNAVIEPLINRIGAGGDAEYGILRIG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
IGGGQAIDLNLVLSAIINFLLIAAVVYFVILMPYKKLRERGKVEQAQDTELSLLTEIRNI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
LADTSGTPRQVTGPGTGPSPDTAETTSADRR
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA