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The map label for this gene is gdh [H]

Identifier: 119870382

GI number: 119870382

Start: 4573057

End: 4574403

Strand: Direct

Name: gdh [H]

Synonym: Mkms_4353

Alternate gene names: 119870382

Gene position: 4573057-4574403 (Clockwise)

Preceding gene: 119870381

Following gene: 119870383

Centisome position: 79.71

GC content: 66.3

Gene sequence:

>1347_bases
ATGAACGGACTGCACGAGAACCTGCAGGGCATCTTCGAAGAGGTGGCGCGGCGCAACCCGGGCGAGACGGAGTTCCACCA
GGCCGTCTACGAGGTGCTCCAGAGCCTCGGACCGGTGGTGGCCAAACACCCCGAGTACGCCGACAGCGCGATCATCCGCC
GGCTGTGCGAGCCGGAGCGCCAGATCCTGTTCCGCGTGCCGTGGGTCGACGACAGCGGCGCGGTCCAGATGAACCGTGGG
TTCCGCGTCGAGTTCAACTCGGCGCTGGGCCCGTTCAAGGGCGGCCTGCGGTTCCACCCGTCGGTGTACCTCGGCATCAT
CAAATTCCTCGGCTTCGAGCAGATCTTCAAGAACTCGCTGACCGGGATGCCGATCGGCGGCGCCAAGGGCGGTTCGGACT
TCGACCCGAAGGGCCGCTCGAACGGCGAGATCATGCGGTTCTGCCAGTCGTTCATGACCGAGCTGTACCGCCACATCGGT
GAGTACACCGACGTGCCCGCCGGTGACATCGGCGTCGGCATGCGCGAGATCGGTTACCTGTTCGGCCAGTACAAGCGCAT
CACCAACCGCTACGAATCCGGTGTTCTCACCGGTAAGGGCATCACGTGGGGCGGGTCGCTGGTACGCACCGAGGCCACCG
GCTACGGCACCGTCTACTTCATCGCCGACATCCTCAAGTCGCGTGGGGAGTCATTCGAGGGCACACGTGCCGTGGTGTCG
GGTTCGGGCAACGTCGCCATCTACGCGATCGAGAAGATCCAGCACCTCGGCGGCACGGTCATCGCGTGTTCGGACTCCGA
CGGCTACGTGGTCGACCCCGACGGCATCGACCTCGCGCTGCTCAAGGAGGTCAAGGAGGTCCAGCGCGGCCGGGTGGCGG
ACTACGCCGAGATGCGCTGCGGCCGAGCACGTTTCGTACACGGCAACGTGTGGGACGTGGAATGCGACATCGCGGTGCCC
AGCGCCACGCAGAACGAGATCAACGGCGCCGACGCCGCGGCACTGGTCAAGGGCGGCTGTCGCATCGTCGCCGAAGGCGC
GAACATGCCGTGCACGCCCGAGGCGGTGAAACTCTTCGCCGAAGCCGGCACCGTCTTCGCCCCCGGTAAGGCCGTGAACG
CAGGCGGGGTGGCGACCAGCGCGCTGGAGATGCAGCAGAACGCCTCCCGCGATTCGTGGACCTTCGACGAGACCGAGGAC
AAGCTCGCCGAGATCATGGGCCGCATCCACGACCGCTGCCTGCAGACCGCCGAGGAATACGGTCAGCCTGGCAACTACGT
GGCCGGTGCCAACATCGCCGGCTTCACCCGGGTGGCCGACGCGATGCTGGCCCTCGGAATCATCTGA

Upstream 100 bases:

>100_bases
GCCGCCGTTTCGACCCGCCTCACCCCGGGCACCGCACTGCCGAAGCCCGTCGGGGTGTTTCCCAGATACCAGGTGGATTA
GAGATACAGGTGGCCTGAGC

Downstream 100 bases:

>100_bases
GTGACCTAGCTCACATTCGCGGCCTGCGGCGTGACGTTTCCGGCGCGGGCGGTGTCTTGAGGGGCATCACATCCCCGAGA
CACAAGGAGGCACCATGAGC

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNGLHENLQGIFEEVARRNPGETEFHQAVYEVLQSLGPVVAKHPEYADSAIIRRLCEPERQILFRVPWVDDSGAVQMNRG
FRVEFNSALGPFKGGLRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGAKGGSDFDPKGRSNGEIMRFCQSFMTELYRHIG
EYTDVPAGDIGVGMREIGYLFGQYKRITNRYESGVLTGKGITWGGSLVRTEATGYGTVYFIADILKSRGESFEGTRAVVS
GSGNVAIYAIEKIQHLGGTVIACSDSDGYVVDPDGIDLALLKEVKEVQRGRVADYAEMRCGRARFVHGNVWDVECDIAVP
SATQNEINGADAAALVKGGCRIVAEGANMPCTPEAVKLFAEAGTVFAPGKAVNAGGVATSALEMQQNASRDSWTFDETED
KLAEIMGRIHDRCLQTAEEYGQPGNYVAGANIAGFTRVADAMLALGII

Sequences:

>Translated_448_residues
MNGLHENLQGIFEEVARRNPGETEFHQAVYEVLQSLGPVVAKHPEYADSAIIRRLCEPERQILFRVPWVDDSGAVQMNRG
FRVEFNSALGPFKGGLRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGAKGGSDFDPKGRSNGEIMRFCQSFMTELYRHIG
EYTDVPAGDIGVGMREIGYLFGQYKRITNRYESGVLTGKGITWGGSLVRTEATGYGTVYFIADILKSRGESFEGTRAVVS
GSGNVAIYAIEKIQHLGGTVIACSDSDGYVVDPDGIDLALLKEVKEVQRGRVADYAEMRCGRARFVHGNVWDVECDIAVP
SATQNEINGADAAALVKGGCRIVAEGANMPCTPEAVKLFAEAGTVFAPGKAVNAGGVATSALEMQQNASRDSWTFDETED
KLAEIMGRIHDRCLQTAEEYGQPGNYVAGANIAGFTRVADAMLALGII
>Mature_448_residues
MNGLHENLQGIFEEVARRNPGETEFHQAVYEVLQSLGPVVAKHPEYADSAIIRRLCEPERQILFRVPWVDDSGAVQMNRG
FRVEFNSALGPFKGGLRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGAKGGSDFDPKGRSNGEIMRFCQSFMTELYRHIG
EYTDVPAGDIGVGMREIGYLFGQYKRITNRYESGVLTGKGITWGGSLVRTEATGYGTVYFIADILKSRGESFEGTRAVVS
GSGNVAIYAIEKIQHLGGTVIACSDSDGYVVDPDGIDLALLKEVKEVQRGRVADYAEMRCGRARFVHGNVWDVECDIAVP
SATQNEINGADAAALVKGGCRIVAEGANMPCTPEAVKLFAEAGTVFAPGKAVNAGGVATSALEMQQNASRDSWTFDETED
KLAEIMGRIHDRCLQTAEEYGQPGNYVAGANIAGFTRVADAMLALGII

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=356, Percent_Identity=30.8988764044944, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI4885281, Length=377, Percent_Identity=29.4429708222812, Blast_Score=168, Evalue=9e-42,
Organism=Escherichia coli, GI1788059, Length=445, Percent_Identity=55.9550561797753, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17544676, Length=367, Percent_Identity=29.700272479564, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324951, Length=452, Percent_Identity=48.6725663716814, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319256, Length=454, Percent_Identity=48.6784140969163, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI45553475, Length=356, Percent_Identity=30.6179775280899, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45549226, Length=356, Percent_Identity=30.6179775280899, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24649283, Length=411, Percent_Identity=28.2238442822384, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24649460, Length=291, Percent_Identity=30.9278350515464, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 48507; Mature: 48507

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLHENLQGIFEEVARRNPGETEFHQAVYEVLQSLGPVVAKHPEYADSAIIRRLCEPER
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHCCCCH
QILFRVPWVDDSGAVQMNRGFRVEFNSALGPFKGGLRFHPSVYLGIIKFLGFEQIFKNSL
HEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCC
TGMPIGGAKGGSDFDPKGRSNGEIMRFCQSFMTELYRHIGEYTDVPAGDIGVGMREIGYL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
FGQYKRITNRYESGVLTGKGITWGGSLVRTEATGYGTVYFIADILKSRGESFEGTRAVVS
HHHHHHHHHHHHCCCEECCCEECCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEE
GSGNVAIYAIEKIQHLGGTVIACSDSDGYVVDPDGIDLALLKEVKEVQRGRVADYAEMRC
CCCCEEEEEHHHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHCC
GRARFVHGNVWDVECDIAVPSATQNEINGADAAALVKGGCRIVAEGANMPCTPEAVKLFA
CCEEEEECCEEEEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHH
EAGTVFAPGKAVNAGGVATSALEMQQNASRDSWTFDETEDKLAEIMGRIHDRCLQTAEEY
HCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GQPGNYVAGANIAGFTRVADAMLALGII
CCCCCEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNGLHENLQGIFEEVARRNPGETEFHQAVYEVLQSLGPVVAKHPEYADSAIIRRLCEPER
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHCCCCH
QILFRVPWVDDSGAVQMNRGFRVEFNSALGPFKGGLRFHPSVYLGIIKFLGFEQIFKNSL
HEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCC
TGMPIGGAKGGSDFDPKGRSNGEIMRFCQSFMTELYRHIGEYTDVPAGDIGVGMREIGYL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
FGQYKRITNRYESGVLTGKGITWGGSLVRTEATGYGTVYFIADILKSRGESFEGTRAVVS
HHHHHHHHHHHHCCCEECCCEECCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEE
GSGNVAIYAIEKIQHLGGTVIACSDSDGYVVDPDGIDLALLKEVKEVQRGRVADYAEMRC
CCCCEEEEEHHHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHCC
GRARFVHGNVWDVECDIAVPSATQNEINGADAAALVKGGCRIVAEGANMPCTPEAVKLFA
CCEEEEECCEEEEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHH
EAGTVFAPGKAVNAGGVATSALEMQQNASRDSWTFDETEDKLAEIMGRIHDRCLQTAEEY
HCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GQPGNYVAGANIAGFTRVADAMLALGII
CCCCCEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]