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The map label for this gene is cobB [H]

Identifier: 119870167

GI number: 119870167

Start: 4366629

End: 4367342

Strand: Direct

Name: cobB [H]

Synonym: Mkms_4137

Alternate gene names: 119870167

Gene position: 4366629-4367342 (Clockwise)

Preceding gene: 119870165

Following gene: 119870170

Centisome position: 76.11

GC content: 69.89

Gene sequence:

>714_bases
GTGCAGGTGACGGTGCTCAGCGGGGCCGGCATCTCCGCGGAGAGCGGGGTGCCGACCTTTCGTGACGTCGAGACCGGGCT
GTGGGCCAAGGTCGATCCGTACGAGATCTCCAGCGCCGACGGATGGCGGGCCAACCCCGAGAAGGTGTGGGCCTGGTACC
TGTGGCGCCATTACATGATGGACGCGGTGCAGCCCAACAACGGCCACCACGCGGTCGCGGCGTGGCAGGACCATGCCGAC
GTGCACGTGGTCACCCAGAACGTCGACGATCTGCACGAGCGGGCCGGCAGCCGCAACGTCTACCACCTGCACGGCAGTCT
GTTCGAATTCCAGTGCGACGCTTGCGGTTCCCGCTTCGAAGGCAATCTGCCCGCCATGCCCGAGCCGGTCGAGGCGGTCG
ATCCGCCGCAGTGCCCGTGCGGTGGGCTGATCCGCCCCAACGTCGTGTGGTTCGGCGAGGCGCTGCCGGAGGCCGCCTGG
CAGCGCTCGGTCCACGCGGTGCTCACCGCCGACGTGGTGGTCGTGGTGGGCACGTCCTCGATCGTCTACCCGGCGGCCGG
TCTACCCGAGATGGCACTGGCCCGCGGGACGGCGGTCATCGAGGTCAACCCGGAACGCACACCGCTGTCGGACAGCGCGA
CGGTGTCGCTGCGCGAGACCGCCGTGGGCGCGCTGCCCACCCTGCTGCAACGCCTCCCCGATCTACTGCCGTAG

Upstream 100 bases:

>100_bases
ACTGGTCGAACAACGGCCGGGCCGCTCGCGCGTCGAGCGACACCCACTCCGCCAAACCGGCCACGTGCCCAGTATCTCCC
ACACCGGCTAAATTGGTCAT

Downstream 100 bases:

>100_bases
GACGCCGGCGCTCAGGCGGGCCGCACCGCCCGGCCCACCGCCAACTCCGACACCGGCAGCGGCACCCACGACGGGAACAT
TCGTTCCCGCCGGGCGTCCT

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQVTVLSGAGISAESGVPTFRDVETGLWAKVDPYEISSADGWRANPEKVWAWYLWRHYMMDAVQPNNGHHAVAAWQDHAD
VHVVTQNVDDLHERAGSRNVYHLHGSLFEFQCDACGSRFEGNLPAMPEPVEAVDPPQCPCGGLIRPNVVWFGEALPEAAW
QRSVHAVLTADVVVVVGTSSIVYPAAGLPEMALARGTAVIEVNPERTPLSDSATVSLRETAVGALPTLLQRLPDLLP

Sequences:

>Translated_237_residues
MQVTVLSGAGISAESGVPTFRDVETGLWAKVDPYEISSADGWRANPEKVWAWYLWRHYMMDAVQPNNGHHAVAAWQDHAD
VHVVTQNVDDLHERAGSRNVYHLHGSLFEFQCDACGSRFEGNLPAMPEPVEAVDPPQCPCGGLIRPNVVWFGEALPEAAW
QRSVHAVLTADVVVVVGTSSIVYPAAGLPEMALARGTAVIEVNPERTPLSDSATVSLRETAVGALPTLLQRLPDLLP
>Mature_237_residues
MQVTVLSGAGISAESGVPTFRDVETGLWAKVDPYEISSADGWRANPEKVWAWYLWRHYMMDAVQPNNGHHAVAAWQDHAD
VHVVTQNVDDLHERAGSRNVYHLHGSLFEFQCDACGSRFEGNLPAMPEPVEAVDPPQCPCGGLIRPNVVWFGEALPEAAW
QRSVHAVLTADVVVVVGTSSIVYPAAGLPEMALARGTAVIEVNPERTPLSDSATVSLRETAVGALPTLLQRLPDLLP

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=233, Percent_Identity=37.7682403433476, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI6912664, Length=251, Percent_Identity=37.8486055776892, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI13787215, Length=233, Percent_Identity=39.4849785407725, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI6912662, Length=258, Percent_Identity=30.2325581395349, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI13775602, Length=220, Percent_Identity=29.0909090909091, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI13775600, Length=220, Percent_Identity=29.0909090909091, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI300797705, Length=188, Percent_Identity=29.2553191489362, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI6912660, Length=199, Percent_Identity=29.6482412060301, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI63054862, Length=195, Percent_Identity=29.2307692307692, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI7657575, Length=222, Percent_Identity=26.1261261261261, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI308199517, Length=238, Percent_Identity=35.7142857142857, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71990482, Length=252, Percent_Identity=29.3650793650794, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17541892, Length=216, Percent_Identity=29.1666666666667, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71990487, Length=254, Percent_Identity=29.1338582677165, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17567771, Length=250, Percent_Identity=26.8, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6325242, Length=220, Percent_Identity=30.9090909090909, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571445, Length=199, Percent_Identity=32.1608040201005, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648389, Length=197, Percent_Identity=28.4263959390863, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571443, Length=139, Percent_Identity=33.0935251798561, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28571441, Length=139, Percent_Identity=33.0935251798561, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25704; Mature: 25704

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTVLSGAGISAESGVPTFRDVETGLWAKVDPYEISSADGWRANPEKVWAWYLWRHYMM
CEEEEEECCCCCCCCCCCCHHHHCCCCCEECCCEECCCCCCCCCCHHHHHHHHHHHHHHH
DAVQPNNGHHAVAAWQDHADVHVVTQNVDDLHERAGSRNVYHLHGSLFEFQCDACGSRFE
HHCCCCCCCEEEEEECCCCCEEEEECCHHHHHHHHCCCCEEEECCCEEEEECCCCCCCCC
GNLPAMPEPVEAVDPPQCPCGGLIRPNVVWFGEALPEAAWQRSVHAVLTADVVVVVGTSS
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHEEEEEEEEEEECCC
IVYPAAGLPEMALARGTAVIEVNPERTPLSDSATVSLRETAVGALPTLLQRLPDLLP
EEECCCCCCHHHHHCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQVTVLSGAGISAESGVPTFRDVETGLWAKVDPYEISSADGWRANPEKVWAWYLWRHYMM
CEEEEEECCCCCCCCCCCCHHHHCCCCCEECCCEECCCCCCCCCCHHHHHHHHHHHHHHH
DAVQPNNGHHAVAAWQDHADVHVVTQNVDDLHERAGSRNVYHLHGSLFEFQCDACGSRFE
HHCCCCCCCEEEEEECCCCCEEEEECCHHHHHHHHCCCCEEEECCCEEEEECCCCCCCCC
GNLPAMPEPVEAVDPPQCPCGGLIRPNVVWFGEALPEAAWQRSVHAVLTADVVVVVGTSS
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHEEEEEEEEEEECCC
IVYPAAGLPEMALARGTAVIEVNPERTPLSDSATVSLRETAVGALPTLLQRLPDLLP
EEECCCCCCHHHHHCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA