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The map label for this gene is cobB [H]

Identifier: 119869650

GI number: 119869650

Start: 3807401

End: 3808237

Strand: Direct

Name: cobB [H]

Synonym: Mkms_3618

Alternate gene names: 119869650

Gene position: 3807401-3808237 (Clockwise)

Preceding gene: 119869649

Following gene: 119869651

Centisome position: 66.36

GC content: 70.01

Gene sequence:

>837_bases
GTGGAATCACCGGAACTGGTCGCGCTGCTGGCGGGCCGCCGCGTCGCGGTACTCACCGGGGCCGGGATGTCGACCGACTC
GGGTATCCCCGACTACCGCGGGCCGGACTCGCCGCCGAGCAATCCCATGACCATCCGGCAGTTCACGTCCGACCCGGCGT
TCCGGCAGCGGTACTGGGCGCGCAATCACGTCGGCTGGCGGCACATGGCGGCCACCCTGCCCAACGCCGGACACCGCGCG
CTGGCCGCAATGGAACGCACCGGGGTGGTCCTCGGGGTCGTCACGCAGAACGTCGACCTGCTGCACACCAAGGCCGGCAG
CCGCAACGTCGTCGACCTGCACGGCACCTACGCCCGGGTGATCTGCCTCGACTGCGGGTACACGATGTCGCGGGCCGATC
TCGCCGAGATGCTCGAGGCGGCCAACCCCGGATTCCTCGAACGCGCCGAACGGGTCGGCGGCATCGCGGTCGCCCCGGAC
GCCGACGCGATCATCGGCGACACCGACCGCTTCCGCATCGTCGACTGTCCGGCCTGCGGCGGCATGCTCAAACCCGACAT
CGTGTACTTCGGTGAGAGCGTGCCCAAACCCCGCGTCGAGCAGGCCTTCGCGGTGGTCGACGACGCGGACGTGCTGCTGG
TCGCCGGCTCCTCGTTGACGGTGTTCTCCGGCTACCGGTTCGTCCGGCACGCCGCCGCGCATGGGATGCCGGTCGCGATC
ATCAACCGGGGGCCCACCCGTGGTGACGATCTCGCGACGGTGAAACTCGACAACGGTTGTTCGCCGATGCTGGCGCTGCT
GGCCGACGAGCTGCCCGCATTCGCCTCATCGGCGTAG

Upstream 100 bases:

>100_bases
CGGAACTCGGCGAGGCGGCGCTGCGGATGATGGAGCAGAACATGAGCGCCGAACTGATCGCCGCCGCCGATTGTCTGGAC
TGACGTTTAGTCTGGATGAG

Downstream 100 bases:

>100_bases
ATGGCATTAGATGGCGAGGTGCTCTCTGTATTCGGTCTACGGCCCGCACCCGGCGCGATCGACGGACGCTGGGCCGTGGG
GCTCGGCGACGCCCTCGCCA

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MESPELVALLAGRRVAVLTGAGMSTDSGIPDYRGPDSPPSNPMTIRQFTSDPAFRQRYWARNHVGWRHMAATLPNAGHRA
LAAMERTGVVLGVVTQNVDLLHTKAGSRNVVDLHGTYARVICLDCGYTMSRADLAEMLEAANPGFLERAERVGGIAVAPD
ADAIIGDTDRFRIVDCPACGGMLKPDIVYFGESVPKPRVEQAFAVVDDADVLLVAGSSLTVFSGYRFVRHAAAHGMPVAI
INRGPTRGDDLATVKLDNGCSPMLALLADELPAFASSA

Sequences:

>Translated_278_residues
MESPELVALLAGRRVAVLTGAGMSTDSGIPDYRGPDSPPSNPMTIRQFTSDPAFRQRYWARNHVGWRHMAATLPNAGHRA
LAAMERTGVVLGVVTQNVDLLHTKAGSRNVVDLHGTYARVICLDCGYTMSRADLAEMLEAANPGFLERAERVGGIAVAPD
ADAIIGDTDRFRIVDCPACGGMLKPDIVYFGESVPKPRVEQAFAVVDDADVLLVAGSSLTVFSGYRFVRHAAAHGMPVAI
INRGPTRGDDLATVKLDNGCSPMLALLADELPAFASSA
>Mature_278_residues
MESPELVALLAGRRVAVLTGAGMSTDSGIPDYRGPDSPPSNPMTIRQFTSDPAFRQRYWARNHVGWRHMAATLPNAGHRA
LAAMERTGVVLGVVTQNVDLLHTKAGSRNVVDLHGTYARVICLDCGYTMSRADLAEMLEAANPGFLERAERVGGIAVAPD
ADAIIGDTDRFRIVDCPACGGMLKPDIVYFGESVPKPRVEQAFAVVDDADVLLVAGSSLTVFSGYRFVRHAAAHGMPVAI
INRGPTRGDDLATVKLDNGCSPMLALLADELPAFASSA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=262, Percent_Identity=44.6564885496183, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI6912664, Length=261, Percent_Identity=27.9693486590038, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI13787215, Length=239, Percent_Identity=29.2887029288703, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI300795542, Length=261, Percent_Identity=28.3524904214559, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI300797577, Length=266, Percent_Identity=25.187969924812, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI308199517, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71990482, Length=258, Percent_Identity=41.4728682170543, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71990487, Length=260, Percent_Identity=41.1538461538462, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17567771, Length=256, Percent_Identity=38.28125, Blast_Score=200, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17541892, Length=241, Percent_Identity=26.5560165975104, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571445, Length=268, Percent_Identity=47.7611940298507, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI28571443, Length=225, Percent_Identity=48.4444444444444, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28571441, Length=225, Percent_Identity=48.4444444444444, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17137536, Length=260, Percent_Identity=28.4615384615385, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 29586; Mature: 29586

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESPELVALLAGRRVAVLTGAGMSTDSGIPDYRGPDSPPSNPMTIRQFTSDPAFRQRYWA
CCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
RNHVGWRHMAATLPNAGHRALAAMERTGVVLGVVTQNVDLLHTKAGSRNVVDLHGTYARV
HCCCCHHHHHHHCCCCCHHHHHHHHHCCEEEEEEECCCEEEEECCCCCCEEEECCCEEEE
ICLDCGYTMSRADLAEMLEAANPGFLERAERVGGIAVAPDADAIIGDTDRFRIVDCPACG
EEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEECCCCCEEECCCCCEEEEECCCCC
GMLKPDIVYFGESVPKPRVEQAFAVVDDADVLLVAGSSLTVFSGYRFVRHAAAHGMPVAI
CCCCCCEEEECCCCCCCHHHHHHEEECCCCEEEEECCCEEEEHHHHHHHHHHHCCCCEEE
INRGPTRGDDLATVKLDNGCSPMLALLADELPAFASSA
EECCCCCCCCEEEEEECCCCHHHHHHHHHHHCHHHCCC
>Mature Secondary Structure
MESPELVALLAGRRVAVLTGAGMSTDSGIPDYRGPDSPPSNPMTIRQFTSDPAFRQRYWA
CCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
RNHVGWRHMAATLPNAGHRALAAMERTGVVLGVVTQNVDLLHTKAGSRNVVDLHGTYARV
HCCCCHHHHHHHCCCCCHHHHHHHHHCCEEEEEEECCCEEEEECCCCCCEEEECCCEEEE
ICLDCGYTMSRADLAEMLEAANPGFLERAERVGGIAVAPDADAIIGDTDRFRIVDCPACG
EEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEECCCCCEEECCCCCEEEEECCCCC
GMLKPDIVYFGESVPKPRVEQAFAVVDDADVLLVAGSSLTVFSGYRFVRHAAAHGMPVAI
CCCCCCEEEECCCCCCCHHHHHHEEECCCCEEEEECCCEEEEHHHHHHHHHHHCCCCEEE
INRGPTRGDDLATVKLDNGCSPMLALLADELPAFASSA
EECCCCCCCCEEEEEECCCCHHHHHHHHHHHCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]