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The map label for this gene is cysH [H]

Identifier: 119869570

GI number: 119869570

Start: 3731410

End: 3732105

Strand: Direct

Name: cysH [H]

Synonym: Mkms_3538

Alternate gene names: 119869570

Gene position: 3731410-3732105 (Clockwise)

Preceding gene: 119869569

Following gene: 119869571

Centisome position: 65.04

GC content: 68.25

Gene sequence:

>696_bases
ATGTCGGATATCGACCTGCAGCAACTGGCGGAGCGCGGCGCGGCCGAACTCGGCCCGAACGCGTCGGCGATCGACCTGCT
GCGCTGGACCGACGAGAACTTCTCCGGCAACTACGTGGTGGCGTCGAACATGCAGGACGCGGTGCTGGTCGACATGGCGG
CGAAGGTCCGGCCCGGTGTGGACGTGCTGTTCCTCGACACCGGCTACCACTTCGCGGAGACCATCGGCACCCGCGATGCG
GTGCAGGCGGTGTACGACGTGAACGTCGTCAACGTCACCCCCGAGCGGACCGTCGCCGAACAGGAGGCGCTGCTCGGCAA
GGACCTGTTCGCCCGCGAGCCGAACGAGTGCTGCCGCCTGCGCAAGGTCGAACCGCTGACCAAGGCGCTGAGCGGCTATT
CGGCCTGGGTCACCGGCATCCGCCGCGTCGAGGCCCCCACCCGGGCCAACGCACCGCTGATCAGCTGGGACAGGGCGTTC
GGCCTGGTCAAGATCAACCCGATCGCGGCATGGTCGGACGACGACATGCAGGCCTACATCGCCGCCAACGGCGTGCTGGT
CAACCCGCTGGTCGACGAGGGTTACCCGTCGATCGGCTGCGCACCGTGCACGGCCAAGCCGATCGAGGGCGCCGATCCGC
GCAGCGGGCGCTGGCAGGGCCTGAACAAGATCGAATGCGGGCTGCACCAGTCTTGA

Upstream 100 bases:

>100_bases
AGCGGGTGGTTCGCAACTTCGTGAAACAACGCGAGGACGGCGAGCGTTTCGCAACGTGGGCCCTACGAGCAGACGAGGCG
GACTTGCGGTGACGGATGTG

Downstream 100 bases:

>100_bases
GCACGTTGATCCTGACCGCGCACGGCAGCGTCGACCCGCGGTCGGCGGCGGTCACGCATGCGGTGGCCGGCCGGATCCGG
CGGCTGCGACCGTGGCTCGA

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSDIDLQQLAERGAAELGPNASAIDLLRWTDENFSGNYVVASNMQDAVLVDMAAKVRPGVDVLFLDTGYHFAETIGTRDA
VQAVYDVNVVNVTPERTVAEQEALLGKDLFAREPNECCRLRKVEPLTKALSGYSAWVTGIRRVEAPTRANAPLISWDRAF
GLVKINPIAAWSDDDMQAYIAANGVLVNPLVDEGYPSIGCAPCTAKPIEGADPRSGRWQGLNKIECGLHQS

Sequences:

>Translated_231_residues
MSDIDLQQLAERGAAELGPNASAIDLLRWTDENFSGNYVVASNMQDAVLVDMAAKVRPGVDVLFLDTGYHFAETIGTRDA
VQAVYDVNVVNVTPERTVAEQEALLGKDLFAREPNECCRLRKVEPLTKALSGYSAWVTGIRRVEAPTRANAPLISWDRAF
GLVKINPIAAWSDDDMQAYIAANGVLVNPLVDEGYPSIGCAPCTAKPIEGADPRSGRWQGLNKIECGLHQS
>Mature_230_residues
SDIDLQQLAERGAAELGPNASAIDLLRWTDENFSGNYVVASNMQDAVLVDMAAKVRPGVDVLFLDTGYHFAETIGTRDAV
QAVYDVNVVNVTPERTVAEQEALLGKDLFAREPNECCRLRKVEPLTKALSGYSAWVTGIRRVEAPTRANAPLISWDRAFG
LVKINPIAAWSDDDMQAYIAANGVLVNPLVDEGYPSIGCAPCTAKPIEGADPRSGRWQGLNKIECGLHQS

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=208, Percent_Identity=33.1730769230769, Blast_Score=108, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6325425, Length=195, Percent_Identity=32.3076923076923, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011798
- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 25074; Mature: 24942

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIDLQQLAERGAAELGPNASAIDLLRWTDENFSGNYVVASNMQDAVLVDMAAKVRPGV
CCCCCHHHHHHCCCHHCCCCCCEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHCCCCC
DVLFLDTGYHFAETIGTRDAVQAVYDVNVVNVTPERTVAEQEALLGKDLFAREPNECCRL
EEEEEECCCHHHHHHCCHHHHHHHHEEEEEEECCCHHHHHHHHHHCCHHHCCCCHHHHHH
RKVEPLTKALSGYSAWVTGIRRVEAPTRANAPLISWDRAFGLVKINPIAAWSDDDMQAYI
CCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCEEECCCCCCEEEE
AANGVLVNPLVDEGYPSIGCAPCTAKPIEGADPRSGRWQGLNKIECGLHQS
EECCEEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SDIDLQQLAERGAAELGPNASAIDLLRWTDENFSGNYVVASNMQDAVLVDMAAKVRPGV
CCCCHHHHHHCCCHHCCCCCCEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHCCCCC
DVLFLDTGYHFAETIGTRDAVQAVYDVNVVNVTPERTVAEQEALLGKDLFAREPNECCRL
EEEEEECCCHHHHHHCCHHHHHHHHEEEEEEECCCHHHHHHHHHHCCHHHCCCCHHHHHH
RKVEPLTKALSGYSAWVTGIRRVEAPTRANAPLISWDRAFGLVKINPIAAWSDDDMQAYI
CCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCEEECCCCCCEEEE
AANGVLVNPLVDEGYPSIGCAPCTAKPIEGADPRSGRWQGLNKIECGLHQS
EECCEEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA