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The map label for this gene is glmS [H]

Identifier: 119869446

GI number: 119869446

Start: 3579856

End: 3581643

Strand: Direct

Name: glmS [H]

Synonym: Mkms_3414

Alternate gene names: 119869446

Gene position: 3579856-3581643 (Clockwise)

Preceding gene: 119869445

Following gene: 119869447

Centisome position: 62.4

GC content: 69.63

Gene sequence:

>1788_bases
ATGTGCGGCATCATCGCGTGCCGGACGCACCGTCCGGCCGCCGAGTATCTGCTCACCGCACTTCGCCGCCTCGAATACCG
CGGATATGACTCGGTCGGTGTGGCGGTACGGACCACCGCGGGCGACATCGCGCGACTGCGGACCATCGGGCGGATCGGCG
CACTCGAACTGCAACTGCGGCAGTGGACCGGAGCCGAACTCGACGGCACCGGCATCGGCCATACGAGATGGGCCACCCAC
GGTCCGGTGACCGAGGACAACGCGCATCCGCACAATGACTGTTCGGGACGGATCAGCCTCGTGCACAACGGGACCATCGA
GAACGCCGACCGATTGCGCAGCGCGCTCGCCGGCGCGGGCCACCGCTTCACCTCCGCTGTCGACAGCGAGGTGCTGACCC
ACCTGATCGAAGACGAGTTGCTCGTCGCCGACGATCTTCCGTCGGCCGTGCGCAACGCCCTGGCCGTGGCCGAGGGCACC
TGGGCTCTCGCCGTGCTCGAACGCGGTACCGGCCGAATCGTCGTCGCCGCCAACGGGTCTCCCCTGCTCGTCGCCCGCAC
CGCCCACGGGGTGTTCGCCGCGAGCGACATCGCCGCCATCGCCGACTGGGTGGACGAATTCCAGGTCGTCGAAGACGGCG
ACGTGATGGAACTGACCCCCACCGACCCGGTGGCCTGCACCGATCAAAACCGGGTGCAGCCCACCATGGTGCGGTGCATA
TGGCGCAGCGGCGACGCCGACCTGAACGGCTACGCCGACCACATGGCCAAGGAGATCGACGAACAACCCGAAGCGGCGAT
GCGCGTGCTCGACGAACTCGCCGGGGGCGTCGCCGACGGGACGCTGTGGGGCGATCTCGGGCTGGCGCCGTTCGACCGTC
TGCAGGTGATCGCCTGCGGCACCTCGCTCAATGCGGGGATGGTGATCGGTAACGCGGTGCACGGCCTGGCCGGCCTGCCG
GTCACGCGGTGCGTCGCGAGCGAGGCCGGGATGGACCTCCCCGAGCCCCGCACGTTGTGCCTGGCGATCAGCCAGTCCGG
CGAGACCGCCGATGTGCTGCACGCCGTCAGCACACGCGTCGCCGAGGGCTGTTCGATCCTGGCCGTCACCAACAGTTCCC
ACTCCACCCTCGCCCGTCGCGCGGACGGCGTGGTCCACTGCGCCGCGGGCCCGGAGATCGGCGTCGCGGCCACCAAGACT
TTCGTGTGCCAGATCATCGCGGGCGTCGCGGTGACGATCTCGGCGCTGGTCGCGATGAGTCGGGTGTCGCGGATTCAGGC
GATCGGGCTCGTCGACGAACTGCGGCGGTTACCGGACCAACTGGCGCGGGCCGGGACCGTCGCCAAGAGCGTGGTGCCCC
CGCTCGCCGAGGAGTGCATCGACGCCTCCGGCTACGTCTTCATCGCGAGAGGCACCGGCCTGCCCTACGCCGCCGAGGGC
GCACTCAAGCTCAAGGAACTGACCTACCGCTGGGCGGAGCACTATCCGGCCGGTGAACTCAAACACGGTCCGCTGGCCCT
GATCAGCGACGGCACCCCGGTCGTGGTGGTCGACAACGGTGACCCGAAACTGGCCACGAACATCGCCGAGGTGCAGGCTC
GCGGCGGACGGGTCGTGCGGATCGGCCCGCCCGGCAGCTGCGTACCGGTGGTCGAGGACCCGATGGGCCCGTGGGGTCCC
CTCCAGAGCGCGCTCCCGTTGCAGATCCTCGCGCGGACATCGGCGCTGTTGCTGGGCCGCGACGTGGACAAGCCGCGCAA
CCTCGCCAAATCGGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
AACGGGGCATGAGCCCGTTCTCACAACCACACAACAAGGGGGACAACATGATCGACGGACGAACCACCGAGACGGCCGAC
TCACGATCGCGACGCCGCTG

Downstream 100 bases:

>100_bases
CGCGATGACATCGATCGGAGCTCTCTGATGCGCGCCGTCGTCACCGGCGCAGCCGGATTCATCGGGTCCGCGCTGGTGGA
CCGCCTGCTCGACGATGGGC

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MCGIIACRTHRPAAEYLLTALRRLEYRGYDSVGVAVRTTAGDIARLRTIGRIGALELQLRQWTGAELDGTGIGHTRWATH
GPVTEDNAHPHNDCSGRISLVHNGTIENADRLRSALAGAGHRFTSAVDSEVLTHLIEDELLVADDLPSAVRNALAVAEGT
WALAVLERGTGRIVVAANGSPLLVARTAHGVFAASDIAAIADWVDEFQVVEDGDVMELTPTDPVACTDQNRVQPTMVRCI
WRSGDADLNGYADHMAKEIDEQPEAAMRVLDELAGGVADGTLWGDLGLAPFDRLQVIACGTSLNAGMVIGNAVHGLAGLP
VTRCVASEAGMDLPEPRTLCLAISQSGETADVLHAVSTRVAEGCSILAVTNSSHSTLARRADGVVHCAAGPEIGVAATKT
FVCQIIAGVAVTISALVAMSRVSRIQAIGLVDELRRLPDQLARAGTVAKSVVPPLAEECIDASGYVFIARGTGLPYAAEG
ALKLKELTYRWAEHYPAGELKHGPLALISDGTPVVVVDNGDPKLATNIAEVQARGGRVVRIGPPGSCVPVVEDPMGPWGP
LQSALPLQILARTSALLLGRDVDKPRNLAKSVTVE

Sequences:

>Translated_595_residues
MCGIIACRTHRPAAEYLLTALRRLEYRGYDSVGVAVRTTAGDIARLRTIGRIGALELQLRQWTGAELDGTGIGHTRWATH
GPVTEDNAHPHNDCSGRISLVHNGTIENADRLRSALAGAGHRFTSAVDSEVLTHLIEDELLVADDLPSAVRNALAVAEGT
WALAVLERGTGRIVVAANGSPLLVARTAHGVFAASDIAAIADWVDEFQVVEDGDVMELTPTDPVACTDQNRVQPTMVRCI
WRSGDADLNGYADHMAKEIDEQPEAAMRVLDELAGGVADGTLWGDLGLAPFDRLQVIACGTSLNAGMVIGNAVHGLAGLP
VTRCVASEAGMDLPEPRTLCLAISQSGETADVLHAVSTRVAEGCSILAVTNSSHSTLARRADGVVHCAAGPEIGVAATKT
FVCQIIAGVAVTISALVAMSRVSRIQAIGLVDELRRLPDQLARAGTVAKSVVPPLAEECIDASGYVFIARGTGLPYAAEG
ALKLKELTYRWAEHYPAGELKHGPLALISDGTPVVVVDNGDPKLATNIAEVQARGGRVVRIGPPGSCVPVVEDPMGPWGP
LQSALPLQILARTSALLLGRDVDKPRNLAKSVTVE
>Mature_595_residues
MCGIIACRTHRPAAEYLLTALRRLEYRGYDSVGVAVRTTAGDIARLRTIGRIGALELQLRQWTGAELDGTGIGHTRWATH
GPVTEDNAHPHNDCSGRISLVHNGTIENADRLRSALAGAGHRFTSAVDSEVLTHLIEDELLVADDLPSAVRNALAVAEGT
WALAVLERGTGRIVVAANGSPLLVARTAHGVFAASDIAAIADWVDEFQVVEDGDVMELTPTDPVACTDQNRVQPTMVRCI
WRSGDADLNGYADHMAKEIDEQPEAAMRVLDELAGGVADGTLWGDLGLAPFDRLQVIACGTSLNAGMVIGNAVHGLAGLP
VTRCVASEAGMDLPEPRTLCLAISQSGETADVLHAVSTRVAEGCSILAVTNSSHSTLARRADGVVHCAAGPEIGVAATKT
FVCQIIAGVAVTISALVAMSRVSRIQAIGLVDELRRLPDQLARAGTVAKSVVPPLAEECIDASGYVFIARGTGLPYAAEG
ALKLKELTYRWAEHYPAGELKHGPLALISDGTPVVVVDNGDPKLATNIAEVQARGGRVVRIGPPGSCVPVVEDPMGPWGP
LQSALPLQILARTSALLLGRDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=694, Percent_Identity=31.8443804034582, Blast_Score=256, Evalue=5e-68,
Organism=Homo sapiens, GI205277386, Length=693, Percent_Identity=31.024531024531, Blast_Score=249, Evalue=4e-66,
Organism=Escherichia coli, GI1790167, Length=630, Percent_Identity=37.9365079365079, Blast_Score=335, Evalue=6e-93,
Organism=Escherichia coli, GI1788651, Length=184, Percent_Identity=29.8913043478261, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=435, Percent_Identity=33.7931034482759, Blast_Score=161, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=33.1034482758621, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=33.1034482758621, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322745, Length=473, Percent_Identity=31.0782241014799, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=24.7685185185185, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323730, Length=241, Percent_Identity=29.045643153527, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=32.0289855072464, Blast_Score=245, Evalue=8e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 62544; Mature: 62544

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00443 GATASE_TYPE_II ; PS00104 EPSP_SYNTHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIACRTHRPAAEYLLTALRRLEYRGYDSVGVAVRTTAGDIARLRTIGRIGALELQLR
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEEE
QWTGAELDGTGIGHTRWATHGPVTEDNAHPHNDCSGRISLVHNGTIENADRLRSALAGAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
HRFTSAVDSEVLTHLIEDELLVADDLPSAVRNALAVAEGTWALAVLERGTGRIVVAANGS
CHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCC
PLLVARTAHGVFAASDIAAIADWVDEFQVVEDGDVMELTPTDPVACTDQNRVQPTMVRCI
EEEEEECCCCEEHHHHHHHHHHHHHHHEEECCCCEEEECCCCCEEECCCCCCCHHHHHEE
WRSGDADLNGYADHMAKEIDEQPEAAMRVLDELAGGVADGTLWGDLGLAPFDRLQVIACG
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCEEEEEEC
TSLNAGMVIGNAVHGLAGLPVTRCVASEAGMDLPEPRTLCLAISQSGETADVLHAVSTRV
CCCCCCEEECHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
AEGCSILAVTNSSHSTLARRADGVVHCAAGPEIGVAATKTFVCQIIAGVAVTISALVAMS
HCCCEEEEEECCCHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVSRIQAIGLVDELRRLPDQLARAGTVAKSVVPPLAEECIDASGYVFIARGTGLPYAAEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCC
ALKLKELTYRWAEHYPAGELKHGPLALISDGTPVVVVDNGDPKLATNIAEVQARGGRVVR
CHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHCCCEEEE
IGPPGSCVPVVEDPMGPWGPLQSALPLQILARTSALLLGRDVDKPRNLAKSVTVE
ECCCCCEECEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIIACRTHRPAAEYLLTALRRLEYRGYDSVGVAVRTTAGDIARLRTIGRIGALELQLR
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEEE
QWTGAELDGTGIGHTRWATHGPVTEDNAHPHNDCSGRISLVHNGTIENADRLRSALAGAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
HRFTSAVDSEVLTHLIEDELLVADDLPSAVRNALAVAEGTWALAVLERGTGRIVVAANGS
CHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCC
PLLVARTAHGVFAASDIAAIADWVDEFQVVEDGDVMELTPTDPVACTDQNRVQPTMVRCI
EEEEEECCCCEEHHHHHHHHHHHHHHHEEECCCCEEEECCCCCEEECCCCCCCHHHHHEE
WRSGDADLNGYADHMAKEIDEQPEAAMRVLDELAGGVADGTLWGDLGLAPFDRLQVIACG
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCEEEEEEC
TSLNAGMVIGNAVHGLAGLPVTRCVASEAGMDLPEPRTLCLAISQSGETADVLHAVSTRV
CCCCCCEEECHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
AEGCSILAVTNSSHSTLARRADGVVHCAAGPEIGVAATKTFVCQIIAGVAVTISALVAMS
HCCCEEEEEECCCHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVSRIQAIGLVDELRRLPDQLARAGTVAKSVVPPLAEECIDASGYVFIARGTGLPYAAEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCC
ALKLKELTYRWAEHYPAGELKHGPLALISDGTPVVVVDNGDPKLATNIAEVQARGGRVVR
CHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHCCCEEEE
IGPPGSCVPVVEDPMGPWGPLQSALPLQILARTSALLLGRDVDKPRNLAKSVTVE
ECCCCCEECEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA