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The map label for this gene is adh [H]

Identifier: 119869319

GI number: 119869319

Start: 3444800

End: 3445900

Strand: Direct

Name: adh [H]

Synonym: Mkms_3287

Alternate gene names: 119869319

Gene position: 3444800-3445900 (Clockwise)

Preceding gene: 119869318

Following gene: 119869320

Centisome position: 60.04

GC content: 65.4

Gene sequence:

>1101_bases
ATGATCGCCGAGGCGATGGTGCTGACCGGACCGCGGAGTCTGCAGCGGCGCCAGATGACCATCCCCGACGTCGGCGACCG
GGGTGCGATCCTGCGAGTTGAAGCATGCGGTCTGTGCGGAACAGATCACGAACAATTCACCGGACACCTGCCTGCCGGCT
TCTCATTCGTTCCAGGGCACGAAATCGTCGGCATCGTCGAACATGTTGGCGCTGCGGCTGGCCAACGCTGGGGTGTACAA
GCCGGCCAGCGCGTGGCCGTTGAGGTGTTCCGGTCCTGCCGAGACTGCCCCGAGTGCCGCCGCGGCGAATACCGGCGGTG
CGCGGTGAACGGCATCGCCACCATGTTCGGGTTTGTCGACGTGGAGGTCGGCGCGGGCTTATGGGGCGGATACGCCACCC
ATGTGGAGCTTCCGTGGGACGCGATGCTGCTCCCGATTGCCGAAGACATGGACCCCGTTCTCGCCACGTTGTTCAACCCT
CTCGGGGCCGGTATCCAGTGGGGGGCGACTCTTCCCGACACCAAGGCCGGGGACGTCGTAGCGATCCTGGGGCCCGGCAT
CCGCGGAATCTGTGCGGCGGTGGCGGCCAAAGAGGCGGGAGCCGCGTTCGTCGCGATGACCGGCGTAGGCCCACGCGACG
AACAACGACTGGCCATAGCCAGATCATTCGGTGTCGACCTGCCCATCGATGTATCGCAGGACGATGCAGTGACCGCGCTC
CAGCGTGAGACAGGCGGACGGCTTGCCGACGTGGTCGTCGACGTCACCGCTAAAGCACCCTCCGCGTTCGCCGATGCCGT
CGGCCTTGCCAGGCCCGGCGGCACAATTGTGGTGGCCGGCACCCGTGGAGGAGGCGGCGCGCCCCGGTTTGAACCAGACT
TGTTGGTCTATAAAGAATTACACGTCGTAGGCGCACTCGGCGTGGAGTATCCCGCCCACCGGGCAGCCCTCGAGATTCTC
GCCCTGGGCCGCTGGCCGTTCGACCGGATCACCAGAGAATCAACCGGATTCGCTGGGCTCGCGCAGCTGCTCACTTCGCT
TGCAGATGAAAGTGCCCGATCAAGTGGGGCGCTGCACAACGTCTTTTTGCCCACGCCCTAA

Upstream 100 bases:

>100_bases
GCGACGATCCGCAGATCGCCGAGGCGATGGGCGCGGAAATGTACGTAGGTAAAACGGTGTGCCTCCGAAACACAGGGTCG
TTCACCGGGTTCGAGCTTCC

Downstream 100 bases:

>100_bases
CGGCGTGGGCAGAGGTTCAACAGAGAGGGCCACCCGTGACCATGGCGGAACGCGTACCGATGCTCGACCGTGAGCAGGCC
CAGCTGCGAGCTGCCGAATG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MIAEAMVLTGPRSLQRRQMTIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGHEIVGIVEHVGAAAGQRWGVQ
AGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVDVEVGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP
LGAGIQWGATLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAVTAL
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKELHVVGALGVEYPAHRAALEIL
ALGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP

Sequences:

>Translated_366_residues
MIAEAMVLTGPRSLQRRQMTIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGHEIVGIVEHVGAAAGQRWGVQ
AGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVDVEVGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP
LGAGIQWGATLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAVTAL
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKELHVVGALGVEYPAHRAALEIL
ALGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP
>Mature_366_residues
MIAEAMVLTGPRSLQRRQMTIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGHEIVGIVEHVGAAAGQRWGVQ
AGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVDVEVGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP
LGAGIQWGATLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAVTAL
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKELHVVGALGVEYPAHRAALEIL
ALGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI226510992, Length=345, Percent_Identity=27.8260869565217, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788073, Length=354, Percent_Identity=25.7062146892655, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790045, Length=265, Percent_Identity=27.1698113207547, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=21.6374269005848, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=24.8387096774194, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787863, Length=279, Percent_Identity=26.1648745519713, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788407, Length=267, Percent_Identity=23.9700374531835, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786825, Length=274, Percent_Identity=25.5474452554745, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=338, Percent_Identity=27.2189349112426, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=262, Percent_Identity=26.3358778625954, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=339, Percent_Identity=27.1386430678466, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=230, Percent_Identity=27.3913043478261, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=331, Percent_Identity=25.9818731117825, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=331, Percent_Identity=25.9818731117825, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=337, Percent_Identity=24.6290801186944, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38276; Mature: 38276

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAEAMVLTGPRSLQRRQMTIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGH
CCCCEEEECCCHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCEECCCH
EIVGIVEHVGAAAGQRWGVQAGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVD
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHEE
VEVGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNPLGAGIQWGATLPDTKAGDVV
EEECCCCCCCEEEEEECCCCCEEECHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
AILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAVTAL
EEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKEL
HHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEHHHH
HVVGALGVEYPAHRAALEILALGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHN
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VFLPTP
EECCCC
>Mature Secondary Structure
MIAEAMVLTGPRSLQRRQMTIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGH
CCCCEEEECCCHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCEECCCH
EIVGIVEHVGAAAGQRWGVQAGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVD
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHEE
VEVGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNPLGAGIQWGATLPDTKAGDVV
EEECCCCCCCEEEEEECCCCCEEECHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
AILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAVTAL
EEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKEL
HHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEHHHH
HVVGALGVEYPAHRAALEILALGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHN
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VFLPTP
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]