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The map label for this gene is drrC [H]

Identifier: 119869199

GI number: 119869199

Start: 3316299

End: 3317093

Strand: Direct

Name: drrC [H]

Synonym: Mkms_3167

Alternate gene names: 119869199

Gene position: 3316299-3317093 (Clockwise)

Preceding gene: 119869198

Following gene: 119869200

Centisome position: 57.8

GC content: 66.42

Gene sequence:

>795_bases
GTGAACTCAACGTCGGAACACCGGCATTCGTTGCTCACCGAGAGTTGGATCTTCGCCAGCCGGCTTTTCATCCAGTGGCG
TCGTTACCCGATGGTGCCACTGCAGGCACTGCTGTTTCCCACCTTGCTGCTGATCATCTACGGCGCGCTGGTGGGCAAGT
CGATGGTCCGCCTCACGGGCAGCAGCGGGTTGAACGAGCTGATCCCTGTCTGCATGCTCGCCGGTGCCATGGCGGGCGCC
GTCGGCGCCGGACTCATGGTGCCCTGGGACCGCGACAGTGGCCTGCTCACCCGAATGTGGGTCATGCCGGTGCACCGGAC
GGCACCGTTGACCGGTGCGCTGCTTGCCGAAGCGCTGCGCACATTGGTGGCATCGGCAGTCGTCCTCGCAGCCGGGTATC
TGATGGGATTCCGGTTCGCGGGCGGCTGGACCGGCATGCTCGTCTACCTACTGATCCCGGTCATCGTGGTGGTCGTGTTC
GCGACGGTGGTGATCACCCTCGCACTACGGCCACAGGGCCGGATCATCCTGACGTGGGCCCAGACGGTGTGTGTCGGTTT
GGCGTTCGGAACGCTCGCGCCCCCTGAAAGAGTTCCGGCGCTCGTACGGCCGCTCGCGGAGTTCCAGCCGCTCGCGGCGC
CCGCGGCGACCATGCGCGCGCTGGCGTCCGGAGGCGACGTGATGCGGCCCATGCTGCTCACGGCATTGTGGGTGATTGTC
ATCGCGGCCGTGTTCGTACCGCTCACCGTCCGGGGATATCGGGCGGCGGTCGAGGGCGGGAAGATCGACAGCTGA

Upstream 100 bases:

>100_bases
GTCACGTCGACGCGGGCAATCTCGGCGTGAGCCTGGCATGGTGCGTCGGTCTGCTGCTGGTTTTCGGCACGATGGCCGTC
CGATTGCAGGGGCGAACGCC

Downstream 100 bases:

>100_bases
GCAGTACCCGCCGCCCGCGCCGACGCAGGGTAGCCGAGACCGAACCGTAGGCGCCACGCAGGGCGGATGGTGACGTACAC
CACGCCCGCGGGTTGTACGG

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MNSTSEHRHSLLTESWIFASRLFIQWRRYPMVPLQALLFPTLLLIIYGALVGKSMVRLTGSSGLNELIPVCMLAGAMAGA
VGAGLMVPWDRDSGLLTRMWVMPVHRTAPLTGALLAEALRTLVASAVVLAAGYLMGFRFAGGWTGMLVYLLIPVIVVVVF
ATVVITLALRPQGRIILTWAQTVCVGLAFGTLAPPERVPALVRPLAEFQPLAAPAATMRALASGGDVMRPMLLTALWVIV
IAAVFVPLTVRGYRAAVEGGKIDS

Sequences:

>Translated_264_residues
MNSTSEHRHSLLTESWIFASRLFIQWRRYPMVPLQALLFPTLLLIIYGALVGKSMVRLTGSSGLNELIPVCMLAGAMAGA
VGAGLMVPWDRDSGLLTRMWVMPVHRTAPLTGALLAEALRTLVASAVVLAAGYLMGFRFAGGWTGMLVYLLIPVIVVVVF
ATVVITLALRPQGRIILTWAQTVCVGLAFGTLAPPERVPALVRPLAEFQPLAAPAATMRALASGGDVMRPMLLTALWVIV
IAAVFVPLTVRGYRAAVEGGKIDS
>Mature_264_residues
MNSTSEHRHSLLTESWIFASRLFIQWRRYPMVPLQALLFPTLLLIIYGALVGKSMVRLTGSSGLNELIPVCMLAGAMAGA
VGAGLMVPWDRDSGLLTRMWVMPVHRTAPLTGALLAEALRTLVASAVVLAAGYLMGFRFAGGWTGMLVYLLIPVIVVVVF
ATVVITLALRPQGRIILTWAQTVCVGLAFGTLAPPERVPALVRPLAEFQPLAAPAATMRALASGGDVMRPMLLTALWVIV
IAAVFVPLTVRGYRAAVEGGKIDS

Specific function: Probably part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525
- InterPro:   IPR004377
- InterPro:   IPR005943 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 28272; Mature: 28272

Theoretical pI: Translated: 10.94; Mature: 10.94

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTSEHRHSLLTESWIFASRLFIQWRRYPMVPLQALLFPTLLLIIYGALVGKSMVRLTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SSGLNELIPVCMLAGAMAGAVGAGLMVPWDRDSGLLTRMWVMPVHRTAPLTGALLAEALR
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
TLVASAVVLAAGYLMGFRFAGGWTGMLVYLLIPVIVVVVFATVVITLALRPQGRIILTWA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHH
QTVCVGLAFGTLAPPERVPALVRPLAEFQPLAAPAATMRALASGGDVMRPMLLTALWVIV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
IAAVFVPLTVRGYRAAVEGGKIDS
HHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNSTSEHRHSLLTESWIFASRLFIQWRRYPMVPLQALLFPTLLLIIYGALVGKSMVRLTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SSGLNELIPVCMLAGAMAGAVGAGLMVPWDRDSGLLTRMWVMPVHRTAPLTGALLAEALR
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
TLVASAVVLAAGYLMGFRFAGGWTGMLVYLLIPVIVVVVFATVVITLALRPQGRIILTWA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHH
QTVCVGLAFGTLAPPERVPALVRPLAEFQPLAAPAATMRALASGGDVMRPMLLTALWVIV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
IAAVFVPLTVRGYRAAVEGGKIDS
HHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]