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The map label for this gene is drrB [H]

Identifier: 119869198

GI number: 119869198

Start: 3315565

End: 3316302

Strand: Direct

Name: drrB [H]

Synonym: Mkms_3166

Alternate gene names: 119869198

Gene position: 3315565-3316302 (Clockwise)

Preceding gene: 119869197

Following gene: 119869199

Centisome position: 57.79

GC content: 65.85

Gene sequence:

>738_bases
GTGACCGCTATCGCGCTCCTGACGCGCCGCACGCTGGTGCGCGGTCGAGTGGACCTGGTGTTCGCCGTGCTCATGCCGAC
GTTCGTGTTGGCCGGTCTCGTGCTACTGCTGCAGGATGTCATCGCCACCGGCCAGATGAGTTATACGCAATACGTGTTGC
CTGCGGTGGTCGTCCAGGCGATGCTGTTCGGTGCGCTGACCACCACGGATCGGGCGGCCTGGGACACGATCAGCGGGCTG
AGCACACGGATGCGCACACTGCCGATCTCTCCGTACGCGATGTTGACGGCACGAATGATCTACTGCCTGATCCGGGGCGT
GCTGGCGGTGATCGCGTCGGTACTGGCCGCCCACTGGTTCGGGTTCCGGTTCACCACCGGGTTCGGGTACGGCGCGGCCT
TCGTCCTGATGGCACTGACGCTGACCTTGGCGTTGTCACTAGGTGCGGATGTGACCGGGACCAAGGCCGGCCGGACCGAG
GTGGCCAGCCAACTGCTGCTCGTCCCCCAACTGCTCCTCGTGCTGTTGTCGACGGGCCTGGCGCCCCTCGAGGCGTTCCC
GTCGTGGCTGCAAGGCTTCGTGCAGTACCAGCCGGTGTCACAGATCACCGAGGCGATGCGCGGTTTCACCAGCGGTCACG
TCGACGCGGGCAATCTCGGCGTGAGCCTGGCATGGTGCGTCGGTCTGCTGCTGGTTTTCGGCACGATGGCCGTCCGATTG
CAGGGGCGAACGCCGTGA

Upstream 100 bases:

>100_bases
GACGGCTCAGCGACCTGGACATCGAACTGCTCGACATCTCGCTGCGCCGGCCCTCGCTCGACGAGGTGTTCCTTCATCTG
ACCACTCCGGCGACCTCGAA

Downstream 100 bases:

>100_bases
ACTCAACGTCGGAACACCGGCATTCGTTGCTCACCGAGAGTTGGATCTTCGCCAGCCGGCTTTTCATCCAGTGGCGTCGT
TACCCGATGGTGCCACTGCA

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTAIALLTRRTLVRGRVDLVFAVLMPTFVLAGLVLLLQDVIATGQMSYTQYVLPAVVVQAMLFGALTTTDRAAWDTISGL
STRMRTLPISPYAMLTARMIYCLIRGVLAVIASVLAAHWFGFRFTTGFGYGAAFVLMALTLTLALSLGADVTGTKAGRTE
VASQLLLVPQLLLVLLSTGLAPLEAFPSWLQGFVQYQPVSQITEAMRGFTSGHVDAGNLGVSLAWCVGLLLVFGTMAVRL
QGRTP

Sequences:

>Translated_245_residues
MTAIALLTRRTLVRGRVDLVFAVLMPTFVLAGLVLLLQDVIATGQMSYTQYVLPAVVVQAMLFGALTTTDRAAWDTISGL
STRMRTLPISPYAMLTARMIYCLIRGVLAVIASVLAAHWFGFRFTTGFGYGAAFVLMALTLTLALSLGADVTGTKAGRTE
VASQLLLVPQLLLVLLSTGLAPLEAFPSWLQGFVQYQPVSQITEAMRGFTSGHVDAGNLGVSLAWCVGLLLVFGTMAVRL
QGRTP
>Mature_244_residues
TAIALLTRRTLVRGRVDLVFAVLMPTFVLAGLVLLLQDVIATGQMSYTQYVLPAVVVQAMLFGALTTTDRAAWDTISGLS
TRMRTLPISPYAMLTARMIYCLIRGVLAVIASVLAAHWFGFRFTTGFGYGAAFVLMALTLTLALSLGADVTGTKAGRTEV
ASQLLLVPQLLLVLLSTGLAPLEAFPSWLQGFVQYQPVSQITEAMRGFTSGHVDAGNLGVSLAWCVGLLLVFGTMAVRLQ
GRTP

Specific function: Part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004377 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 26216; Mature: 26084

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCC
>Mature Secondary Structure 
TAIALLTRRTLVRGRVDLVFAVLMPTFVLAGLVLLLQDVIATGQMSYTQYVLPAVVVQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
MLFGALTTTDRAAWDTISGLSTRMRTLPISPYAMLTARMIYCLIRGVLAVIASVLAAHWF
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFRFTTGFGYGAAFVLMALTLTLALSLGADVTGTKAGRTEVASQLLLVPQLLLVLLSTGL
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
APLEAFPSWLQGFVQYQPVSQITEAMRGFTSGHVDAGNLGVSLAWCVGLLLVFGTMAVRL
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
QGRTP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]