Click here to switch to the map view.

The map label for this gene is qacE [H]

Identifier: 119868943

GI number: 119868943

Start: 3052166

End: 3052489

Strand: Direct

Name: qacE [H]

Synonym: Mkms_2911

Alternate gene names: 119868943

Gene position: 3052166-3052489 (Clockwise)

Preceding gene: 119868942

Following gene: 119868945

Centisome position: 53.2

GC content: 68.83

Gene sequence:

>324_bases
ATGTACCTCGCACTTGCCGCGGCCATCGCGCTGGAGGTGCTCGCGACGCTGTGCCTGCGGGCGTCCGACGGCTTCCGCAA
GAAGGTGTGGATGGCGCCGGTGGTGATCGGCTACCTGGCGTCCTTCTACCTGCTGTGGCTGACGCTTTCGCTCGGCCTGC
CGGTCGGCATCGCCTACGGCGTGTGGACGGCCTGCGGTGTGGCGCTCGTCGCCGTACTCGCCCGCGTCCTGTTCGGCGAA
CGGCTCACTCCCACGATGGGCGCGGGGATCGCGCTGATCGTGGCCGGCGTGCTCACGATCGAACTGGCCGGCCTCTCACA
TTGA

Upstream 100 bases:

>100_bases
TCACCTGGCCCATTGCCGCCGGCATCGCGCTGATCGTCGGCGGGGTGCTGTTGGTCGAATTCGGCTCGCGCCCGCGGCCG
GAACCCGGTGGCGCGCGGTG

Downstream 100 bases:

>100_bases
GCGCACCCGCGAGCACCATGATCACCAGCCCGGCAACCGGCACGGTCAGCAGTCCGATCCGCAGACTGGTCCAGTCGGCG
ATCAGGCCGACGAGTGGCGG

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MYLALAAAIALEVLATLCLRASDGFRKKVWMAPVVIGYLASFYLLWLTLSLGLPVGIAYGVWTACGVALVAVLARVLFGE
RLTPTMGAGIALIVAGVLTIELAGLSH

Sequences:

>Translated_107_residues
MYLALAAAIALEVLATLCLRASDGFRKKVWMAPVVIGYLASFYLLWLTLSLGLPVGIAYGVWTACGVALVAVLARVLFGE
RLTPTMGAGIALIVAGVLTIELAGLSH
>Mature_107_residues
MYLALAAAIALEVLATLCLRASDGFRKKVWMAPVVIGYLASFYLLWLTLSLGLPVGIAYGVWTACGVALVAVLARVLFGE
RLTPTMGAGIALIVAGVLTIELAGLSH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=101, Percent_Identity=40.5940594059406, Blast_Score=64, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11190; Mature: 11190

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLALAAAIALEVLATLCLRASDGFRKKVWMAPVVIGYLASFYLLWLTLSLGLPVGIAYG
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VWTACGVALVAVLARVLFGERLTPTMGAGIALIVAGVLTIELAGLSH
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYLALAAAIALEVLATLCLRASDGFRKKVWMAPVVIGYLASFYLLWLTLSLGLPVGIAYG
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VWTACGVALVAVLARVLFGERLTPTMGAGIALIVAGVLTIELAGLSH
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]