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The map label for this gene is ggt [H]

Identifier: 119868477

GI number: 119868477

Start: 2559491

End: 2561395

Strand: Reverse

Name: ggt [H]

Synonym: Mkms_2441

Alternate gene names: 119868477

Gene position: 2561395-2559491 (Counterclockwise)

Preceding gene: 119868482

Following gene: 119868476

Centisome position: 44.65

GC content: 71.23

Gene sequence:

>1905_bases
ATGGCCGGATGCTCCGATGCCGAGCAGGCTCCTCCCACCCCGCCTCCGGTGCCGTGCGAAATGGTGTCGAACGGCACTCC
CACGCCCAAGACCCCCGCGGCCGCGCCCCCGGGGCAGGCCGGGGAAGACCTGGCCAACGAGCCGGAGGTGGGCACCGGGT
ACCGCAAGGACATGACGGCGGTGCGCACCGCTCGTTACTCGGTGTCGACGGCGAATCCGCTGGCCACCCAGGCCGCGTGC
CGGGTGCTCCGCAACGGCGGCACTGCGGCCGATGCGATGGTGACCGCCCAGGCGACGCTCGGACTCGTCGAACCCCAGTC
CTCCGGCGTCGGCGGCGGTGGCTTCCTGCTGTACTACGACGCCGCATCGGGCGCGGTGCAGGCCTACGACGGCCGTGAGG
TCGCCCCCGCCGCGGCCACGGAGAACTACCTGCGGTGGGTCAGCGACACCGACCGGACACCACCCAAACCCGATGCGCGG
GCGTCCGGGCGTTCGATCGGCGTCCCCGGCATCGTGCGGCTCTTGCAGACCGCGCACGAGGCGCACGGGAAGACCACATG
GCGTGAGCTGTTCGAACCGGCCGTCCAACTCGCCGACGGCGGCTTCGACGTCAGCCCCCGGCTGGCGGCGGCGATCTCCG
ACAGCCGGGCGGAACTGAGCGGCGACACCGCCGCCGGAAAGTACTTCCTCAACGCCGACGGCAAGCCGAAGACCGCGGGC
AGCCGCCTGACCAACCCCGCCTACGCCAAGACCCTGAGCGCGATCGCCTCCGACGGCGCCGACGCGTTCTACACGGGTGC
GATCGCCGAGGCGGTCGTCGAGGCCGCGGCGGACACCTCGGGTGGACGCACCCCCAGCGCGATGACGCTGCAGGATCTCG
CCGCGTACAAAGTCGAGGTCCGGCAGCCCCTGTGCCGTCCGTACCGCGGTAAGGAGATCTGCGGGATGCCGCCGCCGTCG
TCGGGCGGTCTCGCGGTGCTTGCGACACTCGGGATGCTGGAGCGCTTCCCGATGGCCGACCACCGCCCCGACGACATCGA
CCGCAACGGCGGCAGGCCCGACGCGATGGGCGTGCACCTCATCTCCGAGGCCGAGCGGCTGGCCTACGCGGACCGGGACC
GCTACGTCGCCGACACCGCGTTCGTGCCGCTGCCCGGCGGCACGGCGGACACGCTGCTGAACAGCGCCTACCTGGCCGGC
CGCGCCGCACTGATCAACGAGCAGCGCAGCATGGGCGTCGCCAAACCCGGAGAGTTCGGTCCGCCCGCCGCACCCACCCC
GCAACCACGCGAGCACGGCACCAGCCAGGTCAGCATCGTCGACTCCTACGGGAACGCGGCGTCGCTGACCACCACCGTGG
AGTCGCAGTTCGGCTCGTTCCACATGGTCGACGGGTTCCTGCTGAACAACCAGCTGACCGACTTCGCCGCCGAACCGGCG
GGCCCCGACGGCGTACCCGTGGCCAACCGCGTGCAGCCGGGTAAGCGGCCGCGCAGCACCATGGCCCCGACGCTGGTCTT
CGACGCTTCGACCGGTCCGCCCGGCACCAGGGGTCCGCTCTACGCGGTGCTCGGCTCCCCCGGCGGCGCGGTGATCATCC
AGTTCGTGGTGAAAACCGTTGTCGGAATGTTGGATTGGGGTCTGGATCCGCAGCAGGCGGTGGGCATGGTGGATTTCGGG
GCCGACAACAGCCCGGAGACCAACGTCGGCGGTGAACATCCCAACGTCGACATCGCCGACAACGGCGACCACGATCCGCT
CGTGACAGGTCTGCGCAGACTCGGTCACCGCGTCGATCTGGCCGACCAGTCCAGTGGGCTGTCGGCGATCGTCCGCGACG
ACACCGGCTGGATCGGCGGCGCCGACCCACGCCGCGAGGGAATGGTCATGGGCGACGGCCGGTGA

Upstream 100 bases:

>100_bases
CCTACGGACAGGTCGCGAGTGACTCCGCTACCGTCGAAGGGTGCGGATACCGGCGTCGGTGCAGAAGGTGACCGCCCTGC
TCGGAGGGGTCGTGTTGCTC

Downstream 100 bases:

>100_bases
CCGCACCGCACGTCACCCAGCTGACAGAAGCCGACTGGCAGCAGTTCGCCGTGGTCCGGTTGCGGGCGCTGACCGATTCG
CTCGGTGTCGACGACCCGCA

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MAGCSDAEQAPPTPPPVPCEMVSNGTPTPKTPAAAPPGQAGEDLANEPEVGTGYRKDMTAVRTARYSVSTANPLATQAAC
RVLRNGGTAADAMVTAQATLGLVEPQSSGVGGGGFLLYYDAASGAVQAYDGREVAPAAATENYLRWVSDTDRTPPKPDAR
ASGRSIGVPGIVRLLQTAHEAHGKTTWRELFEPAVQLADGGFDVSPRLAAAISDSRAELSGDTAAGKYFLNADGKPKTAG
SRLTNPAYAKTLSAIASDGADAFYTGAIAEAVVEAAADTSGGRTPSAMTLQDLAAYKVEVRQPLCRPYRGKEICGMPPPS
SGGLAVLATLGMLERFPMADHRPDDIDRNGGRPDAMGVHLISEAERLAYADRDRYVADTAFVPLPGGTADTLLNSAYLAG
RAALINEQRSMGVAKPGEFGPPAAPTPQPREHGTSQVSIVDSYGNAASLTTTVESQFGSFHMVDGFLLNNQLTDFAAEPA
GPDGVPVANRVQPGKRPRSTMAPTLVFDASTGPPGTRGPLYAVLGSPGGAVIIQFVVKTVVGMLDWGLDPQQAVGMVDFG
ADNSPETNVGGEHPNVDIADNGDHDPLVTGLRRLGHRVDLADQSSGLSAIVRDDTGWIGGADPRREGMVMGDGR

Sequences:

>Translated_634_residues
MAGCSDAEQAPPTPPPVPCEMVSNGTPTPKTPAAAPPGQAGEDLANEPEVGTGYRKDMTAVRTARYSVSTANPLATQAAC
RVLRNGGTAADAMVTAQATLGLVEPQSSGVGGGGFLLYYDAASGAVQAYDGREVAPAAATENYLRWVSDTDRTPPKPDAR
ASGRSIGVPGIVRLLQTAHEAHGKTTWRELFEPAVQLADGGFDVSPRLAAAISDSRAELSGDTAAGKYFLNADGKPKTAG
SRLTNPAYAKTLSAIASDGADAFYTGAIAEAVVEAAADTSGGRTPSAMTLQDLAAYKVEVRQPLCRPYRGKEICGMPPPS
SGGLAVLATLGMLERFPMADHRPDDIDRNGGRPDAMGVHLISEAERLAYADRDRYVADTAFVPLPGGTADTLLNSAYLAG
RAALINEQRSMGVAKPGEFGPPAAPTPQPREHGTSQVSIVDSYGNAASLTTTVESQFGSFHMVDGFLLNNQLTDFAAEPA
GPDGVPVANRVQPGKRPRSTMAPTLVFDASTGPPGTRGPLYAVLGSPGGAVIIQFVVKTVVGMLDWGLDPQQAVGMVDFG
ADNSPETNVGGEHPNVDIADNGDHDPLVTGLRRLGHRVDLADQSSGLSAIVRDDTGWIGGADPRREGMVMGDGR
>Mature_633_residues
AGCSDAEQAPPTPPPVPCEMVSNGTPTPKTPAAAPPGQAGEDLANEPEVGTGYRKDMTAVRTARYSVSTANPLATQAACR
VLRNGGTAADAMVTAQATLGLVEPQSSGVGGGGFLLYYDAASGAVQAYDGREVAPAAATENYLRWVSDTDRTPPKPDARA
SGRSIGVPGIVRLLQTAHEAHGKTTWRELFEPAVQLADGGFDVSPRLAAAISDSRAELSGDTAAGKYFLNADGKPKTAGS
RLTNPAYAKTLSAIASDGADAFYTGAIAEAVVEAAADTSGGRTPSAMTLQDLAAYKVEVRQPLCRPYRGKEICGMPPPSS
GGLAVLATLGMLERFPMADHRPDDIDRNGGRPDAMGVHLISEAERLAYADRDRYVADTAFVPLPGGTADTLLNSAYLAGR
AALINEQRSMGVAKPGEFGPPAAPTPQPREHGTSQVSIVDSYGNAASLTTTVESQFGSFHMVDGFLLNNQLTDFAAEPAG
PDGVPVANRVQPGKRPRSTMAPTLVFDASTGPPGTRGPLYAVLGSPGGAVIIQFVVKTVVGMLDWGLDPQQAVGMVDFGA
DNSPETNVGGEHPNVDIADNGDHDPLVTGLRRLGHRVDLADQSSGLSAIVRDDTGWIGGADPRREGMVMGDGR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=551, Percent_Identity=29.4010889292196, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI73915090, Length=551, Percent_Identity=29.4010889292196, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI73915096, Length=551, Percent_Identity=29.4010889292196, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI73915094, Length=551, Percent_Identity=29.4010889292196, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI113429324, Length=552, Percent_Identity=28.804347826087, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI113429326, Length=557, Percent_Identity=28.5457809694794, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI153266885, Length=519, Percent_Identity=27.9383429672447, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI153266901, Length=520, Percent_Identity=27.8846153846154, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI109148539, Length=560, Percent_Identity=28.0357142857143, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI153266907, Length=519, Percent_Identity=27.1676300578035, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI30581157, Length=205, Percent_Identity=30.2439024390244, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI30581155, Length=205, Percent_Identity=30.2439024390244, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789856, Length=499, Percent_Identity=34.8697394789579, Blast_Score=248, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI72000294, Length=509, Percent_Identity=30.6483300589391, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI212646519, Length=509, Percent_Identity=30.6483300589391, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193208245, Length=524, Percent_Identity=31.6793893129771, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI193208247, Length=524, Percent_Identity=31.6793893129771, Blast_Score=185, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17542894, Length=610, Percent_Identity=29.016393442623, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17506189, Length=511, Percent_Identity=28.3757338551859, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI72001497, Length=239, Percent_Identity=25.1046025104602, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=239, Percent_Identity=25.1046025104602, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=475, Percent_Identity=28.4210526315789, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45551474, Length=599, Percent_Identity=27.212020033389, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642670, Length=576, Percent_Identity=27.7777777777778, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24642666, Length=576, Percent_Identity=27.7777777777778, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI161077878, Length=576, Percent_Identity=27.9513888888889, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI161077880, Length=576, Percent_Identity=27.7777777777778, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI18859893, Length=483, Percent_Identity=30.0207039337474, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI18859741, Length=582, Percent_Identity=26.6323024054983, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI161077496, Length=473, Percent_Identity=26.8498942917548, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 65693; Mature: 65562

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGCSDAEQAPPTPPPVPCEMVSNGTPTPKTPAAAPPGQAGEDLANEPEVGTGYRKDMTA
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHH
VRTARYSVSTANPLATQAACRVLRNGGTAADAMVTAQATLGLVEPQSSGVGGGGFLLYYD
HHHHHEECCCCCCHHHHHHHHHHHCCCCHHHHEEEHHHHHEEECCCCCCCCCCEEEEEEE
AASGAVQAYDGREVAPAAATENYLRWVSDTDRTPPKPDARASGRSIGVPGIVRLLQTAHE
CCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AHGKTTWRELFEPAVQLADGGFDVSPRLAAAISDSRAELSGDTAAGKYFLNADGKPKTAG
HCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHCCCCCCCCEEEECCCCCCCCCC
SRLTNPAYAKTLSAIASDGADAFYTGAIAEAVVEAAADTSGGRTPSAMTLQDLAAYKVEV
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RQPLCRPYRGKEICGMPPPSSGGLAVLATLGMLERFPMADHRPDDIDRNGGRPDAMGVHL
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
ISEAERLAYADRDRYVADTAFVPLPGGTADTLLNSAYLAGRAALINEQRSMGVAKPGEFG
HHHHHHHHHHCCCCEEECEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PPAAPTPQPREHGTSQVSIVDSYGNAASLTTTVESQFGSFHMVDGFLLNNQLTDFAAEPA
CCCCCCCCHHHCCCCEEEEEECCCCCCEEEEEHHHHCCCEEEECCEEECCCHHHHHCCCC
GPDGVPVANRVQPGKRPRSTMAPTLVFDASTGPPGTRGPLYAVLGSPGGAVIIQFVVKTV
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
VGMLDWGLDPQQAVGMVDFGADNSPETNVGGEHPNVDIADNGDHDPLVTGLRRLGHRVDL
HHHHHCCCCHHHHCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCC
ADQSSGLSAIVRDDTGWIGGADPRREGMVMGDGR
CCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCC
>Mature Secondary Structure 
AGCSDAEQAPPTPPPVPCEMVSNGTPTPKTPAAAPPGQAGEDLANEPEVGTGYRKDMTA
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHH
VRTARYSVSTANPLATQAACRVLRNGGTAADAMVTAQATLGLVEPQSSGVGGGGFLLYYD
HHHHHEECCCCCCHHHHHHHHHHHCCCCHHHHEEEHHHHHEEECCCCCCCCCCEEEEEEE
AASGAVQAYDGREVAPAAATENYLRWVSDTDRTPPKPDARASGRSIGVPGIVRLLQTAHE
CCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AHGKTTWRELFEPAVQLADGGFDVSPRLAAAISDSRAELSGDTAAGKYFLNADGKPKTAG
HCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHCCCCCCCCEEEECCCCCCCCCC
SRLTNPAYAKTLSAIASDGADAFYTGAIAEAVVEAAADTSGGRTPSAMTLQDLAAYKVEV
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RQPLCRPYRGKEICGMPPPSSGGLAVLATLGMLERFPMADHRPDDIDRNGGRPDAMGVHL
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
ISEAERLAYADRDRYVADTAFVPLPGGTADTLLNSAYLAGRAALINEQRSMGVAKPGEFG
HHHHHHHHHHCCCCEEECEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PPAAPTPQPREHGTSQVSIVDSYGNAASLTTTVESQFGSFHMVDGFLLNNQLTDFAAEPA
CCCCCCCCHHHCCCCEEEEEECCCCCCEEEEEHHHHCCCEEEECCEEECCCHHHHHCCCC
GPDGVPVANRVQPGKRPRSTMAPTLVFDASTGPPGTRGPLYAVLGSPGGAVIIQFVVKTV
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
VGMLDWGLDPQQAVGMVDFGADNSPETNVGGEHPNVDIADNGDHDPLVTGLRRLGHRVDL
HHHHHCCCCHHHHCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCC
ADQSSGLSAIVRDDTGWIGGADPRREGMVMGDGR
CCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA