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The map label for this gene is mhpC [C]

Identifier: 119868254

GI number: 119868254

Start: 2333878

End: 2334900

Strand: Reverse

Name: mhpC [C]

Synonym: Mkms_2218

Alternate gene names: 119868254

Gene position: 2334900-2333878 (Counterclockwise)

Preceding gene: 119868255

Following gene: 119868253

Centisome position: 40.7

GC content: 67.55

Gene sequence:

>1023_bases
TTGACTGACCGCACACCCAACCTCCGCCCGGTCCGCGACGTGACGCCCACGCTGCATTACCGCACCATCCACGGATACCG
CCGAGCCTTCCGGATCGCCGGCGAGGGTCCCGCGATTCTGCTGATCCACGGCATCGGCGACAACTCCACGACGTGGAACA
CGGTGCAGACCAAACTCGCGCAGCGCTTCACCGTCATCGCACCCGACCTGCTCGGACACGGCAAGTCGGACAAACCGCGC
GCGGACTATTCGGTGGCCGCCTACGCCAACGGCATGCGGGATCTGCTCAGCGTCCTCGACATCGACCGGGTGACGGTGGT
CGGCCACTCGCTGGGCGGCGGCGTGGCCATGCAGTTCGCCTACCAGTTCCCGCAGTTCGTCGACCGCCTCATCCTGGTCG
GCGCCGGTGGAGTCACCAAGGACGTCAACATCGCCCTGCGGGTGGCCTCCCTGCCGATGGGAAGTGAGGCGCTCGCACTG
CTGCGCCTGCCGCTGGTGTTGCCGACGCTGCAGGTCGCCGGACGGCTCGCGGGCACGGTGCTCGGCACCACCAAGATGGG
CCGGGATCTCGCCGAGATGATGCGGATACTCGCCGATCTGCCCGAACCGACGGCGTCATCGGCGTTCGCCAGGACATTGC
GCGCAGTGGTCGACTGGCGCGGTCAGGTGGTCACCATGCTCGACCGGTGTTATCTCACCGAATCCGTTCCGGTGCAGCTG
GTTTGGGGCACCCACGATTCGGTGATCCCGGTCAGCCATGCCCGGCTGGCGCACGCGGCGATGCCCGGATCCCGGCTGGA
GGTCTTCGAGGGGGCCGGACACTTCCCCTTCCACGACGATCCGGACCGGTTCGTCGAAATCGTGGAGCGCTTCATCGATT
CGACCGAGCCGGCCAACCACGACCAGGACATCCTGCGCCAGTTGTTGCGGACCGGCCTGAGCGAATCGGCGATCAGCGGG
TCCGTCGACACCCGCGTCGCGGTCCTCGACGCGATGGGCAGCGACGAACGCAGCGCGACCTGA

Upstream 100 bases:

>100_bases
AGAGGACCGGTACCGGGACGGGTTCTCCGACGGCGAGGACCGCAGCTGAACAGACCGCACGCCGCCGGAGTGTTCGCGGC
CCGATGACGAGGTTGGCGAA

Downstream 100 bases:

>100_bases
CCGCCCCGTCACCGCCGAACACGTAGCATCGGCGCATGGCCATCGATGTCCAGGTCTTGCGTGTCTTCACCGATCCTGAC
GGCAACCACGGCAACCCGCT

Product: alpha/beta hydrolase fold protein

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTDRTPNLRPVRDVTPTLHYRTIHGYRRAFRIAGEGPAILLIHGIGDNSTTWNTVQTKLAQRFTVIAPDLLGHGKSDKPR
ADYSVAAYANGMRDLLSVLDIDRVTVVGHSLGGGVAMQFAYQFPQFVDRLILVGAGGVTKDVNIALRVASLPMGSEALAL
LRLPLVLPTLQVAGRLAGTVLGTTKMGRDLAEMMRILADLPEPTASSAFARTLRAVVDWRGQVVTMLDRCYLTESVPVQL
VWGTHDSVIPVSHARLAHAAMPGSRLEVFEGAGHFPFHDDPDRFVEIVERFIDSTEPANHDQDILRQLLRTGLSESAISG
SVDTRVAVLDAMGSDERSAT

Sequences:

>Translated_340_residues
MTDRTPNLRPVRDVTPTLHYRTIHGYRRAFRIAGEGPAILLIHGIGDNSTTWNTVQTKLAQRFTVIAPDLLGHGKSDKPR
ADYSVAAYANGMRDLLSVLDIDRVTVVGHSLGGGVAMQFAYQFPQFVDRLILVGAGGVTKDVNIALRVASLPMGSEALAL
LRLPLVLPTLQVAGRLAGTVLGTTKMGRDLAEMMRILADLPEPTASSAFARTLRAVVDWRGQVVTMLDRCYLTESVPVQL
VWGTHDSVIPVSHARLAHAAMPGSRLEVFEGAGHFPFHDDPDRFVEIVERFIDSTEPANHDQDILRQLLRTGLSESAISG
SVDTRVAVLDAMGSDERSAT
>Mature_339_residues
TDRTPNLRPVRDVTPTLHYRTIHGYRRAFRIAGEGPAILLIHGIGDNSTTWNTVQTKLAQRFTVIAPDLLGHGKSDKPRA
DYSVAAYANGMRDLLSVLDIDRVTVVGHSLGGGVAMQFAYQFPQFVDRLILVGAGGVTKDVNIALRVASLPMGSEALALL
RLPLVLPTLQVAGRLAGTVLGTTKMGRDLAEMMRILADLPEPTASSAFARTLRAVVDWRGQVVTMLDRCYLTESVPVQLV
WGTHDSVIPVSHARLAHAAMPGSRLEVFEGAGHFPFHDDPDRFVEIVERFIDSTEPANHDQDILRQLLRTGLSESAISGS
VDTRVAVLDAMGSDERSAT

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=272, Percent_Identity=23.5294117647059, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI13376164, Length=272, Percent_Identity=23.5294117647059, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI145611434, Length=259, Percent_Identity=25.0965250965251, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI18777795, Length=101, Percent_Identity=34.6534653465347, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI23200008, Length=263, Percent_Identity=27.3764258555133, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI23200012, Length=263, Percent_Identity=27.3764258555133, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI31542303, Length=250, Percent_Identity=24.4, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI50658087, Length=281, Percent_Identity=25.2669039145907, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554012, Length=276, Percent_Identity=22.8260869565217, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI25146278, Length=262, Percent_Identity=27.4809160305344, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32566936, Length=262, Percent_Identity=26.7175572519084, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558492, Length=262, Percent_Identity=26.7175572519084, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586387, Length=293, Percent_Identity=24.2320819112628, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24586391, Length=293, Percent_Identity=24.2320819112628, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24586389, Length=293, Percent_Identity=24.2320819112628, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24586385, Length=276, Percent_Identity=24.2753623188406, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 36962; Mature: 36831

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRTPNLRPVRDVTPTLHYRTIHGYRRAFRIAGEGPAILLIHGIGDNSTTWNTVQTKLA
CCCCCCCCCCHHHCCCCHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCHHHHHHHHH
QRFTVIAPDLLGHGKSDKPRADYSVAAYANGMRDLLSVLDIDRVTVVGHSLGGGVAMQFA
HHHHEECHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
YQFPQFVDRLILVGAGGVTKDVNIALRVASLPMGSEALALLRLPLVLPTLQVAGRLAGTV
HHHHHHHHHHHEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGTTKMGRDLAEMMRILADLPEPTASSAFARTLRAVVDWRGQVVTMLDRCYLTESVPVQL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEE
VWGTHDSVIPVSHARLAHAAMPGSRLEVFEGAGHFPFHDDPDRFVEIVERFIDSTEPANH
EECCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
DQDILRQLLRTGLSESAISGSVDTRVAVLDAMGSDERSAT
HHHHHHHHHHCCCCHHHCCCCCHHHEEEEECCCCCCCCCC
>Mature Secondary Structure 
TDRTPNLRPVRDVTPTLHYRTIHGYRRAFRIAGEGPAILLIHGIGDNSTTWNTVQTKLA
CCCCCCCCCHHHCCCCHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCHHHHHHHHH
QRFTVIAPDLLGHGKSDKPRADYSVAAYANGMRDLLSVLDIDRVTVVGHSLGGGVAMQFA
HHHHEECHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
YQFPQFVDRLILVGAGGVTKDVNIALRVASLPMGSEALALLRLPLVLPTLQVAGRLAGTV
HHHHHHHHHHHEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGTTKMGRDLAEMMRILADLPEPTASSAFARTLRAVVDWRGQVVTMLDRCYLTESVPVQL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEE
VWGTHDSVIPVSHARLAHAAMPGSRLEVFEGAGHFPFHDDPDRFVEIVERFIDSTEPANH
EECCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
DQDILRQLLRTGLSESAISGSVDTRVAVLDAMGSDERSAT
HHHHHHHHHHCCCCHHHCCCCCHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]